Pierre Santucci
@pierresantucci.bsky.social
PI CNRS - Aix Marseille Université 🇫🇷🇪🇺
All about Mycobacteria, Pathogenesis & Antibiotics 🦠🧫🔬💊
https://pierre-santucci.owlstown.net/
All about Mycobacteria, Pathogenesis & Antibiotics 🦠🧫🔬💊
https://pierre-santucci.owlstown.net/
Pinned
Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌
@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
Reposted by Pierre Santucci
November 14, 2025 at 3:17 AM
Reposted by Pierre Santucci
👏👏👏
So proud of our co-PI!
This well-deserved recognition honors Luciana’s outstanding scientific contributions, her dedication to mentoring, and her support for young women in research. Please join me in congratulating her on this incredible achievement!
So proud of our co-PI!
This well-deserved recognition honors Luciana’s outstanding scientific contributions, her dedication to mentoring, and her support for young women in research. Please join me in congratulating her on this incredible achievement!
We are thrilled to congratulate @lucianabalboa.bsky.social, co-leader of our IPBS/CNRS-CONICET lab, for receiving a special mention in the L’Oréal-UNESCO “For Women in Science” Award 2025. This honor recognizes her exceptional career & dedication to research in infectious diseases.
shorturl.at/Gfo4a
shorturl.at/Gfo4a
November 13, 2025 at 6:48 AM
👏👏👏
So proud of our co-PI!
This well-deserved recognition honors Luciana’s outstanding scientific contributions, her dedication to mentoring, and her support for young women in research. Please join me in congratulating her on this incredible achievement!
So proud of our co-PI!
This well-deserved recognition honors Luciana’s outstanding scientific contributions, her dedication to mentoring, and her support for young women in research. Please join me in congratulating her on this incredible achievement!
Reposted by Pierre Santucci
What if even the core of bacterial nanomachines wasn’t static?
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
November 12, 2025 at 4:21 PM
What if even the core of bacterial nanomachines wasn’t static?
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
Reposted by Pierre Santucci
Excited to share our newest manuscript on antigen discovery and vaccine design for tuberculosis lead by Owen Leddy (everyone hiring new faculty in a few years, remember this name!)
www.science.org/doi/10.1126/... #TBsky
www.science.org/doi/10.1126/... #TBsky
Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens
MHC class II immunopeptidomics in human phagocytes infected with Mycobacterium tuberculosis enables vaccine immunogen design and optimization.
www.science.org
November 5, 2025 at 9:57 PM
Excited to share our newest manuscript on antigen discovery and vaccine design for tuberculosis lead by Owen Leddy (everyone hiring new faculty in a few years, remember this name!)
www.science.org/doi/10.1126/... #TBsky
www.science.org/doi/10.1126/... #TBsky
Reposted by Pierre Santucci
The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it!
www.fpbase.org/spectra/
www.fpbase.org/spectra/
FPbase Fluorescence Spectra Viewer
An interactive fluorescence spectra viewer to evaluate the spectral properties of fluorescent proteins, organic dyes, filters, and detectors.
www.fpbase.org
November 4, 2025 at 3:03 PM
The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it!
www.fpbase.org/spectra/
www.fpbase.org/spectra/
Reposted by Pierre Santucci
Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
November 4, 2025 at 5:34 AM
Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Reposted by Pierre Santucci
Interested in a PhD at the intersection of biophysics and microbiology?
Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠
Closing 4 Dec!
www.findaphd.com/phds/project...
Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠
Closing 4 Dec!
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle University on FindAPhD....
PhD Project - MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle Universit...
www.findaphd.com
October 31, 2025 at 1:09 PM
Interested in a PhD at the intersection of biophysics and microbiology?
Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠
Closing 4 Dec!
www.findaphd.com/phds/project...
Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠
Closing 4 Dec!
www.findaphd.com/phds/project...
Reposted by Pierre Santucci
🔋 Start your week with a mito Review!
Mitochondria-associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease
🔓 buff.ly/od81og4
#Mitochondria #MitoMonday #CalciumSignaling
Mitochondria-associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease
🔓 buff.ly/od81og4
#Mitochondria #MitoMonday #CalciumSignaling
November 3, 2025 at 9:01 AM
🔋 Start your week with a mito Review!
Mitochondria-associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease
🔓 buff.ly/od81og4
#Mitochondria #MitoMonday #CalciumSignaling
Mitochondria-associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease
🔓 buff.ly/od81og4
#Mitochondria #MitoMonday #CalciumSignaling
Reposted by Pierre Santucci
Want to find ways to combat TB? Check out this PhD position 👇
November 2, 2025 at 8:44 PM
Want to find ways to combat TB? Check out this PhD position 👇
Reposted by Pierre Santucci
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
October 30, 2025 at 3:21 AM
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
Reposted by Pierre Santucci
🦠🔬🤖🧑💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training
📜 www.biorxiv.org/content/10.1...
📜 www.biorxiv.org/content/10.1...
October 22, 2025 at 11:10 AM
🦠🔬🤖🧑💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training
📜 www.biorxiv.org/content/10.1...
📜 www.biorxiv.org/content/10.1...
Reposted by Pierre Santucci
We're hiring for an Editorial Assistant!
📅 Deadline: 15 November 2025
📩 Send your CV and cover letter explaining your interest in the role to Daniela Ruffell: ruffell@febs.org
Find the full job description here ➡️ www.febs.org/news/jobs-po...
📅 Deadline: 15 November 2025
📩 Send your CV and cover letter explaining your interest in the role to Daniela Ruffell: ruffell@febs.org
Find the full job description here ➡️ www.febs.org/news/jobs-po...
October 21, 2025 at 12:14 PM
We're hiring for an Editorial Assistant!
📅 Deadline: 15 November 2025
📩 Send your CV and cover letter explaining your interest in the role to Daniela Ruffell: ruffell@febs.org
Find the full job description here ➡️ www.febs.org/news/jobs-po...
📅 Deadline: 15 November 2025
📩 Send your CV and cover letter explaining your interest in the role to Daniela Ruffell: ruffell@febs.org
Find the full job description here ➡️ www.febs.org/news/jobs-po...
Reposted by Pierre Santucci
News article in English: www.unil.ch/news/en/1760...
October 14, 2025 at 6:28 PM
News article in English: www.unil.ch/news/en/1760...
Reposted by Pierre Santucci
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
buff.ly/FcDzAY4
October 14, 2025 at 9:02 AM
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
buff.ly/FcDzAY4
Reposted by Pierre Santucci
The future of High-Content Imaging has arrived.
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
October 13, 2025 at 12:44 AM
The future of High-Content Imaging has arrived.
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
Reposted by Pierre Santucci
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Reposted by Pierre Santucci
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
emploi.cnrs.fr
October 9, 2025 at 12:18 PM
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr/Offres/Docto...
Reposted by Pierre Santucci
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply here apply.interfolio.com/174404
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 5, 2025 at 12:03 PM
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply here apply.interfolio.com/174404
Reposted by Pierre Santucci
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
October 5, 2025 at 4:10 PM
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
Reposted by Pierre Santucci
Want to hear a mid-career PI pontificate about science, career and cooking? Today's your lucky day thanks to The Microscopists podcast! Thanks Peter @yorkbioimaging.bsky.social for having me 🎙️🎧
themicroscopists.bitesizebio.com/episodes/chr...
themicroscopists.bitesizebio.com/episodes/chr...
The Microscopists | Christophe Leterrier (CNRS & Aix-Marseille Université)
This time on The Microscopists, we're joined by Christophe Leterrier, team leader at NeuroCyto in Marseille and director of a Nikon Center of Excellence for super-resolution microscopy.Christophe r...
themicroscopists.bitesizebio.com
October 3, 2025 at 12:40 PM
Want to hear a mid-career PI pontificate about science, career and cooking? Today's your lucky day thanks to The Microscopists podcast! Thanks Peter @yorkbioimaging.bsky.social for having me 🎙️🎧
themicroscopists.bitesizebio.com/episodes/chr...
themicroscopists.bitesizebio.com/episodes/chr...
Reposted by Pierre Santucci
During chlorite-induced #OxidativeStress MsrPQ repairs periplasmic proteins oxidized at Met residues. @ben-ezraty.bsky.social &co show that in these conditions the #Ecoli chaperone Spy is overproduced & oxidized; its reduction by MsrPQ helps maintain functionality @plosbiology.org 🧪 plos.io/3VHTAI9
October 1, 2025 at 7:41 AM
During chlorite-induced #OxidativeStress MsrPQ repairs periplasmic proteins oxidized at Met residues. @ben-ezraty.bsky.social &co show that in these conditions the #Ecoli chaperone Spy is overproduced & oxidized; its reduction by MsrPQ helps maintain functionality @plosbiology.org 🧪 plos.io/3VHTAI9
Reposted by Pierre Santucci
Now published! www.nature.com/articles/s41...
Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
September 29, 2025 at 2:24 PM
Now published! www.nature.com/articles/s41...
Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
Extremely happy to share the fruit of a beautiful collaborative research study.
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification
Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...
doi.org
September 29, 2025 at 5:51 AM
Extremely happy to share the fruit of a beautiful collaborative research study.
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺
Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇
doi.org/10.1101/2025...
Reposted by Pierre Santucci
New study shows pyrazinamide kills TB by acidifying bacterial cytosol — not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky
✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q
✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q
September 29, 2025 at 4:08 AM
New study shows pyrazinamide kills TB by acidifying bacterial cytosol — not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky
✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q
✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q
Reposted by Pierre Santucci
Great collaborative work driven by @pierresantucci.bsky.social which provides clear evidence on the mode of action of a well-known first-line anti-TB drug.
Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification https://www.biorxiv.org/content/10.1101/2025.09.26.678883v1
September 28, 2025 at 7:20 AM
Great collaborative work driven by @pierresantucci.bsky.social which provides clear evidence on the mode of action of a well-known first-line anti-TB drug.