Sander Smits
@sander1507.bsky.social
Biochemistry structural biology
Center for Structural Studies HHU
Center for Structural Studies HHU
Reposted by Sander Smits
Super happy to share that our Chemical Science article ‘Structural control of dynamic covalent cages: kinetic vs. thermodynamic assembly and PFAS removal from water’ (pubs.rsc.org/doi/D5SC02247A) has been selected for the 2025 most popular supramolecular articles collection 🎉
February 17, 2026 at 3:48 PM
Super happy to share that our Chemical Science article ‘Structural control of dynamic covalent cages: kinetic vs. thermodynamic assembly and PFAS removal from water’ (pubs.rsc.org/doi/D5SC02247A) has been selected for the 2025 most popular supramolecular articles collection 🎉
Reposted by Sander Smits
Happy to announce that our review article on vesicle-coupled mRNA trafficking is now availalbe
@mibinet.bsky.social
#EMBOrnaLocalization
link.springer.com/article/10.1...
@mibinet.bsky.social
#EMBOrnaLocalization
link.springer.com/article/10.1...
February 2, 2026 at 3:56 PM
Happy to announce that our review article on vesicle-coupled mRNA trafficking is now availalbe
@mibinet.bsky.social
#EMBOrnaLocalization
link.springer.com/article/10.1...
@mibinet.bsky.social
#EMBOrnaLocalization
link.springer.com/article/10.1...
Reposted by Sander Smits
I feel very grateful that our recent publication on rapid biosensor creation has been announced by HHU (Heinrich Heine University Düsseldorf). 🍀🙏🏼🤩🧪🦠🧫🔬
www.hhu.de/news-einzela...
www.hhu.de/news-einzela...
Strukturanalyse: Veröffentlichung in ACS Sensors
Um Stoffwechselprozesse zu verstehen, ist es wichtig, einzelne wichtige Elemente in lebenden Organismen nachweisen zu können. Forschenden der Heinrich-Heine-Universität Düsseldorf (HHU) entwickelten n...
www.hhu.de
January 19, 2026 at 10:44 AM
I feel very grateful that our recent publication on rapid biosensor creation has been announced by HHU (Heinrich Heine University Düsseldorf). 🍀🙏🏼🤩🧪🦠🧫🔬
www.hhu.de/news-einzela...
www.hhu.de/news-einzela...
Reposted by Sander Smits
✨ I am thrilled to share ✨ that our paper on computational biosensor design has just been published!
Huge thanks to all co-authors and collaborators for the great teamwork and dedication throughout this journey! 🙌
📄 Read the paper here:
pubs.acs.org/doi/10.1021/...
Huge thanks to all co-authors and collaborators for the great teamwork and dedication throughout this journey! 🙌
📄 Read the paper here:
pubs.acs.org/doi/10.1021/...
A Novel Biosensor for Ferrous Iron Developed via CoBiSe: A Computational Method for Rapid Biosensor Design
Genetically encoded biosensors enable the monitoring of metabolite dynamics in living organisms. We present CoBiSe, a computational biosensor design approach using Constraint Network Analysis to ident...
pubs.acs.org
January 12, 2026 at 10:45 AM
✨ I am thrilled to share ✨ that our paper on computational biosensor design has just been published!
Huge thanks to all co-authors and collaborators for the great teamwork and dedication throughout this journey! 🙌
📄 Read the paper here:
pubs.acs.org/doi/10.1021/...
Huge thanks to all co-authors and collaborators for the great teamwork and dedication throughout this journey! 🙌
📄 Read the paper here:
pubs.acs.org/doi/10.1021/...
We Are very happy that our Paper was published. Thank to everyone involved
pubs.acs.org/doi/10.1021/...
@mibinet.bsky.social @mfeldbruegge.bsky.social @frunzkelab.bsky.social
pubs.acs.org/doi/10.1021/...
@mibinet.bsky.social @mfeldbruegge.bsky.social @frunzkelab.bsky.social
A Novel Biosensor for Ferrous Iron Developed via CoBiSe: A Computational Method for Rapid Biosensor Design
Genetically encoded biosensors enable the monitoring of metabolite dynamics in living organisms. We present CoBiSe, a computational biosensor design approach using Constraint Network Analysis to ident...
pubs.acs.org
January 12, 2026 at 9:48 AM
We Are very happy that our Paper was published. Thank to everyone involved
pubs.acs.org/doi/10.1021/...
@mibinet.bsky.social @mfeldbruegge.bsky.social @frunzkelab.bsky.social
pubs.acs.org/doi/10.1021/...
@mibinet.bsky.social @mfeldbruegge.bsky.social @frunzkelab.bsky.social
Reposted by Sander Smits
🔬 Job Alert! 🚨
Goethe University Frankfurt is hiring a Head of our new Imaging Facility at Campus Riedberg!
Lead and support a vibrant imaging community, working with cutting-edge microscopes, e.g. a new Zeiss LSM 980, a Z1 Light Sheet, and a new Leica Stellaris.
gerbi-gmb.de/resources/ca...
Goethe University Frankfurt is hiring a Head of our new Imaging Facility at Campus Riedberg!
Lead and support a vibrant imaging community, working with cutting-edge microscopes, e.g. a new Zeiss LSM 980, a Z1 Light Sheet, and a new Leica Stellaris.
gerbi-gmb.de/resources/ca...
January 3, 2026 at 12:17 PM
🔬 Job Alert! 🚨
Goethe University Frankfurt is hiring a Head of our new Imaging Facility at Campus Riedberg!
Lead and support a vibrant imaging community, working with cutting-edge microscopes, e.g. a new Zeiss LSM 980, a Z1 Light Sheet, and a new Leica Stellaris.
gerbi-gmb.de/resources/ca...
Goethe University Frankfurt is hiring a Head of our new Imaging Facility at Campus Riedberg!
Lead and support a vibrant imaging community, working with cutting-edge microscopes, e.g. a new Zeiss LSM 980, a Z1 Light Sheet, and a new Leica Stellaris.
gerbi-gmb.de/resources/ca...
Reposted by Sander Smits
Werde Teil des Teams @hhu.de:
#Stellenangebot, scheinbar unbefristet. Grüße an #ichbinHanna & #ichbinReyhan
#Stellenangebot, scheinbar unbefristet. Grüße an #ichbinHanna & #ichbinReyhan
Abteilungsleitung (m/w/d) Forschungsmanagement und Transfer - Heinrich-Heine-Universität Düsseldorf
Heinrich-Heine-Universität Düsseldorf bietet Stelle als Abteilungsleitung (m/w/d) Forschungsmanagement und Transfer in Düsseldorf - jetzt bewerben!
jobs.zeit.de
December 19, 2025 at 7:51 AM
Werde Teil des Teams @hhu.de:
#Stellenangebot, scheinbar unbefristet. Grüße an #ichbinHanna & #ichbinReyhan
#Stellenangebot, scheinbar unbefristet. Grüße an #ichbinHanna & #ichbinReyhan
Reposted by Sander Smits
Reposted by Sander Smits
Finally out – It is all about cholesterol
Thanks to all for this excellent collaboration
Thanks to all for this excellent collaboration
December 5, 2025 at 2:34 PM
Finally out – It is all about cholesterol
Thanks to all for this excellent collaboration
Thanks to all for this excellent collaboration
Reposted by Sander Smits
📢Postdoc position available!🧪🧫🧬
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Postdoc (m/f/d) in Endosymbiosis Research
karriere.hhu.de
November 25, 2025 at 11:21 AM
📢Postdoc position available!🧪🧫🧬
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!
Reposted by Sander Smits
Die DFG fördert Projekte für ressourceneffizientere Großgerätenutzung in der Forschung mit insgesamt ca. 5,5 Mio €. Außerdem werden zusammen mit der GWK bis Ende 2025 Anträge unter dem üblichen Schwellenwert möglich, die eine längere Nutzung vorhandener Geräte erlauben.
Details: sohub.io/r4km
Details: sohub.io/r4km
DFG fördert Projekte für ressourceneffizientere Großgerätenutzung in der Forschung
sohub.io
November 7, 2025 at 12:04 PM
Die DFG fördert Projekte für ressourceneffizientere Großgerätenutzung in der Forschung mit insgesamt ca. 5,5 Mio €. Außerdem werden zusammen mit der GWK bis Ende 2025 Anträge unter dem üblichen Schwellenwert möglich, die eine längere Nutzung vorhandener Geräte erlauben.
Details: sohub.io/r4km
Details: sohub.io/r4km
Reposted by Sander Smits
✨X-ray crystallography reveals surprising twist in how proteins enter the unique photosynthetic organelles of Paulinella. The chromatophore targeting peptide (crTP) folds into a 3D structure, hinting that folded proteins cross peptidoglycan and inner membrane. (1/2)
academic.oup.com/plphys/artic...
academic.oup.com/plphys/artic...
November 1, 2025 at 7:34 AM
✨X-ray crystallography reveals surprising twist in how proteins enter the unique photosynthetic organelles of Paulinella. The chromatophore targeting peptide (crTP) folds into a 3D structure, hinting that folded proteins cross peptidoglycan and inner membrane. (1/2)
academic.oup.com/plphys/artic...
academic.oup.com/plphys/artic...
Reposted by Sander Smits
New publication in J Mol Biol
New insights in to the function of the CLD and the entire hemolysin secretion machinery. Thanks to Holger Gohlke’s lab and CSS for the wonderful collaboration. Congrats to Sakshi and Cigdem!
New insights in to the function of the CLD and the entire hemolysin secretion machinery. Thanks to Holger Gohlke’s lab and CSS for the wonderful collaboration. Congrats to Sakshi and Cigdem!
October 26, 2025 at 9:54 AM
New publication in J Mol Biol
New insights in to the function of the CLD and the entire hemolysin secretion machinery. Thanks to Holger Gohlke’s lab and CSS for the wonderful collaboration. Congrats to Sakshi and Cigdem!
New insights in to the function of the CLD and the entire hemolysin secretion machinery. Thanks to Holger Gohlke’s lab and CSS for the wonderful collaboration. Congrats to Sakshi and Cigdem!
Reposted by Sander Smits
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
www.nature.com
October 16, 2025 at 2:06 PM
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Reposted by Sander Smits
Please RT:
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...
Interested candidates are encouraged to contact me via email for further details.
@spp2330.bsky.social; @mibinet.bsky.social
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...
Interested candidates are encouraged to contact me via email for further details.
@spp2330.bsky.social; @mibinet.bsky.social
Junior Group Leader - Phage Biology & Biotechnology
As a leading research institution for microbial biotechnology the Institute of Bio- and Geosciences - Biotechnology (IBG-1, https://www.fz-juelich.de/de/ibg/ibg-1 ) at the Forschungszentrum Jülich foc...
www.fz-juelich.de
October 8, 2025 at 6:50 AM
Please RT:
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...
Interested candidates are encouraged to contact me via email for further details.
@spp2330.bsky.social; @mibinet.bsky.social
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...
Interested candidates are encouraged to contact me via email for further details.
@spp2330.bsky.social; @mibinet.bsky.social
Reposted by Sander Smits
Excited to share our latest work, spearheaded by @gabmrojas.bsky.social!
GPCRs are central sensors in eukaryotes, but little is known about them in fungi. In Ustilago maydis, we now uncovered a host-dependent GPCR mechanism that promotes fungal infection.
Gabriel nicely explains the full story👇
GPCRs are central sensors in eukaryotes, but little is known about them in fungi. In Ustilago maydis, we now uncovered a host-dependent GPCR mechanism that promotes fungal infection.
Gabriel nicely explains the full story👇
🧵How does a pathogen know it has entered its host?
New preprint!🎉It’s a pleasure to share my first first-author preprint from my PhD journey!
We uncover a novel co-evolved peptide–GPCR system in the fungus Ustilago maydis that senses host entry and triggers infection (doi.org/10.1101/2025...)
(1/5)
New preprint!🎉It’s a pleasure to share my first first-author preprint from my PhD journey!
We uncover a novel co-evolved peptide–GPCR system in the fungus Ustilago maydis that senses host entry and triggers infection (doi.org/10.1101/2025...)
(1/5)
A co-evolved peptide-GPCR system senses host entry to drive fungal infection https://www.biorxiv.org/content/10.1101/2025.09.26.678928v1
October 1, 2025 at 7:40 AM
Excited to share our latest work, spearheaded by @gabmrojas.bsky.social!
GPCRs are central sensors in eukaryotes, but little is known about them in fungi. In Ustilago maydis, we now uncovered a host-dependent GPCR mechanism that promotes fungal infection.
Gabriel nicely explains the full story👇
GPCRs are central sensors in eukaryotes, but little is known about them in fungi. In Ustilago maydis, we now uncovered a host-dependent GPCR mechanism that promotes fungal infection.
Gabriel nicely explains the full story👇
Reposted by Sander Smits
The evolution of land plants involved a charge-based adaption in the targeting sequences for #mitochondria and #chloroplasts and the origin of their de/phosphorylation.
#science 🧪
academic.oup.com/mbe/advance-...
#science 🧪
academic.oup.com/mbe/advance-...
Evolutionary refinement of mitochondrial and plastid targeting sequences coincides with the late diversification of land plants
Abstract. Plastids and mitochondria are key to plant survival and adaptation. The evolutionary progress of land plants (embryophytes) witnessed gene and ge
academic.oup.com
September 25, 2025 at 7:47 AM
The evolution of land plants involved a charge-based adaption in the targeting sequences for #mitochondria and #chloroplasts and the origin of their de/phosphorylation.
#science 🧪
academic.oup.com/mbe/advance-...
#science 🧪
academic.oup.com/mbe/advance-...
Reposted by Sander Smits
✨ Lust auf ein Studium mit bunten Farben, spannenden Apparaturen und mikroskopisch kleinen Stoffen? ✨👩🏼🔬👨🔬
🧪 Chemie oder Wirtschaftschemie könnten da genau das richtige für dich sein!
💡 Neu: Wirtschaftschemie ist ab sofort zulassungsfrei.
🧪 Chemie oder Wirtschaftschemie könnten da genau das richtige für dich sein!
💡 Neu: Wirtschaftschemie ist ab sofort zulassungsfrei.
August 20, 2025 at 6:18 AM
✨ Lust auf ein Studium mit bunten Farben, spannenden Apparaturen und mikroskopisch kleinen Stoffen? ✨👩🏼🔬👨🔬
🧪 Chemie oder Wirtschaftschemie könnten da genau das richtige für dich sein!
💡 Neu: Wirtschaftschemie ist ab sofort zulassungsfrei.
🧪 Chemie oder Wirtschaftschemie könnten da genau das richtige für dich sein!
💡 Neu: Wirtschaftschemie ist ab sofort zulassungsfrei.
Reposted by Sander Smits
Just moved online:
Glutathione S-Transferase Mediated Epoxide Conversion: Functional and Structural Properties of an Enantioselective Catalyst | ACS Catalysis pubs.acs.org/doi/10.1021/...
Glutathione S-Transferase Mediated Epoxide Conversion: Functional and Structural Properties of an Enantioselective Catalyst | ACS Catalysis pubs.acs.org/doi/10.1021/...
Glutathione S-Transferase Mediated Epoxide Conversion: Functional and Structural Properties of an Enantioselective Catalyst
Styrene is a naturally occurring but mainly anthropogenically produced aromatic compound. It is degraded via different routes in nature but often activated to styrene oxide, predominantly to its (S)-e...
pubs.acs.org
July 7, 2025 at 5:21 PM
Just moved online:
Glutathione S-Transferase Mediated Epoxide Conversion: Functional and Structural Properties of an Enantioselective Catalyst | ACS Catalysis pubs.acs.org/doi/10.1021/...
Glutathione S-Transferase Mediated Epoxide Conversion: Functional and Structural Properties of an Enantioselective Catalyst | ACS Catalysis pubs.acs.org/doi/10.1021/...
Reposted by Sander Smits
I am honored and excited that our research on #nitrogenases and the conversion of #CO2 to hydrocarbons is highlighted in the Yearbook 2024 of the Max Planck Society, see page 29. An English and a German version of the Yearbook are available in www.mpg.de/13631298/yea....
July 3, 2025 at 12:18 PM
I am honored and excited that our research on #nitrogenases and the conversion of #CO2 to hydrocarbons is highlighted in the Yearbook 2024 of the Max Planck Society, see page 29. An English and a German version of the Yearbook are available in www.mpg.de/13631298/yea....
Reposted by Sander Smits
Fachliche Exzellenz und menschliche Nähe: diese Kombination beschreibt unseren heutigen #hhuLehrpreis2025-Nominierten Prof. Dr. Michael Schmitt @lasermichel.bsky.social aus der Chemie @hhu.de perfekt. In seinen Vorlesungen gibt er viel Raum für Diskussion. 🎓💬
June 17, 2025 at 5:20 AM
Fachliche Exzellenz und menschliche Nähe: diese Kombination beschreibt unseren heutigen #hhuLehrpreis2025-Nominierten Prof. Dr. Michael Schmitt @lasermichel.bsky.social aus der Chemie @hhu.de perfekt. In seinen Vorlesungen gibt er viel Raum für Diskussion. 🎓💬
Reposted by Sander Smits
Excited to share that our T7 RNA polymerase-based expression system brings a new level of versatility to Angomonas deanei as a model for studying endosymbiosis!
doi.org/10.1371/jour...
doi.org/10.1371/jour...
T7 RNA polymerase-based gene expression from a transcriptionally silent rDNA spacer in the endosymbiont-harboring trypanosomatid Angomonas deanei
Eukaryotic life has been shaped fundamentally by the integration of bacterial endosymbionts. The trypanosomatid Angomonas deanei that contains a β-proteobacterial endosymbiont, represents an emerging ...
doi.org
June 2, 2025 at 3:21 PM
Excited to share that our T7 RNA polymerase-based expression system brings a new level of versatility to Angomonas deanei as a model for studying endosymbiosis!
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Reposted by Sander Smits
🚨 Our new publication out now
🍄☠️“The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B”
🔗 doi.org/10.1002/pro....
👏Congrats to first authors Xiaoli Yang & Pablo Cea-Medina @dfg.de #RTG2158 & thnx to Holger Gohlke for the great collaboration!
@hhu.de #RostockUniversityMedicalCenter
🍄☠️“The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B”
🔗 doi.org/10.1002/pro....
👏Congrats to first authors Xiaoli Yang & Pablo Cea-Medina @dfg.de #RTG2158 & thnx to Holger Gohlke for the great collaboration!
@hhu.de #RostockUniversityMedicalCenter
The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B
Beauvericin (BEA), a cyclic depsipeptide, is a mycotoxin of the enniatin family and the secondary metabolite of various toxigenic fungi. Multiple biological functions of BEA have been well investigat....
doi.org
May 30, 2025 at 8:35 AM
🚨 Our new publication out now
🍄☠️“The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B”
🔗 doi.org/10.1002/pro....
👏Congrats to first authors Xiaoli Yang & Pablo Cea-Medina @dfg.de #RTG2158 & thnx to Holger Gohlke for the great collaboration!
@hhu.de #RostockUniversityMedicalCenter
🍄☠️“The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B”
🔗 doi.org/10.1002/pro....
👏Congrats to first authors Xiaoli Yang & Pablo Cea-Medina @dfg.de #RTG2158 & thnx to Holger Gohlke for the great collaboration!
@hhu.de #RostockUniversityMedicalCenter
Reposted by Sander Smits
Mit ihrem Modul „Bio110“ ermöglichen Prof. Dr. Petra Bauer @botanyhhu.bsky.social , Dr. Hans-Jörg Mai und Prof. Dr. Jürgen Zeier aus der Biologie @hhu.de Studierenden einen klaren Überblick über das weitläufige Fachgebiet. Das Trio ist für den #hhuLehrpreis2025 nominiert 🌿📖
May 30, 2025 at 5:22 AM
Mit ihrem Modul „Bio110“ ermöglichen Prof. Dr. Petra Bauer @botanyhhu.bsky.social , Dr. Hans-Jörg Mai und Prof. Dr. Jürgen Zeier aus der Biologie @hhu.de Studierenden einen klaren Überblick über das weitläufige Fachgebiet. Das Trio ist für den #hhuLehrpreis2025 nominiert 🌿📖