Taking to the stage to present your science is a key part of research, but talks often fall flat, says John Tregoning. Can scientists learn from performers to better engage an audience?

The study shows that vaccination with two doses of recombinant zoster vaccine is associated with a 51% reduction in the risk of dementia in adults aged ≥65 years. Reduction in risk is comparable acros...

Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

YouTube video by Bruce Springsteen

In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship be...

T cells initiate targeted immune responses using T cell receptors (TCRs) to recognize specific antigens. Mapping TCRs to antigens at scale remains a m…

Somewhere in the back of my head I have been thinking that the worst impact of NIH allocating ~50% of funds via Multi-Year Funding would be FY2026 if, and that is a huge IF, the overall budget stay…

Shinzawa et al. developed CD8Dual mice that express CD8 co-receptors from both Cd4 and Cd8 gene loci. Using this model they find that thymic distribution of major histocompatibility complex class I pe...

Nature Medicine - Preparing for tomorrow’s threats by enhancing our ability to help patients today.

Epstein-Barr virus (EBV) colonizes secondary lymphoid tissues to establish persistent infection and is strongly associated with malignancy and autoimmunity. Our understanding of EBV infection biology is hindered by a lack of models that capture infected B cell activity in the lymphoid tissue microenvironment. We therefore developed an EBV human tonsil organoid model to evaluate key B cell states and antiviral responses, including after primary infection. EBV promoted B cell differentiation into germinal center (GC)-like phenotypes and transcriptomic analyses highlighted numerous B cell transcriptional programs unique to EBV-infected cells. B cell receptor repertoire analysis revealed that most EBV-infected B cells underwent class switching but only rarely participated in somatic hypermutation. CD4 T cells, highly activated by organoid infection, limited EBV+ B cell outgrowth. Our findings demonstrate human tonsil organoids as a physiologically relevant model to investigate key aspects of EBV immunity and pathogenesis. ### Competing Interest Statement L.E.W declares inventor status on a US patent (US-20230235284-A1) describing the immune organoid technology. The other authors declare no competing interests. Wellcome Leap HOPE Program, National Institutes of Health, R01AI173023, R01CA228700, R01DE033907 Immunology Training grant, University of California Irvine, GU12093 American Cancer Society Post-doctoral Fellowship, PF-23-1144614-01-IBCD National Center for Advancing Translational Sciences, National Institutes of Health, UM1 TR004927