Steffen Grosser
@steffengrosser.bsky.social
Postdoc Junior Leader Fellow @Fundació ”la Caixa”, at Xavier Trepat Lab, IBEC Barcelona
Stoked to announce that I received a poster award! 🔥😍
Many thanks to the #25EngLife organizers for the amazing meeting!
Many thanks to the #25EngLife organizers for the amazing meeting!
Congratulations to the poster prize winners of the #25EngLife Thank you again for the organisation. It's been a fantastic meeting!
September 3, 2025 at 6:49 PM
Stoked to announce that I received a poster award! 🔥😍
Many thanks to the #25EngLife organizers for the amazing meeting!
Many thanks to the #25EngLife organizers for the amazing meeting!
Keep an eye on the upcoming tissue force (tension) sensors 🔥🔥
from @baldaufsci.bsky.social
from @baldaufsci.bsky.social
Fantastic work presented by Lucia Baldauf from @gcharras.bsky.social on force sensors for living tissues 🤯 Looking forward to the upcoming ... #25EngLife
September 3, 2025 at 6:47 PM
Keep an eye on the upcoming tissue force (tension) sensors 🔥🔥
from @baldaufsci.bsky.social
from @baldaufsci.bsky.social
Reposted by Steffen Grosser
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
www.nature.com
August 27, 2025 at 5:18 PM
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Reposted by Steffen Grosser
📢Conference alert📢
Only one week left to register for the Engineering Life 2025 Symposium at Dresden September 1-3. This year's edition focuses on the function of mechanical forces in biology.
engineering-life-dresden.de
Only one week left to register for the Engineering Life 2025 Symposium at Dresden September 1-3. This year's edition focuses on the function of mechanical forces in biology.
engineering-life-dresden.de
Engineering Life 2025: ORIGIN AND FUNCTION OF MECHANICAL FORCES IN BIOLOGY
Engineering Life 2025, biological forces, force spectroscopy, measuring forces, developmental forces, molecular motors, forces in morphogenesis, cytoskeleton, DNA mechanics, bionanotechnology
engineering-life-dresden.de
June 22, 2025 at 9:12 AM
📢Conference alert📢
Only one week left to register for the Engineering Life 2025 Symposium at Dresden September 1-3. This year's edition focuses on the function of mechanical forces in biology.
engineering-life-dresden.de
Only one week left to register for the Engineering Life 2025 Symposium at Dresden September 1-3. This year's edition focuses on the function of mechanical forces in biology.
engineering-life-dresden.de
Reposted by Steffen Grosser
Great success for Dresden and Saxony!
Physics of Life is one of the excellence clusters
@poldresden.bsky.social
Physics of Life is one of the excellence clusters
@poldresden.bsky.social
These Clusters will be funded:
🔹CARE: Climate-Neutral & Resource-Efficient Construction
🔹CeTI: Centre for Tactile Internet with Human-in-the-Loop
🔹ctd.qmat: Complexity, Topology & Dynamics in Quantum Matter
🔹@poldresden.bsky.social
🔹REC2: Responsible Electronics in the Climate-Change Era
🔹CARE: Climate-Neutral & Resource-Efficient Construction
🔹CeTI: Centre for Tactile Internet with Human-in-the-Loop
🔹ctd.qmat: Complexity, Topology & Dynamics in Quantum Matter
🔹@poldresden.bsky.social
🔹REC2: Responsible Electronics in the Climate-Change Era
May 23, 2025 at 9:31 AM
Great success for Dresden and Saxony!
Physics of Life is one of the excellence clusters
@poldresden.bsky.social
Physics of Life is one of the excellence clusters
@poldresden.bsky.social
Reposted by Steffen Grosser
Positional memory has implications for bioengineering. Transplanting salamander cells in a way that alters their spatial organisation changes signalling topology and results in predictable (but amazing) phenotypes such as too many fingers - or even extra limbs!
🧵3/14
🧵3/14
May 21, 2025 at 3:05 PM
Positional memory has implications for bioengineering. Transplanting salamander cells in a way that alters their spatial organisation changes signalling topology and results in predictable (but amazing) phenotypes such as too many fingers - or even extra limbs!
🧵3/14
🧵3/14
Reposted by Steffen Grosser
1/14 “Epithelial” & “Mesenchymal” aren’t binary categories—they form a spectrum, or better yet, a multidimensional space. This becomes especially clear in collective cell migration, which often depends on a finely tuned degree of “mesenchymal-ness”.
#cellbio #devbio #cellmigration
#cellbio #devbio #cellmigration
April 20, 2025 at 7:32 AM
1/14 “Epithelial” & “Mesenchymal” aren’t binary categories—they form a spectrum, or better yet, a multidimensional space. This becomes especially clear in collective cell migration, which often depends on a finely tuned degree of “mesenchymal-ness”.
#cellbio #devbio #cellmigration
#cellbio #devbio #cellmigration
Reposted by Steffen Grosser
In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
March 28, 2025 at 11:46 AM
In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by Steffen Grosser
all of human knowledge at my fingertips
March 19, 2025 at 2:18 AM
all of human knowledge at my fingertips
We're so back
March 18, 2025 at 6:33 AM
We're so back
Will visit it when I am in Dresden on April 16!
🎉Exciting announcement about our new exhibition!🎉
Curious about the world of biophysics? Our "Physics of Life" exhibition opens every Tues, Weds, and Thurs from 1-6pm.
Entry is free!
📍Find us at Cosmo Wissenschaftsforum, at the Kulturpalast, Dresden until May 8th.
#Biophysics #Dresden #Science
Curious about the world of biophysics? Our "Physics of Life" exhibition opens every Tues, Weds, and Thurs from 1-6pm.
Entry is free!
📍Find us at Cosmo Wissenschaftsforum, at the Kulturpalast, Dresden until May 8th.
#Biophysics #Dresden #Science
March 17, 2025 at 3:56 PM
Will visit it when I am in Dresden on April 16!
Reposted by Steffen Grosser
einstein sent this to curie in 1911 when she was being harassed by tabloids. it contains everything you’d want in such a letter:
(1) your haters are trash
(2) you’re a baller, a true queen
(3) i have determined the statistical law of motion of the diatomic molecule in planck’s radiation field 🧪⚛️
(1) your haters are trash
(2) you’re a baller, a true queen
(3) i have determined the statistical law of motion of the diatomic molecule in planck’s radiation field 🧪⚛️
June 27, 2024 at 2:17 PM
einstein sent this to curie in 1911 when she was being harassed by tabloids. it contains everything you’d want in such a letter:
(1) your haters are trash
(2) you’re a baller, a true queen
(3) i have determined the statistical law of motion of the diatomic molecule in planck’s radiation field 🧪⚛️
(1) your haters are trash
(2) you’re a baller, a true queen
(3) i have determined the statistical law of motion of the diatomic molecule in planck’s radiation field 🧪⚛️
Reposted by Steffen Grosser
this is a good time to note that the proposed candidate for NIH director has never run a lab, cared for patients, led a major research and healthcare institution, or been a principal investigator on an NIH grant
February 8, 2025 at 12:31 AM
this is a good time to note that the proposed candidate for NIH director has never run a lab, cared for patients, led a major research and healthcare institution, or been a principal investigator on an NIH grant
The spheroid fusion analysis I did in this new study is much better than in my old paper!
I don't "fit" any dumb-bell 2D shape anymore to the data (unstable).
Instead, I use moment analysis/aspect ratios, which can be converted to tissue fluidity (very robust).
I don't "fit" any dumb-bell 2D shape anymore to the data (unstable).
Instead, I use moment analysis/aspect ratios, which can be converted to tissue fluidity (very robust).
@steffengrosser.bsky.social, who performed tissue fluidity analysis.
and Calvin Lam, who performed, ages ago, the first simulations of a potential circuit for tissue elongation!
and Calvin Lam, who performed, ages ago, the first simulations of a potential circuit for tissue elongation!
December 17, 2024 at 7:15 PM
The spheroid fusion analysis I did in this new study is much better than in my old paper!
I don't "fit" any dumb-bell 2D shape anymore to the data (unstable).
Instead, I use moment analysis/aspect ratios, which can be converted to tissue fluidity (very robust).
I don't "fit" any dumb-bell 2D shape anymore to the data (unstable).
Instead, I use moment analysis/aspect ratios, which can be converted to tissue fluidity (very robust).
Reposted by Steffen Grosser
This circuit can be used to propagate a change in cell fate in 2D in a wave-like pattern… And also in 3D!
In this animation, a spheroid of “sender” cells (red+green=yellow) is fused with a spheroid of “transceiver” cells. Activated transceivers become green.
In this animation, a spheroid of “sender” cells (red+green=yellow) is fused with a spheroid of “transceiver” cells. Activated transceivers become green.
December 17, 2024 at 2:03 PM
This circuit can be used to propagate a change in cell fate in 2D in a wave-like pattern… And also in 3D!
In this animation, a spheroid of “sender” cells (red+green=yellow) is fused with a spheroid of “transceiver” cells. Activated transceivers become green.
In this animation, a spheroid of “sender” cells (red+green=yellow) is fused with a spheroid of “transceiver” cells. Activated transceivers become green.
And look at this stunning synthetic biology!
Delighted to share our last preprint!!! 🎉🎉🎉
biorxiv.org/content/10.1101/2024.12.11.627621v1
We share the first synthetic gene circuit guiding the self-organization of mammalian tissues in elongating structures by dynamically tuning growth, viscosity and adhesion.
biorxiv.org/content/10.1101/2024.12.11.627621v1
We share the first synthetic gene circuit guiding the self-organization of mammalian tissues in elongating structures by dynamically tuning growth, viscosity and adhesion.
December 17, 2024 at 7:09 PM
And look at this stunning synthetic biology!
Stunning optogenetic guidance!
For more details, check out the preprint www.biorxiv.org/content/10.1... - or ask anything here! (+here's a bonus movie that didn't quite make the cut) 🌀
December 17, 2024 at 7:04 PM
Stunning optogenetic guidance!
Reposted by Steffen Grosser
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
December 3, 2024 at 9:18 AM
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
Good morning, and wtf is this
December 3, 2024 at 7:25 AM
Good morning, and wtf is this
Reposted by Steffen Grosser
Large-scale collective motion of epithelial cells not as a fluid, but as a polar elastic solid.
Our new study posted on Biorxiv:
www.biorxiv.org/content/10.1...
Our new study posted on Biorxiv:
www.biorxiv.org/content/10.1...
November 21, 2024 at 4:17 PM
Large-scale collective motion of epithelial cells not as a fluid, but as a polar elastic solid.
Our new study posted on Biorxiv:
www.biorxiv.org/content/10.1...
Our new study posted on Biorxiv:
www.biorxiv.org/content/10.1...
Reposted by Steffen Grosser
Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN
November 13, 2024 at 8:28 PM
Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN