Josquin Courte, PhD
josquincourte.bsky.social
Josquin Courte, PhD
@josquincourte.bsky.social
Scientist.
Microfluidics, synthetic biology, neurodegeneration, tissue engineering.
I want to develop better in vitro disease models.
Currently looking for positions in the biotech sector in Switzerland / France / Belgium.

Also DM, TTRPG enthusiast.
January 20, 2025 at 1:53 PM
Delighted to share our last preprint!!! 🎉🎉🎉
biorxiv.org/content/10.1101/2024.12.11.627621v1

We share the first synthetic gene circuit guiding the self-organization of mammalian tissues in elongating structures by dynamically tuning growth, viscosity and adhesion.
December 17, 2024 at 2:03 PM
An exciting result about controling signaling with density (doi.org/10.1038/s41467-024-53078-8)

=> As distal parts of rod-shaped aggregates are less dense., we get "free" spatial patterning in 3D!

=> Some interesting potential for feedback loops, if this circuit controls tissue physics...
December 6, 2024 at 2:53 PM
I am thrilled to share that our work is finally published in Nature Communications!!! 🎉 🎉 🎉

I had the honor of leading the project to its finish line during my last years at USC, building on the groundbreaking work of my co-first authors Pranav Bhamidipati and Marco Santorelli.

(1/n)
Control of spatio-temporal patterning via cell growth in a multicellular synthetic gene circuit - Nature Communications
A major goal in synthetic development is to build gene regulatory circuits that control patterning. Here the authors discover that elevated cell density dampens SynNotch signaling, enabling the design...
www.nature.com
November 25, 2024 at 1:34 PM