@saligramalab.bsky.social
#TCR and #human diseases “We are all smart. Distinguish yourself by being kind.”—Charles Gordon. Studying T cells in brain doesn't make me a neuroimmunologist!
Pinned
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils
Human T cell responses are often studied using blood, yet most T cells reside in tissues.
By comparing T cell receptor repertoires from millions of T cells from autologous
tonsils and blood, Sureshcha...
www.cell.com
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
February 18, 2026 at 12:01 AM
When it #comes to #TCR #sequencing -the word I #detest is #oligoclonality -what does that even mean? It means something if one #sequenced #enough otherwise it means #nothing
February 17, 2026 at 12:57 PM
When it #comes to #TCR #sequencing -the word I #detest is #oligoclonality -what does that even mean? It means something if one #sequenced #enough otherwise it means #nothing
February 16, 2026 at 9:29 PM
February 16, 2026 at 5:30 PM
Thanks to #Hopecenter #pilot #grant @washuneurology.bsky.social for #funding our proposal to explore adaptive immunity in #neurodegeneration < lead by #Juliabals in our lab
February 14, 2026 at 5:14 PM
Thanks to #Hopecenter #pilot #grant @washuneurology.bsky.social for #funding our proposal to explore adaptive immunity in #neurodegeneration < lead by #Juliabals in our lab
Back in #2019 I was cleaning my bench at #stanford and heading over to #saintlouis time flies -I was #young
February 12, 2026 at 4:13 PM
Back in #2019 I was cleaning my bench at #stanford and heading over to #saintlouis time flies -I was #young
interesting article, what #BS -As #scientists we should be like #performers -what the world has come to!! Public-speaking tips from the experts: what scientists can learn from comics, musicians and actors www.nature.com/articles/d41...
Public-speaking tips from the experts: what scientists can learn from comics, musicians and actors
Taking to the stage to present your science is a key part of research, but talks often fall flat, says John Tregoning. Can scientists learn from performers to better engage an audience?
www.nature.com
February 10, 2026 at 4:43 PM
interesting article, what #BS -As #scientists we should be like #performers -what the world has come to!! Public-speaking tips from the experts: what scientists can learn from comics, musicians and actors www.nature.com/articles/d41...
After accounting for healthy vaccinee bias, #RZV #vaccination remains associated with a statistically #significant #lower #risk of #dementia www.nature.com/articles/s41...
Recombinant zoster vaccine is associated with a reduced risk of dementia - Nature Communications
The study shows that vaccination with two doses of recombinant zoster vaccine is associated with a 51% reduction in the risk of dementia in adults aged ≥65 years. Reduction in risk is comparable acros...
www.nature.com
February 9, 2026 at 3:33 PM
After accounting for healthy vaccinee bias, #RZV #vaccination remains associated with a statistically #significant #lower #risk of #dementia www.nature.com/articles/s41...
Projection was, 70 million people tuning into last night's event...what happened?? Oh well, lol!
February 9, 2026 at 11:47 AM
Projection was, 70 million people tuning into last night's event...what happened?? Oh well, lol!
Any #suggestion on #companies selling #leukopaks -we are #specifically looking for #HLA typed #Leukopaks?
February 6, 2026 at 2:41 PM
Any #suggestion on #companies selling #leukopaks -we are #specifically looking for #HLA typed #Leukopaks?
"There are several possible reasons for this unsettling state of affairs" www.nature.com/articles/s41...
On the balance of knowledge - Nature Reviews Immunology
Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.
www.nature.com
February 5, 2026 at 9:04 PM
"There are several possible reasons for this unsettling state of affairs" www.nature.com/articles/s41...
#NOA is in #today from #NIH. We are very much looking for #postdocs with expertise in #TCR #molecular #biology and #protein #engineering #autoimmunity
January 29, 2026 at 3:28 PM
#NOA is in #today from #NIH. We are very much looking for #postdocs with expertise in #TCR #molecular #biology and #protein #engineering #autoimmunity
I know all of us are busy with our lives. I am sure all of us will reflect after 5 minutes listening #streets #of #mineapolis @brucespringsteen.net youtu.be/wWKSoxG1K7w?...
Bruce Springsteen - Streets Of Minneapolis (Official Audio)
YouTube video by Bruce Springsteen
youtu.be
January 28, 2026 at 10:58 PM
I know all of us are busy with our lives. I am sure all of us will reflect after 5 minutes listening #streets #of #mineapolis @brucespringsteen.net youtu.be/wWKSoxG1K7w?...
I must have #missed #something #new from this paper "Overall, given the numerous immunological parallels between pet shop mice and humans observed by us .. these findings may provide at least a partial explanation for the rise of allergic disease over the last century" www.nature.com/articles/s41...
Environmentally driven immune imprinting protects against allergy - Nature
In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship be...
www.nature.com
January 28, 2026 at 10:11 PM
I must have #missed #something #new from this paper "Overall, given the numerous immunological parallels between pet shop mice and humans observed by us .. these findings may provide at least a partial explanation for the rise of allergic disease over the last century" www.nature.com/articles/s41...
@CellPressNews For the #love of #TCRs -#Read this >#Scalable #TCR synthesis and screening enable antigen reactivity mapping... www.sciencedirect.com/science/arti...
Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo
T cells initiate targeted immune responses using T cell receptors (TCRs) to recognize specific antigens. Mapping TCRs to antigens at scale remains a m…
www.sciencedirect.com
January 28, 2026 at 5:08 PM
@CellPressNews For the #love of #TCRs -#Read this >#Scalable #TCR synthesis and screening enable antigen reactivity mapping... www.sciencedirect.com/science/arti...
January 27, 2026 at 9:29 AM
January 22, 2026 at 6:32 PM
there is relief that there may not be reduction in #NIH #funding (allocated)..with #multiyear #funding "there will be many labs closing and PIs getting out of the grant-proposal pool" The #administration #achieved their #goal of #sacking #science/scientists drugmonkey.wordpress.com/2026/01/20/c...
Considering the impact of Multi-Year Funding at NIH
Somewhere in the back of my head I have been thinking that the worst impact of NIH allocating ~50% of funds via Multi-Year Funding would be FY2026 if, and that is a huge IF, the overall budget stay…
drugmonkey.wordpress.com
January 22, 2026 at 11:51 AM
there is relief that there may not be reduction in #NIH #funding (allocated)..with #multiyear #funding "there will be many labs closing and PIs getting out of the grant-proposal pool" The #administration #achieved their #goal of #sacking #science/scientists drugmonkey.wordpress.com/2026/01/20/c...
January 21, 2026 at 2:35 AM
I cant explain, how #beautifully #executed this paper is -I wonder, how we may #loose I#nterrogation/experimental skills like this in the #era of #scRNAseq and other modern technologies...which reveals what - #heterogeneity and #UMAPS
Now this is a paper to read www.nature.com/articles/s41...
Unraveling CD8 lineage decisions reveals that functionally distinct CD8+ T cells are selected by different MHC-I thymic peptides - Nature Immunology
Shinzawa et al. developed CD8Dual mice that express CD8 co-receptors from both Cd4 and Cd8 gene loci. Using this model they find that thymic distribution of major histocompatibility complex class I pe...
www.nature.com
January 20, 2026 at 12:28 PM
I cant explain, how #beautifully #executed this paper is -I wonder, how we may #loose I#nterrogation/experimental skills like this in the #era of #scRNAseq and other modern technologies...which reveals what - #heterogeneity and #UMAPS
Now this is a paper to read www.nature.com/articles/s41...
Unraveling CD8 lineage decisions reveals that functionally distinct CD8+ T cells are selected by different MHC-I thymic peptides - Nature Immunology
Shinzawa et al. developed CD8Dual mice that express CD8 co-receptors from both Cd4 and Cd8 gene loci. Using this model they find that thymic distribution of major histocompatibility complex class I pe...
www.nature.com
January 20, 2026 at 3:41 AM
Now this is a paper to read www.nature.com/articles/s41...
The #new #vision from the National Institute of Allergy and Infectious Diseases (NIAID) rdcu.be/eZn6i
The new vision from the National Institute of Allergy and Infectious Diseases (NIAID)
Nature Medicine - Preparing for tomorrow’s threats by enhancing our ability to help patients today.
rdcu.be
January 16, 2026 at 9:27 PM
The #new #vision from the National Institute of Allergy and Infectious Diseases (NIAID) rdcu.be/eZn6i