Daniel Krüger
@danielkrueger.bsky.social
Researcher in the Netherlands. Postdoc with Hans Clevers. Organoid models. Sozi aus Deutschland.
Great to see our conclusions align with the beautiful work from @marija-matejcic.bsky.social in the Trepat lab 3D force mapping, Ca²⁺-triggered myosin-IIA meshwork dissolution, and neighbour lamellipodia generating traction. Great synergy, highlighting the role of tension in extrusion regulation.
September 12, 2025 at 11:15 AM
Great to see our conclusions align with the beautiful work from @marija-matejcic.bsky.social in the Trepat lab 3D force mapping, Ca²⁺-triggered myosin-IIA meshwork dissolution, and neighbour lamellipodia generating traction. Great synergy, highlighting the role of tension in extrusion regulation.
Thanks for highlighting this! My background in fly morphogenesis shaped how I think about tissue forces, their interplay with signaling, and experimental design. An experience I’d wholeheartedly recommend — Drosophila remains a rich source of inspiration, continuing to reveal fundamental concepts.
I may have a biased interpretation here, but I suspect the background of @danielkrueger.bsky.social in fly morphogenesis brought a lot here (congrat for the impressive work !) , a good example of virtuous background mixing and work built on important conceptual/technical premise from model organism
September 12, 2025 at 10:40 AM
Thanks for highlighting this! My background in fly morphogenesis shaped how I think about tissue forces, their interplay with signaling, and experimental design. An experience I’d wholeheartedly recommend — Drosophila remains a rich source of inspiration, continuing to reveal fundamental concepts.
Reposted by Daniel Krüger
This is very complementary with the recent preprint of @xaviertrepat.bsky.social and Maria Matejcic using 2D organoids and providing 3D mechanical characterisation of the process
September 9, 2025 at 8:53 PM
This is very complementary with the recent preprint of @xaviertrepat.bsky.social and Maria Matejcic using 2D organoids and providing 3D mechanical characterisation of the process
Reposted by Daniel Krüger
Important story dissecting the mechanism of gut cell extrusion using organoids. Local heterogeneity of tension promotes live extrusion and basal relaxation is sufficient to kick the cell out. Nice combination of optogenetics and live imaging to demonstrate this
www.science.org/doi/abs/10.1...
www.science.org/doi/abs/10.1...
September 9, 2025 at 8:53 PM
Important story dissecting the mechanism of gut cell extrusion using organoids. Local heterogeneity of tension promotes live extrusion and basal relaxation is sufficient to kick the cell out. Nice combination of optogenetics and live imaging to demonstrate this
www.science.org/doi/abs/10.1...
www.science.org/doi/abs/10.1...
👉 Check out our key findings in this detailed thread by Hans Clevers.
1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...
Epithelial tension controls intestinal cell extrusion
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
www.science.org
September 6, 2025 at 8:12 PM
👉 Check out our key findings in this detailed thread by Hans Clevers.
Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Epithelial tension controls intestinal cell extrusion
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
www.science.org
September 6, 2025 at 9:28 AM
Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Daniel Krüger
📣 It is my pleasure to announce our recent review with Margherita on the current approaches, challenges, and perspectives in studying human maternal-fetal interface using in vitro models www.cell.com/cell-stem-ce... 🚀✨️
September 5, 2025 at 9:07 AM
📣 It is my pleasure to announce our recent review with Margherita on the current approaches, challenges, and perspectives in studying human maternal-fetal interface using in vitro models www.cell.com/cell-stem-ce... 🚀✨️
Reposted by Daniel Krüger
Jeey! @nfdi4bioimage.bsky.social published their #RDM-related postcards FAIRly (made by Henning Falk, licensed CC-BY 4.0) 🔬💾😍
github.com/NFDI4BIOIMAG...
github.com/NFDI4BIOIMAG...
December 13, 2024 at 11:31 AM
Jeey! @nfdi4bioimage.bsky.social published their #RDM-related postcards FAIRly (made by Henning Falk, licensed CC-BY 4.0) 🔬💾😍
github.com/NFDI4BIOIMAG...
github.com/NFDI4BIOIMAG...
Reposted by Daniel Krüger
First time that my cartoons are printed on postcards! Have a look 👇
Oh yes, we did! Here are our new postcards - educational outreach material that pinpoints challenges in bioimaging #RDM complexity. Turn them around to find out about solutions and support! And all illustrations are free for reuse (CC-BY). doi.org/10.5281/zeno...
Many thanks to Henning Falk!
Many thanks to Henning Falk!
December 21, 2024 at 12:57 PM
First time that my cartoons are printed on postcards! Have a look 👇
Reposted by Daniel Krüger
Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineages”. www.cell.com/cell/fulltex...
New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/
New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/
Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages
Identification of an LGR5 as a marker for a tripotent stem/progenitor cell of the
human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term
expansion in vitro and genera...
www.cell.com
December 3, 2024 at 10:52 AM
Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineages”. www.cell.com/cell/fulltex...
New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/
New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/
Reposted by Daniel Krüger
"The state of German-Polish relations is a European tragedy in the same way that the Warschauer Kniefall was a moment of European reconciliation."
Brilliant analysis by @JeremyCliffe and also an important read before the Polish elections this weekend.
There is so much at stake.
Brilliant analysis by @JeremyCliffe and also an important read before the Polish elections this weekend.
There is so much at stake.
Europe’s east-west divide is widening
Relations between Germany and Poland define the continent. But, ahead of the latter’s election this weekend, they are in crisis and getting worse.
www.newstatesman.com
October 12, 2023 at 7:08 AM
"The state of German-Polish relations is a European tragedy in the same way that the Warschauer Kniefall was a moment of European reconciliation."
Brilliant analysis by @JeremyCliffe and also an important read before the Polish elections this weekend.
There is so much at stake.
Brilliant analysis by @JeremyCliffe and also an important read before the Polish elections this weekend.
There is so much at stake.
Reposted by Daniel Krüger
Anhören!
Wie sich große branchenfremde Investoren (ALDI, Immobilien etc) riesengroße Ackerflächen 🚜 in Ostdeutschland kaufen.
Am Staat vorbei, ohne Steuern zu zahlen, mit dem Segen des Bauernverbandes und zum Schaden der kleinen Landwirtschaftsbetriebe.
👇
Wie sich große branchenfremde Investoren (ALDI, Immobilien etc) riesengroße Ackerflächen 🚜 in Ostdeutschland kaufen.
Am Staat vorbei, ohne Steuern zu zahlen, mit dem Segen des Bauernverbandes und zum Schaden der kleinen Landwirtschaftsbetriebe.
👇
Warum Investoren immer mehr Ackerland kaufen
Überregionale Investoren kaufen immer mehr Ackerland in Sachsen-Anhalt auf, die Preise sind stark gestiegen. Seit der Energiewende gibt es noch mehr Konkurrenz.
share.deutschlandradio.de
October 6, 2023 at 5:56 PM
Anhören!
Wie sich große branchenfremde Investoren (ALDI, Immobilien etc) riesengroße Ackerflächen 🚜 in Ostdeutschland kaufen.
Am Staat vorbei, ohne Steuern zu zahlen, mit dem Segen des Bauernverbandes und zum Schaden der kleinen Landwirtschaftsbetriebe.
👇
Wie sich große branchenfremde Investoren (ALDI, Immobilien etc) riesengroße Ackerflächen 🚜 in Ostdeutschland kaufen.
Am Staat vorbei, ohne Steuern zu zahlen, mit dem Segen des Bauernverbandes und zum Schaden der kleinen Landwirtschaftsbetriebe.
👇
Reposted by Daniel Krüger
Jugendarbeitslosigkeit in der EU, August 2023:
🇪🇸26.8%
🇪🇪23.5%
🇬🇷22.5%
🇷🇴22.3%
🇮🇹22.0%
🇸🇪21.1%
🇵🇹20.3%
🇭🇷20.0%
🇸🇰19.8%
🇱🇺19.2%
🇨🇾16.3%
🇫🇮16.1%
🇫🇷16.0%
🇧🇪14.2%
🇪🇺14.0%
🇭🇺12.8%
🇧🇬11.8%
🇩🇰11.6%
🇦🇹11.4%
🇮🇪11.2%
🇵🇱11.1%
🇸🇮10.4%
🇱🇻9.0%
🇲🇹9.0%
🇳🇱8.7%
🇱🇹8.6%
🇨🇿8.5%
🇩🇪5.7%
via: ec.europa.eu/eurostat/doc...
🇪🇸26.8%
🇪🇪23.5%
🇬🇷22.5%
🇷🇴22.3%
🇮🇹22.0%
🇸🇪21.1%
🇵🇹20.3%
🇭🇷20.0%
🇸🇰19.8%
🇱🇺19.2%
🇨🇾16.3%
🇫🇮16.1%
🇫🇷16.0%
🇧🇪14.2%
🇪🇺14.0%
🇭🇺12.8%
🇧🇬11.8%
🇩🇰11.6%
🇦🇹11.4%
🇮🇪11.2%
🇵🇱11.1%
🇸🇮10.4%
🇱🇻9.0%
🇲🇹9.0%
🇳🇱8.7%
🇱🇹8.6%
🇨🇿8.5%
🇩🇪5.7%
via: ec.europa.eu/eurostat/doc...
October 4, 2023 at 4:17 PM
Jugendarbeitslosigkeit in der EU, August 2023:
🇪🇸26.8%
🇪🇪23.5%
🇬🇷22.5%
🇷🇴22.3%
🇮🇹22.0%
🇸🇪21.1%
🇵🇹20.3%
🇭🇷20.0%
🇸🇰19.8%
🇱🇺19.2%
🇨🇾16.3%
🇫🇮16.1%
🇫🇷16.0%
🇧🇪14.2%
🇪🇺14.0%
🇭🇺12.8%
🇧🇬11.8%
🇩🇰11.6%
🇦🇹11.4%
🇮🇪11.2%
🇵🇱11.1%
🇸🇮10.4%
🇱🇻9.0%
🇲🇹9.0%
🇳🇱8.7%
🇱🇹8.6%
🇨🇿8.5%
🇩🇪5.7%
via: ec.europa.eu/eurostat/doc...
🇪🇸26.8%
🇪🇪23.5%
🇬🇷22.5%
🇷🇴22.3%
🇮🇹22.0%
🇸🇪21.1%
🇵🇹20.3%
🇭🇷20.0%
🇸🇰19.8%
🇱🇺19.2%
🇨🇾16.3%
🇫🇮16.1%
🇫🇷16.0%
🇧🇪14.2%
🇪🇺14.0%
🇭🇺12.8%
🇧🇬11.8%
🇩🇰11.6%
🇦🇹11.4%
🇮🇪11.2%
🇵🇱11.1%
🇸🇮10.4%
🇱🇻9.0%
🇲🇹9.0%
🇳🇱8.7%
🇱🇹8.6%
🇨🇿8.5%
🇩🇪5.7%
via: ec.europa.eu/eurostat/doc...
BlueSkye, let's go!
October 1, 2023 at 3:32 PM
BlueSkye, let's go!