John Lindner
@johnmlindner.bsky.social
Molecular Immunologist
TCRs, BCRs, and their ligands
Head of Immunology Discovery at BioMed X
Heidelberg, Germany and New Haven, CT
TCRs, BCRs, and their ligands
Head of Immunology Discovery at BioMed X
Heidelberg, Germany and New Haven, CT
Only two weeks left to apply for #ResearchFunding and join us in Ridgefield, Connecticut. Establish your own group and receive 890k USD/year for up to 5 years, access cutting-edge infrastructure!
career.bmedx.com/call/2025-RD...
#ScienceWithImpact #Ophthalmology #TissueEngineering #Biotherapeutics
career.bmedx.com/call/2025-RD...
#ScienceWithImpact #Ophthalmology #TissueEngineering #Biotherapeutics
BioMed X Institute
BioMed X Application System
career.bmedx.com
July 7, 2025 at 10:27 AM
Only two weeks left to apply for #ResearchFunding and join us in Ridgefield, Connecticut. Establish your own group and receive 890k USD/year for up to 5 years, access cutting-edge infrastructure!
career.bmedx.com/call/2025-RD...
#ScienceWithImpact #Ophthalmology #TissueEngineering #Biotherapeutics
career.bmedx.com/call/2025-RD...
#ScienceWithImpact #Ophthalmology #TissueEngineering #Biotherapeutics
Do you have expertise in one or more of the following areas? #Ophthalmology #organotypic models #TissueEngineering #proteinengineering
Just over one month left in our newly opened call for applications to a new research group in Ridgefield, Conn.!
career.bmedx.com/call/2025-RD...
#ResearchJobs
Just over one month left in our newly opened call for applications to a new research group in Ridgefield, Conn.!
career.bmedx.com/call/2025-RD...
#ResearchJobs
BioMed X Institute
BioMed X Application System
career.bmedx.com
June 11, 2025 at 6:51 PM
Do you have expertise in one or more of the following areas? #Ophthalmology #organotypic models #TissueEngineering #proteinengineering
Just over one month left in our newly opened call for applications to a new research group in Ridgefield, Conn.!
career.bmedx.com/call/2025-RD...
#ResearchJobs
Just over one month left in our newly opened call for applications to a new research group in Ridgefield, Conn.!
career.bmedx.com/call/2025-RD...
#ResearchJobs
Our latest call for applications is now open! Early-career researchers in the fields of biotherapeutic engineering, ocular models, and assay technology are invited to join our Ridgefield, Connecticut location as part of an exciting new team! career.bio.mx/call/2025-RD...
BioMed X Institute
BioMed X Application System
career.bio.mx
May 22, 2025 at 8:43 AM
Our latest call for applications is now open! Early-career researchers in the fields of biotherapeutic engineering, ocular models, and assay technology are invited to join our Ridgefield, Connecticut location as part of an exciting new team! career.bio.mx/call/2025-RD...
Blending my personal and professional lives a bit here, but this is a great short read (and cool "then vs. now" perspective) on a rising star in a related field:
Chemists amid coronavirus five years on: @grynova.bsky.social www.chemistryworld.com/opinion/chem...
Chemists amid coronavirus five years on: @grynova.bsky.social www.chemistryworld.com/opinion/chem...
Chemists amid coronavirus five years on: Anya Gryn’ova
A computational chemist has moved from being group leader at a German research institute to an associate computational chemistry prof in the UK
www.chemistryworld.com
March 11, 2025 at 12:46 PM
Blending my personal and professional lives a bit here, but this is a great short read (and cool "then vs. now" perspective) on a rising star in a related field:
Chemists amid coronavirus five years on: @grynova.bsky.social www.chemistryworld.com/opinion/chem...
Chemists amid coronavirus five years on: @grynova.bsky.social www.chemistryworld.com/opinion/chem...
Reposted by John Lindner
My lab is hiring a research assistant. If you love culturing cells but wish they weren't so flat, come bioprint with us: we culture in spheres! We culture in cubes! We culture in bioprinted vessels!
www.linkedin.com/jobs/view/41...
www.linkedin.com/jobs/view/41...
BioMed X Institute hiring Research Assistant - Complex Human Ex Vivo Models of Tissue Inflammation in New Haven, CT | LinkedIn
Posted 4:57:18 PM. About BioMed XBioMed X is an independent research institute with sites in Heidelberg, Germany, New…See this and similar jobs on LinkedIn.
www.linkedin.com
March 11, 2025 at 2:27 AM
My lab is hiring a research assistant. If you love culturing cells but wish they weren't so flat, come bioprint with us: we culture in spheres! We culture in cubes! We culture in bioprinted vessels!
www.linkedin.com/jobs/view/41...
www.linkedin.com/jobs/view/41...
In the face of pushback against workplace inclusion and diversity practices by some in power, it is incumbent on responsible leaders everywhere to ensure true fairness, recognize talent, and support the careers particularly of those given an inherent societal disadvantage! #InternationalWomensDay
March 8, 2025 at 9:00 AM
In the face of pushback against workplace inclusion and diversity practices by some in power, it is incumbent on responsible leaders everywhere to ensure true fairness, recognize talent, and support the careers particularly of those given an inherent societal disadvantage! #InternationalWomensDay
Reposted by John Lindner
EFIS mourns the passing of Fritz Melchers
www.efis.org/news/fritz-m...
We extend heartfelt condolences to Fritz Melchers' family, friends, colleagues and the immunology community around the world.
Photo credit: Jacqueline Hirscher
www.efis.org/news/fritz-m...
We extend heartfelt condolences to Fritz Melchers' family, friends, colleagues and the immunology community around the world.
Photo credit: Jacqueline Hirscher
February 28, 2025 at 1:58 PM
EFIS mourns the passing of Fritz Melchers
www.efis.org/news/fritz-m...
We extend heartfelt condolences to Fritz Melchers' family, friends, colleagues and the immunology community around the world.
Photo credit: Jacqueline Hirscher
www.efis.org/news/fritz-m...
We extend heartfelt condolences to Fritz Melchers' family, friends, colleagues and the immunology community around the world.
Photo credit: Jacqueline Hirscher
To any and all affected scientists @altnih4science.bsky.social (or other opportunity-seekers), we're hiring in New Haven! Postdoc and RA position, please reach out to me or PI @anothercutler.bsky.social if interested, immunology/macrophage experience ideal, please share with your networks #immunosky
February 25, 2025 at 11:06 PM
To any and all affected scientists @altnih4science.bsky.social (or other opportunity-seekers), we're hiring in New Haven! Postdoc and RA position, please reach out to me or PI @anothercutler.bsky.social if interested, immunology/macrophage experience ideal, please share with your networks #immunosky
Reposted by John Lindner
Fantastic News & Views article Nature Portfolio by @michelalocci.bsky.social & @sapostolidis.bsky.social, highlighting our recent study on mRNA vaccines and SLE, its findings, and the key questions to address next!
rdcu.be/d4332
#immunosky #SLE #mRNA #Bcells 🦠 👩🔬 💉
rdcu.be/d4332
#immunosky #SLE #mRNA #Bcells 🦠 👩🔬 💉
SLE B cells take an extrafollicular detour after mRNA vaccination
Nature Immunology - Systemic lupus erythematosus (SLE) is an autoimmune disease with considerable clinical heterogeneity and diverse treatment options. A study now shows that heightened...
rdcu.be
December 28, 2024 at 11:08 AM
Fantastic News & Views article Nature Portfolio by @michelalocci.bsky.social & @sapostolidis.bsky.social, highlighting our recent study on mRNA vaccines and SLE, its findings, and the key questions to address next!
rdcu.be/d4332
#immunosky #SLE #mRNA #Bcells 🦠 👩🔬 💉
rdcu.be/d4332
#immunosky #SLE #mRNA #Bcells 🦠 👩🔬 💉
Not my work but I wish it was… general advice is to avoid buzz phrases like “tour de force” but let’s make an exception here and compliments to the authors for the precision in the title! Thanks @anothercutler.bsky.social for the heads up www.cell.com/cell/fulltex...
Atlas of the plasma proteome in health and disease in 53,026 adults
A large-scale proteomics study involving 53,026 individuals maps 2,920 plasma proteins
to 406 prevalent diseases, 660 incident diseases, and 986 health-related traits, identifying
promising biomarkers...
www.cell.com
November 30, 2024 at 3:17 PM
Not my work but I wish it was… general advice is to avoid buzz phrases like “tour de force” but let’s make an exception here and compliments to the authors for the precision in the title! Thanks @anothercutler.bsky.social for the heads up www.cell.com/cell/fulltex...
I’m biased of course but this is a detailed new mechanism for the direct action of IL-2 on antigen-experiencing B cells, driving early/extrafollicular antibody responses! Congrats to @katyely.bsky.social and all co-authors on a job diligently and well done! Glad I could help #immunosky #bcells
✨ Ever wondered why B cells are so fond of IL-2? Wonder no more! Our study is now published in Immunity @cellpress.bsky.social 🔍📑 A truly perfect Thanksgiving gift! 🧑🔬💉🔬https://authors.elsevier.com/c/1kAq43qNrUxuTR
November 28, 2024 at 7:39 PM
I’m biased of course but this is a detailed new mechanism for the direct action of IL-2 on antigen-experiencing B cells, driving early/extrafollicular antibody responses! Congrats to @katyely.bsky.social and all co-authors on a job diligently and well done! Glad I could help #immunosky #bcells
🙋♂️ Is IL6R D358A also protective against fibrotic progression?
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
Our findings propose a causal relationship between reduced IL-6 signalling and lower
risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This
study suggests that IL-6 antago...
www.thelancet.com
November 22, 2024 at 12:59 AM
🙋♂️ Is IL6R D358A also protective against fibrotic progression?
Super cool repository, free for (non-commercial) use and still… should never, ever, under any circumstances be used in a PowerPoint presentation
sound-effects.bbcrewind.co.uk/search?resul...
sound-effects.bbcrewind.co.uk/search?resul...
BBC Sound Effects
BBC Sound Effects
sound-effects.bbcrewind.co.uk
November 21, 2024 at 4:01 PM
Super cool repository, free for (non-commercial) use and still… should never, ever, under any circumstances be used in a PowerPoint presentation
sound-effects.bbcrewind.co.uk/search?resul...
sound-effects.bbcrewind.co.uk/search?resul...
Kids, drugs are bad, don’t do them… also, learn to play the cello… also, forget the first part of what I said… you know what, just google “cello goblin” youtu.be/ucWTdsxL25E?...
Ear to the Ground: Rushad Eggleston
YouTube video by Beehive Productions
youtu.be
November 20, 2024 at 12:11 PM
Kids, drugs are bad, don’t do them… also, learn to play the cello… also, forget the first part of what I said… you know what, just google “cello goblin” youtu.be/ucWTdsxL25E?...
Indeed a fascinating new look at intratumoral T cell subsets! Would be great to learn about TCR clonality of “Subset 3” and whether these cells are (pre-)enriched for tumor specificities! #immunosky
I’m very fascinated about this study showing stem cell-like effector CD4 T cells that can become the classic T helper subsets. In tumors, Tregs suppress these cells, blocking Th1 seeding and anti-tumor effects! Jenkins lab also recently described a similar CD4 phenotype with different implications.
Differentiation fate of a stem-like CD4 T cell controls immunity to cancer - Nature
A population of tumour-specific PD1+TCF1+ CD4 T cells in tumour-draining lymph nodes is capable of self-renewal and differentiation into CD4 effector cells, thereby controlling CD8 T cell activity.
www.nature.com
November 20, 2024 at 1:22 AM
Indeed a fascinating new look at intratumoral T cell subsets! Would be great to learn about TCR clonality of “Subset 3” and whether these cells are (pre-)enriched for tumor specificities! #immunosky
Agree 💯 and will add that the only substantial way to make those models better at this point is to increase the quality and quantity of training data, which for us only happens in the wet lab
Every day a new foundation model drops, and as an experimentalist, I just skim the preprint and go back to my pipettes. Foundation model fatigue. The bar for adoption is high and requires experimental validation.
November 19, 2024 at 6:53 PM
Agree 💯 and will add that the only substantial way to make those models better at this point is to increase the quality and quantity of training data, which for us only happens in the wet lab
Reposted by John Lindner
next #globalimmuno talk is on this Wednesday, November 20th at 9am PST, noon EST, 5pm GMT by Dr. Padmanee Sharma.
Title: “Mechanisms of Response and Resistance to Immune Checkpoint Therapy”
LINK: ucsd.zoom.us/j/91053505061
Current schedule : www.globalimmunotalks.org/schedule
Title: “Mechanisms of Response and Resistance to Immune Checkpoint Therapy”
LINK: ucsd.zoom.us/j/91053505061
Current schedule : www.globalimmunotalks.org/schedule
Welcome! You are invited to join a webinar: GLOBAL IMMUNOTALKS . After registering, you will receive a confirmation email about joining the webinar.
Virtual immunology seminar series
2024 Organizers: Miriam Merad, Kazuyo Moro, Bali Pulendran, Gabriel Rabinovich, Caetano Reis e Sousa, Asya Rolls and Dietmar Zehn
Q&A via X (former Twitter) @glob...
ucsd.zoom.us
November 18, 2024 at 10:23 PM
next #globalimmuno talk is on this Wednesday, November 20th at 9am PST, noon EST, 5pm GMT by Dr. Padmanee Sharma.
Title: “Mechanisms of Response and Resistance to Immune Checkpoint Therapy”
LINK: ucsd.zoom.us/j/91053505061
Current schedule : www.globalimmunotalks.org/schedule
Title: “Mechanisms of Response and Resistance to Immune Checkpoint Therapy”
LINK: ucsd.zoom.us/j/91053505061
Current schedule : www.globalimmunotalks.org/schedule
Reposted by John Lindner
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
docs.bsky.app
November 18, 2024 at 2:48 PM
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
As part of my role as Head of Research for US-based BioMed X teams: Alicia Cutler's Team CHM (based in New Haven, CT) is #recruiting an #immunology expert (postdoctoral fellow) to study the role of #inflammation in #vasculature using unique, complex, 3-D models: career.bio.mx/call/2024-NH...
BioMed X Institute
BioMed X Application System
career.bio.mx
November 18, 2024 at 12:02 PM
As part of my role as Head of Research for US-based BioMed X teams: Alicia Cutler's Team CHM (based in New Haven, CT) is #recruiting an #immunology expert (postdoctoral fellow) to study the role of #inflammation in #vasculature using unique, complex, 3-D models: career.bio.mx/call/2024-NH...
Reposted by John Lindner
This worked for me!
🐦➡️🦋 Looking to rebuild your network on Bluesky by reconnecting with your existing X/Twitter contacts? The Skylink browser extension makes it easy!
chromewebstore.google.com/detail/sky-f...
Thanks @jmschreiber91.bsky.social!
#scicomm #cancer #tumorimmunology
chromewebstore.google.com/detail/sky-f...
Thanks @jmschreiber91.bsky.social!
#scicomm #cancer #tumorimmunology
Sky Follower Bridge - Chrome Web Store
Instantly find and follow the same users from your Twitter follows on Bluesky.
chromewebstore.google.com
November 17, 2024 at 12:32 PM
This worked for me!
Reposted by John Lindner
NIAID releases alternative to BioRender, all illustrations freely available in public domain
bioart.niaid.nih.gov
bioart.niaid.nih.gov
October 30, 2024 at 2:46 PM
NIAID releases alternative to BioRender, all illustrations freely available in public domain
bioart.niaid.nih.gov
bioart.niaid.nih.gov
Happy to have played a (small) role in this study, thanks @katyely.bsky.social for the opportunity to collaborate! Great read on the effects of #autoimmunity on #covid #vaccination!
Our study just out!
"Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE".
🔗
* rdcu.be/dZWI9
* lnkd.in/desv-ZrV
#SLE | #Autoimmunity | #mRNAvaccines | Disease-associated #Bcells shape anti-vaccine immunity in SLE. 👩🔬 💉💉💉 🦠
"Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE".
🔗
* rdcu.be/dZWI9
* lnkd.in/desv-ZrV
#SLE | #Autoimmunity | #mRNAvaccines | Disease-associated #Bcells shape anti-vaccine immunity in SLE. 👩🔬 💉💉💉 🦠
Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE
Nature Immunology - SLE is a heterogeneous disorder that is characterized by different immune endotypes. Faliti et al. follow the immune memory responses upon mRNA COVID-19 vaccinations in a large...
rdcu.be
November 16, 2024 at 8:47 PM
Happy to have played a (small) role in this study, thanks @katyely.bsky.social for the opportunity to collaborate! Great read on the effects of #autoimmunity on #covid #vaccination!