Isabela Corina Fortunato, PhD
@icfortunato.bsky.social
Postdoc at @idisba.bsky.social.
🔬 Developing 3D NVU models.
PhD with @xaviertrepat.bsky.social at @ibecbarcelona.eu & MSc with @ClaudioAFranco1 at @gimmfoundation.bsky.social
🔬 Developing 3D NVU models.
PhD with @xaviertrepat.bsky.social at @ibecbarcelona.eu & MSc with @ClaudioAFranco1 at @gimmfoundation.bsky.social
Pinned
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
Happy to share that my PhD has finally taken the shape of a paper! ✨
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Reposted by Isabela Corina Fortunato, PhD
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
September 27, 2025 at 8:48 AM
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
Happy to share that my PhD has finally taken the shape of a paper! ✨
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
September 27, 2025 at 12:01 PM
Happy to share that my PhD has finally taken the shape of a paper! ✨
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Reposted by Isabela Corina Fortunato, PhD
Stoked to announce that I received a poster award! 🔥😍
Many thanks to the #25EngLife organizers for the amazing meeting!
Many thanks to the #25EngLife organizers for the amazing meeting!
Congratulations to the poster prize winners of the #25EngLife Thank you again for the organisation. It's been a fantastic meeting!
September 3, 2025 at 6:49 PM
Stoked to announce that I received a poster award! 🔥😍
Many thanks to the #25EngLife organizers for the amazing meeting!
Many thanks to the #25EngLife organizers for the amazing meeting!
Reposted by Isabela Corina Fortunato, PhD
The role of MicroRNAs in #MesenchymalStemCell differentiation into vascular #SmoothMuscleCell
miR-1/-133/-206
miR-143/-145
miR-221/-222-5p
miR-24
miR-181
miR-503
#CellDiv 2025
celldiv.biomedcentral.com/articles/10....
miR-1/-133/-206
miR-143/-145
miR-221/-222-5p
miR-24
miR-181
miR-503
#CellDiv 2025
celldiv.biomedcentral.com/articles/10....
The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells - Cell Division
MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a vital role in regulating gene expression, especially in the differentiation of mesenchymal stem cells (MSCs) into vascular smooth musc...
celldiv.biomedcentral.com
March 11, 2025 at 11:43 AM
The role of MicroRNAs in #MesenchymalStemCell differentiation into vascular #SmoothMuscleCell
miR-1/-133/-206
miR-143/-145
miR-221/-222-5p
miR-24
miR-181
miR-503
#CellDiv 2025
celldiv.biomedcentral.com/articles/10....
miR-1/-133/-206
miR-143/-145
miR-221/-222-5p
miR-24
miR-181
miR-503
#CellDiv 2025
celldiv.biomedcentral.com/articles/10....
Reposted by Isabela Corina Fortunato, PhD
Looking for #MaterialStiffness of #BasementMembrane across tissues?
Excellent literature resource here😆👇
The basement membrane as a structured surface – role in vascular health and disease
@claireleclech.bsky.social @jcellsci.bsky.social 2020
journals.biologists.com/jcs/article/...
Excellent literature resource here😆👇
The basement membrane as a structured surface – role in vascular health and disease
@claireleclech.bsky.social @jcellsci.bsky.social 2020
journals.biologists.com/jcs/article/...
March 7, 2025 at 12:51 PM
Looking for #MaterialStiffness of #BasementMembrane across tissues?
Excellent literature resource here😆👇
The basement membrane as a structured surface – role in vascular health and disease
@claireleclech.bsky.social @jcellsci.bsky.social 2020
journals.biologists.com/jcs/article/...
Excellent literature resource here😆👇
The basement membrane as a structured surface – role in vascular health and disease
@claireleclech.bsky.social @jcellsci.bsky.social 2020
journals.biologists.com/jcs/article/...
Reposted by Isabela Corina Fortunato, PhD
Might be an interesting review on that topic !
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology
Endothelial cells (ENCs) and epithelial cells (EPCs) form monolayers whose barrier
function is critical for the maintenance of physiological processes and extremely
sensitive to mechanical cues. Compu...
www.cell.com
January 21, 2025 at 7:57 AM
Might be an interesting review on that topic !
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Reposted by Isabela Corina Fortunato, PhD
1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵
Read more: www.nature.com/articles/s41...
Read more: www.nature.com/articles/s41...
Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing - Nature Communications
Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro p...
www.nature.com
February 10, 2025 at 4:42 PM
1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵
Read more: www.nature.com/articles/s41...
Read more: www.nature.com/articles/s41...
Reposted by Isabela Corina Fortunato, PhD
Regrowing a zebrafish heart. Credit to @cao-lab.bsky.social. #ZebrafishZunday 🧪
January 26, 2025 at 9:52 AM
Regrowing a zebrafish heart. Credit to @cao-lab.bsky.social. #ZebrafishZunday 🧪
Reposted by Isabela Corina Fortunato, PhD
Let's look at some cool bilateral cellular flows videos
IMHO: this is a goldmine for #EpithelialMechanics
Movie from Asai et al 2024 shows beautiful counter rotating flows.
IMHO: this is a goldmine for #EpithelialMechanics
Movie from Asai et al 2024 shows beautiful counter rotating flows.
January 26, 2025 at 11:42 AM
Let's look at some cool bilateral cellular flows videos
IMHO: this is a goldmine for #EpithelialMechanics
Movie from Asai et al 2024 shows beautiful counter rotating flows.
IMHO: this is a goldmine for #EpithelialMechanics
Movie from Asai et al 2024 shows beautiful counter rotating flows.
Reposted by Isabela Corina Fortunato, PhD
Is endothelium a type of epithelium?
I am @icfortunato.bsky.social & I would like to discuss this with a short🧵 focused on cell-cell junctions, specifically adherens junctions.
I am @icfortunato.bsky.social & I would like to discuss this with a short🧵 focused on cell-cell junctions, specifically adherens junctions.
January 18, 2025 at 9:34 AM
Is endothelium a type of epithelium?
I am @icfortunato.bsky.social & I would like to discuss this with a short🧵 focused on cell-cell junctions, specifically adherens junctions.
I am @icfortunato.bsky.social & I would like to discuss this with a short🧵 focused on cell-cell junctions, specifically adherens junctions.
Reposted by Isabela Corina Fortunato, PhD
Curvature-sensing BAR proteins control junction turnover to promote collective migration of endothelial cells in angiogenesis. rdcu.be/d6a04
January 14, 2025 at 11:32 AM
Curvature-sensing BAR proteins control junction turnover to promote collective migration of endothelial cells in angiogenesis. rdcu.be/d6a04
Reposted by Isabela Corina Fortunato, PhD
Thrilled to share our new manuscript on how force transmission can regulate mechanical cell competition!
Fun collaboration between the @bladoux.bsky.social / @rmmege.bsky.social and the Doostmohammadi group combining experiments and simulations.
Main points below 👇
www.biorxiv.org/content/10.1...
Fun collaboration between the @bladoux.bsky.social / @rmmege.bsky.social and the Doostmohammadi group combining experiments and simulations.
Main points below 👇
www.biorxiv.org/content/10.1...
Force transmission is a master regulator of mechanical cell competition
Cell competition is a tissue surveillance mechanism for eliminating unwanted cells and as such is indispensable in development, infection and tumorigenesis. Although different biochemical mechanisms a...
www.biorxiv.org
December 21, 2024 at 7:32 PM
Thrilled to share our new manuscript on how force transmission can regulate mechanical cell competition!
Fun collaboration between the @bladoux.bsky.social / @rmmege.bsky.social and the Doostmohammadi group combining experiments and simulations.
Main points below 👇
www.biorxiv.org/content/10.1...
Fun collaboration between the @bladoux.bsky.social / @rmmege.bsky.social and the Doostmohammadi group combining experiments and simulations.
Main points below 👇
www.biorxiv.org/content/10.1...
Reposted by Isabela Corina Fortunato, PhD
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
December 3, 2024 at 9:18 AM
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1