Zehao-Tommy Zhang
@tommyz626.bsky.social
Graduate fellow at Junyue Cao's lab at the Rockefeller University
Studying aging biology and genomics
Studying aging biology and genomics
This work wouldn't have been possible without the CR samples & generous support from NIH and NIA, and crucial funding from Stavros Niarchos Foundation and Kellen Women’s Entrepreneurship Fund, Center for Integrated Cellular Analysis & AFAR. Thank you all!
May 12, 2025 at 4:09 PM
This work wouldn't have been possible without the CR samples & generous support from NIH and NIA, and crucial funding from Stavros Niarchos Foundation and Kellen Women’s Entrepreneurship Fund, Center for Integrated Cellular Analysis & AFAR. Thank you all!
Alex, Chloe & I are deeply grateful for the incredible support from all co-authors @junyuecao.bsky.social ’s lab & @rockefelleruniv.bsky.social !
May 12, 2025 at 4:09 PM
Alex, Chloe & I are deeply grateful for the incredible support from all co-authors @junyuecao.bsky.social ’s lab & @rockefelleruniv.bsky.social !
Looking ahead, we're keen to apply our scalable & low-cost EasySci & IRISeq methods to diverse aging interventions and across species, with the goal in mind to uncover evolutionarily conserved and broadly applicable cellular and molecular targets to promote healthy aging for all.
May 12, 2025 at 4:09 PM
Looking ahead, we're keen to apply our scalable & low-cost EasySci & IRISeq methods to diverse aging interventions and across species, with the goal in mind to uncover evolutionarily conserved and broadly applicable cellular and molecular targets to promote healthy aging for all.
A key limitation: we studied only male mice & are excited to see if female samples show similar/different effects!
May 12, 2025 at 4:09 PM
A key limitation: we studied only male mice & are excited to see if female samples show similar/different effects!
Our study offers a deep atlas of CR's impact on the aging mouse brain. We are excited to further explore if CR modulates aging cell population dynamics through inter-cellular signaling OR by direct action on aging-associated cells.
May 12, 2025 at 4:09 PM
Our study offers a deep atlas of CR's impact on the aging mouse brain. We are excited to further explore if CR modulates aging cell population dynamics through inter-cellular signaling OR by direct action on aging-associated cells.
CR also takes a swing at cellular senescence! With IRISeq, We observed a significant reduction in senescence-associated gene expression across various brain regions and cell types upon CR.
May 12, 2025 at 4:09 PM
CR also takes a swing at cellular senescence! With IRISeq, We observed a significant reduction in senescence-associated gene expression across various brain regions and cell types upon CR.
Intriguingly, CR’s boost to neurogenesis is time-sensitive! 🕰️ It helps preserve neurogenic cell populations (stem cells & neuroblasts) earlier in life (e.g., at 12 months), delaying their depletion. However, this effect wasn't sustained at much later time points (18 & 24 months).
May 12, 2025 at 4:09 PM
Intriguingly, CR’s boost to neurogenesis is time-sensitive! 🕰️ It helps preserve neurogenic cell populations (stem cells & neuroblasts) earlier in life (e.g., at 12 months), delaying their depletion. However, this effect wasn't sustained at much later time points (18 & 24 months).
CR significantly counteracts the age-related expansion of disease-associated glial cells. We observed a striking reduction in inflammatory cell states like disease-associated microglia & oligodendrocytes – pointing to CR’s power to dampen brain inflammation.
May 12, 2025 at 4:09 PM
CR significantly counteracts the age-related expansion of disease-associated glial cells. We observed a striking reduction in inflammatory cell states like disease-associated microglia & oligodendrocytes – pointing to CR’s power to dampen brain inflammation.
We previously proposed that altered cell population dynamics play an essential role in brain aging and could serve as treatment targets (www.nature.com/articles/s41...). Now, with >500K cells profiled, we see how CR directly remodels these dynamics!
A global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains - Nature Genetics
Single-cell transcriptomes and single-cell chromatin accessibility profiles generated using EasySci provide a global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics in h...
www.nature.com
May 12, 2025 at 4:09 PM
We previously proposed that altered cell population dynamics play an essential role in brain aging and could serve as treatment targets (www.nature.com/articles/s41...). Now, with >500K cells profiled, we see how CR directly remodels these dynamics!
The precise cellular & regional mechanisms of CR's benefits to the aging brain have been elusive. To bridge this gap, we brought cutting-edge tech – highly scalable single-nuc(EasySci) & spatial transcriptomics (IRISeq, kudos to Abdul & Weirong) – to dissect this age-old yet resilient strategy.
May 12, 2025 at 4:09 PM
The precise cellular & regional mechanisms of CR's benefits to the aging brain have been elusive. To bridge this gap, we brought cutting-edge tech – highly scalable single-nuc(EasySci) & spatial transcriptomics (IRISeq, kudos to Abdul & Weirong) – to dissect this age-old yet resilient strategy.
But how does it truly work on the aging brain? We investigated! 🧠 www.biorxiv.org/content/10.1...
Spatiotemporal profiling reveals the impact of caloric restriction on mammalian brain aging
Aging induces functional declines in the mammalian brain, increasing its vulnerability to cognitive impairments and neurodegenerative disorders. Among various interventions to slow the aging process, ...
www.biorxiv.org
May 12, 2025 at 4:09 PM
But how does it truly work on the aging brain? We investigated! 🧠 www.biorxiv.org/content/10.1...
Thank you Szen!!
December 11, 2024 at 11:37 PM
Thank you Szen!!