Zehao-Tommy Zhang
@tommyz626.bsky.social
Graduate fellow at Junyue Cao's lab at the Rockefeller University
Studying aging biology and genomics
Studying aging biology and genomics
Reposted by Zehao-Tommy Zhang
New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)
Lineage recording in monoclonal gastruloids reveals heritable modes of early development
Mammalian stem cells possess a remarkable capacity for self-organization, a property that underlies increasingly sophisticated in vitro models of early development. However, even under carefully contr...
www.biorxiv.org
May 27, 2025 at 2:57 PM
New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)
Why do many aging interventions come & go, yet Caloric Restriction (CR) remains a robust pillar, extending healthspan across species? Its benefits are even noted in ancient eastern texts like The Yellow Emperor’s Classic of Internal Medicine!
May 12, 2025 at 4:09 PM
Why do many aging interventions come & go, yet Caloric Restriction (CR) remains a robust pillar, extending healthspan across species? Its benefits are even noted in ancient eastern texts like The Yellow Emperor’s Classic of Internal Medicine!
Reposted by Zehao-Tommy Zhang
The importance of the immune system for healthy aging.
A large multi-cohort study identifies a mechanism of immune resilience with substantial impact for outcomes
onlinelibrary.wiley.com/doi/10.1111/...
A large multi-cohort study identifies a mechanism of immune resilience with substantial impact for outcomes
onlinelibrary.wiley.com/doi/10.1111/...
The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging
Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health-promoting trait (more common in women) linked to strong i....
onlinelibrary.wiley.com
April 23, 2025 at 12:47 PM
The importance of the immune system for healthy aging.
A large multi-cohort study identifies a mechanism of immune resilience with substantial impact for outcomes
onlinelibrary.wiley.com/doi/10.1111/...
A large multi-cohort study identifies a mechanism of immune resilience with substantial impact for outcomes
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Zehao-Tommy Zhang
Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of
February 26, 2025 at 11:21 PM
Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of
Reposted by Zehao-Tommy Zhang
Biological sex is a key modifier of #aging phenotypes, including #Brain 🧠 aging.
See this piece out today in #Neuron, spearheaded by @denadubal.bsky.social, co-authored by #YousinSuh, @ctmurphy1.bsky.social and myself on the topic:
www.sciencedirect.com/science/arti...
#GeroSky #SexDifferences
See this piece out today in #Neuron, spearheaded by @denadubal.bsky.social, co-authored by #YousinSuh, @ctmurphy1.bsky.social and myself on the topic:
www.sciencedirect.com/science/arti...
#GeroSky #SexDifferences
January 8, 2025 at 4:54 PM
Biological sex is a key modifier of #aging phenotypes, including #Brain 🧠 aging.
See this piece out today in #Neuron, spearheaded by @denadubal.bsky.social, co-authored by #YousinSuh, @ctmurphy1.bsky.social and myself on the topic:
www.sciencedirect.com/science/arti...
#GeroSky #SexDifferences
See this piece out today in #Neuron, spearheaded by @denadubal.bsky.social, co-authored by #YousinSuh, @ctmurphy1.bsky.social and myself on the topic:
www.sciencedirect.com/science/arti...
#GeroSky #SexDifferences
Reposted by Zehao-Tommy Zhang
Interested in brain aging? We are super excited to share our new review!!
"Brain aging and rejuvenation at single-cell resolution" 🧪🧠
Massive CONGRATS to Eric Sun, Rahul Nagvekar, and Angie Pogson, three phenomenal graduate students in the lab!!
authors.elsevier.com/sd/article/S...
"Brain aging and rejuvenation at single-cell resolution" 🧪🧠
Massive CONGRATS to Eric Sun, Rahul Nagvekar, and Angie Pogson, three phenomenal graduate students in the lab!!
authors.elsevier.com/sd/article/S...
January 9, 2025 at 12:16 AM
Interested in brain aging? We are super excited to share our new review!!
"Brain aging and rejuvenation at single-cell resolution" 🧪🧠
Massive CONGRATS to Eric Sun, Rahul Nagvekar, and Angie Pogson, three phenomenal graduate students in the lab!!
authors.elsevier.com/sd/article/S...
"Brain aging and rejuvenation at single-cell resolution" 🧪🧠
Massive CONGRATS to Eric Sun, Rahul Nagvekar, and Angie Pogson, three phenomenal graduate students in the lab!!
authors.elsevier.com/sd/article/S...
Reposted by Zehao-Tommy Zhang
A newly created atlas of 21 million cells from @junyuecao.bsky.social's lab led by @tommyz626.bsky.social could upend long-held assumptions about how we age and provide fresh directions for anti-aging therapies. #RockefellerScience
Study reveals how unexpected shifts in cell populations are revising our understanding of the aging process - News
A newly created atlas of 21 million cells could provide fresh directions for anti-aging therapies.
www.rockefeller.edu
December 11, 2024 at 7:21 PM
A newly created atlas of 21 million cells from @junyuecao.bsky.social's lab led by @tommyz626.bsky.social could upend long-held assumptions about how we age and provide fresh directions for anti-aging therapies. #RockefellerScience
Joined @junyuecao.bsky.social's lab without knowing single-cell genomics - after 3 years of failing, crying, learning, and growing, I’m proud to share the PanSci! Huge thanks to amazing mentors Jun & Wei and support from @rockefelleruniv.bsky.social. The secrets of aging are starting to unfold!
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
A panoramic view of cell population dynamics in mammalian aging
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...
tinyurl.com
December 11, 2024 at 9:57 PM
Joined @junyuecao.bsky.social's lab without knowing single-cell genomics - after 3 years of failing, crying, learning, and growing, I’m proud to share the PanSci! Huge thanks to amazing mentors Jun & Wei and support from @rockefelleruniv.bsky.social. The secrets of aging are starting to unfold!