Jacobo de la Cuesta-Zuluaga
jdlcz.bsky.social
Jacobo de la Cuesta-Zuluaga
@jdlcz.bsky.social
Microbiome 🦠 data science 📈 computational biology 💻 and other crazy stuff at the amazing Maier Lab in Tübingen. He/Him.
Pinned
It's finally out!🎉

We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠

So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...
www.nature.com
Reposted by Jacobo de la Cuesta-Zuluaga
We’re hiring 2 Postdocs (f/m/d) in Drug–Microbiome–Host Interactions 🦠💊

Focus: how non-antibiotic drugs shape the gut microbiome, drug efficacy & side effects.

#PostdocJobs #Microbiome #AcademicJobs

Full job ad:
lisamaierlab.com/wp-content/u...
lisamaierlab.com
December 22, 2025 at 2:08 PM
Reposted by Jacobo de la Cuesta-Zuluaga
🎓If you are truly curious about the epigenetic mechanisms driving adaptive evolution. Here is your chance to join Thanvi's team as a PhD Student and study plant altitude adaptation through epigenetic genome regulation.

www.sciencedirect.com/science/arti...
December 16, 2025 at 8:25 AM
Reposted by Jacobo de la Cuesta-Zuluaga
✨Call open for a fully-funded PhD position✨
Looking for an enthusiastic student to join my upcoming Ambizione research group (🌱 Epigenome Diversity Lab 🌱, www.epidiversitylab.org) at ETH Zürich, starting August 2026! Apply here ↘️
jobs.ethz.ch/job/view/JOP...
Application deadline: January 31st, 2026
PhD position to study epigenomic diversity and altitude adaptation in Arabis alpina
jobs.ethz.ch
December 15, 2025 at 5:35 PM
Reposted by Jacobo de la Cuesta-Zuluaga
Really cool story from @lisamaierlab.bsky.social!
We are happy that @luuuprz.bsky.social (PhD student in our lab) contributed a small part.
New paper from the lab!
Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides.
A neat twist on drug–microbe interactions... www.tandfonline.com/doi/full/10....
December 11, 2025 at 8:41 PM
Reposted by Jacobo de la Cuesta-Zuluaga
New paper from the lab!
Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides.
A neat twist on drug–microbe interactions... www.tandfonline.com/doi/full/10....
December 9, 2025 at 10:33 AM
Reposted by Jacobo de la Cuesta-Zuluaga
My new Emmy Noether Group is recruiting!

🔬 Two PhD positions in plant pathogen evolution

🧬 Start: April 2026 (flexible)

📍 Dept. of Phytopathology & Plant Protection @rstam.bsky.social @uni-kiel.de

⏰ Apply by 15 Dec 2025

🔗 More info: www.uni-kiel.de/personal/de/...

Do get in touch or share 😊
Aktuelle Ausschreibungen
Aktuelle Ausschreibungen
www.uni-kiel.de
November 3, 2025 at 9:03 AM
Reposted by Jacobo de la Cuesta-Zuluaga
Research prizes for our lab: Anne has been awarded the DZIF Doctoral Award of the DGHM, and Lisa has received the DGHM Main Award. A wonderful recognition of the creativity, curiosity, and persistence of the entire team! www.dghm.org/dghm-preisve...
September 26, 2025 at 3:19 PM
Reposted by Jacobo de la Cuesta-Zuluaga
We're very happy to release our new database Metalog metalog.embl.de ! It offers manually curated and harmonised contextual data for 110k metagenomics samples across the globe, incl. precomputed taxonomic profiles, for interactive browsing and for download 🧵 1/7

#microsky
Metalog
Metalog is a repository of manually annotated metadata (or contextual data) for metagenomic sequencing data from across the globe.
metalog.embl.de
August 15, 2025 at 8:07 AM
Reposted by Jacobo de la Cuesta-Zuluaga
Unexpected side-effect: how common medications clear the way for pathogens

CMFI's @lisamaierlab.bsky.social @unituebingen.bsky.social show in @nature.com: many non-antibiotics weaken the natural protective function of the intestine.

Press release: www.cmfi.uni-tuebingen.de/en/news-even...
July 17, 2025 at 8:13 PM
Reposted by Jacobo de la Cuesta-Zuluaga
Seeing this published is even better than eating sweets! I am so happy and proud of whole @lisamaierlab.bsky.social, especially Lisa and @jdlcz.bsky.social who walked the funny/exciting/rocky road with me until the very end. Check it out!
#science #microbiome #health

www.nature.com/articles/s41...
Non-antibiotics disrupt colonization resistance against enteropathogens - Nature
Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of such drugs.
www.nature.com
July 17, 2025 at 9:06 AM
Reposted by Jacobo de la Cuesta-Zuluaga
The paper is definitely worth a read—and if you're curious for a glimpse behind the scenes of how the story developed, don’t miss this short blog post by Anne and Jacobo.
communities.springernature.com/posts/silent...
Silent influencer: How non-antibiotics tip the microbial balance of the gut microbiome
Some human-targeted drugs can alter gut microbes, creating a favorable environment for pathogens like Salmonella to thrive.
communities.springernature.com
July 16, 2025 at 9:20 PM
Reposted by Jacobo de la Cuesta-Zuluaga
A tremendous team effort that spanned several years, led by two outstanding scientists in our lab: Anne Grießhammer (@ghammeranne.bsky.social) and Jacobo de la Cuesta-Zuluaga (@jdlcz.bsky.social). Huge thanks to everyone who contributed, to @cmfi.bsky.social, & to our superb collaboration partners.
July 16, 2025 at 9:20 PM
Reposted by Jacobo de la Cuesta-Zuluaga
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Non-antibiotics disrupt colonization resistance against enteropathogens
Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...
rdcu.be
July 16, 2025 at 9:20 PM
It's finally out!🎉

We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠

So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...
www.nature.com
July 16, 2025 at 3:04 PM
Reposted by Jacobo de la Cuesta-Zuluaga
Excited to share some key details on our latest research in @natmicrobiol.nature.com reporting intra-cellular accumulation of #PFAS (aka forever chemicals) by certain human gut bacteria. #microsky #mevosky #microbiomesky
www.nature.com/articles/s41...
July 2, 2025 at 2:57 PM
Reposted by Jacobo de la Cuesta-Zuluaga
We asked our current student Elisabeth Limunga some questions about the IBC master programme and her ambitions 🤓 🤩

Application deadline: July 15!

uni-tuebingen.de/ibc

@daadworldwide.bsky.social @unituebingen.bsky.social @pasteur.fr @pasteuredu.bsky.social @steffenbo.bsky.social
June 5, 2025 at 1:39 PM
Reposted by Jacobo de la Cuesta-Zuluaga
I am very excited to share our latest publication on the effect of systemic #endotoxin on intestinal #microbiota spearheaded by the brilliant Sanne Kroon at the Hardt lab @eth-dbiol.bsky.social @ethzurich.bsky.social @naturecomms.bsky.social

👉🏼 rdcu.be/eelLn
Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition
Nature Communications - Acute systemic immune activation may affect gut-luminal colonisation dynamics. Here, the authors show that LPS exposure in mice elevates gut-luminal oxygen species levels,...
rdcu.be
March 23, 2025 at 9:15 AM
What a better chance to read our review on how to counteract the negative effects of antibiotics and human targeted drugs 💊 our #microbiome🦠 if you haven't yet!

www.cell.com/trends/micro...
March 7, 2025 at 12:00 PM
Every time I write the discussion of a microbiome paper
My students trying to write up their microbial ecology data
March 4, 2025 at 9:31 AM
Mechanism to mean everything and nothing at the same time. Do they mean a molecular interaction? A cellular process? An ecological dynamic?
If you could fix one☝🏻 piece of terminology in your field, what would it be?

I’ll go first👇🏻(replying to myself like it’s normal)
December 10, 2024 at 7:59 AM
Reposted by Jacobo de la Cuesta-Zuluaga
In a great collaboration with @typaslab.bsky.social, @lisamaierlab.bsky.social and @biocs.bsky.social found that 24% of the tested human-targeted drugs inhibit the growth of gut commensal bacteria.

"Extensive impact of non-antibiotic drugs on human gut bacteria" (2018) www.nature.com/artic...
Extensive impact of non-antibiotic drugs on human gut bacteria
Nature - Some non-antibiotic drugs have been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. Athanasios Typas and colleagues screened more than...
www.nature.com
December 3, 2024 at 2:00 PM
And if you want to read how we're using these little critters to investigate the effect of #medication 💊 on the #microbiome 🦠and resistance against #pathogens 🧫, check our work (led by @ghammeranne.bsky.social) doi.org/10.1101/2023...
December 2, 2024 at 2:02 PM
Reposted by Jacobo de la Cuesta-Zuluaga
Our short piece highlighting the impressive work by @fatimacpereira.bsky.social on how the Parkinson’s disease drug entacapone disrupts gut microbiome via iron sequestration.
www.nature.com/articles/s41...
November 22, 2024 at 8:14 PM