Karl Koehler
@krkoehler.bsky.social
Neurobiologist and #organoid wrangler
Associate Professor, #otolaryngology, #neurobiology
@Bostonchildrens.bsky.social
@Harvardmed.bsky.social
Studying sensory #development through inner ear, skin and retinal organoids
Lab: https://koehler-lab.org
Associate Professor, #otolaryngology, #neurobiology
@Bostonchildrens.bsky.social
@Harvardmed.bsky.social
Studying sensory #development through inner ear, skin and retinal organoids
Lab: https://koehler-lab.org
The latest story from my group. Working toward build regionally distinct skin and amnion piece by piece.
Lateral plate mesoderm directs human amnion and ventral skin organoid formation https://www.biorxiv.org/content/10.1101/2025.11.05.685987v1
November 7, 2025 at 12:39 PM
The latest story from my group. Working toward build regionally distinct skin and amnion piece by piece.
Reposted by Karl Koehler
📢 The September Issue of the JID is here!
Explore the latest issue here:
www.jidonline.org/current
#DermatologyJournal #dermsky
On the cover: A cross-section of a 146 day-old hair-bearing skin organoid derived from human pluripotent stem cells.
@krkoehler.bsky.social @BostonChildrens.bsky.social
Explore the latest issue here:
www.jidonline.org/current
#DermatologyJournal #dermsky
On the cover: A cross-section of a 146 day-old hair-bearing skin organoid derived from human pluripotent stem cells.
@krkoehler.bsky.social @BostonChildrens.bsky.social
August 23, 2025 at 5:34 PM
📢 The September Issue of the JID is here!
Explore the latest issue here:
www.jidonline.org/current
#DermatologyJournal #dermsky
On the cover: A cross-section of a 146 day-old hair-bearing skin organoid derived from human pluripotent stem cells.
@krkoehler.bsky.social @BostonChildrens.bsky.social
Explore the latest issue here:
www.jidonline.org/current
#DermatologyJournal #dermsky
On the cover: A cross-section of a 146 day-old hair-bearing skin organoid derived from human pluripotent stem cells.
@krkoehler.bsky.social @BostonChildrens.bsky.social
I am moderating the upcoming ISSCR Digital Webinar: Modeling Human Neural Development and Disease with iPSCs. Join me to explore the latest science on neural development, disease mechanisms, and genetic variability from ISSCR 2025 Poster Award Winners. invt.io/1bxbs3ez8ty
I'm moderating the upcoming ISSCR Digital Webinar. Join me!
Register now
invt.io
July 21, 2025 at 4:25 PM
I am moderating the upcoming ISSCR Digital Webinar: Modeling Human Neural Development and Disease with iPSCs. Join me to explore the latest science on neural development, disease mechanisms, and genetic variability from ISSCR 2025 Poster Award Winners. invt.io/1bxbs3ez8ty
All #organoid enthusiasts, please consider joining us in Heidelberg, Germany, October 2025. My co-organizers, Meri Huch, @lancasterlab.bsky.social, Esther Schnapp, and I have assembled an excellent speaker list, with keynotes from Paola Arlotta and Matthias Lütolf. Hope to see you there!
The 5th edition of #EESOrgan is now open for registration! 🥳 The meeting will incorporate more complementary technologies, such as multiomics, engineered embryo models and bioengineering as well as put a bigger focus on cancer.
💻 https://s.embl.org/ees25-10-x
📥 Submit your abstract by 16 Jul
💻 https://s.embl.org/ees25-10-x
📥 Submit your abstract by 16 Jul
December 20, 2024 at 1:44 PM
All #organoid enthusiasts, please consider joining us in Heidelberg, Germany, October 2025. My co-organizers, Meri Huch, @lancasterlab.bsky.social, Esther Schnapp, and I have assembled an excellent speaker list, with keynotes from Paola Arlotta and Matthias Lütolf. Hope to see you there!
Reposted by Karl Koehler
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
A panoramic view of cell population dynamics in mammalian aging
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...
tinyurl.com
November 29, 2024 at 4:17 PM
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
Posting one of my favorite #organoid images for #microscopymonday. A 100+ day-old skin organoid with emerging hair follicles (ECAD, cyan) and endothelial cells (CD31, red). See: www.nature.com/immersive/d4.... Credit: Jiyoon Lee and Matt Steinhart from our lab. #devbio #stemcells
November 25, 2024 at 3:53 PM
Posting one of my favorite #organoid images for #microscopymonday. A 100+ day-old skin organoid with emerging hair follicles (ECAD, cyan) and endothelial cells (CD31, red). See: www.nature.com/immersive/d4.... Credit: Jiyoon Lee and Matt Steinhart from our lab. #devbio #stemcells
Reposted by Karl Koehler
#Organoid research starter pack.
I didn't find many researchers from the field yet, please comment/text me to be added!
go.bsky.app/RmXgs6d
I didn't find many researchers from the field yet, please comment/text me to be added!
go.bsky.app/RmXgs6d
November 24, 2024 at 8:32 AM
#Organoid research starter pack.
I didn't find many researchers from the field yet, please comment/text me to be added!
go.bsky.app/RmXgs6d
I didn't find many researchers from the field yet, please comment/text me to be added!
go.bsky.app/RmXgs6d
Reposted by Karl Koehler
Thrilled to announce that our latest work has been published in Science and featured on the front cover!
www.linkedin.com/posts/scienc...
www.linkedin.com/posts/scienc...
Science Magazine on LinkedIn: This light-sheet microscopy three-dimensional rendering shows a…
This light-sheet microscopy three-dimensional rendering shows a first-of-its-kind mouse whole-brain mRNA analysis at single-cell resolution.
Learn more in…
www.linkedin.com
November 22, 2024 at 12:43 AM
Thrilled to announce that our latest work has been published in Science and featured on the front cover!
www.linkedin.com/posts/scienc...
www.linkedin.com/posts/scienc...
Exciting to see the collection of HCA papers out this week in Nature. Honored to be in the mix with our collaboration with @mhaniffa.bsky.social and Sarah Teichmann on a fetal skin atlas. Bravo to Hudaa, Elena, and Bayanne et al, for pulling this study together. A tremendous effort! rdcu.be/d02Yx
A prenatal skin atlas reveals immune regulation of human skin morphogenesis
Nature - A comprehensive multi-omics reference atlas of prenatal human skin shows that innate immune cells crosstalk with non-immune cells to perform pivotal roles in skin morphogenesis, including...
rdcu.be
November 21, 2024 at 6:34 PM
Exciting to see the collection of HCA papers out this week in Nature. Honored to be in the mix with our collaboration with @mhaniffa.bsky.social and Sarah Teichmann on a fetal skin atlas. Bravo to Hudaa, Elena, and Bayanne et al, for pulling this study together. A tremendous effort! rdcu.be/d02Yx
Reposted by Karl Koehler
A collection published across Nature Portfolio journals presents early draft maps of cells in the human body from the Human Cell Atlas initiative. The research leverages new data and analytical tools to aid our understanding of human health and disease at a cellular level. 🧪
The Human Cell Atlas: towards a first draft atlas
In a collection of research articles and related content, the Human Cell Atlas consortium presents tools, data and ideas towards the generation of their first draft atlas of cells in the human body.
go.nature.com
November 20, 2024 at 4:50 PM
A collection published across Nature Portfolio journals presents early draft maps of cells in the human body from the Human Cell Atlas initiative. The research leverages new data and analytical tools to aid our understanding of human health and disease at a cellular level. 🧪