Gabriele Pollara
@gpollara.bsky.social
Infectious Diseases doctor (at UCLH) and academic (at UCL). Research focuses on immune responses to TB and leprosy, but I'm also involved in too many other projects I probably shouldn't be...
Pinned
Gabriele Pollara
@gpollara.bsky.social
· Nov 21
Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
Our findings propose a causal relationship between reduced IL-6 signalling and lower
risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This
study suggests that IL-6 antago...
www.thelancet.com
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.
Lead author @gushamilton.bsky.social
#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
The uncomfortable question this paper leaves open...
👉 How many other high-risk #AntimicrobialResistance genes are carried on tiny plasmids we’re not even watching for yet?
doi.org/10.1016/j.dr...
#AMR #FutureOfHealth #Surveillance #GlobalHealthThreats
🖥️🧬💻
#AcademicSky
#MicroSky
#IDSky
🧪🧫🦠
👉 How many other high-risk #AntimicrobialResistance genes are carried on tiny plasmids we’re not even watching for yet?
doi.org/10.1016/j.dr...
#AMR #FutureOfHealth #Surveillance #GlobalHealthThreats
🖥️🧬💻
#AcademicSky
#MicroSky
#IDSky
🧪🧫🦠
Redirecting
doi.org
January 5, 2026 at 10:47 PM
Reposted by Gabriele Pollara
Prospective cohort study of adult community-acquired bacterial meningitis in the Netherlands.
Almost 70% caused by vaccine-preventable strep pneumo, with 18% mortality and 62% of survivors having neurological sequelae.
pubmed.ncbi.nlm.nih.gov/41323877/ #IDSky #vaccinessavebrains
Almost 70% caused by vaccine-preventable strep pneumo, with 18% mortality and 62% of survivors having neurological sequelae.
pubmed.ncbi.nlm.nih.gov/41323877/ #IDSky #vaccinessavebrains
Outcomes of adults with community-acquired bacterial meningitis in the Netherlands: a prospective nationwide cohort study - PubMed
Netherlands Organization for Health Research and Development (ZonMW).
pubmed.ncbi.nlm.nih.gov
January 5, 2026 at 2:55 PM
Prospective cohort study of adult community-acquired bacterial meningitis in the Netherlands.
Almost 70% caused by vaccine-preventable strep pneumo, with 18% mortality and 62% of survivors having neurological sequelae.
pubmed.ncbi.nlm.nih.gov/41323877/ #IDSky #vaccinessavebrains
Almost 70% caused by vaccine-preventable strep pneumo, with 18% mortality and 62% of survivors having neurological sequelae.
pubmed.ncbi.nlm.nih.gov/41323877/ #IDSky #vaccinessavebrains
Intirguing button on the Wellcome Open Research website! Wonder where it could lead me....😅
#AcademicSky #MedSky
#AcademicSky #MedSky
January 5, 2026 at 10:39 PM
Intirguing button on the Wellcome Open Research website! Wonder where it could lead me....😅
#AcademicSky #MedSky
#AcademicSky #MedSky
Reposted by Gabriele Pollara
How likely is ‘likely’? Does ‘likely’ have a higher probability than ‘probable’? I put together a quick quiz so you can see how you interpret probability phrases, then see how you compare with others: probability.kucharski.io
January 3, 2026 at 4:15 PM
How likely is ‘likely’? Does ‘likely’ have a higher probability than ‘probable’? I put together a quick quiz so you can see how you interpret probability phrases, then see how you compare with others: probability.kucharski.io
Reposted by Gabriele Pollara
A wonderful addition to the brave new world of human cell-based infection models as an alternative to animals - in many ways far more relevant for host/pathogen interactions at the interface (I know I’m biased, but…!)
Very happy to see this out! Work led by
@jaksonluk.bsky.social together with an amazing team @crick.ac.uk Jakson et al established a scalable and reproducible multicellular system based on human stem cells to mimic the human alveolar space in a micro-physiological system. Congratulations everyone!👏
@jaksonluk.bsky.social together with an amazing team @crick.ac.uk Jakson et al established a scalable and reproducible multicellular system based on human stem cells to mimic the human alveolar space in a micro-physiological system. Congratulations everyone!👏
I am thrilled to share that the work from @maxgg.bsky.social team @crick.ac.uk engineering a lung-on-chip from human iPSC is published in #ScienceAdvances @science.org in the new year.
January 4, 2026 at 4:03 PM
A wonderful addition to the brave new world of human cell-based infection models as an alternative to animals - in many ways far more relevant for host/pathogen interactions at the interface (I know I’m biased, but…!)
If interested in meta-analysis of TB patient data from trials, do get in touch with colleagues at UCL below! 👇
#IDSky #MedSky #TBSky
#IDSky #MedSky #TBSky
🚀 The TB Individual Patient Data (IPD) Platform is now on Bluesky!
Hosted at UCL and overseen by the UCL Centre for Global Tuberculosis Research, we bring together individual patient data to strengthen TB research, policy, and public health.
🔗 www.ucl.ac.uk/population-h...
Hosted at UCL and overseen by the UCL Centre for Global Tuberculosis Research, we bring together individual patient data to strengthen TB research, policy, and public health.
🔗 www.ucl.ac.uk/population-h...
TB-IPD platform
The TB treatment individual patient data platform (TB-IPD) is a collaborative initiative to support the generation of reliable evidence on the treatment of TB to inform future TB treatment guidelines.
www.ucl.ac.uk
January 4, 2026 at 6:37 PM
Reposted by Gabriele Pollara
🚨 Want to know how we demonstrated the importance of sterol-rich membrane microdomains for M. marinum infection?
Check out our latest paper published in Science Advances 👇
www.science.org/doi/10.1126/...
✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨
Check out our latest paper published in Science Advances 👇
www.science.org/doi/10.1126/...
✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨
Membrane microdomains are crucial for Mycobacterium marinum EsxA-dependent membrane damage, escape to the cytosol, and infection
Sterol-rich microdomain accumulation at the MCV is crucial for Mm-induced damage and infection in D. discoideum and BV-2 cells.
www.science.org
January 4, 2026 at 10:54 AM
🚨 Want to know how we demonstrated the importance of sterol-rich membrane microdomains for M. marinum infection?
Check out our latest paper published in Science Advances 👇
www.science.org/doi/10.1126/...
✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨
Check out our latest paper published in Science Advances 👇
www.science.org/doi/10.1126/...
✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨
Reposted by Gabriele Pollara
I’ve jotted down a few general points about paper rejection, if it’s of interest to anyone
open.substack.com/pub/onisillo...
open.substack.com/pub/onisillo...
January 3, 2026 at 9:22 PM
I’ve jotted down a few general points about paper rejection, if it’s of interest to anyone
open.substack.com/pub/onisillo...
open.substack.com/pub/onisillo...
I see this from a glass half full perspective. It'll be hard to be 100% reliant on renewable energy sources but direction of travel is good. www.bbc.co.uk/news/a...
#climatechange #wind #solar
#climatechange #wind #solar
Record year for wind and solar electricity in Great Britain in 2025
Wind, solar and other renewables hit a new high last year but the government is still some way off its clean power target.
www.bbc.co.uk
January 3, 2026 at 11:32 AM
I see this from a glass half full perspective. It'll be hard to be 100% reliant on renewable energy sources but direction of travel is good. www.bbc.co.uk/news/a...
#climatechange #wind #solar
#climatechange #wind #solar
Lucky break this morning. Looked out of the window and noticed this massive ball in the sky - turns out it's a supermoon day! 🎉 🎑
Impressive but photo doesn't do it justice. Resolution not great - in 2026 I definitely "need" to get a phone with optical zoom... 😉
#supermoon #wolfmoon #moon
Impressive but photo doesn't do it justice. Resolution not great - in 2026 I definitely "need" to get a phone with optical zoom... 😉
#supermoon #wolfmoon #moon
January 3, 2026 at 8:14 AM
Lucky break this morning. Looked out of the window and noticed this massive ball in the sky - turns out it's a supermoon day! 🎉 🎑
Impressive but photo doesn't do it justice. Resolution not great - in 2026 I definitely "need" to get a phone with optical zoom... 😉
#supermoon #wolfmoon #moon
Impressive but photo doesn't do it justice. Resolution not great - in 2026 I definitely "need" to get a phone with optical zoom... 😉
#supermoon #wolfmoon #moon
This is an interesting scheme - making compelling journal submissions is hard, and early rejections are often met with little to no feedback.
Nice to see a journal offering to make this a learning process for early career researchers.
@idsainfo.bsky.social
#IDSky #MedSky #ClinMicro #AcademicSky
Nice to see a journal offering to make this a learning process for early career researchers.
@idsainfo.bsky.social
#IDSky #MedSky #ClinMicro #AcademicSky
Early-career ID researchers: OFID is piloting a new, mentored peer review pathway to support developing authors. Get structured feedback from editors and reviewers and strengthen your submission.
Learn more and secure your spot today: https://bit.ly/48YuVoP
Learn more and secure your spot today: https://bit.ly/48YuVoP
January 3, 2026 at 7:11 AM
This is an interesting scheme - making compelling journal submissions is hard, and early rejections are often met with little to no feedback.
Nice to see a journal offering to make this a learning process for early career researchers.
@idsainfo.bsky.social
#IDSky #MedSky #ClinMicro #AcademicSky
Nice to see a journal offering to make this a learning process for early career researchers.
@idsainfo.bsky.social
#IDSky #MedSky #ClinMicro #AcademicSky
Reposted by Gabriele Pollara
Very happy to see this out! Work led by
@jaksonluk.bsky.social together with an amazing team @crick.ac.uk Jakson et al established a scalable and reproducible multicellular system based on human stem cells to mimic the human alveolar space in a micro-physiological system. Congratulations everyone!👏
@jaksonluk.bsky.social together with an amazing team @crick.ac.uk Jakson et al established a scalable and reproducible multicellular system based on human stem cells to mimic the human alveolar space in a micro-physiological system. Congratulations everyone!👏
I am thrilled to share that the work from @maxgg.bsky.social team @crick.ac.uk engineering a lung-on-chip from human iPSC is published in #ScienceAdvances @science.org in the new year.
January 2, 2026 at 10:41 PM
Very happy to see this out! Work led by
@jaksonluk.bsky.social together with an amazing team @crick.ac.uk Jakson et al established a scalable and reproducible multicellular system based on human stem cells to mimic the human alveolar space in a micro-physiological system. Congratulations everyone!👏
@jaksonluk.bsky.social together with an amazing team @crick.ac.uk Jakson et al established a scalable and reproducible multicellular system based on human stem cells to mimic the human alveolar space in a micro-physiological system. Congratulations everyone!👏
Excellent as always 👇
Also struck by the definition "moderate coffee consumption—typically three to five cups per day". Glad to often sit in the "mild" category on 🍵 consumption! 😉
#coffee
Also struck by the definition "moderate coffee consumption—typically three to five cups per day". Glad to often sit in the "mild" category on 🍵 consumption! 😉
#coffee
How fortunate that two of the things I love the most in life are associated with prolonged survival. Plus, a very important "recent" paper. Happy New Year! #IDsky #Medsky open.substack.com/pub/paulsaxm...
Two Things that Prolong Life and a Great Recent Paper
A Happy New Year gift to me and everyone who shares one or both of these enthusiasms.
open.substack.com
January 2, 2026 at 4:51 PM
Excellent as always 👇
Also struck by the definition "moderate coffee consumption—typically three to five cups per day". Glad to often sit in the "mild" category on 🍵 consumption! 😉
#coffee
Also struck by the definition "moderate coffee consumption—typically three to five cups per day". Glad to often sit in the "mild" category on 🍵 consumption! 😉
#coffee
2nd January. Chocolate Easter eggs and bunnies for sale. 🤷♂️
January 2, 2026 at 3:15 PM
2nd January. Chocolate Easter eggs and bunnies for sale. 🤷♂️
This is so funny. Podcast appearance circularity and self-referencing is such a (tedious) thing! 🤣
January 2, 2026 at 10:44 AM
This is so funny. Podcast appearance circularity and self-referencing is such a (tedious) thing! 🤣
Reposted by Gabriele Pollara
The 3rd and 4th commentaries on recent ID trials are up on the CLARITY website (we aim to publish in depth reviews of important ID stuies).
This time looking at the GAMECHANGER trial:
clarityinitiative.org/commentaries...
@erinmccreary.bsky.social with Ahmad Mourad
@gurujosh.bsky.social
#IDSky
This time looking at the GAMECHANGER trial:
clarityinitiative.org/commentaries...
@erinmccreary.bsky.social with Ahmad Mourad
@gurujosh.bsky.social
#IDSky
How Do We Win? The GAME CHANGER Trial
Erin K. McCreary, PharmD (1), Ahmad Mourad, MD MHS (2, 3)
clarityinitiative.org
January 1, 2026 at 11:50 PM
The 3rd and 4th commentaries on recent ID trials are up on the CLARITY website (we aim to publish in depth reviews of important ID stuies).
This time looking at the GAMECHANGER trial:
clarityinitiative.org/commentaries...
@erinmccreary.bsky.social with Ahmad Mourad
@gurujosh.bsky.social
#IDSky
This time looking at the GAMECHANGER trial:
clarityinitiative.org/commentaries...
@erinmccreary.bsky.social with Ahmad Mourad
@gurujosh.bsky.social
#IDSky
Reposted by Gabriele Pollara
January 1, 2026 at 10:30 AM
Reposted by Gabriele Pollara
Reposted by Gabriele Pollara
January 1, 2026 at 12:31 AM
I don't understand bursts of fireworks going off outside my window in London several hours before midnight. Do people celebrate New Year in other time zones?! 🤷🎆 #NYE2025
December 31, 2025 at 6:48 PM
I don't understand bursts of fireworks going off outside my window in London several hours before midnight. Do people celebrate New Year in other time zones?! 🤷🎆 #NYE2025
Reposted by Gabriele Pollara
What viruses are up your nose? We asked 50 volunteers to swab their noses every week for a year to find out
#flutracking #COVID #rhinovirus #IDSky
academic.oup.com/jid/advance-...
#flutracking #COVID #rhinovirus #IDSky
academic.oup.com/jid/advance-...
The Pandemic Respiratory Virus Epidemiological Surveillance Trial - A Self-swab Surveillance System for Respiratory Viruses Nested Within FluTracking
PREVENT aimed to evaluate the feasibility of a community self-swab respiratory surveillance system embedded within the FluTracking Australia Framework. Hig
academic.oup.com
December 30, 2025 at 11:42 PM
What viruses are up your nose? We asked 50 volunteers to swab their noses every week for a year to find out
#flutracking #COVID #rhinovirus #IDSky
academic.oup.com/jid/advance-...
#flutracking #COVID #rhinovirus #IDSky
academic.oup.com/jid/advance-...
Discovery of the day....
Coco Pops scented bubble bath!! 😮
Coco Pops scented bubble bath!! 😮
December 30, 2025 at 12:02 PM
Discovery of the day....
Coco Pops scented bubble bath!! 😮
Coco Pops scented bubble bath!! 😮
Endotypes and disease stratification are increasingly going to become a thing in #MedSky. Question is whether we'll be able to harness it for better, more appropriate treatments.
Scientists discover 2 new subtypes of multiple sclerosis, paving the way for personalised treatments & better outcomes for patients.
Experts say the “exciting” breakthrough could revolutionise treatment of the disease.
🧪🧠 #medsky #neuroskyence
www.theguardian.com/society/2025...
Experts say the “exciting” breakthrough could revolutionise treatment of the disease.
🧪🧠 #medsky #neuroskyence
www.theguardian.com/society/2025...
Two new subtypes of MS found in ‘exciting’ breakthrough
Exclusive: Scientists uncovered biological strands using artificial intelligence and hope discovery will revolutionise treatment
www.theguardian.com
December 30, 2025 at 9:36 AM
Endotypes and disease stratification are increasingly going to become a thing in #MedSky. Question is whether we'll be able to harness it for better, more appropriate treatments.
Interesting #food history piece - I need to try a pizza naan!!!
(photo from the article)
Naan: How the 'world's best bread' travelled from Islamic courts to our plates - BBC News www.bbc.co.uk/news/article...
(photo from the article)
Naan: How the 'world's best bread' travelled from Islamic courts to our plates - BBC News www.bbc.co.uk/news/article...
December 30, 2025 at 8:03 AM
Interesting #food history piece - I need to try a pizza naan!!!
(photo from the article)
Naan: How the 'world's best bread' travelled from Islamic courts to our plates - BBC News www.bbc.co.uk/news/article...
(photo from the article)
Naan: How the 'world's best bread' travelled from Islamic courts to our plates - BBC News www.bbc.co.uk/news/article...