By facilitating an **inhibitory** immune signaling pathway using 2’3-cdiAMP, bacterial viruses face an evolutionary choice: inhibit signaling immune systems or disrupt mCpol’s “healthy” signaling.
This has major consequences in the genetic tools phages can use to subvert immune systems!
This has major consequences in the genetic tools phages can use to subvert immune systems!
October 1, 2025 at 5:57 PM
By facilitating an **inhibitory** immune signaling pathway using 2’3-cdiAMP, bacterial viruses face an evolutionary choice: inhibit signaling immune systems or disrupt mCpol’s “healthy” signaling.
This has major consequences in the genetic tools phages can use to subvert immune systems!
This has major consequences in the genetic tools phages can use to subvert immune systems!
We found that the structural group with the broadest substrate scope contained PDEs with notable differences in targeting. In particular, 2H PDE-9 robustly degrades 3’3’-cGAMP, a common CBASS immune messenger, but shows minimal activity against other messengers including 2’3’-cdiAMP.
August 22, 2025 at 7:16 PM
We found that the structural group with the broadest substrate scope contained PDEs with notable differences in targeting. In particular, 2H PDE-9 robustly degrades 3’3’-cGAMP, a common CBASS immune messenger, but shows minimal activity against other messengers including 2’3’-cdiAMP.
👉 c-di-AMP is synthesized in eukaryotes: The second messenger activates the NLRP3 inflammasome!
👇👇👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@natchembio.nature.com #cdiAMP
👇👇👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@natchembio.nature.com #cdiAMP
Eukaryotic ADCY7 catalyzes the production of c-di-AMP to activate the NLRP3 inflammasome - Nature Chemical Biology
Cyclic dimeric adenosine monophosphate is found to be a second messenger in eukaryotic cells that is generated by adenylate cyclase 7 and connects Toll-like receptor 9 stimulation to nucleotide-bindin...
www.nature.com
May 26, 2025 at 9:44 AM
👉 c-di-AMP is synthesized in eukaryotes: The second messenger activates the NLRP3 inflammasome!
👇👇👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@natchembio.nature.com #cdiAMP
👇👇👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@natchembio.nature.com #cdiAMP
Happy to share our latest finding @natureportfolio.nature.com on #cdiAMP signaling roles in #cyanobacteria natural competence via #ComFB (a new family of #cdiNMP receptors)
@hhu.de @cmfi.bsky.social @biologyunifreiburg.bsky.social
Fund @dfg.de @sfb1381.bsky.social
@mibinet.bsky.social
rdcu.be/eyLXT
@hhu.de @cmfi.bsky.social @biologyunifreiburg.bsky.social
Fund @dfg.de @sfb1381.bsky.social
@mibinet.bsky.social
rdcu.be/eyLXT
The second messenger c-di-AMP controls natural competence via ComFB signaling protein
Cell Discovery - The second messenger c-di-AMP controls natural competence via ComFB signaling protein
rdcu.be
August 1, 2025 at 8:51 AM
Happy to share our latest finding @natureportfolio.nature.com on #cdiAMP signaling roles in #cyanobacteria natural competence via #ComFB (a new family of #cdiNMP receptors)
@hhu.de @cmfi.bsky.social @biologyunifreiburg.bsky.social
Fund @dfg.de @sfb1381.bsky.social
@mibinet.bsky.social
rdcu.be/eyLXT
@hhu.de @cmfi.bsky.social @biologyunifreiburg.bsky.social
Fund @dfg.de @sfb1381.bsky.social
@mibinet.bsky.social
rdcu.be/eyLXT
July 24, 2025 at 2:57 PM
Big News (a bit late 🙃): my group is moving to Düsseldorf
@hhu.bsky.social
Looking for next adventure w awesome colleagues @frunzkelab.bsky.social @kedrov-lab.bsky.social @apmweber.bsky.social
Plz RT, positions available for #PhD & #postdoc w focus #CryoEM & #cdiAMP
www.hhu.de/news-einzela...
@hhu.bsky.social
Looking for next adventure w awesome colleagues @frunzkelab.bsky.social @kedrov-lab.bsky.social @apmweber.bsky.social
Plz RT, positions available for #PhD & #postdoc w focus #CryoEM & #cdiAMP
www.hhu.de/news-einzela...
January 31, 2025 at 4:30 PM
Big News (a bit late 🙃): my group is moving to Düsseldorf
@hhu.bsky.social
Looking for next adventure w awesome colleagues @frunzkelab.bsky.social @kedrov-lab.bsky.social @apmweber.bsky.social
Plz RT, positions available for #PhD & #postdoc w focus #CryoEM & #cdiAMP
www.hhu.de/news-einzela...
@hhu.bsky.social
Looking for next adventure w awesome colleagues @frunzkelab.bsky.social @kedrov-lab.bsky.social @apmweber.bsky.social
Plz RT, positions available for #PhD & #postdoc w focus #CryoEM & #cdiAMP
www.hhu.de/news-einzela...
This add on to the functional catalog of #cdiAMP by showing it's involvement in ROS balance, photosyn., motility & proteome stability to regulate day-night switches in #cyano
part of this work was done by my former PhD, Michael Haffner @cmfi.bsky.social and some support by @sfb1381.bsky.social ...
part of this work was done by my former PhD, Michael Haffner @cmfi.bsky.social and some support by @sfb1381.bsky.social ...
October 7, 2025 at 6:58 PM
This add on to the functional catalog of #cdiAMP by showing it's involvement in ROS balance, photosyn., motility & proteome stability to regulate day-night switches in #cyano
part of this work was done by my former PhD, Michael Haffner @cmfi.bsky.social and some support by @sfb1381.bsky.social ...
part of this work was done by my former PhD, Michael Haffner @cmfi.bsky.social and some support by @sfb1381.bsky.social ...
A bit late 🙃 but happy to share our recent findings on #cdiAMP signaling in controlling #cyanobacteria #diurnal rhythm in @cp-iscience.bsky.social
www.cell.com/iscience/ful...
#cdiAMP is involved in almost all cellular processes, explaining it's essentiality in #cyano
@hhu.de
@mibinet.bsky.social
www.cell.com/iscience/ful...
#cdiAMP is involved in almost all cellular processes, explaining it's essentiality in #cyano
@hhu.de
@mibinet.bsky.social
Diurnal rhythm causes metabolic crises in the cyanobacterial mutants of c-di-AMP signaling cascade
Biological sciences; Biochemistry; Microbiology; PII-like protein SbtB; c-di-AMP signaling;
Cyanobacteria; Carbon/Nitrogen metabolism; Redox imbalance; Photosynthesis; Reactive
oxygen species (ROS); C...
www.cell.com
October 7, 2025 at 6:51 PM
A bit late 🙃 but happy to share our recent findings on #cdiAMP signaling in controlling #cyanobacteria #diurnal rhythm in @cp-iscience.bsky.social
www.cell.com/iscience/ful...
#cdiAMP is involved in almost all cellular processes, explaining it's essentiality in #cyano
@hhu.de
@mibinet.bsky.social
www.cell.com/iscience/ful...
#cdiAMP is involved in almost all cellular processes, explaining it's essentiality in #cyano
@hhu.de
@mibinet.bsky.social
🫴 Borrelia burgdorferi c-di-AMP is a key extracellular pathogen-associated molecular pattern to elicit type I interferon responses in mammalian hosts:
academic.oup.com/jimmunol/art...
#cdiAMP #Borrelia
academic.oup.com/jimmunol/art...
#cdiAMP #Borrelia
Borrelia burgdorferi c-di-AMP is a key extracellular pathogen-associated molecular pattern to elicit type I interferon responses in mammalian hosts
Abstract. Borrelia burgdorferi (or Borreliella burgdorferi), the extracellular spirochete responsible for Lyme disease, elicits a type I interferon (IFN-I)
academic.oup.com
July 9, 2025 at 7:10 AM
🫴 Borrelia burgdorferi c-di-AMP is a key extracellular pathogen-associated molecular pattern to elicit type I interferon responses in mammalian hosts:
academic.oup.com/jimmunol/art...
#cdiAMP #Borrelia
academic.oup.com/jimmunol/art...
#cdiAMP #Borrelia
Very cool study showing how to deal with protein flexibility in cryoEM with very short blotting time in ms of #cdiAMP target KtrA...
Also #cdiAMP was crucial to stabilize the flexibility and enhance cryoEM map
www.sciencedirect.com/science/arti...
Also #cdiAMP was crucial to stabilize the flexibility and enhance cryoEM map
www.sciencedirect.com/science/arti...
June 14, 2025 at 1:05 PM
Very cool study showing how to deal with protein flexibility in cryoEM with very short blotting time in ms of #cdiAMP target KtrA...
Also #cdiAMP was crucial to stabilize the flexibility and enhance cryoEM map
www.sciencedirect.com/science/arti...
Also #cdiAMP was crucial to stabilize the flexibility and enhance cryoEM map
www.sciencedirect.com/science/arti...
#cdiAMP Small molecule w/ big roles
We showed that #cdiAMP plays an essential role in regulating natural competence and DNA 🧬 uptake in #cyanobacteria through controlling pilus biogenesis
a great collaboration with @archaellum.bsky.social
Could be interesting for community @cyanotrans.bsky.social
We showed that #cdiAMP plays an essential role in regulating natural competence and DNA 🧬 uptake in #cyanobacteria through controlling pilus biogenesis
a great collaboration with @archaellum.bsky.social
Could be interesting for community @cyanotrans.bsky.social
August 1, 2025 at 9:22 AM
#cdiAMP Small molecule w/ big roles
We showed that #cdiAMP plays an essential role in regulating natural competence and DNA 🧬 uptake in #cyanobacteria through controlling pilus biogenesis
a great collaboration with @archaellum.bsky.social
Could be interesting for community @cyanotrans.bsky.social
We showed that #cdiAMP plays an essential role in regulating natural competence and DNA 🧬 uptake in #cyanobacteria through controlling pilus biogenesis
a great collaboration with @archaellum.bsky.social
Could be interesting for community @cyanotrans.bsky.social