Jan Böttcher
@jboettcherlab.bsky.social
Professor of Experimental Immunology at the University of Tübingen, M3 Research Center & Institute of Immunology. 🧪🔬 Interested in immunity in cancer and infection. Fascinated by dendritic cells, T cells and NK cells
Excited to share our new collaborative study with the Sebastian Kobold lab! www.nature.com/articles/s41...
By deleting the PGE2 receptors EP2/EP4, we render CAR T cells resistant to suppression in solid tumors - boosting persistence and anticancer activity in preclinical models and patient samples.
By deleting the PGE2 receptors EP2/EP4, we render CAR T cells resistant to suppression in solid tumors - boosting persistence and anticancer activity in preclinical models and patient samples.
Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours - Nature Biomedical Engineering
Targeted ablation of prostaglandin E2 (PGE2) signalling in CAR T cells enhances their activity in PGE2-rich solid tumours, with demonstrations of efficacy in vitro, in mouse xenografts and in patient-...
www.nature.com
February 12, 2026 at 3:51 PM
Excited to share our new collaborative study with the Sebastian Kobold lab! www.nature.com/articles/s41...
By deleting the PGE2 receptors EP2/EP4, we render CAR T cells resistant to suppression in solid tumors - boosting persistence and anticancer activity in preclinical models and patient samples.
By deleting the PGE2 receptors EP2/EP4, we render CAR T cells resistant to suppression in solid tumors - boosting persistence and anticancer activity in preclinical models and patient samples.
Thrilled to share that my #ERCCoG EICO-CODE has been selected for funding!🚀 We will study how eicosanoids shape T cell immunity across tissues. 🧬🔬🧪✨ I am deeply grateful for this recognition of the team’s work - and to everyone supporting us in our research. Exciting years ahead!
December 9, 2025 at 11:10 AM
Thrilled to share that my #ERCCoG EICO-CODE has been selected for funding!🚀 We will study how eicosanoids shape T cell immunity across tissues. 🧬🔬🧪✨ I am deeply grateful for this recognition of the team’s work - and to everyone supporting us in our research. Exciting years ahead!
Reposted by Jan Böttcher
Less than one week left to apply 🔜
Join us at Charité University and the IMPRS-IDI Graduate Program in Berlin to unravel NK cell clonality and memory! We are looking for motivated PhD candidates who are passionate about immunology. @romagnanilab.bsky.social
@timorckert.bsky.social
Apply now 👉 www.imprs-idi.org/home/
@timorckert.bsky.social
Apply now 👉 www.imprs-idi.org/home/
December 6, 2025 at 2:43 AM
Less than one week left to apply 🔜
Very happy to join the team of the CRC 1479 initiative for the 2nd funding period to study mechanisms of immune evasion in cancer! www.sfb1479.uni-freiburg.de/news/great-n...
November 27, 2025 at 2:32 PM
Very happy to join the team of the CRC 1479 initiative for the 2nd funding period to study mechanisms of immune evasion in cancer! www.sfb1479.uni-freiburg.de/news/great-n...
🚨Our lab has a new review article out today!
We revisit prostaglandins in cancer—how they’re produced, how PGE₂ reshapes immune responses in tumors, and what this means for future therapies.
Work led by team members Erik Müller & Bastian Kruse @bkru.bsky.social
🔗 doi.org/10.1182/bloo...
We revisit prostaglandins in cancer—how they’re produced, how PGE₂ reshapes immune responses in tumors, and what this means for future therapies.
Work led by team members Erik Müller & Bastian Kruse @bkru.bsky.social
🔗 doi.org/10.1182/bloo...
Prostaglandins in cancer revisited: principles of production, mechanisms of immune regulation, and therapeutic perspectives
The cyclooxygenase (COX) signaling pathway is frequently dysregulated in cancer, resulting in aberrant production of prostaglandins - a distinct class of b
doi.org
November 27, 2025 at 12:35 PM
🚨Our lab has a new review article out today!
We revisit prostaglandins in cancer—how they’re produced, how PGE₂ reshapes immune responses in tumors, and what this means for future therapies.
Work led by team members Erik Müller & Bastian Kruse @bkru.bsky.social
🔗 doi.org/10.1182/bloo...
We revisit prostaglandins in cancer—how they’re produced, how PGE₂ reshapes immune responses in tumors, and what this means for future therapies.
Work led by team members Erik Müller & Bastian Kruse @bkru.bsky.social
🔗 doi.org/10.1182/bloo...
Reposted by Jan Böttcher
Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here: rdcu.be/eBB5e
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells
Nature Immunology - Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells....
rdcu.be
August 20, 2025 at 8:33 PM
Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here: rdcu.be/eBB5e
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jan Böttcher
Wonderful to see Klaus Rajewsky honored with the first ever EFIS Lifetime Achievement Award! #iIUIS2025 in Vienna.
August 19, 2025 at 10:49 AM
Wonderful to see Klaus Rajewsky honored with the first ever EFIS Lifetime Achievement Award! #iIUIS2025 in Vienna.
🍾Many congratulations to former PhD student Philippa Meiser - now Postdoc with Laura Mackay @thedohertyinst.bsky.social - for receiving this years PhD award 🥇 from @dgfi-org.bsky.social at @iuis-online.bsky.social !
August 18, 2025 at 9:29 AM
🍾Many congratulations to former PhD student Philippa Meiser - now Postdoc with Laura Mackay @thedohertyinst.bsky.social - for receiving this years PhD award 🥇 from @dgfi-org.bsky.social at @iuis-online.bsky.social !
Interesting study by @reisesousalab.bsky.social, highlighting functionally distinct states of activated cDC1s in tumors. 🔬🧪
Delighted that our paper describing cDC1 states and their distribution in mouse tumours is out today in @eurjimmunol.bsky.social. Many congratulations to Cécile Piot who led this work and brought it to conclusion! onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
August 4, 2025 at 8:25 AM
Interesting study by @reisesousalab.bsky.social, highlighting functionally distinct states of activated cDC1s in tumors. 🔬🧪
Looking forward to great talks and discussions with friends and colleagues in London👇!
#Immunologists - have you signed up for BSI's @london-immuno.bsky.social 1d conference yet?
Fri 11th July
Speakers include: Jan Böttcher, Tao Dong, @labliston.bsky.social, @beecell.bsky.social, Claudia Mauri & Claire Malone
REPOST to share as widely as poss
www.immunology.org/events/diver...
Fri 11th July
Speakers include: Jan Böttcher, Tao Dong, @labliston.bsky.social, @beecell.bsky.social, Claudia Mauri & Claire Malone
REPOST to share as widely as poss
www.immunology.org/events/diver...
Diversity in immunology | British Society for Immunology
www.immunology.org
June 17, 2025 at 9:41 AM
Looking forward to great talks and discussions with friends and colleagues in London👇!
Reposted by Jan Böttcher
🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
Adaptive immunity in barrier tissues
Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…
meetings.embo.org
April 30, 2025 at 3:04 PM
🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
thrilled to share that I’ve officially been appointed as Professor of Experimental Immunology @unituebingen.bsky.social, with the lab based at both the M3 Research Center and the Institute of Immunology, continuing interdisciplinary and translational research in cancer and tissue immunology 🧪🧫🧬🔬
April 16, 2025 at 8:49 PM
thrilled to share that I’ve officially been appointed as Professor of Experimental Immunology @unituebingen.bsky.social, with the lab based at both the M3 Research Center and the Institute of Immunology, continuing interdisciplinary and translational research in cancer and tissue immunology 🧪🧫🧬🔬
Reposted by Jan Böttcher
📣 !! JOB ALERT for PhD students !!
My lab is moving to the M3 Research Center at the University of Tübingen and is looking for PhD students who are enthusiastic about translational research.
If you are, read on below ⬇️
My lab is moving to the M3 Research Center at the University of Tübingen and is looking for PhD students who are enthusiastic about translational research.
If you are, read on below ⬇️
March 4, 2025 at 1:33 PM
📣 !! JOB ALERT for PhD students !!
My lab is moving to the M3 Research Center at the University of Tübingen and is looking for PhD students who are enthusiastic about translational research.
If you are, read on below ⬇️
My lab is moving to the M3 Research Center at the University of Tübingen and is looking for PhD students who are enthusiastic about translational research.
If you are, read on below ⬇️
Reposted by Jan Böttcher
We're hiring at all levels! Feel free to reach out if you have questions:
academicjobsonline.org/ajo/jobs/29722
academicjobsonline.org/ajo/jobs/29722
Cornell University, Microbiology & Immunology
Full service online faculty recruitment and application management system for academic institutions worldwide. We offer unique solutions tailored for academic communities.
academicjobsonline.org
February 14, 2025 at 5:30 PM
We're hiring at all levels! Feel free to reach out if you have questions:
academicjobsonline.org/ajo/jobs/29722
academicjobsonline.org/ajo/jobs/29722
Reposted by Jan Böttcher
Unsere Recherchen zu den Auswirkungen des US-Hilfsstopps sind heute bei Zeit Online nachzulesen mit Stimmen aus den USA, Kenia, Thailand, Südafrika und dem Sudan:
#USAID #PEPFAR
www.zeit.de/gesundheit/2...
#USAID #PEPFAR
www.zeit.de/gesundheit/2...
USAid: Die Zerstörung hat schon begonnen
Ob Projekte gegen HIV, Malaria oder vernachlässigte Tropenkrankheiten: Die USA streichen ihre medizinische Entwicklungshilfe. Die Folgen sind schon jetzt dramatisch.
www.zeit.de
February 20, 2025 at 1:44 PM
Unsere Recherchen zu den Auswirkungen des US-Hilfsstopps sind heute bei Zeit Online nachzulesen mit Stimmen aus den USA, Kenia, Thailand, Südafrika und dem Sudan:
#USAID #PEPFAR
www.zeit.de/gesundheit/2...
#USAID #PEPFAR
www.zeit.de/gesundheit/2...
Reposted by Jan Böttcher
„Anyone who has studied science under the Nazis, as I did for my book Serving the Reich, cannot fail to be dismayed and alarmed at the parallels in the response so far of scientific institutions and academies to the purges and abuses of power following Trump’s executive orders“ 🧪
Scientific institutions have a long history of anticipatory obedience
Societies should learn from this and speak up to support inclusion
www.chemistryworld.com
February 8, 2025 at 10:38 PM
„Anyone who has studied science under the Nazis, as I did for my book Serving the Reich, cannot fail to be dismayed and alarmed at the parallels in the response so far of scientific institutions and academies to the purges and abuses of power following Trump’s executive orders“ 🧪
Reposted by Jan Böttcher
NIH has cut billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com/health/2025/...
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com/health/2025/...
NIH cuts billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com
February 8, 2025 at 2:35 PM
NIH has cut billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com/health/2025/...
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com/health/2025/...
Reposted by Jan Böttcher
Some learnings about our immune system from Covid @nature.com
—importance of T cells (not just neutralizing antibodies)
—key role of interferons, the first line of defense
—hybrid immunity
—underpinnings of Long Covid
www.nature.com/articles/d41...
—importance of T cells (not just neutralizing antibodies)
—key role of interferons, the first line of defense
—hybrid immunity
—underpinnings of Long Covid
www.nature.com/articles/d41...
Four lessons COVID taught us about the immune system
In the midst of pandemic upheaval, researchers have gained fundamental insights about how the body fends off infections.
www.nature.com
January 27, 2025 at 4:04 PM
Some learnings about our immune system from Covid @nature.com
—importance of T cells (not just neutralizing antibodies)
—key role of interferons, the first line of defense
—hybrid immunity
—underpinnings of Long Covid
www.nature.com/articles/d41...
—importance of T cells (not just neutralizing antibodies)
—key role of interferons, the first line of defense
—hybrid immunity
—underpinnings of Long Covid
www.nature.com/articles/d41...
Reposted by Jan Böttcher
Join the next #globalimmuno talk this Wednesday, January 15th, at 9 am PST, 12 Noon EST, 4 pm GMT featuring AAI Member Jenny Ting!
We look forward to hearing many more impactful Global ImmunoTalks from other AAI members in 2025.
ucsd.zoom.us/j/91053505061
We look forward to hearing many more impactful Global ImmunoTalks from other AAI members in 2025.
ucsd.zoom.us/j/91053505061
January 13, 2025 at 6:15 PM
Join the next #globalimmuno talk this Wednesday, January 15th, at 9 am PST, 12 Noon EST, 4 pm GMT featuring AAI Member Jenny Ting!
We look forward to hearing many more impactful Global ImmunoTalks from other AAI members in 2025.
ucsd.zoom.us/j/91053505061
We look forward to hearing many more impactful Global ImmunoTalks from other AAI members in 2025.
ucsd.zoom.us/j/91053505061
🧪 elegant study using rabies-based retrograde tracing to map and manipulate GBM-neuron networks. www.cell.com/cell/fulltex...
Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing
Rapid integration of glioblastoma into neuronal circuits promotes glioblastoma invasion and growth, as shown by rabies-based retrograde tracing. Targeting of neuron-tumor networks with pharmacological or rabies-mediated disconnection offers therapeutic potential.
www.cell.com
December 7, 2024 at 1:36 PM
🧪 elegant study using rabies-based retrograde tracing to map and manipulate GBM-neuron networks. www.cell.com/cell/fulltex...
Reposted by Jan Böttcher
Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Wonderful to see the #immunology community growing here.
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
November 29, 2024 at 4:47 PM
Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
🧪Cross-Dressing intratumoral monocytes fulfill the job of cDC1s in supporting tumor-infiltrating CD8 T cells in their anti-cancer functions. Great to have contributed some 🔬&🧫 to this tour de force study by @obenaufa.bsky.social
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 9:43 PM
🧪Cross-Dressing intratumoral monocytes fulfill the job of cDC1s in supporting tumor-infiltrating CD8 T cells in their anti-cancer functions. Great to have contributed some 🔬&🧫 to this tour de force study by @obenaufa.bsky.social
🧪Exciting read on the role of dendritic cells supporting CAR T cells in tumors 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 27, 2024 at 9:44 AM
🧪Exciting read on the role of dendritic cells supporting CAR T cells in tumors 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jan Böttcher
Both #Cancer #Research starter packs are now completely full!
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
November 23, 2024 at 1:27 PM
Both #Cancer #Research starter packs are now completely full!
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️
I hope you'll find these useful to build our community here
Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA
