Junyue Cao
@junyuecao.bsky.social
Assistant Professor, Rockefeller University
Reposted by Junyue Cao
New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)
Lineage recording in monoclonal gastruloids reveals heritable modes of early development
Mammalian stem cells possess a remarkable capacity for self-organization, a property that underlies increasingly sophisticated in vitro models of early development. However, even under carefully contr...
www.biorxiv.org
May 27, 2025 at 2:57 PM
New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)
Excited to share our first anti-aging intervention analysis, led by brilliant Zehao @tommyz626.bsky.social, Alex, and Chloe from our lab at @rockefelleruniv.bsky.social! We identified the aging-associated cell populations that can be rescued by caloric restriction in the mammalian brain!
May 12, 2025 at 6:12 PM
Excited to share our first anti-aging intervention analysis, led by brilliant Zehao @tommyz626.bsky.social, Alex, and Chloe from our lab at @rockefelleruniv.bsky.social! We identified the aging-associated cell populations that can be rescued by caloric restriction in the mammalian brain!
Reposted by Junyue Cao
Hero lawyers in state AG offices busted their asses over the weekend to get this done. Now do your part: call your Representative and Senators TODAY. Call your AG AND governor and voice your support for these lawsuits.
BREAKING: 22 states sue NIH over Trump administration's new 15% cap on overhead for federal research grants. Suit filed federal court in Boston contends lifesaving research 'will grind to a halt' under the policy. Doc: storage.courtlistener.com/recap/gov.us...
storage.courtlistener.com
February 10, 2025 at 5:31 PM
Hero lawyers in state AG offices busted their asses over the weekend to get this done. Now do your part: call your Representative and Senators TODAY. Call your AG AND governor and voice your support for these lawsuits.
Reposted by Junyue Cao
Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Multiplex generation and single-cell analysis of structural variants in mammalian genomes
Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...
www.science.org
January 31, 2025 at 7:41 PM
Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Junyue Cao
Joined @junyuecao.bsky.social's lab without knowing single-cell genomics - after 3 years of failing, crying, learning, and growing, I’m proud to share the PanSci! Huge thanks to amazing mentors Jun & Wei and support from @rockefelleruniv.bsky.social. The secrets of aging are starting to unfold!
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
A panoramic view of cell population dynamics in mammalian aging
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...
tinyurl.com
December 11, 2024 at 9:57 PM
Joined @junyuecao.bsky.social's lab without knowing single-cell genomics - after 3 years of failing, crying, learning, and growing, I’m proud to share the PanSci! Huge thanks to amazing mentors Jun & Wei and support from @rockefelleruniv.bsky.social. The secrets of aging are starting to unfold!
Reposted by Junyue Cao
A newly created atlas of 21 million cells from @junyuecao.bsky.social's lab led by @tommyz626.bsky.social could upend long-held assumptions about how we age and provide fresh directions for anti-aging therapies. #RockefellerScience
Study reveals how unexpected shifts in cell populations are revising our understanding of the aging process - News
A newly created atlas of 21 million cells could provide fresh directions for anti-aging therapies.
www.rockefeller.edu
December 11, 2024 at 7:21 PM
A newly created atlas of 21 million cells from @junyuecao.bsky.social's lab led by @tommyz626.bsky.social could upend long-held assumptions about how we age and provide fresh directions for anti-aging therapies. #RockefellerScience
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
A panoramic view of cell population dynamics in mammalian aging
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...
tinyurl.com
November 29, 2024 at 4:17 PM
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!