Pierre Santucci
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pierresantucci.bsky.social
Pierre Santucci
@pierresantucci.bsky.social
780 followers 1.2K following 23 posts
PI CNRS - Aix Marseille Université 🇫🇷🇪🇺

All about Mycobacteria, Pathogenesis & Antibiotics 🦠🧫🔬💊

https://pierre-santucci.owlstown.net/
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pierresantucci.bsky.social
Pierre Santucci @pierresantucci.bsky.social · Feb 24
Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌

@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social
Reposted by Pierre Santucci
thebrysonlab.bsky.social
Excited to share our newest manuscript on antigen discovery and vaccine design for tuberculosis lead by Owen Leddy (everyone hiring new faculty in a few years, remember this name!)

www.science.org/doi/10.1126/... #TBsky
Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens
MHC class II immunopeptidomics in human phagocytes infected with Mycobacterium tuberculosis enables vaccine immunogen design and optimization.
www.science.org
November 5, 2025 at 9:57 PM
Reposted by Pierre Santucci
fpbase.org
The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it!

www.fpbase.org/spectra/
FPbase Fluorescence Spectra Viewer
An interactive fluorescence spectra viewer to evaluate the spectral properties of fluorescent proteins, organic dyes, filters, and detectors.
www.fpbase.org
November 4, 2025 at 3:03 PM
Reposted by Pierre Santucci
ipbstoulouse.bsky.social
Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens

Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
November 4, 2025 at 5:34 AM
Reposted by Pierre Santucci
kevindwhitley.bsky.social
Interested in a PhD at the intersection of biophysics and microbiology?

Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠

Closing 4 Dec!

www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle University on FindAPhD....
PhD Project - MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle Universit...
www.findaphd.com
October 31, 2025 at 1:09 PM
Reposted by Pierre Santucci
febsopenbio.bsky.social
🔋 Start your week with a mito Review!

Mitochondria-associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

🔓 buff.ly/od81og4

#Mitochondria #MitoMonday #CalciumSignaling
November 3, 2025 at 9:01 AM
Reposted by Pierre Santucci
kshbeckham.bsky.social
Want to find ways to combat TB? Check out this PhD position 👇
November 2, 2025 at 8:44 PM
Reposted by Pierre Santucci
johnrubinstein.bsky.social
New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz
Cryo-EM maps and atomic models of the biotin-containing 3-methylcrotonyl-CoA carboxylase (MCC) complex and long-chain acyl-CoA carboxylase (LCC) complex
October 30, 2025 at 3:21 AM
Reposted by Pierre Santucci
henriqueslab.bsky.social
🦠🔬🤖🧑‍💻 #mAIcrobe is out! With @pinholab.bsky.social's lab, we launched an open-source framework for high-throughput bacterial image analysis. By rockstars A. Brito & B. Saraiva et al, making #DeepLearning for phenotyping accessible! Easy to use, plus model training

📜 www.biorxiv.org/content/10.1...
October 22, 2025 at 11:10 AM
Reposted by Pierre Santucci
febsletters.bsky.social
We're hiring for an Editorial Assistant!

📅 Deadline: 15 November 2025
📩 Send your CV and cover letter explaining your interest in the role to Daniela Ruffell: ruffell@febs.org

Find the full job description here ➡️ www.febs.org/news/jobs-po...
October 21, 2025 at 12:14 PM
Reposted by Pierre Santucci
veeninglab.com
News article in English: www.unil.ch/news/en/1760...
October 14, 2025 at 6:28 PM
Reposted by Pierre Santucci
femsjournals.bsky.social
New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4
October 14, 2025 at 9:02 AM
Reposted by Pierre Santucci
amsikking.bsky.social
The future of High-Content Imaging has arrived.

-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!

See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
October 13, 2025 at 12:44 AM
Reposted by Pierre Santucci
jamesbriscoe.bsky.social
The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
Reposted by Pierre Santucci
cascaleslab.bsky.social
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
emploi.cnrs.fr
October 9, 2025 at 12:18 PM
Reposted by Pierre Santucci
khadershabaana.bsky.social
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 5, 2025 at 12:03 PM
Reposted by Pierre Santucci
khadershabaana.bsky.social
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
October 5, 2025 at 4:10 PM
Reposted by Pierre Santucci
christlet.bsky.social
Want to hear a mid-career PI pontificate about science, career and cooking? Today's your lucky day thanks to The Microscopists podcast! Thanks Peter @yorkbioimaging.bsky.social for having me 🎙️🎧
themicroscopists.bitesizebio.com/episodes/chr...
The Microscopists | Christophe Leterrier (CNRS & Aix-Marseille Université)
This time on The Microscopists, we're joined by Christophe Leterrier, team leader at NeuroCyto in Marseille and director of a Nikon Center of Excellence for super-resolution microscopy.Christophe r...
themicroscopists.bitesizebio.com
October 3, 2025 at 12:40 PM
Reposted by Pierre Santucci
plosbiology.org
During chlorite-induced #OxidativeStress MsrPQ repairs periplasmic proteins oxidized at Met residues. @ben-ezraty.bsky.social &co show that in these conditions the #Ecoli chaperone Spy is overproduced & oxidized; its reduction by MsrPQ helps maintain functionality @plosbiology.org 🧪 plos.io/3VHTAI9
Maintaining Spy in its reduced state (left) by MsrP during chlorite stress is critical for its chaperone activity. Image credit: Benjamin Ezraty.
October 1, 2025 at 7:41 AM
Reposted by Pierre Santucci
bugsinblood.bsky.social
Now published! www.nature.com/articles/s41...

Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.
September 29, 2025 at 2:24 PM
pierresantucci.bsky.social
Extremely happy to share the fruit of a beautiful collaborative research study.

France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺

Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇

doi.org/10.1101/2025...
Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification
Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...
doi.org
September 29, 2025 at 5:51 AM
Reposted by Pierre Santucci
sfmpathogenesis.bsky.social
New study shows pyrazinamide kills TB by acidifying bacterial cytosol — not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky

✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q
Revisited model of PZA/HPOA efficacy, supporting a pH-dependent mechanism of weak acid permeation and cytosolic acidification as main mechanism of bactericidal activity. In this model, the authors propose that the presence of glycerol potentiates PZA/HPOA efficacy by generating acidic intermediates that lower IBpH. Accordingly, β-alanine and pantothenate might mitigate this effect by acting as buffering molecules that alleviate acidosis. Finally, PanD enzymatic activity consumes protons which in turn increases IBpH. Therefore, in this model PanD minimally contributes to PZA tolerance and cannot be considered as the primary target of the drug.
September 29, 2025 at 4:08 AM
Reposted by Pierre Santucci
jefcavalier.bsky.social
Great collaborative work driven by @pierresantucci.bsky.social which provides clear evidence on the mode of action of a well-known first-line anti-TB drug.
biorxiv-microbiol.bsky.social bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Sep 28
Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification https://www.biorxiv.org/content/10.1101/2025.09.26.678883v1
September 28, 2025 at 7:20 AM
Reposted by Pierre Santucci
cascaleslab.bsky.social
We will have soon an Open position for a PhD thesis position to work on bacterial secretion systems !

Stay tuned !!
September 28, 2025 at 9:25 AM
Reposted by Pierre Santucci
lalouxlab.bsky.social
📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...
Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle
The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...
www.biorxiv.org
September 25, 2025 at 7:12 AM
Reposted by Pierre Santucci
febsopenbio.bsky.social
📢FEBS Open Bio is an affiliate journal in @ReviewCommons

📩We can receive your refereed preprint with no need to re-submit!

🔎Focus on technical and ethical quality
📖Publish #OpenAccess
👐Not-for-profit: net income supports science

#BioPhysics #Biochemistry #CellBiology
September 24, 2025 at 9:01 AM