Functional Metabolomics Lab
@func-metabo-lab.bsky.social
www.functional-metabolomics.com
Reposted by Functional Metabolomics Lab
Preprint from our lab and @func-metabo-lab.bsky.social: In synthetic nasal communities a single Corynebacterium propinquum strain can exclude Staphylococcus aureus through nutrient competition. www.biorxiv.org/content/10.6...
Community composition and strain identity drive metabolic competition and Staphylococcus aureus colonization resistance in Synthetic Nasal Communities
The human nasal microbiome is a low-diversity ecosystem whose assembly principles and mechanisms of colonization resistance remain poorly understood. In particular, Staphylococcus aureus colonization ...
www.biorxiv.org
January 12, 2026 at 1:52 PM
Preprint from our lab and @func-metabo-lab.bsky.social: In synthetic nasal communities a single Corynebacterium propinquum strain can exclude Staphylococcus aureus through nutrient competition. www.biorxiv.org/content/10.6...
A huge thank you to Nike and the Forchhammer Lab and to Khaled Selim and all co-authors, especially our Natural-Product-Partner-in-Crime Chambers Hughes for solving the structure of 2’-deoxyxanthopterin B2, and Karoline Steuer-Lodd and the Ansel Hsiao lab for generating the mutants.
November 27, 2025 at 2:18 AM
A huge thank you to Nike and the Forchhammer Lab and to Khaled Selim and all co-authors, especially our Natural-Product-Partner-in-Crime Chambers Hughes for solving the structure of 2’-deoxyxanthopterin B2, and Karoline Steuer-Lodd and the Ansel Hsiao lab for generating the mutants.
Our data show that CutA binds copper more strongly in the presence of pteridines, suggesting that these metabolites act as co-factors that modulate copper binding and redox homeostasis.
November 27, 2025 at 2:17 AM
Our data show that CutA binds copper more strongly in the presence of pteridines, suggesting that these metabolites act as co-factors that modulate copper binding and redox homeostasis.
New paper from our team:
Led by @nike-wagner.bsky.social, we just published our findings on how the metabolite class of pteridines binds to the previously cryptic CutA protein. We used our native metabolomics approach to identify pteridines as ligands of CutA.
www.pnas.org/doi/10.1073/...
Led by @nike-wagner.bsky.social, we just published our findings on how the metabolite class of pteridines binds to the previously cryptic CutA protein. We used our native metabolomics approach to identify pteridines as ligands of CutA.
www.pnas.org/doi/10.1073/...
November 27, 2025 at 2:16 AM
New paper from our team:
Led by @nike-wagner.bsky.social, we just published our findings on how the metabolite class of pteridines binds to the previously cryptic CutA protein. We used our native metabolomics approach to identify pteridines as ligands of CutA.
www.pnas.org/doi/10.1073/...
Led by @nike-wagner.bsky.social, we just published our findings on how the metabolite class of pteridines binds to the previously cryptic CutA protein. We used our native metabolomics approach to identify pteridines as ligands of CutA.
www.pnas.org/doi/10.1073/...
Combining the new tool with the bioluminescent bioreporter strains from Heike Brötz-Oesterhelt and her students Julian Schubert and Leonard Boldt was a key element to achieve the high sensitivity of the bioactivity assays needed for microfractions.
October 26, 2025 at 9:53 PM
Combining the new tool with the bioluminescent bioreporter strains from Heike Brötz-Oesterhelt and her students Julian Schubert and Leonard Boldt was a key element to achieve the high sensitivity of the bioactivity assays needed for microfractions.
Most importantly, the paper wouldn't have been possible without Christian Geibel, who led the project, optimized the method, and pushed the paper over the finish line.
Thanks a lot Christian and everybody else at the University of Tuebingen and UC Riverside who were involved in the project 🧡🧡🧡
Thanks a lot Christian and everybody else at the University of Tuebingen and UC Riverside who were involved in the project 🧡🧡🧡
October 26, 2025 at 9:39 PM
Most importantly, the paper wouldn't have been possible without Christian Geibel, who led the project, optimized the method, and pushed the paper over the finish line.
Thanks a lot Christian and everybody else at the University of Tuebingen and UC Riverside who were involved in the project 🧡🧡🧡
Thanks a lot Christian and everybody else at the University of Tuebingen and UC Riverside who were involved in the project 🧡🧡🧡
Another key component was the analysis software, which Simon Knoblauch, back then a master’s student in our group, built and which, thanks to the help of @mingxunwang.bsky.social, is now available through @gnps2.bsky.social.
October 26, 2025 at 9:32 PM
Another key component was the analysis software, which Simon Knoblauch, back then a master’s student in our group, built and which, thanks to the help of @mingxunwang.bsky.social, is now available through @gnps2.bsky.social.
Its great to see the project in completion after almost four years ago, when Albert Hernandez, a mechanical engineer from UCSD, joined us in Tübingen, and started building the microspotter.
October 26, 2025 at 9:29 PM
Its great to see the project in completion after almost four years ago, when Albert Hernandez, a mechanical engineer from UCSD, joined us in Tübingen, and started building the microspotter.
This was a large interdisciplinary effort together with the groups of Heike Brötz-Oesterhelt within the @cmfi.bsky.social Tübingen, and @mingxunwang.bsky.social at @ucriverside.bsky.social.
October 26, 2025 at 9:29 PM
This was a large interdisciplinary effort together with the groups of Heike Brötz-Oesterhelt within the @cmfi.bsky.social Tübingen, and @mingxunwang.bsky.social at @ucriverside.bsky.social.
Making use of high-speed, low-volume fractionation, we can achieve similar sampling rates for bioactivity measurements as for the mass spec DDA cycles, which enables correlation of LC-MS and LC-bioactivity data and pinpoints individual active metabolites.
www.youtube.com/watch?v=PTC9...
www.youtube.com/watch?v=PTC9...
Microspotter1.0
YouTube video by Functional Metabolomics Lab
www.youtube.com
October 26, 2025 at 9:26 PM
Making use of high-speed, low-volume fractionation, we can achieve similar sampling rates for bioactivity measurements as for the mass spec DDA cycles, which enables correlation of LC-MS and LC-bioactivity data and pinpoints individual active metabolites.
www.youtube.com/watch?v=PTC9...
www.youtube.com/watch?v=PTC9...
We are super excited that our new paper on microfluidic-based LC-MS/MS fractionation in combination with bioluminescence bioreporters readouts, for compound-resolved bioactivity metabolomics, was just published: pubs.acs.org/doi/10.1021/...
October 26, 2025 at 9:24 PM
We are super excited that our new paper on microfluidic-based LC-MS/MS fractionation in combination with bioluminescence bioreporters readouts, for compound-resolved bioactivity metabolomics, was just published: pubs.acs.org/doi/10.1021/...
Reposted by Functional Metabolomics Lab
New paper from the group. Together with Chambers Hughes, Giovanni Vitale and our amazing collaborators, we developed a multiplexed chemical metabolomics workflow to assign functional groups in non-targeted LC-MS/MS data:
www.nature.com/articles/s41...
Behind the paper story:
go.nature.com/45ljV4d
www.nature.com/articles/s41...
Behind the paper story:
go.nature.com/45ljV4d
Enhancing tandem mass spectrometry-based metabolite annotation with online chemical labeling - Nature Communications
To improve annotation in non-targeted metabolomics studies, authors develop a Multiplexed Chemical Metabolomics (MCheM) platform, combining post-column derivatization with integrated data processing. ...
www.nature.com
July 27, 2025 at 6:33 PM
New paper from the group. Together with Chambers Hughes, Giovanni Vitale and our amazing collaborators, we developed a multiplexed chemical metabolomics workflow to assign functional groups in non-targeted LC-MS/MS data:
www.nature.com/articles/s41...
Behind the paper story:
go.nature.com/45ljV4d
www.nature.com/articles/s41...
Behind the paper story:
go.nature.com/45ljV4d
We are super excited to start a new project with support from the Simons Foundation.
We will leverage our metabolomics tools and SynCom models to study how microbes shape the production, transformation, and fate of marine DOM.
Thanks so much @simonsfoundation.org for making this possible!
We will leverage our metabolomics tools and SynCom models to study how microbes shape the production, transformation, and fate of marine DOM.
Thanks so much @simonsfoundation.org for making this possible!
Congratulations to our six new 2025 Simons Early Career Investigators in Aquatic Microbial Ecology and Evolution! See full list: www.simonsfoundation.org/2025/07/01/a... #science @systemsecology.bsky.social @daniel-petras.bsky.social @kendraturkkubo.bsky.social
Announcing the 2025 Simons Early Career Investigators in Aquatic Microbial Ecology and Evolution
The Simons Foundation and Simons Foundation International have named six scientists as 2025 Simons Early Career Investigators in Aquatic Microbial Ecology and Evolution. The two-year awards are intend...
www.simonsfoundation.org
July 4, 2025 at 5:33 PM
We are super excited to start a new project with support from the Simons Foundation.
We will leverage our metabolomics tools and SynCom models to study how microbes shape the production, transformation, and fate of marine DOM.
Thanks so much @simonsfoundation.org for making this possible!
We will leverage our metabolomics tools and SynCom models to study how microbes shape the production, transformation, and fate of marine DOM.
Thanks so much @simonsfoundation.org for making this possible!
If you want to read more about how the changing reef exo-metabolome, driven by invasive red algae, affects kelp survival, you can find the paper here: www.science.org/doi/10.1126/...
Turf algae redefine the chemical landscape of temperate reefs, limiting kelp forest recovery
In temperate regions experiencing rapid ocean warming, kelp forests are being replaced by chemically rich turf algae. However, the extent to which these turf algae alter the surrounding chemical envir...
www.science.org
May 22, 2025 at 11:03 PM
If you want to read more about how the changing reef exo-metabolome, driven by invasive red algae, affects kelp survival, you can find the paper here: www.science.org/doi/10.1126/...
We are pretty stoked that our paper on chemical shifts in kelp forests in the Gulf of Maine made it onto the front cover of @science.org
Big congratulations to Shane Farrell and everybody involved! ✌️✌️✌️
Big congratulations to Shane Farrell and everybody involved! ✌️✌️✌️
Kelp forests on the coast of Maine are in decline owing to rapid ocean warming and are being replaced by turf algae, which alter the ecosystem’s chemistry, hindering the recovery of kelp forests.
Learn more in this week's issue of Science: scim.ag/4dwzl8j
Learn more in this week's issue of Science: scim.ag/4dwzl8j
May 22, 2025 at 11:03 PM
We are pretty stoked that our paper on chemical shifts in kelp forests in the Gulf of Maine made it onto the front cover of @science.org
Big congratulations to Shane Farrell and everybody involved! ✌️✌️✌️
Big congratulations to Shane Farrell and everybody involved! ✌️✌️✌️
Reposted by Functional Metabolomics Lab
Exciting invited talk by Daniel Petras @daniel-petras.bsky.social Functional #Metabolomics Approaches for Understanding Microbial Community Dynamics at the Molecular Level. #ICTC13 @func-metabo-lab.bsky.social
May 7, 2025 at 5:49 AM
Exciting invited talk by Daniel Petras @daniel-petras.bsky.social Functional #Metabolomics Approaches for Understanding Microbial Community Dynamics at the Molecular Level. #ICTC13 @func-metabo-lab.bsky.social
Thanks for the shout-out! Most credits are due to @nike-wagner.bsky.social
April 13, 2025 at 7:44 PM
Thanks for the shout-out! Most credits are due to @nike-wagner.bsky.social
Reposted by Functional Metabolomics Lab
Another success story of native MS. Pteridines, found also in #cyanobacteria, bind to cutA, possibly bridging copper homeostasis and cellular redox regulation.
doi.org/10.1101/2025...
More about functional metabolomics at #ICTC13 from @daniel-petras.bsky.social (Invited speaker).
doi.org/10.1101/2025...
More about functional metabolomics at #ICTC13 from @daniel-petras.bsky.social (Invited speaker).
doi.org
April 13, 2025 at 5:57 PM
Another success story of native MS. Pteridines, found also in #cyanobacteria, bind to cutA, possibly bridging copper homeostasis and cellular redox regulation.
doi.org/10.1101/2025...
More about functional metabolomics at #ICTC13 from @daniel-petras.bsky.social (Invited speaker).
doi.org/10.1101/2025...
More about functional metabolomics at #ICTC13 from @daniel-petras.bsky.social (Invited speaker).
This was a big collaborative effort with multiple groups from
@cmfi.bsky.social (Forchhammer, Selim, Link, Hughes) and @maxplanck.de Tuebingen (Hartmann), from microbiology phenotyping to metabolomics, natural product structure elucidation, and biophysical interaction studies. 🧡
@cmfi.bsky.social (Forchhammer, Selim, Link, Hughes) and @maxplanck.de Tuebingen (Hartmann), from microbiology phenotyping to metabolomics, natural product structure elucidation, and biophysical interaction studies. 🧡
April 4, 2025 at 10:30 PM
This was a big collaborative effort with multiple groups from
@cmfi.bsky.social (Forchhammer, Selim, Link, Hughes) and @maxplanck.de Tuebingen (Hartmann), from microbiology phenotyping to metabolomics, natural product structure elucidation, and biophysical interaction studies. 🧡
@cmfi.bsky.social (Forchhammer, Selim, Link, Hughes) and @maxplanck.de Tuebingen (Hartmann), from microbiology phenotyping to metabolomics, natural product structure elucidation, and biophysical interaction studies. 🧡
We screened cell extracts from the cyanobacterium Synechococcus, for interaction with the homotrimer CutA, which can be found across the tree of life. Our results identified pteridines, to be ligands which enhances CutA copper binding and redox balance.
April 4, 2025 at 10:18 PM
We screened cell extracts from the cyanobacterium Synechococcus, for interaction with the homotrimer CutA, which can be found across the tree of life. Our results identified pteridines, to be ligands which enhances CutA copper binding and redox balance.
New reprint from the team: Lead by @nike-wagner.bsky.social, we used our native metabolomics setup to shed new light onto the function of the CutA protein.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 4, 2025 at 10:17 PM
New reprint from the team: Lead by @nike-wagner.bsky.social, we used our native metabolomics setup to shed new light onto the function of the CutA protein.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
There will be also a remote participation option and all sessions will be recorded.
The recordings from our past summer schools are on youtube and linked on our web page:
www.functional-metabolomics.com/resources
The recordings from our past summer schools are on youtube and linked on our web page:
www.functional-metabolomics.com/resources
Resources
www.functional-metabolomics.com
March 2, 2025 at 1:38 AM
There will be also a remote participation option and all sessions will be recorded.
The recordings from our past summer schools are on youtube and linked on our web page:
www.functional-metabolomics.com/resources
The recordings from our past summer schools are on youtube and linked on our web page:
www.functional-metabolomics.com/resources
Good news: We will have another summer school on non-targeted metabolomics this year! Organized by Martin Hansen and Scott Jarmusch, this year's summer school will be hosted at DTU in Copenhagen from August 18-22, inc. a summer camp style accommodation option at DTU.
Sign up:
tinyurl.com/NTMS2025
Sign up:
tinyurl.com/NTMS2025
March 2, 2025 at 1:38 AM
Good news: We will have another summer school on non-targeted metabolomics this year! Organized by Martin Hansen and Scott Jarmusch, this year's summer school will be hosted at DTU in Copenhagen from August 18-22, inc. a summer camp style accommodation option at DTU.
Sign up:
tinyurl.com/NTMS2025
Sign up:
tinyurl.com/NTMS2025
New preprint from our collaboration with @aliciaperezlorente.bsky.social from Diego Romero's group, who spend some time with us at @cmfi.bsky.social. It's great to see all the puzzle pieces coming together, providing a detailed snapshot of the molecular interplay between Bacillus and and Botrytis.
February 12, 2025 at 1:18 AM
New preprint from our collaboration with @aliciaperezlorente.bsky.social from Diego Romero's group, who spend some time with us at @cmfi.bsky.social. It's great to see all the puzzle pieces coming together, providing a detailed snapshot of the molecular interplay between Bacillus and and Botrytis.
We are very proud that after a long repair/upgrade and moves across continents, our most critical piece of equipment is fully functional again. 💪💪💪
Big thanks to Jorge and Karo for fixing it and for generating the tutorial.
❤️
www.youtube.com/watch?v=Bf43...
Big thanks to Jorge and Karo for fixing it and for generating the tutorial.
❤️
www.youtube.com/watch?v=Bf43...
La Pavoni - Espresso Tutorial
YouTube video by Functional Metabolomics Lab
www.youtube.com
December 17, 2024 at 9:35 PM
We are very proud that after a long repair/upgrade and moves across continents, our most critical piece of equipment is fully functional again. 💪💪💪
Big thanks to Jorge and Karo for fixing it and for generating the tutorial.
❤️
www.youtube.com/watch?v=Bf43...
Big thanks to Jorge and Karo for fixing it and for generating the tutorial.
❤️
www.youtube.com/watch?v=Bf43...