Quang NN
@quang-n-nguyen.bsky.social
NDMOxford DPhil| Erasmus Vaccinology MSc| Duke BS| ArtisVentures Fellow, Computational vaccinology enthusiast 👾 SLO CD8 T cell diversity
Reposted by Quang NN
Excited to share our atlas build&use guide, out @naturemethods today. Led by @KHrovatin & @SikkemaLisa w @MDLuecken, our review highlights best practices for building, sharing, and leveraging atlases to unlock new biological discoveries. 🌍@humancellatlas
nature.com/articles/s41592-024-02532-y
nature.com/articles/s41592-024-02532-y
December 13, 2024 at 11:10 AM
Excited to share our atlas build&use guide, out @naturemethods today. Led by @KHrovatin & @SikkemaLisa w @MDLuecken, our review highlights best practices for building, sharing, and leveraging atlases to unlock new biological discoveries. 🌍@humancellatlas
nature.com/articles/s41592-024-02532-y
nature.com/articles/s41592-024-02532-y
Reposted by Quang NN
1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇
biorxiv.org/content/10.1101/2024.12.11.627935v1
biorxiv.org/content/10.1101/2024.12.11.627935v1
December 12, 2024 at 2:48 PM
1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇
biorxiv.org/content/10.1101/2024.12.11.627935v1
biorxiv.org/content/10.1101/2024.12.11.627935v1
Reposted by Quang NN
Maternal gut microbiota influence stem cell function in offspring
”the maternal microbiome and offspring’s stem cells are bona fide candidates that seem to play central roles governing early life development”
www.cell.com/cell-stem-ce...
”the maternal microbiome and offspring’s stem cells are bona fide candidates that seem to play central roles governing early life development”
www.cell.com/cell-stem-ce...
Maternal gut microbiota influence stem cell function in offspring
Dang et al. demonstrate that maternal gut microbiota during pregnancy program the intestinal and neuronal stem cell characteristics of offspring. This crosstalk between maternal microbiota and fetal stem cells, mediated by circulating metabolites, impacts offspring development, long-term health, behavior, and disease recovery.
www.cell.com
December 11, 2024 at 10:42 PM
Maternal gut microbiota influence stem cell function in offspring
”the maternal microbiome and offspring’s stem cells are bona fide candidates that seem to play central roles governing early life development”
www.cell.com/cell-stem-ce...
”the maternal microbiome and offspring’s stem cells are bona fide candidates that seem to play central roles governing early life development”
www.cell.com/cell-stem-ce...
Reposted by Quang NN
3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience.
A MUST READ if you're doing transcriptomics.
3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year!
(mini thread)
A MUST READ if you're doing transcriptomics.
3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year!
(mini thread)
December 11, 2024 at 5:04 PM
3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience.
A MUST READ if you're doing transcriptomics.
3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year!
(mini thread)
A MUST READ if you're doing transcriptomics.
3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year!
(mini thread)
Reposted by Quang NN
Excited to share this major work in #LabOnAChip! Dr. Sophie Cook created a tubing-free, multi-compartment chip for organ co-cultures, and partnered with fellow PhD alum Alex Ball to test early responses to vaccination on-chip. #OrganOnChip #3Dprinting #ImmunoEngineering
pubs.rsc.org/en/Content/A...
pubs.rsc.org/en/Content/A...
A 3D-printed multi-compartment organ-on-chip platform with a tubing-free pump models communication with the lymph node
Multi-organ-on-chip systems (MOOCs) have the potential to mimic communication between organ systems and reveal mechanisms of health and disease. However, many existing MOOCs are challenging for non-ex...
pubs.rsc.org
December 11, 2024 at 5:36 PM
Excited to share this major work in #LabOnAChip! Dr. Sophie Cook created a tubing-free, multi-compartment chip for organ co-cultures, and partnered with fellow PhD alum Alex Ball to test early responses to vaccination on-chip. #OrganOnChip #3Dprinting #ImmunoEngineering
pubs.rsc.org/en/Content/A...
pubs.rsc.org/en/Content/A...
Reposted by Quang NN
Stunning free #science vector art for your next poster, paper or talk 🤩
The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes
bioart.niaid.nih.gov
#rstats #dataviz #phd #illustration
The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes
bioart.niaid.nih.gov
#rstats #dataviz #phd #illustration
December 10, 2024 at 7:52 AM
Stunning free #science vector art for your next poster, paper or talk 🤩
The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes
bioart.niaid.nih.gov
#rstats #dataviz #phd #illustration
The #NIH has compiled over 2,000 illustrations including swatches and pattern brushes
bioart.niaid.nih.gov
#rstats #dataviz #phd #illustration
Reposted by Quang NN
it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
Neuroinflammation in Alzheimer disease - Nature Reviews Immunology
This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...
www.nature.com
December 10, 2024 at 3:03 AM
it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
Reposted by Quang NN
Nice summary of the cool paper by @poholeklab.bsky.social's lab on IL-2 microniches in Th2 cell differentiation #ImmunoSky
It’s the little things in life: Lymph node microniches drive TH2 formation in allergic asthma
Lymph node IL-2 microniches guide development of TH2 cells through induction of Blimp-1 expression and an IL-10–positive feedback loop.
www.science.org
December 9, 2024 at 3:03 PM
Nice summary of the cool paper by @poholeklab.bsky.social's lab on IL-2 microniches in Th2 cell differentiation #ImmunoSky
Reposted by Quang NN
Repertoire-based mapping and time-tracking of helper T cell subsets in scRNA-Seq
doi.org/10.1101/2023...
doi.org/10.1101/2023...
Repertoire-based mapping and time-tracking of helper T cell subsets in scRNA-Seq
The functional programs selected by CD4+ helper (Th) T cell clones fundamentally determine the architecture of the immune response to distinct challenges. Advances in scRNA-Seq have enhanced our under...
doi.org
December 10, 2024 at 1:02 PM
Repertoire-based mapping and time-tracking of helper T cell subsets in scRNA-Seq
doi.org/10.1101/2023...
doi.org/10.1101/2023...
Reposted by Quang NN
B CELL FUN FACT: Secrets of the GC #2
There are 300 billion B cells with total mass of 60g in the human body. That is 3 times the number of stars in the Milky Way! Naïve B cell express >10 million unique antibodies to protect us from this universe of possible antigens!
www.pnas.org/doi/10.1073/...
There are 300 billion B cells with total mass of 60g in the human body. That is 3 times the number of stars in the Milky Way! Naïve B cell express >10 million unique antibodies to protect us from this universe of possible antigens!
www.pnas.org/doi/10.1073/...
The total mass, number, and distribution of immune cells in the human body | PNAS
The immune system is a complex network of cells with critical functions in health
and disease. However, a comprehensive census of the cells compris...
www.pnas.org
December 9, 2024 at 11:22 AM
B CELL FUN FACT: Secrets of the GC #2
There are 300 billion B cells with total mass of 60g in the human body. That is 3 times the number of stars in the Milky Way! Naïve B cell express >10 million unique antibodies to protect us from this universe of possible antigens!
www.pnas.org/doi/10.1073/...
There are 300 billion B cells with total mass of 60g in the human body. That is 3 times the number of stars in the Milky Way! Naïve B cell express >10 million unique antibodies to protect us from this universe of possible antigens!
www.pnas.org/doi/10.1073/...
Reposted by Quang NN
Contrary to what was thought - that immune cells cannot infiltrate the brain - anticancer active T cells do exist in the brain, specifically inside the bone marrow in the skull.
These exact cells might be the future of immune therapies against brain cancers.
www.nature.com/articles/d41...
These exact cells might be the future of immune therapies against brain cancers.
www.nature.com/articles/d41...
December 3, 2024 at 12:22 AM
Contrary to what was thought - that immune cells cannot infiltrate the brain - anticancer active T cells do exist in the brain, specifically inside the bone marrow in the skull.
These exact cells might be the future of immune therapies against brain cancers.
www.nature.com/articles/d41...
These exact cells might be the future of immune therapies against brain cancers.
www.nature.com/articles/d41...
Reposted by Quang NN
"We designed synthetic suppressor T cells by engineering conventional CD4+ T cells with synthetic Notch (synNotch) regulatory circuits that drive antigen-induced production of custom anti-inflammatory payloads."
#Immunology
www.science.org/doi/10.1126/...
#Immunology
www.science.org/doi/10.1126/...
Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs
Immune homeostasis requires a balance of inflammatory and suppressive activities. To design cells potentially useful for local immune suppression, we engineered conventional CD4+ T cells with syntheti...
www.science.org
December 8, 2024 at 8:21 AM
"We designed synthetic suppressor T cells by engineering conventional CD4+ T cells with synthetic Notch (synNotch) regulatory circuits that drive antigen-induced production of custom anti-inflammatory payloads."
#Immunology
www.science.org/doi/10.1126/...
#Immunology
www.science.org/doi/10.1126/...
Reposted by Quang NN
Reposted by Quang NN
Worth reading this excerpt from Ben Barres posthumous memoir - to the point & a reminder on the need and value of visible support of #LGTBQ in all of our professional and non-professional arenas #academicsky #glia
"It is very difficult to live life in a closet. It does not make sense to do this because of an occasional bigot. I have yet to have anyone tell me they regretted their decision to be open."
The Coming Out of a Transgender Scientist
"I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."
buff.ly
December 6, 2024 at 5:10 PM
Worth reading this excerpt from Ben Barres posthumous memoir - to the point & a reminder on the need and value of visible support of #LGTBQ in all of our professional and non-professional arenas #academicsky #glia
Reposted by Quang NN
#Tcell and #crossreactivity #No #one is #naive: the significance of #heterologous #Tcell #immunity www.nature.com/articles/nri...
No one is naive: the significance of heterologous T-cell immunity - Nature Reviews Immunology
Nature Reviews Immunology - No one is naive: the significance of heterologous T-cell immunity
www.nature.com
December 5, 2024 at 3:27 PM
#Tcell and #crossreactivity #No #one is #naive: the significance of #heterologous #Tcell #immunity www.nature.com/articles/nri...
Reposted by Quang NN
Reposted by Quang NN
Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states
@joelbabdor.bsky.social
doi.org/10.1101/2024...
@joelbabdor.bsky.social
doi.org/10.1101/2024...
December 5, 2024 at 12:53 AM
Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states
@joelbabdor.bsky.social
doi.org/10.1101/2024...
@joelbabdor.bsky.social
doi.org/10.1101/2024...
Reposted by Quang NN
A landscape of X-inactivation during human T cell development
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 5, 2024 at 12:02 AM
A landscape of X-inactivation during human T cell development
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Yes. About time to leverage learning from therapeutic vax to advance prophylaxis against cancers by vaccination #cancervaccines #prophylactic
REVIEW: Vaccines for cancer prevention: exploring opportunities and navigating challenges
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Vaccines for cancer prevention: exploring opportunities and navigating challenges - Nature Reviews Drug Discovery
Cancer-preventive vaccines can reduce cancer occurrence by inducing a specific immune response against tumours before they can fully develop. This Review discusses results from pioneering clinical stu...
www.nature.com
December 2, 2024 at 10:38 PM
Yes. About time to leverage learning from therapeutic vax to advance prophylaxis against cancers by vaccination #cancervaccines #prophylactic
Reposted by Quang NN
T cell receptor–centric perspective improves single-cell analysis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
T cell receptor–centric perspective to multimodal single-cell data analysis
T cell receptor–centric perspective improves single-cell analysis.
www.science.org
December 2, 2024 at 10:14 PM
T cell receptor–centric perspective improves single-cell analysis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Quang NN
Over the past year I gave some lectures on AI and Immunology including the keynote at NIAID and GSK Palio Meeting. I've been asked about sharing my slides, here they are:
1. slides: zenodo.org/records/1425...
2. NIAID meeting report: rdcu.be/d1VRw
3. Related: www.dropbox.com/scl/fi/y67z0...
1. slides: zenodo.org/records/1425...
2. NIAID meeting report: rdcu.be/d1VRw
3. Related: www.dropbox.com/scl/fi/y67z0...
Towards AI Models of Human Immunity: Past, Present, Future
These are the slides I presented at the 2024 AI and Immunology - Exploring Opportunities and Challenges meeting.
zenodo.org
December 1, 2024 at 8:22 PM
Over the past year I gave some lectures on AI and Immunology including the keynote at NIAID and GSK Palio Meeting. I've been asked about sharing my slides, here they are:
1. slides: zenodo.org/records/1425...
2. NIAID meeting report: rdcu.be/d1VRw
3. Related: www.dropbox.com/scl/fi/y67z0...
1. slides: zenodo.org/records/1425...
2. NIAID meeting report: rdcu.be/d1VRw
3. Related: www.dropbox.com/scl/fi/y67z0...
And ofc what makes reg a reg is its function and not necessarily detectable FoxP3 expression #treg
More #evidence for the existence of #CD8 #Regulatory #Tcells www.nature.com/articles/s41... Check our previous paper also> #KIR+CD8+ #T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19 | Science www.science.org/doi/10.1126/...
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma - Nature Immunology
Tumor-antigen-specific CD8+ T cells are generally thought to help fight against cancer, but here the authors identify a subpopulation of CD8+ T cells that are associated with a poor clinical outcome i...
www.nature.com
December 1, 2024 at 12:18 PM
And ofc what makes reg a reg is its function and not necessarily detectable FoxP3 expression #treg
Reposted by Quang NN
REVIEW: Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level
www.nature.com/articles/s41...
@davidfinlaytcd.bsky.social
www.nature.com/articles/s41...
@davidfinlaytcd.bsky.social
December 1, 2024 at 3:26 AM
REVIEW: Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level
www.nature.com/articles/s41...
@davidfinlaytcd.bsky.social
www.nature.com/articles/s41...
@davidfinlaytcd.bsky.social
Reposted by Quang NN
I’m biased of course but this is a detailed new mechanism for the direct action of IL-2 on antigen-experiencing B cells, driving early/extrafollicular antibody responses! Congrats to @katyely.bsky.social and all co-authors on a job diligently and well done! Glad I could help #immunosky #bcells
✨ Ever wondered why B cells are so fond of IL-2? Wonder no more! Our study is now published in Immunity @cellpress.bsky.social 🔍📑 A truly perfect Thanksgiving gift! 🧑🔬💉🔬https://authors.elsevier.com/c/1kAq43qNrUxuTR
November 28, 2024 at 7:39 PM
I’m biased of course but this is a detailed new mechanism for the direct action of IL-2 on antigen-experiencing B cells, driving early/extrafollicular antibody responses! Congrats to @katyely.bsky.social and all co-authors on a job diligently and well done! Glad I could help #immunosky #bcells