Andreas Peschel
@andreaspeschel.bsky.social
Professor of Microbiology at the University of Tübingen, studying Staphylococcus biology and pathogenicity
Congratulations Jodi, have a good start!
November 13, 2025 at 9:22 PM
Congratulations Jodi, have a good start!
S. aureus has an intrinsic rifampicin resistance mechanism! See the recent study by M. Otto's lab with important clinical implications:
Export by a quorum sensing–controlled drug exporter underlies rifampicin’s strong activity against staphylococcal biofilms | www.science.org/doi/10.1126/...
Export by a quorum sensing–controlled drug exporter underlies rifampicin’s strong activity against staphylococcal biofilms | www.science.org/doi/10.1126/...
Export by a quorum sensing–controlled drug exporter underlies rifampicin’s strong activity against staphylococcal biofilms
Rifampicin is more effective against biofilm infections because it targets biofilm-forming mutants that are highly resistant to other antibiotics.
www.science.org
November 10, 2025 at 4:03 PM
S. aureus has an intrinsic rifampicin resistance mechanism! See the recent study by M. Otto's lab with important clinical implications:
Export by a quorum sensing–controlled drug exporter underlies rifampicin’s strong activity against staphylococcal biofilms | www.science.org/doi/10.1126/...
Export by a quorum sensing–controlled drug exporter underlies rifampicin’s strong activity against staphylococcal biofilms | www.science.org/doi/10.1126/...
Reposted by Andreas Peschel
The rise of ‘nightmare bacteria’: antimicrobial resistance in five charts www.nature.com/articles/d41...
The rise of ‘nightmare bacteria’: antimicrobial resistance in five charts
Data reveal how the global challenge to reduce deaths and infections from drug-resistant bacteria is not going according to plan.
www.nature.com
November 6, 2025 at 8:29 AM
The rise of ‘nightmare bacteria’: antimicrobial resistance in five charts www.nature.com/articles/d41...
Reposted by Andreas Peschel
We're just 6 months away from @keystoneSymposia.bsky.social Beyond #Antibiotics : Emerging Strategies Combating #BacterialInfection, May 2026 in Breckenridge! 👉Scholarship and short talk abstract deadlines are Jan 7! 🧐 keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26
Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone Symposia
Join us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!
keysym.us
November 4, 2025 at 2:47 PM
We're just 6 months away from @keystoneSymposia.bsky.social Beyond #Antibiotics : Emerging Strategies Combating #BacterialInfection, May 2026 in Breckenridge! 👉Scholarship and short talk abstract deadlines are Jan 7! 🧐 keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26
Reposted by Andreas Peschel
ournals.asm.org/doi/10.1128/spectrum.02278-25?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Pleased to present our latest work from Doctoral candidate Camryn Bonn. Emergence of S. aureus strains with increased resistance to antimicrobial fatty acids.
Widespread emergence of Staphylococcus aureus with variant FarR regulators and enhanced resistance to antimicrobial fatty acids within clonal complex CC5, CC8, and CC97 strains from human and bovine h...
Staphylococcus aureus is a priority pathogen for the World Health Organization due to its association with
human morbidity, mortality, and acquisition of multiple drug resistance. In addition
to acqui...
ournals.asm.org
November 2, 2025 at 8:44 PM
ournals.asm.org/doi/10.1128/spectrum.02278-25?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Pleased to present our latest work from Doctoral candidate Camryn Bonn. Emergence of S. aureus strains with increased resistance to antimicrobial fatty acids.
Reposted by Andreas Peschel
Our new paper on type VII - showing a role in delaying macrophage death-
The staphylococcal type VII secretion system delays macrophage cell death through modulating multiple cell death pathways https://www.biorxiv.org/content/10.1101/2025.10.30.685513v1
November 1, 2025 at 2:10 PM
Our new paper on type VII - showing a role in delaying macrophage death-
Reposted by Andreas Peschel
🏥 Die geplante #Krankenhausreform gefährdet die infektionsmedizinische Versorgung. In einer gemeinsamen Stellungnahme fordern zahlreiche Fachgesellschaften und Verbände die Wiederaufnahme der Leistungsgruppe „Klinische Infektiologie“, um die Versorgungsqualität und Patientensicherheit zu sichern.
Sinkende Qualität, Gefahr für die Patientensicherheit, steigende Kosten: KHAG gefährdet die infektionsmedizinische Versorgung | Deutsches Zentrum für Infektionsforschung
Am 8. Oktober 2025 hat das Bundeskabinett den Entwurf eines Gesetzes zur Anpassung der Krankenhausreform (KHAG) beschlossen.
www.dzif.de
October 20, 2025 at 12:48 PM
🏥 Die geplante #Krankenhausreform gefährdet die infektionsmedizinische Versorgung. In einer gemeinsamen Stellungnahme fordern zahlreiche Fachgesellschaften und Verbände die Wiederaufnahme der Leistungsgruppe „Klinische Infektiologie“, um die Versorgungsqualität und Patientensicherheit zu sichern.
Reposted by Andreas Peschel
Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...
A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics - Nature Microbiology
The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.
www.nature.com
October 10, 2025 at 1:24 PM
Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...
Reposted by Andreas Peschel
and Staphylococcus story in this paper....
www.microbiologyresearch.org/content/jour...
All dependent on friends in @universityofhull.bsky.social Michelle Rudden, Holly Wilkinson and Matt Hardman & co., & Unilever colleagues Barry Murphy, Jo Hunt & Rob Cornmell & Yorkies @seanmeaden.bsky.social
www.microbiologyresearch.org/content/jour...
All dependent on friends in @universityofhull.bsky.social Michelle Rudden, Holly Wilkinson and Matt Hardman & co., & Unilever colleagues Barry Murphy, Jo Hunt & Rob Cornmell & Yorkies @seanmeaden.bsky.social
High-resolution Staphylococcus profiling reveals intra-species diversity in a single skin niche
The skin microbiome is dominated by a few key genera, among which Staphylococcus is one of the most well characterized. Recent studies have examined the roles of various Staphylococcus species such as...
www.microbiologyresearch.org
October 10, 2025 at 3:08 PM
and Staphylococcus story in this paper....
www.microbiologyresearch.org/content/jour...
All dependent on friends in @universityofhull.bsky.social Michelle Rudden, Holly Wilkinson and Matt Hardman & co., & Unilever colleagues Barry Murphy, Jo Hunt & Rob Cornmell & Yorkies @seanmeaden.bsky.social
www.microbiologyresearch.org/content/jour...
All dependent on friends in @universityofhull.bsky.social Michelle Rudden, Holly Wilkinson and Matt Hardman & co., & Unilever colleagues Barry Murphy, Jo Hunt & Rob Cornmell & Yorkies @seanmeaden.bsky.social
Reposted by Andreas Peschel
DZIF Start-up Fund: Support for spin-offs in infection research with mentoring + up to €500K funding. Focus: preventive & therapeutic anti-infectives. Apply by Nov 30, 2025!
More info ➡️
More info ➡️
The German Center for Infection Research establishes a new funding initiative | German Center for Infection Research
The German Center for Infection Research (DZIF) is launching the DZIF Start-up Fund, a new funding initiative to support spin-offs in translational infection research.
buff.ly
October 9, 2025 at 5:01 AM
DZIF Start-up Fund: Support for spin-offs in infection research with mentoring + up to €500K funding. Focus: preventive & therapeutic anti-infectives. Apply by Nov 30, 2025!
More info ➡️
More info ➡️
Reposted by Andreas Peschel
Check it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social
The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model https://www.biorxiv.org/content/10.1101/2025.10.04.680436v1
October 5, 2025 at 8:11 AM
Check it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social
Reposted by Andreas Peschel
Happy to share this new article online at #mSphere journals.asm.org/doi/10.1128/...
Human nasal organoids (HNOs) are a new model system for studying bacterial colonization and interspecies interactions. A big congratulations to the whole team, especially co-first authors: Andrea Boyd and Leah Kafer
Human nasal organoids (HNOs) are a new model system for studying bacterial colonization and interspecies interactions. A big congratulations to the whole team, especially co-first authors: Andrea Boyd and Leah Kafer
Nasal microbionts differentially colonize and elicit cytokines in human nasal epithelial organoids | mSphere
Human nasal microbiota often includes highly pathogenic members, many of which are
antimicrobial resistance threats, e.g., methicillin-resistant Staphylococcus aureus and drug-resistant Streptococcus ...
journals.asm.org
October 1, 2025 at 5:29 PM
Happy to share this new article online at #mSphere journals.asm.org/doi/10.1128/...
Human nasal organoids (HNOs) are a new model system for studying bacterial colonization and interspecies interactions. A big congratulations to the whole team, especially co-first authors: Andrea Boyd and Leah Kafer
Human nasal organoids (HNOs) are a new model system for studying bacterial colonization and interspecies interactions. A big congratulations to the whole team, especially co-first authors: Andrea Boyd and Leah Kafer
Reposted by Andreas Peschel
#ResearchCareers: Just finishing your #PhD and wondering if the DFG’s Walter Benjamin Programme is a #funding option for your next step in academia? Come and find out in our digital info talk on 14 October. No registration, the meeting link will be published here:
➡️ www.dfg.de/en/research-...
➡️ www.dfg.de/en/research-...
October 2, 2025 at 10:23 AM
#ResearchCareers: Just finishing your #PhD and wondering if the DFG’s Walter Benjamin Programme is a #funding option for your next step in academia? Come and find out in our digital info talk on 14 October. No registration, the meeting link will be published here:
➡️ www.dfg.de/en/research-...
➡️ www.dfg.de/en/research-...
Reposted by Andreas Peschel
Our work deciphering the substrate preferences of a di-/tripeptide transporter from S. aureus is now available as a proof at @plos.org Pathogens! Big thanks to the reviewers and to all the brilliant co-authors, particularly Callum who helped get those last few crucial experiments across the line
Defined roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages
Author summary The environments where bacterial pathogens thrive are often rich in proteins and their degradation products, including oligopeptides, which can be taken up by the bacterium and used as ...
journals.plos.org
September 30, 2025 at 7:30 AM
Our work deciphering the substrate preferences of a di-/tripeptide transporter from S. aureus is now available as a proof at @plos.org Pathogens! Big thanks to the reviewers and to all the brilliant co-authors, particularly Callum who helped get those last few crucial experiments across the line
Congratulations @lisamaierlab.bsky.social and Anne, much deserved. You are also such an asset for @cmfi.bsky.social and @dzif.bsky.social
Research prizes for our lab: Anne has been awarded the DZIF Doctoral Award of the DGHM, and Lisa has received the DGHM Main Award. A wonderful recognition of the creativity, curiosity, and persistence of the entire team! www.dghm.org/dghm-preisve...
September 27, 2025 at 6:13 AM
Congratulations @lisamaierlab.bsky.social and Anne, much deserved. You are also such an asset for @cmfi.bsky.social and @dzif.bsky.social
Reposted by Andreas Peschel
CDC reports that the 'nightmare bacteria' with the NDM gene infections rose ~ 70% from 2019–2023 & is resistant to almost all antibiotics.
At GARDP, Shionogi’s approved antibiotic cefiderocol & Bugworks’ BWC0977, now in clinical development, show activity against it.
🔗Read: bit.ly/4pFG05H
At GARDP, Shionogi’s approved antibiotic cefiderocol & Bugworks’ BWC0977, now in clinical development, show activity against it.
🔗Read: bit.ly/4pFG05H
‘Nightmare bacteria’ cases are increasing in the U.S.
It’s likely that many people are unrecognized carriers of the drug-resistant bacteria, which could lead to community spread, CDC scientists said.
bit.ly
September 26, 2025 at 6:00 AM
CDC reports that the 'nightmare bacteria' with the NDM gene infections rose ~ 70% from 2019–2023 & is resistant to almost all antibiotics.
At GARDP, Shionogi’s approved antibiotic cefiderocol & Bugworks’ BWC0977, now in clinical development, show activity against it.
🔗Read: bit.ly/4pFG05H
At GARDP, Shionogi’s approved antibiotic cefiderocol & Bugworks’ BWC0977, now in clinical development, show activity against it.
🔗Read: bit.ly/4pFG05H
Reposted by Andreas Peschel
Fascinating study delineating plasmid evolution during the last 100 years.
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
Thread 1/n
September 26, 2025 at 6:11 AM
Fascinating study delineating plasmid evolution during the last 100 years.
Reposted by Andreas Peschel
Latest from Lizzie Ledger in the lab…. Very cool story demonstrating the cross reactivity of a single AMR mechanism to confer resistance/tolerance to two distinct classes of antibiotics.
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Expression of mecA increases daptomycin tolerance in Staphylococcus aureus | mBio
The incidence of Staphylococcus aureus bacteremia is on a steady incline in many parts of the world. Given the associated
mortality rates have changed little in the last 10 years, this is a major heal...
journals.asm.org
September 22, 2025 at 12:08 PM
Latest from Lizzie Ledger in the lab…. Very cool story demonstrating the cross reactivity of a single AMR mechanism to confer resistance/tolerance to two distinct classes of antibiotics.
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Andreas Peschel
#NewResearch
Nasal colonisation by S. aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain
#MicroSky #Depression
www.nature.com/articles/s41...
Nasal colonisation by S. aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain
#MicroSky #Depression
www.nature.com/articles/s41...
Nasal Staphylococcus aureus carriage promotes depressive behaviour in mice via sex hormone degradation - Nature Microbiology
Nasal colonization by Staphylococcus aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain.
www.nature.com
September 22, 2025 at 3:27 PM
#NewResearch
Nasal colonisation by S. aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain
#MicroSky #Depression
www.nature.com/articles/s41...
Nasal colonisation by S. aureus is linked with depression in a human cohort and shown in a mouse model to cause decreased serotonin and dopamine in the brain
#MicroSky #Depression
www.nature.com/articles/s41...
Reposted by Andreas Peschel
How much of selection in human microbiomes is driven by phage?
Excited to share our latest, led by A. Delphine Tripp, showing a case where phage is just not that important:
Phage-mediated lysis does not determine Cutibacterium acnes colonization on human skin
www.biorxiv.org/content/10.1...
🧵
Excited to share our latest, led by A. Delphine Tripp, showing a case where phage is just not that important:
Phage-mediated lysis does not determine Cutibacterium acnes colonization on human skin
www.biorxiv.org/content/10.1...
🧵
Phage-mediated lysis does not determine Cutibacterium acnes colonization on human skin
Despite Cutibacterium acnes being the most abundant and prevalent bacteria on human skin, only a single type of phage has been identified that infects this host. Here, we leverage this one-to-one syst...
www.biorxiv.org
September 22, 2025 at 5:57 PM
How much of selection in human microbiomes is driven by phage?
Excited to share our latest, led by A. Delphine Tripp, showing a case where phage is just not that important:
Phage-mediated lysis does not determine Cutibacterium acnes colonization on human skin
www.biorxiv.org/content/10.1...
🧵
Excited to share our latest, led by A. Delphine Tripp, showing a case where phage is just not that important:
Phage-mediated lysis does not determine Cutibacterium acnes colonization on human skin
www.biorxiv.org/content/10.1...
🧵
Reposted by Andreas Peschel
CRISPR-Cas9 enables efficient genome engineering of the strictly lytic, broad-host-range staphylococcal bacteriophage K | Applied and Environmental Microbiology journals.asm.org/doi/10.1128/...
CRISPR-Cas9 enables efficient genome engineering of the strictly lytic, broad-host-range staphylococcal bacteriophage K | Applied and Environmental Microbiology
Phage engineering, the process of modifying bacteriophages to enhance or customize
their properties, offers significant potential for advancing precision antimicrobial
therapies and diagnostics. While...
journals.asm.org
September 22, 2025 at 10:18 AM
CRISPR-Cas9 enables efficient genome engineering of the strictly lytic, broad-host-range staphylococcal bacteriophage K | Applied and Environmental Microbiology journals.asm.org/doi/10.1128/...
Reposted by Andreas Peschel
📃 New paper alert!
The Zychlinsky Lab and @raunser-lab.bsky.social identified the first protein that converts chromatin into an immune effector: Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Now published in @nature.com:
www.nature.com/articles/s41...
The Zychlinsky Lab and @raunser-lab.bsky.social identified the first protein that converts chromatin into an immune effector: Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Now published in @nature.com:
www.nature.com/articles/s41...
Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature
Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.
www.nature.com
September 19, 2025 at 7:16 AM
📃 New paper alert!
The Zychlinsky Lab and @raunser-lab.bsky.social identified the first protein that converts chromatin into an immune effector: Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Now published in @nature.com:
www.nature.com/articles/s41...
The Zychlinsky Lab and @raunser-lab.bsky.social identified the first protein that converts chromatin into an immune effector: Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Now published in @nature.com:
www.nature.com/articles/s41...
Reposted by Andreas Peschel
Dynamic visualization of extracellular matrix components in S. aureus colony biofilms reveals functional amyloids leading to the formation of cap-like structures
@biofilmjournal.bsky.social from Agneta Richter-Dahlfors
www.sciencedirect.com/science/arti...
@biofilmjournal.bsky.social from Agneta Richter-Dahlfors
www.sciencedirect.com/science/arti...
Dynamic visualization of extracellular matrix components in S. aureus colony biofilms reveals functional amyloids leading to the formation of cap-like structures
Staphylococcus aureus infections represent a clinical challenge due to their propensity to form biofilms and the increasing prevalence of antibiotic r…
www.sciencedirect.com
September 19, 2025 at 11:23 AM
Dynamic visualization of extracellular matrix components in S. aureus colony biofilms reveals functional amyloids leading to the formation of cap-like structures
@biofilmjournal.bsky.social from Agneta Richter-Dahlfors
www.sciencedirect.com/science/arti...
@biofilmjournal.bsky.social from Agneta Richter-Dahlfors
www.sciencedirect.com/science/arti...
Reposted by Andreas Peschel
Microgeography of staphyloccoci in human tissue explains antibiotic failure https://www.biorxiv.org/content/10.1101/2025.09.12.675782v1
September 13, 2025 at 6:15 AM
Congratulations @kengmo.bsky.social !
Grateful to the DFG for funding our project on how Staphylococcus aureus reprograms host lipids in the context of infection and inflammation. Thanks to @andreaspeschel.bsky.social @cmfi.bsky.social and everyone supporting us!
September 11, 2025 at 9:36 AM
Congratulations @kengmo.bsky.social !