Adrien Peyrache
@apeyrache.bsky.social
Space, Sleep, and Spikes | Associate Prof @ McGill, Montreal Neurological Institute | Co-director, The Quebec Sleep Research Network
"The time for passive consumption has expired. Every scholar should begin contributing their expertise to Wikipedia — not as charity, but as a core duty"
www.nature.com/articles/d41...
www.nature.com/articles/d41...
The academic community failed Wikipedia for 25 years — now it might fail us
Artificial-intelligence systems are feeding on Wikipedia without giving back, and academic indifference is threatening the survival of what is arguably the most widely used reference work on the plane...
www.nature.com
January 19, 2026 at 4:18 PM
"The time for passive consumption has expired. Every scholar should begin contributing their expertise to Wikipedia — not as charity, but as a core duty"
www.nature.com/articles/d41...
www.nature.com/articles/d41...
To all our Iranian friends: we know how heavy these past few days have been. Please know you have our support, reach out if there is anything we can do. Hang in there.
January 16, 2026 at 1:31 PM
To all our Iranian friends: we know how heavy these past few days have been. Please know you have our support, reach out if there is anything we can do. Hang in there.
So cool to see this one out! Congrats @markbrandonlab.bsky.social and the gang!!!!
January 15, 2026 at 1:53 PM
So cool to see this one out! Congrats @markbrandonlab.bsky.social and the gang!!!!
Revealing a universal architecture of sleep by recording from different (and evolutionary distant) species.
How cooler can it be???
Congrats to @antbergel.bsky.social and PA Libourel for this masterpiece.
How cooler can it be???
Congrats to @antbergel.bsky.social and PA Libourel for this masterpiece.
⚠️ New paper alert and what a way to end 2025! 🎉
Happy to share our story “Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.” published today in Nature Neuroscience.
Sleeping dragons 🦎 and functional ultrasound!
Read the full paper here: rdcu.be/eWJHb 1/8
Happy to share our story “Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.” published today in Nature Neuroscience.
Sleeping dragons 🦎 and functional ultrasound!
Read the full paper here: rdcu.be/eWJHb 1/8
Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals
Nature Neuroscience - Bergel et al. show that an infraslow rhythm connecting the brain and body during sleep is shared by lizards, mammals and birds, revealing an ancestral process and reshaping...
rdcu.be
December 29, 2025 at 11:24 PM
Revealing a universal architecture of sleep by recording from different (and evolutionary distant) species.
How cooler can it be???
Congrats to @antbergel.bsky.social and PA Libourel for this masterpiece.
How cooler can it be???
Congrats to @antbergel.bsky.social and PA Libourel for this masterpiece.
Reposted by Adrien Peyrache
📢 Join us, the Haberkern lab, @uni-wuerzburg.de for a postdoc studying neural circuit mechanisms of navigation. You’ll spearheading neurophysiology experiments on our brand new 2P!
⏳ Apply by 28th February 2026
Details: www.haberkernlab.de/docs/ENPostd...
#neuroscience #academicjobs #postdoc
⏳ Apply by 28th February 2026
Details: www.haberkernlab.de/docs/ENPostd...
#neuroscience #academicjobs #postdoc
December 23, 2025 at 11:27 AM
📢 Join us, the Haberkern lab, @uni-wuerzburg.de for a postdoc studying neural circuit mechanisms of navigation. You’ll spearheading neurophysiology experiments on our brand new 2P!
⏳ Apply by 28th February 2026
Details: www.haberkernlab.de/docs/ENPostd...
#neuroscience #academicjobs #postdoc
⏳ Apply by 28th February 2026
Details: www.haberkernlab.de/docs/ENPostd...
#neuroscience #academicjobs #postdoc
Great read by @alexkwan.bsky.social on how fundamental neuroscience research has paved the way for new drug development.
I’d also highlight orexin’s role in sleep–wake regulation and the upcoming wave of dual orexin receptor antagonists (DORAs) for sleep disorders (& soon agonists for narcolepsy).
I’d also highlight orexin’s role in sleep–wake regulation and the upcoming wave of dual orexin receptor antagonists (DORAs) for sleep disorders (& soon agonists for narcolepsy).
A growing list of medications—such as zuranolone for postpartum depression, suzetrigine for pain, and the gepants class of migraine medicines—exist because of insights from basic research, writes @alexkwan.bsky.social.
www.thetransmitter.org/drug-develop...
#neuroskyence
www.thetransmitter.org/drug-develop...
#neuroskyence
How basic neuroscience has paved the path to new drugs
A growing list of medications—such as zuranolone for postpartum depression, suzetrigine for pain, and the gepants class of migraine medicines—exist because of insights from basic research.
www.thetransmitter.org
December 15, 2025 at 10:05 PM
Great read by @alexkwan.bsky.social on how fundamental neuroscience research has paved the way for new drug development.
I’d also highlight orexin’s role in sleep–wake regulation and the upcoming wave of dual orexin receptor antagonists (DORAs) for sleep disorders (& soon agonists for narcolepsy).
I’d also highlight orexin’s role in sleep–wake regulation and the upcoming wave of dual orexin receptor antagonists (DORAs) for sleep disorders (& soon agonists for narcolepsy).
We all screw up from times to times when reviewing. It’s frustrating for the authors, sure, but the planet keeps rotating. A strong paper will find its readers and its citations anyway.
This is a great example.
This is a great example.
How I contributed to rejecting one of my favorite papers of all times, Yes, I teach it to students daily, and refer to it in lots of papers. Sorry. open.substack.com/pub/kording/...
How I contributed to rejecting one of my favorite papers of all time
I believe we should talk about the mistakes we make.
open.substack.com
December 2, 2025 at 2:43 AM
We all screw up from times to times when reviewing. It’s frustrating for the authors, sure, but the planet keeps rotating. A strong paper will find its readers and its citations anyway.
This is a great example.
This is a great example.
An AI agent, run by collaborators on another continent, generated equations that explain the dynamics of the neurons we recorded 🤯
Finally had the time to read the paper after post-SfN recovery. The approach is v cool, & the Gaussian parametrization feels almost embarrassingly obvious in hindsight.
Finally had the time to read the paper after post-SfN recovery. The approach is v cool, & the Gaussian parametrization feels almost embarrassingly obvious in hindsight.
1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Characterizing neuronal population geometry with AI equation discovery
The visual cortex contains millions of neurons, whose combined activity forms a population code representing visual stimuli. There is, however, a discrepancy between our understanding of this code at ...
www.biorxiv.org
November 26, 2025 at 7:03 PM
An AI agent, run by collaborators on another continent, generated equations that explain the dynamics of the neurons we recorded 🤯
Finally had the time to read the paper after post-SfN recovery. The approach is v cool, & the Gaussian parametrization feels almost embarrassingly obvious in hindsight.
Finally had the time to read the paper after post-SfN recovery. The approach is v cool, & the Gaussian parametrization feels almost embarrassingly obvious in hindsight.
This important study provides new insights into the synchronization of ripple oscillations in the hippocampus, both within and across hemispheres. While power is correlated across hemispheres, synchrony is significantly higher within a hemisphere than across.
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...
On CA1 ripple oscillations: reevaluating asynchronicity evidence
doi.org
November 21, 2025 at 5:32 PM
This important study provides new insights into the synchronization of ripple oscillations in the hippocampus, both within and across hemispheres. While power is correlated across hemispheres, synchrony is significantly higher within a hemisphere than across.
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...
Reposted by Adrien Peyrache
I am recruiting graduate students for the experimental side of my lab @mcgill.ca for admission in Fall 2026!
Get in touch if you're interested in how brain circuits implement distributed computation, including dopamine-based distributed RL and probabilistic representations.
Get in touch if you're interested in how brain circuits implement distributed computation, including dopamine-based distributed RL and probabilistic representations.
November 19, 2025 at 6:04 PM
I am recruiting graduate students for the experimental side of my lab @mcgill.ca for admission in Fall 2026!
Get in touch if you're interested in how brain circuits implement distributed computation, including dopamine-based distributed RL and probabilistic representations.
Get in touch if you're interested in how brain circuits implement distributed computation, including dopamine-based distributed RL and probabilistic representations.
Reposted by Adrien Peyrache
Arrived in San Diego for my first SfN, looking forward to showing you all my work with @apeyrache.bsky.social ; untangling the contribution of inhibition to the thalamic head direction attractor 💍
Come see me tonight at the TPDA poster session or on Tuesday morning with the lab!
#SfN25
Come see me tonight at the TPDA poster session or on Tuesday morning with the lab!
#SfN25
November 15, 2025 at 6:14 PM
Arrived in San Diego for my first SfN, looking forward to showing you all my work with @apeyrache.bsky.social ; untangling the contribution of inhibition to the thalamic head direction attractor 💍
Come see me tonight at the TPDA poster session or on Tuesday morning with the lab!
#SfN25
Come see me tonight at the TPDA poster session or on Tuesday morning with the lab!
#SfN25
Reposted by Adrien Peyrache
Will be presenting a poster on @apeyrache.bsky.social row, Tues AM, with an update our sequential predictive learning preprint:
-CA3-like (sparse lognormal) connectivity gives a hippocampus-like (orthogonalized) map
-non-spatial representation! splitters, lap/time cells, action plan…we got it all🤑
-CA3-like (sparse lognormal) connectivity gives a hippocampus-like (orthogonalized) map
-non-spatial representation! splitters, lap/time cells, action plan…we got it all🤑
TFW you land in San Diego and the bsky is hopping #sfn25
November 15, 2025 at 5:02 AM
Will be presenting a poster on @apeyrache.bsky.social row, Tues AM, with an update our sequential predictive learning preprint:
-CA3-like (sparse lognormal) connectivity gives a hippocampus-like (orthogonalized) map
-non-spatial representation! splitters, lap/time cells, action plan…we got it all🤑
-CA3-like (sparse lognormal) connectivity gives a hippocampus-like (orthogonalized) map
-non-spatial representation! splitters, lap/time cells, action plan…we got it all🤑
Five-star hydrotherapy for hardware that costs more than my car.
We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol.
(And yes, I don’t have a car).
We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol.
(And yes, I don’t have a car).
November 13, 2025 at 3:02 PM
Five-star hydrotherapy for hardware that costs more than my car.
We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol.
(And yes, I don’t have a car).
We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol.
(And yes, I don’t have a car).
Reposted by Adrien Peyrache
The Sosa Lab is going to #SfN25 and actively recruiting ✨postdocs✨ with systems neuroscience experience! We study both fundamental memory processes and how memory changes during pregnancy and postpartum.
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
Sosa Lab - Postdoctoral Researchers
We are seeking postdocs to start in 2026!
www.sosaneurolab.com
November 7, 2025 at 10:53 PM
The Sosa Lab is going to #SfN25 and actively recruiting ✨postdocs✨ with systems neuroscience experience! We study both fundamental memory processes and how memory changes during pregnancy and postpartum.
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
Great study showing how histaminergic signaling shapes head-direction cell activity in the presence of objects, with important implications for how animals get oriented. A huge amount of work, really impressive.
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
A Neuromodulatory Circuit Amplifies Object-based Head-direction Tuning for Spatial Memory
While the head-direction (HD) system is well-established as the brain’s internal compass, the mechanisms that allow it to be flexibly shaped by landmarks have remained unclear. Here we discovered that...
www.researchsquare.com
November 7, 2025 at 5:22 PM
Great study showing how histaminergic signaling shapes head-direction cell activity in the presence of objects, with important implications for how animals get oriented. A huge amount of work, really impressive.
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
A chemical extracted from carrot roots helped pave the way for flat-screen TVs, and six other discoveries that unintentionally changed the world.
Perfect talking points for when you need to defend basic science, whether it’s to your grumpy uncle or your MP.
www.nature.com/articles/d41...
Perfect talking points for when you need to defend basic science, whether it’s to your grumpy uncle or your MP.
www.nature.com/articles/d41...
7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
www.nature.com
November 5, 2025 at 3:08 PM
A chemical extracted from carrot roots helped pave the way for flat-screen TVs, and six other discoveries that unintentionally changed the world.
Perfect talking points for when you need to defend basic science, whether it’s to your grumpy uncle or your MP.
www.nature.com/articles/d41...
Perfect talking points for when you need to defend basic science, whether it’s to your grumpy uncle or your MP.
www.nature.com/articles/d41...
Reposted by Adrien Peyrache
🚨Job alert🚨
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
3 Postdoctoral Research Fellows
Champalimaud Foundation (Fundação D. Anna de Sommer Champalimaud e Dr.
euraxess.ec.europa.eu
November 4, 2025 at 5:11 PM
🚨Job alert🚨
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
Reposted by Adrien Peyrache
a gross parliamentary overreach — article by @picardonhealth.bsky.social in the globe and mail; #academicsky #neuroskyence #psychscisky www.theglobeandmail.com/gift/91587b9...
How much are MPs entitled to know about research grants? Not as much as they think
A parliamentary committee is asking for academics’ private information on a strange anti-DEI crusade
www.theglobeandmail.com
November 4, 2025 at 11:30 AM
a gross parliamentary overreach — article by @picardonhealth.bsky.social in the globe and mail; #academicsky #neuroskyence #psychscisky www.theglobeandmail.com/gift/91587b9...
New lab colormap, courtesy of the tree outside my house.
October 24, 2025 at 5:32 PM
New lab colormap, courtesy of the tree outside my house.
Reposted by Adrien Peyrache
Various theoretical properties derived for gamma oscillations based on canonical E-SOM-PV microcircuit connectivity using mean-field modelling, which moves beyond classic Wilson-Cowan models in important ways
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
A mean-field model of neural networks with PV and SOM interneurons reveals connectivity-based mechanisms of gamma oscillations
Classic theoretical models of cortical oscillations are based on the interactions between two populations of excitatory and inhibitory neurons. Nevertheless, experimental studies and network simulatio...
biorxiv.org
October 24, 2025 at 11:02 AM
Various theoretical properties derived for gamma oscillations based on canonical E-SOM-PV microcircuit connectivity using mean-field modelling, which moves beyond classic Wilson-Cowan models in important ways
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
Looking forward to seeing all the great science that will come out of @adrian-du.bsky.social’s lab, aka the DuLab!!
Congrats Adrian!
Congrats Adrian!
Thrilled to announce I'll be joining the Division of Neuroscience at @manchester.ac.uk as a Lecturer in Feb '26!
The DuLab will explore how the brain integrates sensory streams into internal maps 🌐 using the rodent head-direction circuit, the 'neural compass', as a starting point for the journey 🧭
The DuLab will explore how the brain integrates sensory streams into internal maps 🌐 using the rodent head-direction circuit, the 'neural compass', as a starting point for the journey 🧭
October 20, 2025 at 8:39 PM
Looking forward to seeing all the great science that will come out of @adrian-du.bsky.social’s lab, aka the DuLab!!
Congrats Adrian!
Congrats Adrian!
Reposted by Adrien Peyrache
Really excited to share this Opinion piece we've been working on with fellow head-direction cell geeks @apeyrache.bsky.social @desdemonafricker.bsky.social and (bsky-less?) Andrea Burgalossi! While head-direction cells pop up in many cortical regions, we think that one of them is quite unique (1/8)
The postsubiculum as a head-direction cortex
The organisation of thalamocortical networks follows a conserved structure. Traditionally, these are divided into primary sensory systems that receive…
www.sciencedirect.com
October 15, 2025 at 8:10 PM
Really excited to share this Opinion piece we've been working on with fellow head-direction cell geeks @apeyrache.bsky.social @desdemonafricker.bsky.social and (bsky-less?) Andrea Burgalossi! While head-direction cells pop up in many cortical regions, we think that one of them is quite unique (1/8)
🚨new paper: the head-direction circuit as a model of primary thalamocortical system. Check this out 👇
kudos to @adrian-du.bsky.social for the huge amount of work put into this opinion piece, starting with the beautiful figures comparing the different thalamocortical systems 🤩
kudos to @adrian-du.bsky.social for the huge amount of work put into this opinion piece, starting with the beautiful figures comparing the different thalamocortical systems 🤩
Really excited to share this Opinion piece we've been working on with fellow head-direction cell geeks @apeyrache.bsky.social @desdemonafricker.bsky.social and (bsky-less?) Andrea Burgalossi! While head-direction cells pop up in many cortical regions, we think that one of them is quite unique (1/8)
The postsubiculum as a head-direction cortex
The organisation of thalamocortical networks follows a conserved structure. Traditionally, these are divided into primary sensory systems that receive…
www.sciencedirect.com
October 15, 2025 at 9:39 PM
🚨new paper: the head-direction circuit as a model of primary thalamocortical system. Check this out 👇
kudos to @adrian-du.bsky.social for the huge amount of work put into this opinion piece, starting with the beautiful figures comparing the different thalamocortical systems 🤩
kudos to @adrian-du.bsky.social for the huge amount of work put into this opinion piece, starting with the beautiful figures comparing the different thalamocortical systems 🤩
Totally agree with @gershbrain.bsky.social. Science will never explain art.
Yet the two share an important trait: a constant search for new representations of nature, of data, of reality, of emotions, in forms that make sense of what once seemed inscrutable.
Yet the two share an important trait: a constant search for new representations of nature, of data, of reality, of emotions, in forms that make sense of what once seemed inscrutable.
When I was an undergrad, I saw a talk by Oliver Sacks about music. During the Q&A, someone asked Sacks if he thought science would reveal the deepest mysteries of art. Sacks (a rare humanist among scientists) said that he doubted it, at which Eric Kandel (the host) leaped up and grabbed the mic.
October 15, 2025 at 1:19 PM
Totally agree with @gershbrain.bsky.social. Science will never explain art.
Yet the two share an important trait: a constant search for new representations of nature, of data, of reality, of emotions, in forms that make sense of what once seemed inscrutable.
Yet the two share an important trait: a constant search for new representations of nature, of data, of reality, of emotions, in forms that make sense of what once seemed inscrutable.
Reposted by Adrien Peyrache
The Wu Tsai Institute at Yale is hiring another faculty member in neurocomputation. Come work with us in a growing community at the interface of neuroscience and AI!
More info below 👇
More info below 👇
📣 WTI is hiring faculty positions! Are you interested in advancing our understanding of the brain + how it gives rise to cognition?
Two calls are open:
Open-rank search, Neurocomputation, deadline: 12.1.25
Senior search, Neurodevelopment, rolling review
🔗 wti.yale.edu/opportunities
#KnowTogether
Two calls are open:
Open-rank search, Neurocomputation, deadline: 12.1.25
Senior search, Neurodevelopment, rolling review
🔗 wti.yale.edu/opportunities
#KnowTogether
October 8, 2025 at 12:14 PM
The Wu Tsai Institute at Yale is hiring another faculty member in neurocomputation. Come work with us in a growing community at the interface of neuroscience and AI!
More info below 👇
More info below 👇