@natimmunol.nature.com
Nature Immunology publishes original research, reviews and commentary of the highest quality and significance in all areas of immunology.
Congratulations to Fred Ramsdell, Mary Brunkow and Shimon Sakaguchi - the 2025 Winners of the Nobel Prize in Physiology or Medicine. #Treg_cells #Foxp3 #Immune_regulation
October 6, 2025 at 3:37 PM
Congratulations to Fred Ramsdell, Mary Brunkow and Shimon Sakaguchi - the 2025 Winners of the Nobel Prize in Physiology or Medicine. #Treg_cells #Foxp3 #Immune_regulation
Reposted
Thrilled to make the cover of @natimmunol.nature.com this month.
A version of this warhol-inspired image has been in my head almost since we first conceived this Tfh diversity project (many, many years ago) @wehi-research.bsky.social
A version of this warhol-inspired image has been in my head almost since we first conceived this Tfh diversity project (many, many years ago) @wehi-research.bsky.social
September 30, 2025 at 9:08 PM
Thrilled to make the cover of @natimmunol.nature.com this month.
A version of this warhol-inspired image has been in my head almost since we first conceived this Tfh diversity project (many, many years ago) @wehi-research.bsky.social
A version of this warhol-inspired image has been in my head almost since we first conceived this Tfh diversity project (many, many years ago) @wehi-research.bsky.social
Check out the August issue of Nature Aging featuring a focus on immune aging. See www.nature.com/nataging and rdcu.be/eC58o
August 29, 2025 at 6:18 PM
Check out the August issue of Nature Aging featuring a focus on immune aging. See www.nature.com/nataging and rdcu.be/eC58o
Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here: rdcu.be/eBB5e
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells
Nature Immunology - Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells....
rdcu.be
August 20, 2025 at 8:33 PM
Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here: rdcu.be/eBB5e
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sun and colleagues show that the transcription factor TCF19 drives a transcriptional program that coordinates both innate and adaptive NK cell responses against viral infection. Read it here:https://rdcu.be/eBB3K
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TCF19 drives a broad transcriptional program that potentiates optimal innate and adaptive functions of antiviral NK cells - Nature Immunology
Sun and colleagues report that the transcription factor TCF19 regulates calcium signaling and cell cycling progression in NK cells and is required for innate and adaptive NK cell responses to viral in...
www.nature.com
August 20, 2025 at 8:29 PM
Sun and colleagues show that the transcription factor TCF19 drives a transcriptional program that coordinates both innate and adaptive NK cell responses against viral infection. Read it here:https://rdcu.be/eBB3K
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Klein and colleagues find that cathepsin L shapes CD4+ T cell selection by promoting full repertoire diversity and fine-tuning CD4+ T cell functionality. Read it here: rdcu.be/etDy2
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells
Nature Immunology - Klein and colleagues show that the lysosomal cysteine protease cathepsin L shapes the diversity and optimizes the fitness of clones that enter the CD4+ T cell repertoire.
rdcu.be
June 26, 2025 at 8:35 PM
Klein and colleagues find that cathepsin L shapes CD4+ T cell selection by promoting full repertoire diversity and fine-tuning CD4+ T cell functionality. Read it here: rdcu.be/etDy2
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Fang and colleagues find that succinate can suppress Foxp3 expression and enhance colitis severity. Read it here: rdcu.be/etDuE
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch
Nature Immunology - Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor...
rdcu.be
June 26, 2025 at 8:23 PM
Fang and colleagues find that succinate can suppress Foxp3 expression and enhance colitis severity. Read it here: rdcu.be/etDuE
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Amarnath and colleagues find that PD-1 controls coinhibitory receptor expression in Tregs. Read it here: rdcu.be/etDtN
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PD-1 receptor deficiency enhances CD30+ Treg cell function in melanoma
Nature Immunology - Here the authors show that PD-1 controls coinhibitory receptor expression by Treg cells. The absence of PD-1 expression could induce CD30 expression, thereby enhancing Treg...
rdcu.be
June 26, 2025 at 8:21 PM
Amarnath and colleagues find that PD-1 controls coinhibitory receptor expression in Tregs. Read it here: rdcu.be/etDtN
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We Stand Up for Science!!!
“In an unusual act of public protest, more than 340 scientists and staff at the National Institutes of Health today released a statement charging NIH officials and their superiors with politicizing science.”
www.science.org/content/arti...
#StandUpForScience
#BethesdaDeclaration
www.science.org/content/arti...
#StandUpForScience
#BethesdaDeclaration
NIH staff and biomedical community sound alarm about agency politicization, funding slowdown
In test of NIH director’s support of dissent, NIH staff sign Bethesda Declaration urging reversal of grant cuts and freezes
www.science.org
June 9, 2025 at 5:51 PM
We Stand Up for Science!!!
Joulia et al use single cell spatial transcriptomics to profile the lung in health and during asthma and identify discrete proinflammatory spatial niches that produce alarmins and chemokines. Read it here: rdcu.be/epjN7
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma
Nature Immunology - Here, the authors use single-cell spatial transcriptomics to profile the airway wall landscape in health and during asthma. Discrete proinflammatory ecosystems containing...
rdcu.be
June 3, 2025 at 8:56 PM
Joulia et al use single cell spatial transcriptomics to profile the lung in health and during asthma and identify discrete proinflammatory spatial niches that produce alarmins and chemokines. Read it here: rdcu.be/epjN7
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mak and colleagues find that double positive thymocytes express α9 nicotinic ACh receptors and these control negative selection. Read it here: rdcu.be/epjNm
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cholinergic regulation of thymocyte negative selection
Nature Immunology - Acetylcholine–α9 nAChR signaling regulates thymic negative selection.
rdcu.be
June 3, 2025 at 8:51 PM
Mak and colleagues find that double positive thymocytes express α9 nicotinic ACh receptors and these control negative selection. Read it here: rdcu.be/epjNm
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Penninger and colleagues developed bat respiratory and intestinal organoids and find there are type I and III IFN responses to viruses, including Marburg virus. Read it here: rdcu.be/epjMK
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bat organoids reveal antiviral responses at epithelial surfaces
Nature Immunology - Kellner et al. develop respiratory and intestinal organoids from Rousettus aegyptiacus to show elevated basal expression of interferon-ε (IFNε) and IFN-stimulated...
rdcu.be
June 3, 2025 at 8:47 PM
Penninger and colleagues developed bat respiratory and intestinal organoids and find there are type I and III IFN responses to viruses, including Marburg virus. Read it here: rdcu.be/epjMK
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congratulations to all of the trainee awardees at the recent Aegean Conference on Innate Immunity. Well done all!!!
Congratulations to all 17 trainee award recipients of the 20th Int’l Conference on #InnateImmunity #Sissi #Greece #Crete Fantastic Work!
May 21, 2025 at 1:42 PM
Congratulations to all of the trainee awardees at the recent Aegean Conference on Innate Immunity. Well done all!!!
Chaudhry et al show that the transcriptional repressor GFI1 is required for the generation and maintenance of stem cell memory CD8+ T cells. Read it here:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
GFI1-driven transcriptional and epigenetic programs maintain CD8+ T cell stemness and persistence - Nature Immunology
Belz and colleagues show that GFI1, a transcriptional repressor that recruits histone-modifying enzymes, is necessary for the generation and maintenance of stem cell memory CD8+ T cells.
www.nature.com
May 15, 2025 at 9:42 AM
Chaudhry et al show that the transcriptional repressor GFI1 is required for the generation and maintenance of stem cell memory CD8+ T cells. Read it here:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Paul Klenerman and colleagues combine single cell and spatial transcriptomics to provide a resource of the immune environment in adults and children with celiac disease. Read it here: rdcu.be/el8rn
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease
Nature Immunology - FitzPatrick et al. use single-cell RNA and spatial transcriptomics to dissect the immune microenvironments within the small bowel mucosa in celiac disease.
rdcu.be
May 15, 2025 at 8:49 AM
Paul Klenerman and colleagues combine single cell and spatial transcriptomics to provide a resource of the immune environment in adults and children with celiac disease. Read it here: rdcu.be/el8rn
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Iwasaki and colleagues show that mucosal vaccine boosters can induce protective immune responses without any adjuvant by retooling lymph node resident memory B cells with memory T cells acting as a natural adjuvant. Read it here: rdcu.be/elTur
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice
Nature Immunology - Iwasaki and colleagues show that an intranasal booster with an unadjuvanted recombinant SARS-CoV-2 spike protein, after intramuscular immunization with an mRNA vaccine encoding...
rdcu.be
May 13, 2025 at 5:27 PM
Iwasaki and colleagues show that mucosal vaccine boosters can induce protective immune responses without any adjuvant by retooling lymph node resident memory B cells with memory T cells acting as a natural adjuvant. Read it here: rdcu.be/elTur
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sanders et al find that T cells in the tumor can take up adenosine via ENT1 and this suppresses their anti-tumor response, ENT1 inhibition combined with anti-PD1 could control tumor growth in models resistant to immune checkpoint blockade. Read it here: rdcu.be/elTq8
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer
Nature Immunology - Metabolites in the tumor microenvironment, including adenosine, have been shown to suppress anti-tumor immune responses. Here, the authors show that T cell expression of...
rdcu.be
May 13, 2025 at 5:16 PM
Sanders et al find that T cells in the tumor can take up adenosine via ENT1 and this suppresses their anti-tumor response, ENT1 inhibition combined with anti-PD1 could control tumor growth in models resistant to immune checkpoint blockade. Read it here: rdcu.be/elTq8
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
A Review in Nature provides an overview of progress and future directions in the development of nasally administered vaccines for respiratory infections. go.nature.com/44PuKMr #medsky 🧪
May 12, 2025 at 1:45 PM
A Review in Nature provides an overview of progress and future directions in the development of nasally administered vaccines for respiratory infections. go.nature.com/44PuKMr #medsky 🧪
Reposted
Exciting news...Nature Methods is hiring a new editor! This exciting and dynamic role will be shared with the Nature Research Cross-Journal Editorial Team.
Apply here by June 1!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Apply here by June 1!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
a yellow sign that says we 're hiring
ALT: a yellow sign that says we 're hiring
media.tenor.com
May 9, 2025 at 2:00 PM
Exciting news...Nature Methods is hiring a new editor! This exciting and dynamic role will be shared with the Nature Research Cross-Journal Editorial Team.
Apply here by June 1!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Apply here by June 1!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Reposted
On the Covid SARS-CoV-2 variant front, new CDC update today
—LP.8.1 furthers its dominance
—No new emerging one of concern (some increase in XFC noted and will keep an eye on that)
—good, important for these reports to continue
—LP.8.1 furthers its dominance
—No new emerging one of concern (some increase in XFC noted and will keep an eye on that)
—good, important for these reports to continue
May 9, 2025 at 3:15 PM
On the Covid SARS-CoV-2 variant front, new CDC update today
—LP.8.1 furthers its dominance
—No new emerging one of concern (some increase in XFC noted and will keep an eye on that)
—good, important for these reports to continue
—LP.8.1 furthers its dominance
—No new emerging one of concern (some increase in XFC noted and will keep an eye on that)
—good, important for these reports to continue
Reposted
Our application for the 2026 Vilcek Prizes in Creative Promise is now open through June 9th!! This year, we will be awarding 9 immigrants $50K prizes in Biomedical Science, Fashion & Culture, and Fashion & Design. Learn more and apply! vilcek.co/3FgJWYb
March 11, 2025 at 1:25 PM
Our application for the 2026 Vilcek Prizes in Creative Promise is now open through June 9th!! This year, we will be awarding 9 immigrants $50K prizes in Biomedical Science, Fashion & Culture, and Fashion & Design. Learn more and apply! vilcek.co/3FgJWYb
Reposted
Join me at the @aai.org ASPIRE awards symposium and networking in room 312 starting now with @cobarnes27.bsky.social @guthmillerjenna.bsky.social and Mohammad Arifuzzaman #AAI2025
May 4, 2025 at 9:44 PM
Join me at the @aai.org ASPIRE awards symposium and networking in room 312 starting now with @cobarnes27.bsky.social @guthmillerjenna.bsky.social and Mohammad Arifuzzaman #AAI2025
Reposted
😱 Tumors sabotaging the immune system! New study in @natcellbio.nature.com shows that phosphoethanolamine in tumor interstitial fluid disables T cells by depleting diacylglycerol, crippling their signaling. Big find from @delgoffelab.bsky.social.
🧪 doi.org/10.1038/s415...
🧪 doi.org/10.1038/s415...
Tumour interstitial fluid-enriched phosphoethanolamine suppresses T cell function
Nature Cell Biology - Wang, Wilfahrt and colleagues show that phosphoethanolamine, a phospholipid intermediate, is enriched in tumour interstitial fluid and induces T cell dysfunction, in part by...
doi.org
May 5, 2025 at 6:46 AM
😱 Tumors sabotaging the immune system! New study in @natcellbio.nature.com shows that phosphoethanolamine in tumor interstitial fluid disables T cells by depleting diacylglycerol, crippling their signaling. Big find from @delgoffelab.bsky.social.
🧪 doi.org/10.1038/s415...
🧪 doi.org/10.1038/s415...
Reposted
Viral immune evasion:
Cytomegalovirus Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity
#virology #immunology
Cytomegalovirus Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity
#virology #immunology
Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity - Nature Communications
The role of viral Fc-gamma receptors in rhesus cytomegalovirus (RhCMV) infection is unclear. Here, the authors characterized RhCMV vFcγRs and report that their deletion did not affect virus replication, tropism or superinfection in rhesus macaques but increased susceptibility of the virus to antibody control.
bit.ly
May 5, 2025 at 12:39 PM
Viral immune evasion:
Cytomegalovirus Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity
#virology #immunology
Cytomegalovirus Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity
#virology #immunology
Reposted
GlycoCaging, a targeted drug delivery system using plant oligosaccharide glycoconjugates, enables microbiota-activated colonic drug release, reducing off-target effects while maintaining drug efficacy in inflammatory bowel disease #NBThighlight www.science.org/doi/10.1126/...
Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting
The gut microbiota of mammals possess unique metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a t...
www.science.org
May 5, 2025 at 2:41 PM
GlycoCaging, a targeted drug delivery system using plant oligosaccharide glycoconjugates, enables microbiota-activated colonic drug release, reducing off-target effects while maintaining drug efficacy in inflammatory bowel disease #NBThighlight www.science.org/doi/10.1126/...