Jan Homolak
@janhomolak.bsky.social
MD, PhD, postdoc in @lisamaierlab.bsky.social exploring the crosstalk between gut bugs and CNS drugs.
Reposted by Jan Homolak
Unexpected side-effect: how common medications clear the way for pathogens
CMFI's @lisamaierlab.bsky.social @unituebingen.bsky.social show in @nature.com: many non-antibiotics weaken the natural protective function of the intestine.
Press release: www.cmfi.uni-tuebingen.de/en/news-even...
CMFI's @lisamaierlab.bsky.social @unituebingen.bsky.social show in @nature.com: many non-antibiotics weaken the natural protective function of the intestine.
Press release: www.cmfi.uni-tuebingen.de/en/news-even...
July 17, 2025 at 8:13 PM
Unexpected side-effect: how common medications clear the way for pathogens
CMFI's @lisamaierlab.bsky.social @unituebingen.bsky.social show in @nature.com: many non-antibiotics weaken the natural protective function of the intestine.
Press release: www.cmfi.uni-tuebingen.de/en/news-even...
CMFI's @lisamaierlab.bsky.social @unituebingen.bsky.social show in @nature.com: many non-antibiotics weaken the natural protective function of the intestine.
Press release: www.cmfi.uni-tuebingen.de/en/news-even...
Reposted by Jan Homolak
Another fantastic study from @lisamaierlab.bsky.social showing how non-antibiotics impact gut ecosytem. Congratulations @ghammeranne.bsky.social et al.!
Seeing this published is even better than eating sweets! I am so happy and proud of whole @lisamaierlab.bsky.social, especially Lisa and @jdlcz.bsky.social who walked the funny/exciting/rocky road with me until the very end. Check it out!
#science #microbiome #health
www.nature.com/articles/s41...
#science #microbiome #health
www.nature.com/articles/s41...
Non-antibiotics disrupt colonization resistance against enteropathogens - Nature
Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of such drugs.
www.nature.com
July 17, 2025 at 12:23 PM
Another fantastic study from @lisamaierlab.bsky.social showing how non-antibiotics impact gut ecosytem. Congratulations @ghammeranne.bsky.social et al.!
Reposted by Jan Homolak
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Non-antibiotics disrupt colonization resistance against enteropathogens
Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...
rdcu.be
July 16, 2025 at 9:20 PM
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Reposted by Jan Homolak
It's finally out!🎉
We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠
So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...
We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠
So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...
www.nature.com
July 16, 2025 at 3:04 PM
It's finally out!🎉
We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠
So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...
We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠
So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...
Reposted by Jan Homolak
Stephan Kamrad and Tara Davis in the Patil lab at the MRC Toxicology Unit have identified that some drugs and environmental contaminants alter gut bacterial amine metabolism.
Find out more here: buff.ly/5akzsgs
@kiranrpatil.bsky.social @skamrad.bsky.social
Find out more here: buff.ly/5akzsgs
@kiranrpatil.bsky.social @skamrad.bsky.social
June 30, 2025 at 2:05 PM
Stephan Kamrad and Tara Davis in the Patil lab at the MRC Toxicology Unit have identified that some drugs and environmental contaminants alter gut bacterial amine metabolism.
Find out more here: buff.ly/5akzsgs
@kiranrpatil.bsky.social @skamrad.bsky.social
Find out more here: buff.ly/5akzsgs
@kiranrpatil.bsky.social @skamrad.bsky.social
Reposted by Jan Homolak
Gut bacteria to the rescue! 🦠✨
They can shield us from harmful chemicals—and the latest study from Kiran Patil's lab (@kiranrpatil.bsky.social)
uncovers how. We’re proud to have contributed to this exciting work!
#Microbiome #Detox
www.nature.com/articles/s41...
They can shield us from harmful chemicals—and the latest study from Kiran Patil's lab (@kiranrpatil.bsky.social)
uncovers how. We’re proud to have contributed to this exciting work!
#Microbiome #Detox
www.nature.com/articles/s41...
Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology
Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...
www.nature.com
July 1, 2025 at 10:03 AM
Gut bacteria to the rescue! 🦠✨
They can shield us from harmful chemicals—and the latest study from Kiran Patil's lab (@kiranrpatil.bsky.social)
uncovers how. We’re proud to have contributed to this exciting work!
#Microbiome #Detox
www.nature.com/articles/s41...
They can shield us from harmful chemicals—and the latest study from Kiran Patil's lab (@kiranrpatil.bsky.social)
uncovers how. We’re proud to have contributed to this exciting work!
#Microbiome #Detox
www.nature.com/articles/s41...
Reposted by Jan Homolak
🎓 Big milestone for our lab — our very first PhD is finished! Huge congratulations to @ghammeranne.bsky.social for an incredibly impressive piece of work. We are so proud of you and can’t wait to see what you’ll do next. 💫 #PhD #proudPI
April 13, 2025 at 3:06 PM
🎓 Big milestone for our lab — our very first PhD is finished! Huge congratulations to @ghammeranne.bsky.social for an incredibly impressive piece of work. We are so proud of you and can’t wait to see what you’ll do next. 💫 #PhD #proudPI
Reposted by Jan Homolak
What timing! 🎉 Lab member Julia’s first first-author paper got accepted just 8 minutes before her PhD defense started! Huge congrats on a successful PhD and an impressive defense! 🥳📚 #AcademicLife #PhDDefense #TimingIsEverything
June 5, 2025 at 3:50 PM
What timing! 🎉 Lab member Julia’s first first-author paper got accepted just 8 minutes before her PhD defense started! Huge congrats on a successful PhD and an impressive defense! 🥳📚 #AcademicLife #PhDDefense #TimingIsEverything
Reposted by Jan Homolak
Do people in the same household share strains when they have the same species?
How many cells transmit when a strain is shared?
Can strain composition be dynamic when species composition is stable?
We answer these and related questions for the facial skin microbiome in our latest paper.
🧵[1/10]
How many cells transmit when a strain is shared?
Can strain composition be dynamic when species composition is stable?
We answer these and related questions for the facial skin microbiome in our latest paper.
🧵[1/10]
May 1, 2025 at 6:41 PM
Do people in the same household share strains when they have the same species?
How many cells transmit when a strain is shared?
Can strain composition be dynamic when species composition is stable?
We answer these and related questions for the facial skin microbiome in our latest paper.
🧵[1/10]
How many cells transmit when a strain is shared?
Can strain composition be dynamic when species composition is stable?
We answer these and related questions for the facial skin microbiome in our latest paper.
🧵[1/10]
Thanks for sharing @drpaulwicks.bsky.social I think next time we also have to bring cheese! (-:
A novel take on #betterposter at #adpd2025 - turn your preclinical experimentation into an AI generated comic strip! Truly novel scicomms approach from this Croatian team! 🧀
April 5, 2025 at 9:59 PM
Thanks for sharing @drpaulwicks.bsky.social I think next time we also have to bring cheese! (-:
Reposted by Jan Homolak
I am very excited to share our latest publication on the effect of systemic #endotoxin on intestinal #microbiota spearheaded by the brilliant Sanne Kroon at the Hardt lab @eth-dbiol.bsky.social @ethzurich.bsky.social @naturecomms.bsky.social
👉🏼 rdcu.be/eelLn
👉🏼 rdcu.be/eelLn
Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition
Nature Communications - Acute systemic immune activation may affect gut-luminal colonisation dynamics. Here, the authors show that LPS exposure in mice elevates gut-luminal oxygen species levels,...
rdcu.be
March 23, 2025 at 9:15 AM
I am very excited to share our latest publication on the effect of systemic #endotoxin on intestinal #microbiota spearheaded by the brilliant Sanne Kroon at the Hardt lab @eth-dbiol.bsky.social @ethzurich.bsky.social @naturecomms.bsky.social
👉🏼 rdcu.be/eelLn
👉🏼 rdcu.be/eelLn
Reposted by Jan Homolak
Brochado and Maier labs in Germany are looking for a PhD student to study horizontal gene transfer in bacteria. ENDAMR Marie Curie doctoral network (endamr.eu) - an amazing opportunity to work with top scientists in the field all around Europe!
www.cmfi.uni-tuebingen.de/mariecuriephd
www.cmfi.uni-tuebingen.de/mariecuriephd
endamr.eu
February 20, 2025 at 9:15 AM
Brochado and Maier labs in Germany are looking for a PhD student to study horizontal gene transfer in bacteria. ENDAMR Marie Curie doctoral network (endamr.eu) - an amazing opportunity to work with top scientists in the field all around Europe!
www.cmfi.uni-tuebingen.de/mariecuriephd
www.cmfi.uni-tuebingen.de/mariecuriephd
Reposted by Jan Homolak
OUT NOW: SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome
@harriswang.bsky.social & co
www.nature.com/articles/s41...
@harriswang.bsky.social & co
www.nature.com/articles/s41...
SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome - Nature Microbiology
Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.
www.nature.com
February 3, 2025 at 6:23 PM
OUT NOW: SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome
@harriswang.bsky.social & co
www.nature.com/articles/s41...
@harriswang.bsky.social & co
www.nature.com/articles/s41...
Reposted by Jan Homolak
How intriguing and interesting! Here, authors suggest that Microviridae phages, particularly Gokushovirus WZ-2015a, are linked to obesity and food addiction variables in humans from multiple cohorts, with a direct suggested link to serotonin and dopamine metabolism.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Microviridae bacteriophages influence behavioural hallmarks of food addiction via tryptophan and tyrosine signalling pathways - Nature Metabolism
Castells-Nobau et al. provide insight into how bacteriophages in the gut microbiome contribute to regulating food addiction by modulating tryptophan and tyrosine metabolism in the host.
www.nature.com
December 13, 2024 at 5:52 AM
How intriguing and interesting! Here, authors suggest that Microviridae phages, particularly Gokushovirus WZ-2015a, are linked to obesity and food addiction variables in humans from multiple cohorts, with a direct suggested link to serotonin and dopamine metabolism.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Jan Homolak
So at the beginning of my postdoc I struggled to amplify Chlamy genes (easily 75%+ GC) and did pretty much the same comparison and found the same results
DMSO= helps but kills pol processivity
Betaine= Lots of spurious products
1,2-propandiol= processivity retained and usually specific product
DMSO= helps but kills pol processivity
Betaine= Lots of spurious products
1,2-propandiol= processivity retained and usually specific product
RESULTS
Gel order:
Upstream homology arm, downstream homology arm, full length locus with target gene in middle, a not so great detection primer set. Ladders are NEB 1KB Plus. Arms 1kbp. Full locus 2880bp. All amplified in same conditions.
10/n
Gel order:
Upstream homology arm, downstream homology arm, full length locus with target gene in middle, a not so great detection primer set. Ladders are NEB 1KB Plus. Arms 1kbp. Full locus 2880bp. All amplified in same conditions.
10/n
December 12, 2024 at 7:00 AM
So at the beginning of my postdoc I struggled to amplify Chlamy genes (easily 75%+ GC) and did pretty much the same comparison and found the same results
DMSO= helps but kills pol processivity
Betaine= Lots of spurious products
1,2-propandiol= processivity retained and usually specific product
DMSO= helps but kills pol processivity
Betaine= Lots of spurious products
1,2-propandiol= processivity retained and usually specific product
Reposted by Jan Homolak
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Jan Homolak
Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. https://go.nature.com/49of3Mk 🧪
December 7, 2024 at 4:42 PM
Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. https://go.nature.com/49of3Mk 🧪
Reposted by Jan Homolak
Reposted by Jan Homolak
Pulled together this starter pack for Microbiota-Gut-Brain Axis Research.
🧠🦠🥼
Hope it is helpful for the people joining in here and nucleating a community.
May have missed people, please leave a reply and I can then add to the pack.
Cheers.
go.bsky.app/PZhXP7R
🧠🦠🥼
Hope it is helpful for the people joining in here and nucleating a community.
May have missed people, please leave a reply and I can then add to the pack.
Cheers.
go.bsky.app/PZhXP7R
November 22, 2024 at 10:22 PM
Pulled together this starter pack for Microbiota-Gut-Brain Axis Research.
🧠🦠🥼
Hope it is helpful for the people joining in here and nucleating a community.
May have missed people, please leave a reply and I can then add to the pack.
Cheers.
go.bsky.app/PZhXP7R
🧠🦠🥼
Hope it is helpful for the people joining in here and nucleating a community.
May have missed people, please leave a reply and I can then add to the pack.
Cheers.
go.bsky.app/PZhXP7R
Reposted by Jan Homolak
In a great collaboration with @typaslab.bsky.social, @lisamaierlab.bsky.social and @biocs.bsky.social found that 24% of the tested human-targeted drugs inhibit the growth of gut commensal bacteria.
"Extensive impact of non-antibiotic drugs on human gut bacteria" (2018) www.nature.com/artic...
"Extensive impact of non-antibiotic drugs on human gut bacteria" (2018) www.nature.com/artic...
Extensive impact of non-antibiotic drugs on human gut bacteria
Nature - Some non-antibiotic drugs have been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. Athanasios Typas and colleagues screened more than...
www.nature.com
December 3, 2024 at 2:00 PM
In a great collaboration with @typaslab.bsky.social, @lisamaierlab.bsky.social and @biocs.bsky.social found that 24% of the tested human-targeted drugs inhibit the growth of gut commensal bacteria.
"Extensive impact of non-antibiotic drugs on human gut bacteria" (2018) www.nature.com/artic...
"Extensive impact of non-antibiotic drugs on human gut bacteria" (2018) www.nature.com/artic...
Reposted by Jan Homolak
Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...
Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics - Nature Microbiology
Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. This study presents an approach to systematically discover and ...
www.nature.com
December 2, 2024 at 10:33 AM
Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...
Reposted by Jan Homolak
Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!
December 2, 2024 at 12:10 PM
Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!
Reposted by Jan Homolak
Fish brains host microbes- could human brains host them too? I shared my "inherently skeptical", but intrigued, thoughts in this fun article.
Thanks @quantamagazine.bsky.social for this lovely piece on our #brainmicrobiome work on salmonids www.quantamagazine.org/fish-have-a-...
Enjoy!
Enjoy!
Fish Have a Brain Microbiome. Could Humans Have One Too? | Quanta Magazine
The discovery that other vertebrates have healthy, microbial brains is fueling the still controversial possibility that we might have them as well.
www.quantamagazine.org
December 2, 2024 at 8:51 PM
Fish brains host microbes- could human brains host them too? I shared my "inherently skeptical", but intrigued, thoughts in this fun article.
"The cognitive switch between the attention to detail required to do lab work, so that you don’t lose track of whether you added the right reagent to the last of 96 identical wells, and the free-flowing dissociative state needed for creation is nigh on impossible."
www.nature.com/articles/d41...
www.nature.com/articles/d41...
‘That’s funny’: creative solutions for time-starved researchers
An immunologist and his illustrator friend reveal tips and tricks to help scientists to reach peak performance and creativity.
www.nature.com
December 1, 2024 at 1:36 PM
"The cognitive switch between the attention to detail required to do lab work, so that you don’t lose track of whether you added the right reagent to the last of 96 identical wells, and the free-flowing dissociative state needed for creation is nigh on impossible."
www.nature.com/articles/d41...
www.nature.com/articles/d41...