Molecular Microbiology
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molmicrounihoh.bsky.social
Molecular Microbiology
@molmicrounihoh.bsky.social
260 followers 270 following 150 posts
https://mikrobiologie.uni-hohenheim.de

Dept. of Molecular Microbiology, University of Hohenheim, Stuttgart
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molmicrounihoh.bsky.social
wobbly Tuesday
November 11, 2025 at 8:43 AM
Reposted by Molecular Microbiology
andreaspeschel.bsky.social
S. aureus has an intrinsic rifampicin resistance mechanism! See the recent study by M. Otto's lab with important clinical implications:

Export by a quorum sensing–controlled drug exporter underlies rifampicin’s strong activity against staphylococcal biofilms | www.science.org/doi/10.1126/...
Export by a quorum sensing–controlled drug exporter underlies rifampicin’s strong activity against staphylococcal biofilms
Rifampicin is more effective against biofilm infections because it targets biofilm-forming mutants that are highly resistant to other antibiotics.
www.science.org
November 10, 2025 at 4:03 PM
molmicrounihoh.bsky.social
🫵 Our daily bread: Experimental evolution of gene essentiality in bacteria!

| mBio journals.asm.org/doi/10.1128/...

@mbio.bsky.social
Experimental evolution of gene essentiality in bacteria | mBio
Essential genes are traditionally considered indispensable for bacterial survival, but how they interact with other cellular processes is not well understood. Here, we deleted essential genes from div...
journals.asm.org
November 10, 2025 at 8:13 PM
molmicrounihoh.bsky.social
Conflicts between the DNA replication and repair machineries promote cell death in Gram-positive bacteria:

www.microbiologyresearch.org/content/jour...

@microbiologysociety.org
Conflicts between the DNA replication and repair machineries promote cell death in Gram-positive bacteria
Cellular proliferation relies on the successful coordination and completion of genome replication and segregation. To help achieve this, many bacteria utilize regulatory pathways that ensure DNA repli...
www.microbiologyresearch.org
November 10, 2025 at 8:32 AM
molmicrounihoh.bsky.social
🫳 The stringent response does not influence ribosome pausing in Bacillus subtilis:

academic.oup.com/nar/article/...

@narjournal.bsky.social #subtiwiki
The stringent response does not influence ribosome pausing in Bacillus subtilis
Abstract. The stringent response represses translation and is activated when cells enter the stationary phase and intracellular amino acid levels drop. Bac
academic.oup.com
November 1, 2025 at 4:48 PM
molmicrounihoh.bsky.social
🫴 FrlP, an ABC type I importer component of Bacillus subtilis: regulation and impact in bacterial fitness:

| Journal of Bacteriology journals.asm.org/doi/10.1128/...

@jbacteria.bsky.social
FrlP, an ABC type I importer component of Bacillus subtilis: regulation and impact in bacterial fitness | Journal of Bacteriology
Bacillus subtilis is widely applied in the industry as a microbial cell factory, as a biofertilizer for sustainable agriculture, in the animal feed industry and as human probiotic. In its natural envi...
journals.asm.org
October 31, 2025 at 5:09 PM
molmicrounihoh.bsky.social
Lab outing to Stuttgart Airport (STR) with interesting insights behind the scenes! 🛩️ 🛫 ✈️
October 31, 2025 at 4:26 PM
Reposted by Molecular Microbiology
joergstuelke.bsky.social
Cool new paper on the structure and possible function of the type VII ABC transporter YtrEF in cell wall remodeling in Bacillus subtilis!
#SubtiWiki

www.sciencedirect.com/science/arti...
Structural analysis of a Gram-positive type VII ABC transporter induced by cell wall-targeting antibiotics
Bacteria utilize a variety of mechanisms to remodel the cell wall in response to environmental and antimicrobial stress. In the model organism Bacillu…
www.sciencedirect.com
October 29, 2025 at 3:28 PM
molmicrounihoh.bsky.social
🫴 Structure of Bacillus subtilis Ku-mediated DNA synaptic complex:

👇

academic.oup.com/nar/article/...
Structure of Bacillus subtilis Ku-mediated DNA synaptic complex
Abstract. DNA double-strand breaks (DSBs) pose a severe threat to genomic integrity, and cells rely on two major pathways for repair: homologous recombinat
academic.oup.com
October 22, 2025 at 7:01 AM
molmicrounihoh.bsky.social
Weird: A broadly conserved fungal chorismate mutase targets the plant shikimate pathway to regulate salicylic acid production and other secondary metabolites:

| mBio journals.asm.org/doi/10.1128/...
A broadly conserved fungal chorismate mutase targets the plant shikimate pathway to regulate salicylic acid production and other secondary metabolites | mBio
Microbial effectors are small secreted proteins that help pathogens establish disease within the host environment. In biotrophic fungi, secreted chorismate mutases (CMs) like Cmu1 suppress the product...
journals.asm.org
October 21, 2025 at 9:40 AM
molmicrounihoh.bsky.social
job alert:

@spp2330.bsky.social
October 20, 2025 at 11:18 AM
molmicrounihoh.bsky.social
job alert:

@spp2330.bsky.social
October 20, 2025 at 11:18 AM
molmicrounihoh.bsky.social
🫴 Short tandem gene duplications as potential agents of genetic memory:

| mBio journals.asm.org/doi/10.1128/...

@mbio.bsky.social #Pseudomonas
Short tandem gene duplications as potential agents of genetic memory | mBio
Unstable mutations, such as tandem gene duplications, contribute significantly to the evolution of antibiotic resistance and other traits, but their importance is often underestimated. In this study, ...
journals.asm.org
October 17, 2025 at 4:48 AM
molmicrounihoh.bsky.social
Simply amazing: Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail:

| Science Advances www.science.org/doi/10.1126/...

@spp2330.bsky.social
Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail
This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.
www.science.org
October 16, 2025 at 7:35 PM
molmicrounihoh.bsky.social
🫴 Molecular basis for noncanonical transcription initiation from Np4A alarmones:

www.nature.com/articles/s41...
Molecular basis for noncanonical transcription initiation from Np4A alarmones - Nature Chemical Biology
Duan and Kaushik et al. reveal the structural basis of how Escherichia coli and Thermus thermophilus RNA polymerases initiate transcription from Np4A alarmones producing Np4-capped transcripts. The ca...
www.nature.com
October 15, 2025 at 2:32 PM
molmicrounihoh.bsky.social
🫴 Enhanced microbial production of pyridoxine (Vitamin B6) in Bacillus subtilis via pathway and process optimization:

www.sciencedirect.com/science/arti...

#vitaminB6 #subtilis
Enhanced microbial production of pyridoxine (Vitamin B6) in Bacillus subtilis via pathway and process optimization
Vitamin B6 refers to a family of water-soluble B vitamin, which is essential for various physiological functions, including amino acid metabolism, neu…
www.sciencedirect.com
October 15, 2025 at 11:45 AM
molmicrounihoh.bsky.social
It was a fantastic meeting in Rösrath! Thank you @spp2330.bsky.social !
October 11, 2025 at 5:31 PM
molmicrounihoh.bsky.social
🫴🏻 Binding of Bacillus subtilis dynamin‐like protein DynA to the bacterial membrane is essential for effective phage defense:

Shafqat - The FEBS Journal - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1111/...

#subtiwiki
FEBS Press
The bacterial dynamin-like protein DynA from Bacillus subtilis plays a key role in phage defense. It binds the plasma membrane through a unique paddle domain in its D1 subunit. This membrane associat...
febs.onlinelibrary.wiley.com
October 10, 2025 at 8:27 AM
Reposted by Molecular Microbiology
gruberlab.bsky.social
How do SMC complexes load onto DNA to get ready for loop extrusion?

@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️.

Check out the new paper: www.cell.com/molecular-ce...
October 9, 2025 at 2:43 PM
molmicrounihoh.bsky.social
Katharina presented at the annual @spp2330.bsky.social meeting in Rösrath (North Rhine-Westphalia):
October 9, 2025 at 11:34 AM
molmicrounihoh.bsky.social
🫴 Phage tRNAs: decoding the enigma.

Now in Trends in Microbiology!

👇👇👇

www.cell.com/trends/micro...

@spp2330.bsky.social @cp-trendsmicrobiol.bsky.social
Phage tRNAs: decoding the enigma
The presence of tRNAs in bacteriophage genomes has intrigued scientists since their discovery in the early 1960s, as phages were believed to rely on the host tRNAs for their translation. Over the year...
www.cell.com
October 9, 2025 at 11:13 AM
Reposted by Molecular Microbiology
frunzkelab.bsky.social
Please RT:
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...

Interested candidates are encouraged to contact me via email for further details.

@spp2330.bsky.social; @mibinet.bsky.social
Junior Group Leader - Phage Biology & Biotechnology
As a leading research institution for microbial biotechnology the Institute of Bio- and Geosciences - Biotechnology (IBG-1, https://www.fz-juelich.de/de/ibg/ibg-1 ) at the Forschungszentrum Jülich foc...
www.fz-juelich.de
October 8, 2025 at 6:50 AM
molmicrounihoh.bsky.social
Humans began travelling into space in 1961 with single orbits of the Earth. Now Bacillus subtilis!

👉

www.nature.com/articles/s41...

#subtiwiki

Thank you @joergstuelke.bsky.social for the reading recommendation!
Effects of extreme acceleration, microgravity, and deceleration on Bacillus subtilis onboard a suborbital space flight - npj Microgravity
npj Microgravity - Effects of extreme acceleration, microgravity, and deceleration on Bacillus subtilis onboard a suborbital space flight
www.nature.com
October 6, 2025 at 2:18 PM
molmicrounihoh.bsky.social
Comprehensive genetic interaction analysis of the Bacillus subtilis envelope using double-CRISPRi:

👇

www.sciencedirect.com/science/arti...

@cellpress.bsky.social
Comprehensive genetic interaction analysis of the Bacillus subtilis envelope using double-CRISPRi
Understanding bacterial gene function remains a major challenge. Double-mutant genetic interaction analysis addresses this challenge by uncovering the…
www.sciencedirect.com
October 6, 2025 at 8:21 AM
Reposted by Molecular Microbiology
michiwagner4.bsky.social
Interested in an exciting 2.5 year PostDoc position with a focus on the characterization of novel #nitrifiers? This is a collaborative project between our nitrification group @cemess.bsky.social and C. Singleton and P. Nielsen at @aau.dk

🧪 #MicroSky

www.stillinger.aau.dk/videnskabeli...
Postdoc in Identification and characterization of novel nitrifiers
At the Faculty of Engineering and Science, Department of Chemistry and Bioscience, a 2.5 year position as Postdoc in “Identification and characterization of ...
www.stillinger.aau.dk
October 5, 2025 at 2:54 PM