Andreas Schoenit
@andreasschoenit.bsky.social
PostDoc in the Ladoux-Mège lab at Institute Jacques Monod in Paris. Interested in mechanobiology, epithelial dynamics, cell competition and differentiation
Pinned
What happens between cells with adhesion differences in crowded tissues? Mechanical cell competition!
Check the final version of our study to learn more about compression-independent cell elimination, interactions at tissue interfaces and the role of force transmission in that
tinyurl.com/4yw97bm3
Check the final version of our study to learn more about compression-independent cell elimination, interactions at tissue interfaces and the role of force transmission in that
tinyurl.com/4yw97bm3
Reposted by Andreas Schoenit
The latest story from my group. Working toward build regionally distinct skin and amnion piece by piece.
Lateral plate mesoderm directs human amnion and ventral skin organoid formation https://www.biorxiv.org/content/10.1101/2025.11.05.685987v1
November 7, 2025 at 12:39 PM
The latest story from my group. Working toward build regionally distinct skin and amnion piece by piece.
Truly honoured and grateful to have received alongside other young researchers the prize "Grandes avancées françaises en biologie" from the @academiesciences.bsky.social for our paper on mechanical cell competition together with @luanger.bsky.social and S. Monfared www.nature.com/articles/s41...
October 29, 2025 at 6:54 PM
Truly honoured and grateful to have received alongside other young researchers the prize "Grandes avancées françaises en biologie" from the @academiesciences.bsky.social for our paper on mechanical cell competition together with @luanger.bsky.social and S. Monfared www.nature.com/articles/s41...
Reposted by Andreas Schoenit
Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Epithelial Mechanics Fan Club
epithelialmechanics.github.io
October 23, 2025 at 7:21 AM
Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
Reposted by Andreas Schoenit
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
October 16, 2025 at 9:55 PM
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
Reposted by Andreas Schoenit
Happy to share the last version of our story @currentbiology.bsky.social on the role of interfacial tension in mechanical cell competition led by @leovalon.bsky.social and Alexis Matamoro Vidal
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
October 9, 2025 at 3:27 PM
Happy to share the last version of our story @currentbiology.bsky.social on the role of interfacial tension in mechanical cell competition led by @leovalon.bsky.social and Alexis Matamoro Vidal
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Andreas Schoenit
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted by Andreas Schoenit
Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.
More here: elifesciences.org/reviewed-pre...
More here: elifesciences.org/reviewed-pre...
elifesciences.org
September 29, 2025 at 8:45 AM
Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.
More here: elifesciences.org/reviewed-pre...
More here: elifesciences.org/reviewed-pre...
Reposted by Andreas Schoenit
Now out in final published form - with a new title "Mechanical control of cell fate decisions in the skin epidermis" and simulations/quantifications! See below for thread of how unbalanced tensions can bias fate choices in minimal 3D models of tissues! www.nature.com/articles/s41...
Happy to share the latest work from Preeti Sahu, with Adriana Sanchez-Danes on the biomechanics of cell fate choices during tumor initiation! We implement/test a 3D vertex model with proliferation and fate choices for multilayered tissues! See 🧵 below (1/n) bit.ly/3ZXxJzk
September 26, 2025 at 2:14 PM
Now out in final published form - with a new title "Mechanical control of cell fate decisions in the skin epidermis" and simulations/quantifications! See below for thread of how unbalanced tensions can bias fate choices in minimal 3D models of tissues! www.nature.com/articles/s41...
Reposted by Andreas Schoenit
A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis!
Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)
Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)
September 18, 2025 at 8:32 PM
A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis!
Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)
Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)
Reposted by Andreas Schoenit
How is developmental speed regulated ? 🪰
Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye.
www.biorxiv.org/content/10.1...
A big thanks to everyone involved!
Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye.
www.biorxiv.org/content/10.1...
A big thanks to everyone involved!
September 22, 2025 at 7:07 PM
How is developmental speed regulated ? 🪰
Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye.
www.biorxiv.org/content/10.1...
A big thanks to everyone involved!
Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye.
www.biorxiv.org/content/10.1...
A big thanks to everyone involved!
Reposted by Andreas Schoenit
We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy.
mikeinmemoriam.sciencesconf.org
mikeinmemoriam.sciencesconf.org
September 18, 2025 at 8:50 AM
We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy.
mikeinmemoriam.sciencesconf.org
mikeinmemoriam.sciencesconf.org
Reposted by Andreas Schoenit
Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...
Regulation of epithelial tissue homeostasis by active trans-epithelial transport
Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...
www.biorxiv.org
September 17, 2025 at 2:46 PM
Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...
Reposted by Andreas Schoenit
Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The complex microscopic dynamics of cells in high-density epithelial tissues
Epithelial tissues line the surfaces of vital organs and are often densely packed in a disordered, mechanically arrested state, referred to as jammed or glassy state. While collective migration at low...
www.biorxiv.org
September 10, 2025 at 10:14 AM
Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Andreas Schoenit
Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Epithelial tension controls intestinal cell extrusion
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
www.science.org
September 6, 2025 at 9:28 AM
Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Andreas Schoenit
Are different cell types like oil and water? Over a century ago, researchers found that dissociated sponges and embryonic tissues can self-assemble into functional structures. Join me, @benswedlund.bsky.social to explore the differential adhesion hypothesis & its applications in tissue engineering!
August 31, 2025 at 12:00 PM
Are different cell types like oil and water? Over a century ago, researchers found that dissociated sponges and embryonic tissues can self-assemble into functional structures. Join me, @benswedlund.bsky.social to explore the differential adhesion hypothesis & its applications in tissue engineering!
Excited for my thesis defence, join us for a discussion on the role of mechanical forces in building and maintaining epithelial tissues if you happen to be in Paris in September!
📢 PhD Thesis defense
📅 September 11th
📍 Institut Jacques Monod
Andreas Schoenit @andreasschoenit.bsky.social ( @bladoux.bsky.social / @rmmege.bsky.social Lab) will defend his PhD thesis "Mechanical forces in cell competition and epidermal stratification"
More informations ➡️ buff.ly/yhtJMsu
📅 September 11th
📍 Institut Jacques Monod
Andreas Schoenit @andreasschoenit.bsky.social ( @bladoux.bsky.social / @rmmege.bsky.social Lab) will defend his PhD thesis "Mechanical forces in cell competition and epidermal stratification"
More informations ➡️ buff.ly/yhtJMsu
August 21, 2025 at 12:58 PM
Excited for my thesis defence, join us for a discussion on the role of mechanical forces in building and maintaining epithelial tissues if you happen to be in Paris in September!
Reposted by Andreas Schoenit
📢 Institut Jacques Monod Seminar
📅 September 11th
📍 Institut Jacques Monod
Invited by @bladoux.bsky.social / @rmmege.bsky.social 's Lab , Stephanie Ellis ( @maxperutzlabs.bsky.social ) give the IJM Seminar "Understanding mosaic tissue dynamics through cell competition. "
➡️ buff.ly/V6LaKMz
📅 September 11th
📍 Institut Jacques Monod
Invited by @bladoux.bsky.social / @rmmege.bsky.social 's Lab , Stephanie Ellis ( @maxperutzlabs.bsky.social ) give the IJM Seminar "Understanding mosaic tissue dynamics through cell competition. "
➡️ buff.ly/V6LaKMz
August 21, 2025 at 8:00 AM
📢 Institut Jacques Monod Seminar
📅 September 11th
📍 Institut Jacques Monod
Invited by @bladoux.bsky.social / @rmmege.bsky.social 's Lab , Stephanie Ellis ( @maxperutzlabs.bsky.social ) give the IJM Seminar "Understanding mosaic tissue dynamics through cell competition. "
➡️ buff.ly/V6LaKMz
📅 September 11th
📍 Institut Jacques Monod
Invited by @bladoux.bsky.social / @rmmege.bsky.social 's Lab , Stephanie Ellis ( @maxperutzlabs.bsky.social ) give the IJM Seminar "Understanding mosaic tissue dynamics through cell competition. "
➡️ buff.ly/V6LaKMz
Reposted by Andreas Schoenit
Now published in @natcomms.nature.com! 🥳
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
August 15, 2025 at 12:13 PM
Now published in @natcomms.nature.com! 🥳
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
👉 rdcu.be/eATn3
We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
Reposted by Andreas Schoenit
🚀 New in Advanced Science: RAB5A drives active fluid wetting in breast cancer spheroids by reprogramming cell mechanics.
doi.org/10.1002/advs...
👏 Kudos to first author Grégoire Lemahieu and our amazing co-authors for this joint effort!
#CancerMechanobiology #CellAdhesion #RAB5A #TeamScience
doi.org/10.1002/advs...
👏 Kudos to first author Grégoire Lemahieu and our amazing co-authors for this joint effort!
#CancerMechanobiology #CellAdhesion #RAB5A #TeamScience
RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics
RAB5A-mediated unjamming enhances active wetting through distinct biomechanical processes: a) upregulation of specific integrin subunits, enhanced focal adhesions kinetics and activity; b) supracellu...
doi.org
August 13, 2025 at 3:12 PM
🚀 New in Advanced Science: RAB5A drives active fluid wetting in breast cancer spheroids by reprogramming cell mechanics.
doi.org/10.1002/advs...
👏 Kudos to first author Grégoire Lemahieu and our amazing co-authors for this joint effort!
#CancerMechanobiology #CellAdhesion #RAB5A #TeamScience
doi.org/10.1002/advs...
👏 Kudos to first author Grégoire Lemahieu and our amazing co-authors for this joint effort!
#CancerMechanobiology #CellAdhesion #RAB5A #TeamScience
Reposted by Andreas Schoenit
Hot off the press!!! Proudly presenting our lab's new review on how do cells communicate to control organ size :) We focus specially on dynamic connections that operate at different timescales to regulate organ growth and morphogenesis. #devbio #SizeandShape www.sciencedirect.com/science/arti...
Start-Shape-Stop: Cell communication mechanisms controlling organ size
Accurate growth control is critical for the achievement of proportional organs during animal development and repair processes. Either extra or deficie…
www.sciencedirect.com
August 9, 2025 at 8:39 AM
Hot off the press!!! Proudly presenting our lab's new review on how do cells communicate to control organ size :) We focus specially on dynamic connections that operate at different timescales to regulate organ growth and morphogenesis. #devbio #SizeandShape www.sciencedirect.com/science/arti...
Reposted by Andreas Schoenit
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
August 11, 2025 at 1:18 PM
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
Reposted by Andreas Schoenit
To what extent does crowding modulate diffusion across the cytoplasm?
Thrilled to contribute to this study alongside O. Destrian, M. Chabanon, and B. Goyeau!
www.biorxiv.org/content/10.1...
Thrilled to contribute to this study alongside O. Destrian, M. Chabanon, and B. Goyeau!
www.biorxiv.org/content/10.1...
Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion
Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is known to strongly alter macromolecule mobility, how cytop...
www.biorxiv.org
August 1, 2025 at 9:06 AM
To what extent does crowding modulate diffusion across the cytoplasm?
Thrilled to contribute to this study alongside O. Destrian, M. Chabanon, and B. Goyeau!
www.biorxiv.org/content/10.1...
Thrilled to contribute to this study alongside O. Destrian, M. Chabanon, and B. Goyeau!
www.biorxiv.org/content/10.1...
Reposted by Andreas Schoenit
Preprint by @towalther.bsky.social at al! We design DNA hydrogel microparticles with sequence-controlled stiffness from 30 Pa to 6.5 kPa. They are remodelled in fibroblast spheroids www.biorxiv.org/content/10.1... Thanks @ibecbarcelona.eu @xaviertrepat.bsky.social @pcusachs.bsky.social
July 28, 2025 at 7:35 AM
Preprint by @towalther.bsky.social at al! We design DNA hydrogel microparticles with sequence-controlled stiffness from 30 Pa to 6.5 kPa. They are remodelled in fibroblast spheroids www.biorxiv.org/content/10.1... Thanks @ibecbarcelona.eu @xaviertrepat.bsky.social @pcusachs.bsky.social
Reposted by Andreas Schoenit
On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
July 4, 2025 at 10:21 AM
On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:
3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
Reposted by Andreas Schoenit
Congrats to @luanger.bsky.social and @andreasschoenit.bsky.social for receiving the prestigious 'Les Grandes Avancées en Biologie' award 🏅 from the @academiesciences.bsky.social !
June 18, 2025 at 9:55 AM
Congrats to @luanger.bsky.social and @andreasschoenit.bsky.social for receiving the prestigious 'Les Grandes Avancées en Biologie' award 🏅 from the @academiesciences.bsky.social !