Nimesh Chahare
@onenimesa.bsky.social
Doing #EpithelialMechanics! with chick embryo 🐣
Convenor @epimechfc.bsky.social // Postdoc @NerurkarLab at Columbia // PhD @xaviertrepat.bsky.social lab at IBEC Barcelona
nchahare.github.io
Convenor @epimechfc.bsky.social // Postdoc @NerurkarLab at Columbia // PhD @xaviertrepat.bsky.social lab at IBEC Barcelona
nchahare.github.io
Pinned
Nimesh Chahare
@onenimesa.bsky.social
· Jul 3
Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
Reposted by Nimesh Chahare
Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Epithelial Mechanics Fan Club
epithelialmechanics.github.io
October 23, 2025 at 7:21 AM
Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
Join the coolest club on the internet!
#EpithelialMechanics
#EpithelialMechanics
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Epithelial Mechanics Fan Club
epithelialmechanics.github.io
October 23, 2025 at 3:11 PM
Join the coolest club on the internet!
#EpithelialMechanics
#EpithelialMechanics
Reposted by Nimesh Chahare
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Epithelial Mechanics Fan Club
epithelialmechanics.github.io
October 23, 2025 at 7:00 AM
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Reposted by Nimesh Chahare
📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...
events.ibecbarcelona.eu/embl-ibec-co...
October 22, 2025 at 2:06 PM
📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...
events.ibecbarcelona.eu/embl-ibec-co...
Reposted by Nimesh Chahare
1/ 🐣⚒️ To study mechanics, we need to apply prescribed forces - how can we do that in living tissues? I am @eigenp.bsky.social and in this thread I'll highlight our new approach for applying tension on epithelial tissues in vivo!
October 12, 2025 at 12:51 PM
1/ 🐣⚒️ To study mechanics, we need to apply prescribed forces - how can we do that in living tissues? I am @eigenp.bsky.social and in this thread I'll highlight our new approach for applying tension on epithelial tissues in vivo!
Reposted by Nimesh Chahare
Happy to share that my PhD has finally taken the shape of a paper! ✨
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
September 27, 2025 at 12:01 PM
Happy to share that my PhD has finally taken the shape of a paper! ✨
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Reposted by Nimesh Chahare
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted by Nimesh Chahare
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.
www.science.org
September 24, 2025 at 8:17 PM
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
Reposted by Nimesh Chahare
1/ Link: www.biorxiv.org/content/10.1...
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
Mechanosensitive and Reversible Chromatin-Lamina Dewetting Triggers Cellular Contraction During Wound Healing
Tissue wounding causes rapid mechanical changes in the epithelium, but how these changes affect intracellular organization remains unclear. Using the Drosophila embryonic epidermis, we show that wound...
www.biorxiv.org
September 23, 2025 at 3:40 PM
1/ Link: www.biorxiv.org/content/10.1...
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
👀🚨 Fantastic preprint from @andreuion.bsky.social
There's a lot going on inside the nucleus. #EpithelialMechanics
There's a lot going on inside the nucleus. #EpithelialMechanics
We know tissue mechanics matter in healing, but what happens at the chromatin level?
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
September 24, 2025 at 2:12 AM
👀🚨 Fantastic preprint from @andreuion.bsky.social
There's a lot going on inside the nucleus. #EpithelialMechanics
There's a lot going on inside the nucleus. #EpithelialMechanics
Reposted by Nimesh Chahare
We know tissue mechanics matter in healing, but what happens at the chromatin level?
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
September 23, 2025 at 3:40 PM
We know tissue mechanics matter in healing, but what happens at the chromatin level?
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
Reposted by Nimesh Chahare
If you are interested in cell compression in general (not only in epithelial systems) in how to control it in vitro, in the associated mechanotransduction mechanisms and on their consequences, you can check our latest review!
bsky.app/profile/epim...
bsky.app/profile/epim...
September 21, 2025 at 12:52 PM
If you are interested in cell compression in general (not only in epithelial systems) in how to control it in vitro, in the associated mechanotransduction mechanisms and on their consequences, you can check our latest review!
bsky.app/profile/epim...
bsky.app/profile/epim...
Reposted by Nimesh Chahare
We believe that the combination of various in vitro tools, can complement in vivo observations. By doing so, Conti et al. showed that stem vs differentiated cancer cells present different mechano-phenotypes, suggesting a differential metastatic potential.
bsky.app/profile/epim...
bsky.app/profile/epim...
September 21, 2025 at 12:52 PM
We believe that the combination of various in vitro tools, can complement in vivo observations. By doing so, Conti et al. showed that stem vs differentiated cancer cells present different mechano-phenotypes, suggesting a differential metastatic potential.
bsky.app/profile/epim...
bsky.app/profile/epim...
Reposted by Nimesh Chahare
Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.
September 21, 2025 at 12:52 PM
Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.
Incredible!!! 😍
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
September 18, 2025 at 6:49 PM
Incredible!!! 😍
Reposted by Nimesh Chahare
It allows shaping the electric field, from single cells (first video) to sculpting whole tissues (movie below). This was several years of Yubin and Jeremy's lives; it's now changing what we know and do with electricity to control cell behaviors. It's so cool--please use it, we will help/share!
September 17, 2025 at 5:20 PM
It allows shaping the electric field, from single cells (first video) to sculpting whole tissues (movie below). This was several years of Yubin and Jeremy's lives; it's now changing what we know and do with electricity to control cell behaviors. It's so cool--please use it, we will help/share!
Reposted by Nimesh Chahare
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
September 17, 2025 at 5:20 PM
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
Reposted by Nimesh Chahare
Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.
September 15, 2025 at 2:12 AM
Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.
Reposted by Nimesh Chahare
How can we use cell shapes and geometry to study mechanics of tissues?
I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics
I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics
September 13, 2025 at 7:15 AM
How can we use cell shapes and geometry to study mechanics of tissues?
I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics
I'm @juliaeckert.bsky.social, and with this thread, I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics
Reposted by Nimesh Chahare
📣 New preprint! We present SpinePy, a modular framework that enables automated 3D spatiotemporal quantification of #gastruloids & other multicellular in vitro systems. Spearheaded by @cryaaa.bsky.social @mpi-cbg.de. Check out his thread 👇 & the paper:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 12, 2025 at 4:43 PM
📣 New preprint! We present SpinePy, a modular framework that enables automated 3D spatiotemporal quantification of #gastruloids & other multicellular in vitro systems. Spearheaded by @cryaaa.bsky.social @mpi-cbg.de. Check out his thread 👇 & the paper:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nimesh Chahare
🤔 Can migrating cells 'remember' their past trajectories?
In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:
Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!
www.nature.com/articles/s41...
In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:
Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!
www.nature.com/articles/s41...
The actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature Physics
Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv...
www.nature.com
August 25, 2025 at 9:49 AM
🤔 Can migrating cells 'remember' their past trajectories?
In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:
Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!
www.nature.com/articles/s41...
In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question:
Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history!
www.nature.com/articles/s41...
Reposted by Nimesh Chahare
new out in Nature www.nature.com/articles/d41...
Compression causes cancer cells to start spreading
The switch between proliferation and invasion is triggered by mechanical force.
www.nature.com
September 6, 2025 at 12:50 PM
new out in Nature www.nature.com/articles/d41...
Reposted by Nimesh Chahare
Super excited that our group will be supported by an ERC Starting Grant!
In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions.
We'll have PhD and Postdoc positions available, please get in touch if interested!
In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions.
We'll have PhD and Postdoc positions available, please get in touch if interested!
Why do some cells become neurons and others muscle?
Physicist Prof. David Brückner @davidbrueckner.bsky.social @biozentrum.unibas.ch @unibas.ch receives a prestigious #ERCStartingGrant to uncover how cells make life-shaping decisions. @erc.europa.eu
www.biozentrum.unibas.ch/news/detail/...
Physicist Prof. David Brückner @davidbrueckner.bsky.social @biozentrum.unibas.ch @unibas.ch receives a prestigious #ERCStartingGrant to uncover how cells make life-shaping decisions. @erc.europa.eu
www.biozentrum.unibas.ch/news/detail/...
ERC Starting Grant for Physicist David Brückner
How do cells decide which role to take on in the body? Prof. David Brückner from the Biozentrum of the University of Basel is investigating this and similar questions. Over the next five years, a Star...
www.biozentrum.unibas.ch
September 4, 2025 at 11:27 AM
Super excited that our group will be supported by an ERC Starting Grant!
In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions.
We'll have PhD and Postdoc positions available, please get in touch if interested!
In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions.
We'll have PhD and Postdoc positions available, please get in touch if interested!
Reposted by Nimesh Chahare
The last paper from my PhD is now online! 🥳
👉 pubs.aip.org/aip/rsi/arti...
We have designed a new device based on the elastic micropillar array assay to measure the detachment forces between spread cells.
@leidenphysics.bsky.social
👉 pubs.aip.org/aip/rsi/arti...
We have designed a new device based on the elastic micropillar array assay to measure the detachment forces between spread cells.
@leidenphysics.bsky.social
September 5, 2025 at 1:11 PM
The last paper from my PhD is now online! 🥳
👉 pubs.aip.org/aip/rsi/arti...
We have designed a new device based on the elastic micropillar array assay to measure the detachment forces between spread cells.
@leidenphysics.bsky.social
👉 pubs.aip.org/aip/rsi/arti...
We have designed a new device based on the elastic micropillar array assay to measure the detachment forces between spread cells.
@leidenphysics.bsky.social
Reposted by Nimesh Chahare
Check out the preprint of my main work in the lab of @xaviertrepat.bsky.social @IBECBarcelona. Many thanks to all the people involved!
New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social 🙌
@IBECBarcelona
www.biorxiv.org/content/10.1...
@IBECBarcelona
www.biorxiv.org/content/10.1...
September 2, 2025 at 9:24 AM
Check out the preprint of my main work in the lab of @xaviertrepat.bsky.social @IBECBarcelona. Many thanks to all the people involved!