Finally, we could use control of shape to rationally direct buckling into predictable wrinkle patterns.
9/10

Wait a min, same logic applies to the cell cortex, which is also surrounded by viscous cytosol, we predicted micron size wrinkles on the cell surface.

Guess what: Wrinkling is multiscale!
8/10

These shells are buckling in the viscous medium, so on deflation tissue deforms itself and the fluid medium around it. The pattern comes about as a result of this competition.
7/10

Pretty cool, what about the size, looking from the top, we see smaller shells buckle to form peripheral wrinkle while larger shells form radial folds. Why????
6/10

We find that the buckling emerges for fast deflation relative to the cortex’s relaxation time, and is suppressed by high contractility.
5/10

Do they buckle?? Yes they do!!
Quality is low because this happens very fast!!
4/10

If we deflate the shell in steady state it will buckle!!!

Thanks to A Ouzeri, PK Bal, and Marino Arroyo for their awesome models of the active viscoelastic shell.
doi.org/10.1101/2025...
doi.org/10.1101/2025...

3/10

With our cool device: MOLI, we inflated the flat monolayer into a spherical shell! 2/10

Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?

New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling

I recently enjoyed an amazing EMBO workshop on computational modeling of multicellular systems in Barcelona. I learned various techniques & gained hands-on experience

Thanks to @embo.org @jamesasharpe.bsky.social @torres-sanchez.bsky.social for this wonderful workshop!

We did this 👇from scratch!

Had a lot of fun discussing my favorite topic, #EpithelialMechanics!

Big thanks to @pintofscience.us for the opportunity and to NYC for the great turnout! #pint25