Khaled_Selim Lab
@selimlab.bsky.social
Microbiology | Cell Signaling | Structural Biology | Institute of Phototrophic Microbiology @hhu.de
https://www.phototrophic-microbiology.hhu.de/en/
Central Metabolism Coordination by #PII & #cdiAMP & #cdiGMP & #Ca2+ signaling #Cyanobacteria
https://www.phototrophic-microbiology.hhu.de/en/
Central Metabolism Coordination by #PII & #cdiAMP & #cdiGMP & #Ca2+ signaling #Cyanobacteria
Pinned
Khaled_Selim Lab
@selimlab.bsky.social
· Sep 19
We discovered a new family of c-di-NMP receptors, widespread in bacteria & regulating🦠motility @pnas.org
A great collab. w/ @mygalperin.bsky.social @vikramalva.bsky.social @thethormannden.bsky.social
www.pnas.org/doi/10.1073/...
@hhu.de @cmfi.bsky.social
@sfb1381.bsky.social
@mibinet.bsky.social
A great collab. w/ @mygalperin.bsky.social @vikramalva.bsky.social @thethormannden.bsky.social
www.pnas.org/doi/10.1073/...
@hhu.de @cmfi.bsky.social
@sfb1381.bsky.social
@mibinet.bsky.social
One of the first reviews at our special issue Plant structural biology: insights & technology @theplantjournal.bsky.social
Congrats @doellosofia.bsky.social & @dmitryshvarev.bsky.social
#cyanobacteria
onlinelibrary.wiley.com/doi/10.1111/...
Congrats @doellosofia.bsky.social & @dmitryshvarev.bsky.social
#cyanobacteria
onlinelibrary.wiley.com/doi/10.1111/...
A structural perspective on α‐glucan catabolism in oxygenic phototrophs
Efficient mobilization of carbon storage polymers is essential for the survival of oxygenic phototrophs under fluctuating environmental conditions. Recent structural studies have uncovered the molecu....
onlinelibrary.wiley.com
February 13, 2026 at 9:38 PM
One of the first reviews at our special issue Plant structural biology: insights & technology @theplantjournal.bsky.social
Congrats @doellosofia.bsky.social & @dmitryshvarev.bsky.social
#cyanobacteria
onlinelibrary.wiley.com/doi/10.1111/...
Congrats @doellosofia.bsky.social & @dmitryshvarev.bsky.social
#cyanobacteria
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Khaled_Selim Lab
Stages of biomolecular condensate formation in pro-β-carboxysome assembly www.nature.com/articles/s41...
Stages of biomolecular condensate formation in pro-β-carboxysome assembly - Nature Plants
Carboxysomes are cyanobacterial CO2-concentrating compartments with a proteinaceous shell. The elucidation of the role of the shell adaptor protein ApN in stepwise β-carboxysome assembly will aid the ...
www.nature.com
February 11, 2026 at 8:57 AM
Stages of biomolecular condensate formation in pro-β-carboxysome assembly www.nature.com/articles/s41...
Reposted by Khaled_Selim Lab
Reposted by Khaled_Selim Lab
Long in the making, but happy to present the Chlamydomonas chlororibosome!
Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv 📖: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧵
Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv 📖: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧵
February 10, 2026 at 8:35 AM
Long in the making, but happy to present the Chlamydomonas chlororibosome!
Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv 📖: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧵
Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv 📖: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧵
AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution
By solving a previously unsolved biological question, the AI co-scientist predicted
a complex mechanism of gene transfer and generated hypotheses that opened new research
directions, illustrating AI's...
www.cell.com
February 9, 2026 at 9:57 PM
AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Khaled_Selim Lab
Functional characterisation of bicarbonate transporters from the cyanobacterial SbtA2 family and subsequent expression in tobacco academic.oup.com/jxb/article/... @jxbotany.bsky.social
Functional characterisation of bicarbonate transporters from the cyanobacterial SbtA2 family and subsequent expression in tobacco
Abstract. Cyanobacteria rely on bicarbonate (HCO3-) as the primary inorganic carbon (Ci) source for photosynthesis in aquatic environments. To use this Ci
academic.oup.com
February 6, 2026 at 6:44 PM
Functional characterisation of bicarbonate transporters from the cyanobacterial SbtA2 family and subsequent expression in tobacco academic.oup.com/jxb/article/... @jxbotany.bsky.social
Reposted by Khaled_Selim Lab
Seasonal cycles select for self-sustained circadian oscillators: Current Biology www.cell.com/current-biol...
Seasonal cycles select for self-sustained circadian oscillators
Circadian clocks comprise self-sustained oscillators that anticipate time-of-day changes
in the environment. Dani et al. report that seasonal changes in daylength can alone
provide a strong selective ...
www.cell.com
February 5, 2026 at 9:43 AM
Seasonal cycles select for self-sustained circadian oscillators: Current Biology www.cell.com/current-biol...
Reposted by Khaled_Selim Lab
Happy to announce that our review article on vesicle-coupled mRNA trafficking is now availalbe
@mibinet.bsky.social
#EMBOrnaLocalization
link.springer.com/article/10.1...
@mibinet.bsky.social
#EMBOrnaLocalization
link.springer.com/article/10.1...
February 2, 2026 at 3:56 PM
Happy to announce that our review article on vesicle-coupled mRNA trafficking is now availalbe
@mibinet.bsky.social
#EMBOrnaLocalization
link.springer.com/article/10.1...
@mibinet.bsky.social
#EMBOrnaLocalization
link.springer.com/article/10.1...
Reposted by Khaled_Selim Lab
Our new paper, out today! We resurrected ancient nitrogenases first used by life on Earth 3 billion years ago. We combined synthetic biology and geology & validated their chemical #biosignature in rocks that helps reveal ancient life on Earth!(and beyond!)
Link: www.nature.com/articles/s41...
Link: www.nature.com/articles/s41...
Resurrected nitrogenases recapitulate canonical N-isotope biosignatures over two billion years - Nature Communications
The study shows that nitrogenase enzymes have maintained stable isotope signatures over billions of years, revealing how ancient microbes shaped Earth’s nitrogen cycle and offering a new experimental ...
www.nature.com
January 30, 2026 at 9:12 PM
Our new paper, out today! We resurrected ancient nitrogenases first used by life on Earth 3 billion years ago. We combined synthetic biology and geology & validated their chemical #biosignature in rocks that helps reveal ancient life on Earth!(and beyond!)
Link: www.nature.com/articles/s41...
Link: www.nature.com/articles/s41...
Reposted by Khaled_Selim Lab
Researchers led by Jun.-Prof. Dr. Julie Zedler at #UniJena have developed a sustainable alternative to synthetic food colourings: they have modified cyanobacteria so that they produce yellow natural colourings from light and carbon dioxide alone.
➡️ www.uni-jena.de/en/386595/gel…
➡️ www.uni-jena.de/en/386595/gel…
January 29, 2026 at 4:00 PM
Researchers led by Jun.-Prof. Dr. Julie Zedler at #UniJena have developed a sustainable alternative to synthetic food colourings: they have modified cyanobacteria so that they produce yellow natural colourings from light and carbon dioxide alone.
➡️ www.uni-jena.de/en/386595/gel…
➡️ www.uni-jena.de/en/386595/gel…
Reposted by Khaled_Selim Lab
A prophage-encoded abortive infection protein preserves host and prophage spread www.nature.com/articles/s41...
A prophage-encoded abortive infection protein preserves host and prophage spread - Nature
A Gifsy-1 prophage–encoded higher eukaryotes and prokaryotes nucleotide-binding protein, HepS, senses Siphoviridae infection, activates abortive defence by cleaving host transfer RNAs, blocks rival ph...
www.nature.com
January 28, 2026 at 7:13 PM
A prophage-encoded abortive infection protein preserves host and prophage spread www.nature.com/articles/s41...
Reposted by Khaled_Selim Lab
Formation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells!
Read our paper @cp-cell.bsky.social!
❕Publication: doi.org/10.1016/j.ce...
❕Press Release: www.biochem.mpg.de/en/pressroom
@uoftmedicine.bsky.social
@erc.europa.eu #UPSmeetMet
Read our paper @cp-cell.bsky.social!
❕Publication: doi.org/10.1016/j.ce...
❕Press Release: www.biochem.mpg.de/en/pressroom
@uoftmedicine.bsky.social
@erc.europa.eu #UPSmeetMet
January 28, 2026 at 4:39 PM
Formation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells!
Read our paper @cp-cell.bsky.social!
❕Publication: doi.org/10.1016/j.ce...
❕Press Release: www.biochem.mpg.de/en/pressroom
@uoftmedicine.bsky.social
@erc.europa.eu #UPSmeetMet
Read our paper @cp-cell.bsky.social!
❕Publication: doi.org/10.1016/j.ce...
❕Press Release: www.biochem.mpg.de/en/pressroom
@uoftmedicine.bsky.social
@erc.europa.eu #UPSmeetMet
Reposted by Khaled_Selim Lab
We are looking for new editors for Microbiology, the flagship journal of @microbiologysociety.org
Deadline for applications is 16 Feb 2026
microbiologysociety.org/who-we-are/j...
Deadline for applications is 16 Feb 2026
microbiologysociety.org/who-we-are/j...
Jobs
View the current job vacancies at the Microbiology Society.
microbiologysociety.org
January 28, 2026 at 8:44 AM
We are looking for new editors for Microbiology, the flagship journal of @microbiologysociety.org
Deadline for applications is 16 Feb 2026
microbiologysociety.org/who-we-are/j...
Deadline for applications is 16 Feb 2026
microbiologysociety.org/who-we-are/j...
Reposted by Khaled_Selim Lab
New AI tool “Helixer” identifies genes in newly sequenced organisms. Helixer identifies genes directly from DNA sequences.
Developed by team around @usadellab.bsky.social @fz-juelich.de, @apmweber.bsky.social , @sebtriesch.bsky.social @hhu.de et al. www.fz-juelich.de/en/news/arch...
Developed by team around @usadellab.bsky.social @fz-juelich.de, @apmweber.bsky.social , @sebtriesch.bsky.social @hhu.de et al. www.fz-juelich.de/en/news/arch...
AI tool “Helixer” identifies genes in newly sequenced organisms
Researchers at Forschungszentrum Jülich and Heinrich Heine University Düsseldorf have developed a tool that could significantly transform genome research: Helixer identifies genes directly from DNA se...
www.fz-juelich.de
January 26, 2026 at 6:04 PM
New AI tool “Helixer” identifies genes in newly sequenced organisms. Helixer identifies genes directly from DNA sequences.
Developed by team around @usadellab.bsky.social @fz-juelich.de, @apmweber.bsky.social , @sebtriesch.bsky.social @hhu.de et al. www.fz-juelich.de/en/news/arch...
Developed by team around @usadellab.bsky.social @fz-juelich.de, @apmweber.bsky.social , @sebtriesch.bsky.social @hhu.de et al. www.fz-juelich.de/en/news/arch...
Reposted by Khaled_Selim Lab
PII interactions with the acetyl-CoA carboxylase subunits BADC and BCCP co-regulate lipid and nitrogen metabolism in Arabidopsis (Matthew G Garneau , Gabriel Lemes Jorge , Jay Shockey , Jay J Thelen , Philip D Bates) doi.org/10.1093/plph... #PlantScience @aspbofficial
PII interactions with the acetyl-CoA carboxylase subunits BADC and BCCP co-regulate lipid and nitrogen metabolism in Arabidopsis
The PII protein regulates fatty acid synthesis and through interactions with biotin/lipoyl attachment domain containing and biotin carboxyl carrier protein
doi.org
January 26, 2026 at 6:57 PM
PII interactions with the acetyl-CoA carboxylase subunits BADC and BCCP co-regulate lipid and nitrogen metabolism in Arabidopsis (Matthew G Garneau , Gabriel Lemes Jorge , Jay Shockey , Jay J Thelen , Philip D Bates) doi.org/10.1093/plph... #PlantScience @aspbofficial
Reposted by Khaled_Selim Lab
WE ARE #HIRING: [reposting=👌 🙏 ]
2 funded positions for #nanopore related projects @unibas.ch 🇨🇭:
1️⃣ #PhD Candidate in Single-Molecule Biophysics using Nanopore Trapping.
2️⃣ #PhD Candidate in Microplastic Detection Using Micropores and Microfluidics.
More info: schmid.chemie.unibas.ch/en/join-us-1/
2 funded positions for #nanopore related projects @unibas.ch 🇨🇭:
1️⃣ #PhD Candidate in Single-Molecule Biophysics using Nanopore Trapping.
2️⃣ #PhD Candidate in Microplastic Detection Using Micropores and Microfluidics.
More info: schmid.chemie.unibas.ch/en/join-us-1/
January 23, 2026 at 7:23 PM
WE ARE #HIRING: [reposting=👌 🙏 ]
2 funded positions for #nanopore related projects @unibas.ch 🇨🇭:
1️⃣ #PhD Candidate in Single-Molecule Biophysics using Nanopore Trapping.
2️⃣ #PhD Candidate in Microplastic Detection Using Micropores and Microfluidics.
More info: schmid.chemie.unibas.ch/en/join-us-1/
2 funded positions for #nanopore related projects @unibas.ch 🇨🇭:
1️⃣ #PhD Candidate in Single-Molecule Biophysics using Nanopore Trapping.
2️⃣ #PhD Candidate in Microplastic Detection Using Micropores and Microfluidics.
More info: schmid.chemie.unibas.ch/en/join-us-1/
Reposted by Khaled_Selim Lab
How did eukaryotic cells with complex architecture evolve from simpler prokaryotic cells? DNA analyses offer possible answers @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41... @bristoluni.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41... @bristoluni.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genomic clues to the origin of eukaryotic cells
How did eukaryotic cells with complex architecture evolve from simpler prokaryotic cells? DNA analyses offer possible answers.
www.nature.com
January 15, 2026 at 4:43 PM
How did eukaryotic cells with complex architecture evolve from simpler prokaryotic cells? DNA analyses offer possible answers @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41... @bristoluni.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41... @bristoluni.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.ufz.de/index.php?en...
Here ist a small press about our recent findings about Guanidin metabolism in #cyanobacteria
Toxicity vs. Uptake & Catabolism
A great collaboration between @ufz.de & @hhu.de & @unihalle.bsky.social
HERE is the original publication @pnas.org
www.pnas.org/doi/10.1073/...
Here ist a small press about our recent findings about Guanidin metabolism in #cyanobacteria
Toxicity vs. Uptake & Catabolism
A great collaboration between @ufz.de & @hhu.de & @unihalle.bsky.social
HERE is the original publication @pnas.org
www.pnas.org/doi/10.1073/...
January 15, 2026 at 5:59 PM
www.ufz.de/index.php?en...
Here ist a small press about our recent findings about Guanidin metabolism in #cyanobacteria
Toxicity vs. Uptake & Catabolism
A great collaboration between @ufz.de & @hhu.de & @unihalle.bsky.social
HERE is the original publication @pnas.org
www.pnas.org/doi/10.1073/...
Here ist a small press about our recent findings about Guanidin metabolism in #cyanobacteria
Toxicity vs. Uptake & Catabolism
A great collaboration between @ufz.de & @hhu.de & @unihalle.bsky.social
HERE is the original publication @pnas.org
www.pnas.org/doi/10.1073/...
New enzyme with dual function as methionine synthase and a glycine betaine methyltransferase
Methionine synthesis and glycine betaine demethylation are intricately intertwined in cosmopolitan marine bacteria
www.pnas.org/doi/full/10....
Methionine synthesis and glycine betaine demethylation are intricately intertwined in cosmopolitan marine bacteria
www.pnas.org/doi/full/10....
January 14, 2026 at 9:37 AM
New enzyme with dual function as methionine synthase and a glycine betaine methyltransferase
Methionine synthesis and glycine betaine demethylation are intricately intertwined in cosmopolitan marine bacteria
www.pnas.org/doi/full/10....
Methionine synthesis and glycine betaine demethylation are intricately intertwined in cosmopolitan marine bacteria
www.pnas.org/doi/full/10....
Reposted by Khaled_Selim Lab
We Are very happy that our Paper was published. Thank to everyone involved
pubs.acs.org/doi/10.1021/...
@mibinet.bsky.social @mfeldbruegge.bsky.social @frunzkelab.bsky.social
pubs.acs.org/doi/10.1021/...
@mibinet.bsky.social @mfeldbruegge.bsky.social @frunzkelab.bsky.social
A Novel Biosensor for Ferrous Iron Developed via CoBiSe: A Computational Method for Rapid Biosensor Design
Genetically encoded biosensors enable the monitoring of metabolite dynamics in living organisms. We present CoBiSe, a computational biosensor design approach using Constraint Network Analysis to ident...
pubs.acs.org
January 12, 2026 at 9:48 AM
We Are very happy that our Paper was published. Thank to everyone involved
pubs.acs.org/doi/10.1021/...
@mibinet.bsky.social @mfeldbruegge.bsky.social @frunzkelab.bsky.social
pubs.acs.org/doi/10.1021/...
@mibinet.bsky.social @mfeldbruegge.bsky.social @frunzkelab.bsky.social
Reposted by Khaled_Selim Lab
Happy to share our recent preprint:
"DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity"
www.biorxiv.org/content/10.6...
@spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social
"DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity"
www.biorxiv.org/content/10.6...
@spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social
January 14, 2026 at 8:57 AM
Happy to share our recent preprint:
"DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity"
www.biorxiv.org/content/10.6...
@spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social
"DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity"
www.biorxiv.org/content/10.6...
@spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social
Reposted by Khaled_Selim Lab
Ancestral sequence reconstruction reveals CTP-dependent loading of the bacterial centromere-binding protein ParB as an ancient evolutionary feature
Now published:
tinyurl.com/4ddhwbb3
Thanks to the Hochberg and Bange labs for the great collaboration!
Now published:
tinyurl.com/4ddhwbb3
Thanks to the Hochberg and Bange labs for the great collaboration!
January 9, 2026 at 7:44 PM
Ancestral sequence reconstruction reveals CTP-dependent loading of the bacterial centromere-binding protein ParB as an ancient evolutionary feature
Now published:
tinyurl.com/4ddhwbb3
Thanks to the Hochberg and Bange labs for the great collaboration!
Now published:
tinyurl.com/4ddhwbb3
Thanks to the Hochberg and Bange labs for the great collaboration!
Reposted by Khaled_Selim Lab
We are hiring new faculty!! Come join our amazing community in the Department of Molecular Microbiology at Washington University School of Medicine! The deadline for applications is 2/21, but applications will be reviewed on a rolling basis. facultyopportunities.wustl.edu/Posting/Deta...
Opportunity Details - Faculty Opportunities
facultyopportunities.wustl.edu
January 8, 2026 at 9:05 PM
We are hiring new faculty!! Come join our amazing community in the Department of Molecular Microbiology at Washington University School of Medicine! The deadline for applications is 2/21, but applications will be reviewed on a rolling basis. facultyopportunities.wustl.edu/Posting/Deta...
Reposted by Khaled_Selim Lab
🫴 Genetic switch between unicellularity and multicellularity in marine yeasts:
www.nature.com/articles/s41...
@nature.com
www.nature.com/articles/s41...
@nature.com
Client Challenge
www.nature.com
January 8, 2026 at 3:11 PM
🫴 Genetic switch between unicellularity and multicellularity in marine yeasts:
www.nature.com/articles/s41...
@nature.com
www.nature.com/articles/s41...
@nature.com
Reposted by Khaled_Selim Lab
Registration is open for the 2026 Gordon Research Conference on Microbial Stress Response to be held on July 19-24 2026!! Submit your abstract by February 15th to be considered for a short talk. Apply now before it fills up!! Hope to see you there!! www.grc.org/microbial-st...
2026 Microbial Stress Response Conference GRC
The 2026 Gordon Research Conference on Microbial Stress Response will be held in South Hadley, Massachusetts. Apply today to reserve your spot.
www.grc.org
January 6, 2026 at 7:15 PM
Registration is open for the 2026 Gordon Research Conference on Microbial Stress Response to be held on July 19-24 2026!! Submit your abstract by February 15th to be considered for a short talk. Apply now before it fills up!! Hope to see you there!! www.grc.org/microbial-st...