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cmfi.bsky.social
Cluster of Excellence CMFI
@cmfi.bsky.social
460 followers 390 following 59 posts
“Controlling Microbes to Fight Infections” (CMFI) researchers from different disciplines elucidate the mechanisms of interaction between beneficial and harmful bacteria and the host.
– University of Tübingen, funded by the German Research Foundation (DFG)
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Reposted by Cluster of Excellence CMFI
func-metabo-lab.bsky.social
This was a large interdisciplinary effort together with the groups of Heike Brötz-Oesterhelt within the @cmfi.bsky.social Tübingen, and @mingxunwang.bsky.social at @ucriverside.bsky.social.
October 26, 2025 at 9:29 PM
Reposted by Cluster of Excellence CMFI
andreaspeschel.bsky.social
How do keratinocytes sense bacterial commensals or pathogens?
@cmfi.bsky.social
Here is our recent review:
www.sciencedirect.com/science/arti...
Role of Formyl Peptide Receptor 2 and Toll-Like Receptor 2 in Skin Barrier Function and Atopic Dermatitis
The skin acts as a barrier against external threats and plays an important role in tissue repair. Skin cells, including keratinocytes, sense microbe-a…
www.sciencedirect.com
August 25, 2025 at 7:38 AM
Reposted by Cluster of Excellence CMFI
health-europe-de.bsky.social
#Antibiotika stören das #Mikrobiom im #Darm und ebnen so den Weg für Erkrankungen. Das gilt allerdings auch für viele Nicht-Antibiotika, zeigt eine neue Studie von @ghammeranne.bsky.social und @jdlcz.bsky.social ‪vom @lisamaierlab.bsky.social am @cmfi.bsky.social ‪der @unituebingen.bsky.social‬.
Studie: Nicht nur Antibiotika stören das Darm-Mikrobiom
Studie unter Leitung der Universität Tübingen: Viele Nicht-Antibiotika schwächen die natürliche Schutzfunktion des Darms, sodass sich krankmachende Bakterien leichter dort ansiedeln können
healthcare-in-europe.com
July 28, 2025 at 6:37 AM
Reposted by Cluster of Excellence CMFI
selimlab.bsky.social
A new doctor is born 😊🥳
Welcome with me Dr. Haffner, the first PhD student of the group after wonderful years @cmfi.bsky.social

Michael published 8 articles & a review with 3 as 1st author..
www.science.org/doi/10.1126/...

www.pnas.org/doi/10.1073/...
July 28, 2025 at 9:18 AM
Reposted by Cluster of Excellence CMFI
daniel-petras.bsky.social
New paper from the group. Together with Chambers Hughes, Giovanni Vitale and our amazing collaborators, we developed a multiplexed chemical metabolomics workflow to assign functional groups in non-targeted LC-MS/MS data:

www.nature.com/articles/s41...

Behind the paper story:
go.nature.com/45ljV4d
Enhancing tandem mass spectrometry-based metabolite annotation with online chemical labeling - Nature Communications
To improve annotation in non-targeted metabolomics studies, authors develop a Multiplexed Chemical Metabolomics (MCheM) platform, combining post-column derivatization with integrated data processing. ...
www.nature.com
July 27, 2025 at 6:33 PM
Reposted by Cluster of Excellence CMFI
plosbiology.org
How are bacterial transport machineries regulated by external cues? @brochadolab.bsky.social &co identify environmental chemicals that regulate #transporter transcription, identifying the TF Rob as a key modulator of #EffluxPump expression in #Ecoli #AMR @plosbiology.org 🧪 plos.io/46pUM9Q
Left: Compound-promoter interaction network. Fifty-three significant compound-promoter interactions are shown as edges in a Sankey diagram connecting the compounds (left, source nodes) to the promoters (right, target nodes). Edge thickness represents mean Z-scores (n = 8), while node size represents the total number of interactions. Right: Proposed model for the molecular mechanism of caffeine-ciprofloxacin antagonism. Caffeine triggers expression of MicF small RNA in a Rob-dependent manner, which then binds to the 5′-UTR of ompF mRNA to inhibit and decrease OmpF protein levels. This ultimately prevents ciprofloxacin from entering the cell, resulting in caffeine-ciprofloxacin antagonism
July 23, 2025 at 9:20 AM
cmfi.bsky.social
Study finds #caffeine can weaken effectiveness of certain #antibiotics

Substances from natural environment can trigger bacteria's alert systems – implications for future therapeutic approaches?

Read the press release here: www.cmfi.uni-tuebingen.de/en/news-even...

@unituebingen.bsky.social
Scientist Ana Rita Brochado and her lab team member Laura Sniegula look at data from the pipetting robot. With this laboratory tool the team investigated the effect of 94 different substances – including antibiotics, prescription drugs, and food ingredients – on the bacterium E. coli, a potential pathogen. © Leon Kokkoliadis/CMFI, University of Tübingen
July 24, 2025 at 3:36 PM
Reposted by Cluster of Excellence CMFI
jdlcz.bsky.social
It's finally out!🎉

We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠

So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...
www.nature.com
July 16, 2025 at 3:04 PM
Reposted by Cluster of Excellence CMFI
ghammeranne.bsky.social
Seeing this published is even better than eating sweets! I am so happy and proud of whole @lisamaierlab.bsky.social, especially Lisa and @jdlcz.bsky.social who walked the funny/exciting/rocky road with me until the very end. Check it out!
#science #microbiome #health

www.nature.com/articles/s41...
Non-antibiotics disrupt colonization resistance against enteropathogens - Nature
Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of such drugs.
www.nature.com
July 17, 2025 at 9:06 AM
cmfi.bsky.social
Unexpected side-effect: how common medications clear the way for pathogens

CMFI's @lisamaierlab.bsky.social @unituebingen.bsky.social show in @nature.com: many non-antibiotics weaken the natural protective function of the intestine.

Press release: www.cmfi.uni-tuebingen.de/en/news-even...
Scanning electron microscopy image of a gut bacterial community (1:1.000.000). These interacting microorganisms form an ecosystem that is vital to human health. Medications can severely disrupt this fragile balance – they eliminate beneficial bacteria and thereby promote the growth of harmful species. Image produced by the Maier Lab (Lisa Maier, Anne Grießhammer, Leonardo Boldt) together with the Tübingen Structural Microscopy Core Facility (Michaela Wilsch-Bräuninger, Stefan Fischer); Colouring: Elke Neudert.
July 17, 2025 at 8:13 PM
Reposted by Cluster of Excellence CMFI
jdlcz.bsky.social
This is work of many years and many wonderful people! 🧑‍🔬

Led by Anne Grießhammer @ghammeranne.bsky.social and me at the Maier lab @lisamaierlab.bsky.social in Tübingen @cmfi.bsky.social. Read the TL;DR and how the project and Lisa's lab grew hand in hand here: go.nature.com/3Ix8lu3
Research Communities by Springer Nature
Research Communities by Springer Nature provide a forum for all those interested in research to share the latest discoveries, news, and opinions.
go.nature.com
July 16, 2025 at 3:04 PM
cmfi.bsky.social
🚨 Naming Challenge:
Help redefine the #glycopeptide family!

🏆Submit your idea & win 500 € + authorship credit

Let’s rethink antibiotic classification—together!

🧬 Deadline: Sept 15, 2025

👉 docs.google.com/forms/d/e/1F...

@nadineziemert.bsky.social #NameChallenge #NaturalProducts #Antibiotics
June 30, 2025 at 7:42 AM
cmfi.bsky.social
𝗠𝗶𝗰𝗿𝗼𝗯𝗲𝘀: 𝗞𝗲𝘆 𝗽𝗹𝗮𝘆𝗲𝗿𝘀 𝗶𝗻 𝗵𝘂𝗺𝗮𝗻 𝗵𝗲𝗮𝗹𝘁𝗵

The human microbiome—comprising trillions of microorganisms—interacts closely with our immune, metabolic, and nervous systems. It influences directly our health.

On #WorldMicrobiomeDay, we celebrate the science that shows how much Microbes Matter.
June 27, 2025 at 4:57 AM
Reposted by Cluster of Excellence CMFI
lisamaierlab.bsky.social
Big thanks to scientific writer Libera Lo Presti for this great little piece on our recent work exploring how proton pump inhibitors (PPIs) and pH affect human gut microbes.
Check it out here: go.nature.com/4lf6jNk
The pill that might be relieving your heartburn but killing your gut microbes
Why drugs commonly used against heartburn harm your gut microbiome
go.nature.com
June 19, 2025 at 9:10 PM
Reposted by Cluster of Excellence CMFI
unituebingen.bsky.social
Die @unituebingen feiert Erfolg im Exzellencluster-Wettbewerb 🎉Freude und Jubel bei der Pressekonferenz zur Entscheidung der DFG am 22.05.25 mit gut 200 Gästen. Weitere Infos und Fotos gibt es online 👉 uni-tuebingen.de/universitaet... @cmfi.bsky.social @ml4science.bsky.social
May 26, 2025 at 9:55 AM
Reposted by Cluster of Excellence CMFI
unituebingen.bsky.social
Die Universität Tübingen erhält sechs #Exzellenzcluster, die im Rahmen der #Exzellenzstrategie vom 01.01.2026 an sieben Jahre lang gefördert werden! Darunter drei Cluster, die bereits etabliert sind und eine erneute Förderung erhalten. uni-tuebingen.de/universitaet... #ExStra #Forschung #UniTübingen
Das Bild zeigt einen Brunnen vor der Neuen Aula. Darunter der Text: Sechs Exzellenzcluster werden in Tübingen gefördert.
May 22, 2025 at 5:13 PM
Reposted by Cluster of Excellence CMFI
nadineziemert.bsky.social
We were gathering together this evening to hear the announcement of the new clusters of excellence by the German research foundation. So happy to hear that @cmfi.bsky.social gets another round! Love the Team! #naturalproducts #fightinfections #secmet
May 22, 2025 at 8:50 PM
Reposted by Cluster of Excellence CMFI
andreaspeschel.bsky.social
Yeah! 7 more years for @cmfi.bsky.social
So many people to thank... We are a fantastic team!
May 22, 2025 at 4:40 PM
cmfi.bsky.social
🎉 Fantastic News 🎉

Our CMFI Cluster of Excellence @unituebingen.bsky.social receives funding extension for the next seven years.

Spokesperson Andreas Peschel @andreaspeschel.bsky.social: "We can now advance our research into resistance mechanisms and new antimicrobial agents!"

shorturl.at/rcK1A
CMFI Enters Second Funding Period | CMFI News
The members of CMFI can breathe a sigh of relief: On January 1, 2026, the Tübingen Cluster of Excellence will enter its second funding period with a duration of seven years. This was announced by the ...
www.cmfi.uni-tuebingen.de
May 22, 2025 at 3:37 PM
Reposted by Cluster of Excellence CMFI
bossdorf.bsky.social
After her excellent PhD defense, Maryam Mahmoudi goes on a ride with her supervisor Eric Kemen. Check out her work about temp variation in plant microbiota: doi.org/10.1093/isme... doi.org/10.1128/mbio...
More to come soon!
@zmbp-tuebingen.bsky.social
@cmfi.bsky.social
@unituebingen.bsky.social
May 8, 2025 at 11:54 AM
Reposted by Cluster of Excellence CMFI
andreaspeschel.bsky.social
Join us in Tubingen as a Junior Research Group Leader if you do research on #ESKAPE pathogens and infections and are interested in the highly cooperative environment of @dzif.bsky.social‬ and @cmfi.bsky.social ! Please send your application or forward to colleagues!
uni-tuebingen.de/universitaet...
May 19, 2025 at 9:18 AM
Reposted by Cluster of Excellence CMFI
simonheilbronner.bsky.social
I am happy to share our latest preprint, spearheaded by Laura Camus. We show that tyrosin-dependent interactions can foster integration of S. aureus into the nasal microbiome. @cmfi.bsky.social @lmumuenchen.bsky.social
www.biorxiv.org/content/10.1...
May 7, 2025 at 11:16 AM
Reposted by Cluster of Excellence CMFI
lisamaierlab.bsky.social
Here are our ideas on developing tools and technologies for anaerobic bacteria! We hope you enjoy the read as much as we enjoyed brainstorming on the topic...
April 30, 2025 at 6:53 AM
cmfi.bsky.social
#Podcast Release!

🎙️Folge 4: 𝗗𝗮𝘀 𝗠𝗮𝗹𝗶𝗴𝗻𝗼𝗺 𝘂𝗻𝗱 𝗱𝗮𝘀 𝗠𝗶𝗸𝗿𝗼𝗯𝗶𝗼𝗺

🦠Wirkt sich das Mikrobiom auf die Krebsentstehung aus?

🧪🚨Ja, sagt Christoph Stein-Thoeringer. Ziel seiner Forschung sind personalisierte Medikamente gegen Darmkrebs oder Bauchspeicheldrüsenkrebs.

open.spotify.com/episode/62hK...
Folge 4: Das Malignom und das Mikrobiom
Inside CMFI: Potenziale der Mikrobiomforschung · Episode
open.spotify.com
April 17, 2025 at 10:48 AM
cmfi.bsky.social
🔬 New pathoblocker is to stop Salmonella infections early on

Possible alternative treatment method for infections with antibiotic-resistant germs.

📖 Study: tinyurl.com/2s3u4hwj

#Pathoblocker #Salmonella #Pathogenicity #AMR @dzif.bsky.social @unituebingen.bsky.social @mpi-bio-fml.bsky.social
Cut through a protein: Look inside the HilD Regulator and the binding site for the pathoblocker. The discovered substance C26 (blue) bound to the HilD regulator and acting as pathoblocker. In addition, the HilD AlphaFold predicted structure is depicted (black). Model by Thales Kronenberger. 3D visualization created by Leon Kokkoliadis/CMFI, University of Tübingen. © Leon Kokkoliadis, CC-BY-ND A detailed view of the interior of a protein. The identified pathoblocker C26 (blue) has been shown to bind to the HilD-Regulator. The figure also illustrates the protein structure as predicted by AlphaFold (black). Model by Thales Kronenberger. 3D visualization created by Leon Kokkoliadis/CMFI, University of Tübingen. © Leon Kokkoliadis, CC-BY-ND
April 14, 2025 at 11:29 AM