Nimesh Chahare
@onenimesa.bsky.social
Doing #EpithelialMechanics! with chick embryo 🐣
Convenor @epimechfc.bsky.social // Postdoc @NerurkarLab at Columbia // PhD @xaviertrepat.bsky.social lab at IBEC Barcelona
nchahare.github.io
Convenor @epimechfc.bsky.social // Postdoc @NerurkarLab at Columbia // PhD @xaviertrepat.bsky.social lab at IBEC Barcelona
nchahare.github.io
Pinned
Nimesh Chahare
@onenimesa.bsky.social
· Jul 3
Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling
Reposted by Nimesh Chahare
I’m pleased to share our latest preprint (my first as 1st-author) from Jérôme Gros’ group (@jeromegros.bsky.social), now on bioRxiv. It reports actin and myosin dynamics during epithelial remodeling in avian gastrulation. (doi: doi.org/10.64898/202...)
Actin and myosin dynamics during epithelial remodeling in avian gastrulation
Epithelial remodeling is powered by contractile forces exerted by the actomyosin cytoskeleton. In invertebrates, pulsatile contractile flows of the medio-apical actomyosin cortex have been shown to be...
doi.org
January 9, 2026 at 12:11 PM
Reposted by Nimesh Chahare
Congratulations to Byung Ho from the @anne-grapin.bsky.social lab @mpi-cbg.de and the rest of the team to this fantastic publication: www.nature.com/articles/s41...
Permeability-driven pressure and cell proliferation control lumen morphogenesis in pancreatic organoids - Nature Cell Biology
Using pancreatic organoids, Lee et al. show that the balance between epithelial tissue permeability-driven lumenal pressure and cell proliferation affects ductal morphogenesis.
www.nature.com
January 7, 2026 at 1:43 PM
Congratulations to Byung Ho from the @anne-grapin.bsky.social lab @mpi-cbg.de and the rest of the team to this fantastic publication: www.nature.com/articles/s41...
Reposted by Nimesh Chahare
How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? 🤔
We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.
buff.ly/w56OUJT
We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.
buff.ly/w56OUJT
January 5, 2026 at 8:00 AM
How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? 🤔
We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.
buff.ly/w56OUJT
We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.
buff.ly/w56OUJT
Reposted by Nimesh Chahare
Tissue mechanics and synth morphogenesis folks!
Would you or someone in your lab be up for recording a video of a protocol you use? Something hard to explain without seeing it done?
In the limbo hours 🌀 between today and 2026🌟, if something comes to mind -get in touch!
#JoVE organizes the filming 🤳
Would you or someone in your lab be up for recording a video of a protocol you use? Something hard to explain without seeing it done?
In the limbo hours 🌀 between today and 2026🌟, if something comes to mind -get in touch!
#JoVE organizes the filming 🤳
I am putting together a collection of video-protocols we (will) use in tissue mechanics research🌀
I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field.
Abstract submission by March 2026! Get in touch✨
#JoVETissueMech
#ReproducibleTissueMech
I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field.
Abstract submission by March 2026! Get in touch✨
#JoVETissueMech
#ReproducibleTissueMech
December 30, 2025 at 7:46 PM
Tissue mechanics and synth morphogenesis folks!
Would you or someone in your lab be up for recording a video of a protocol you use? Something hard to explain without seeing it done?
In the limbo hours 🌀 between today and 2026🌟, if something comes to mind -get in touch!
#JoVE organizes the filming 🤳
Would you or someone in your lab be up for recording a video of a protocol you use? Something hard to explain without seeing it done?
In the limbo hours 🌀 between today and 2026🌟, if something comes to mind -get in touch!
#JoVE organizes the filming 🤳
Reposted by Nimesh Chahare
Beads moving around in the lumen of a developing lung, taken my first month of my postdoc when I was playing around with how I could make different viscoelastic material measurments.
December 17, 2025 at 2:16 PM
Beads moving around in the lumen of a developing lung, taken my first month of my postdoc when I was playing around with how I could make different viscoelastic material measurments.
Reposted by Nimesh Chahare
Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...
Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology
Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.
www.nature.com
December 16, 2025 at 10:04 AM
Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...
Reposted by Nimesh Chahare
For this festive season, I’m sending friends and family something a little different: postcards straight from the microscope. 🔬
Featuring my hiPSC Christmas tree from last year and a hiPSC colony turned into a festive bauble, with wishes for a season that’s festive at every scale. 🎄
Featuring my hiPSC Christmas tree from last year and a hiPSC colony turned into a festive bauble, with wishes for a season that’s festive at every scale. 🎄
December 16, 2025 at 3:13 PM
For this festive season, I’m sending friends and family something a little different: postcards straight from the microscope. 🔬
Featuring my hiPSC Christmas tree from last year and a hiPSC colony turned into a festive bauble, with wishes for a season that’s festive at every scale. 🎄
Featuring my hiPSC Christmas tree from last year and a hiPSC colony turned into a festive bauble, with wishes for a season that’s festive at every scale. 🎄
Reposted by Nimesh Chahare
I am putting together a collection of video-protocols we (will) use in tissue mechanics research🌀
I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field.
Abstract submission by March 2026! Get in touch✨
#JoVETissueMech
#ReproducibleTissueMech
I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field.
Abstract submission by March 2026! Get in touch✨
#JoVETissueMech
#ReproducibleTissueMech
December 16, 2025 at 2:28 PM
I am putting together a collection of video-protocols we (will) use in tissue mechanics research🌀
I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field.
Abstract submission by March 2026! Get in touch✨
#JoVETissueMech
#ReproducibleTissueMech
I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field.
Abstract submission by March 2026! Get in touch✨
#JoVETissueMech
#ReproducibleTissueMech
Reposted by Nimesh Chahare
Cells can sense the geometry of their environment, from tiny subcellular features to whole-tissue patterns. How can we engineer environments to systematically probe these responses?
🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!
🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!
December 14, 2025 at 8:08 AM
Cells can sense the geometry of their environment, from tiny subcellular features to whole-tissue patterns. How can we engineer environments to systematically probe these responses?
🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!
🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!
Reposted by Nimesh Chahare
Meet the Epithelial Mechanics Fan Club @epimechfc.bsky.social
Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club.
Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...
Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club.
Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...
Epithelial Mechanics Fan Club - FocalPlane
Epithelial Mechanics Fan Club - News
focalplane.biologists.com
December 5, 2025 at 1:35 PM
Meet the Epithelial Mechanics Fan Club @epimechfc.bsky.social
Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club.
Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...
Nimesh Chahare @onenimesa.bsky.social and Julia Eckert @juliaeckert.bsky.social introduce us to the Epithelial Mechanics Fan Club.
Learn how you can get involved with this community: focalplane.biologists.com/2025/12/04/e...
Reposted by Nimesh Chahare
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
November 23, 2025 at 8:01 AM
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
Reposted by Nimesh Chahare
Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Epithelial Mechanics Fan Club
epithelialmechanics.github.io
October 23, 2025 at 7:21 AM
Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
👉 epithelialmechanics.github.io
Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them.
Would you like to share your story? Please DM us!
Join the coolest club on the internet!
#EpithelialMechanics
#EpithelialMechanics
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Epithelial Mechanics Fan Club
epithelialmechanics.github.io
October 23, 2025 at 3:11 PM
Join the coolest club on the internet!
#EpithelialMechanics
#EpithelialMechanics
Reposted by Nimesh Chahare
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Epithelial Mechanics Fan Club
epithelialmechanics.github.io
October 23, 2025 at 7:00 AM
🎉🎉 We finally have a website! 🎉🎉
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Did you miss a thread?
Want to know who our delegates are?
Do you want to join our big club?
Check it out:
epithelialmechanics.github.io
Huge thanks to all thread-contributors and to you for following us!
Reposted by Nimesh Chahare
📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...
events.ibecbarcelona.eu/embl-ibec-co...
October 22, 2025 at 2:06 PM
📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...
events.ibecbarcelona.eu/embl-ibec-co...
Reposted by Nimesh Chahare
1/ 🐣⚒️ To study mechanics, we need to apply prescribed forces - how can we do that in living tissues? I am @eigenp.bsky.social and in this thread I'll highlight our new approach for applying tension on epithelial tissues in vivo!
October 12, 2025 at 12:51 PM
1/ 🐣⚒️ To study mechanics, we need to apply prescribed forces - how can we do that in living tissues? I am @eigenp.bsky.social and in this thread I'll highlight our new approach for applying tension on epithelial tissues in vivo!
Reposted by Nimesh Chahare
Happy to share that my PhD has finally taken the shape of a paper! ✨
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
September 27, 2025 at 12:01 PM
Happy to share that my PhD has finally taken the shape of a paper! ✨
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Reposted by Nimesh Chahare
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted by Nimesh Chahare
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.
www.science.org
September 24, 2025 at 8:17 PM
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes.
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
www.science.org/doi/10.1126/...
Thread ⬇️
(1/n)
Reposted by Nimesh Chahare
1/ Link: www.biorxiv.org/content/10.1...
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
Mechanosensitive and Reversible Chromatin-Lamina Dewetting Triggers Cellular Contraction During Wound Healing
Tissue wounding causes rapid mechanical changes in the epithelium, but how these changes affect intracellular organization remains unclear. Using the Drosophila embryonic epidermis, we show that wound...
www.biorxiv.org
September 23, 2025 at 3:40 PM
1/ Link: www.biorxiv.org/content/10.1...
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
👀🚨 Fantastic preprint from @andreuion.bsky.social
There's a lot going on inside the nucleus. #EpithelialMechanics
There's a lot going on inside the nucleus. #EpithelialMechanics
We know tissue mechanics matter in healing, but what happens at the chromatin level?
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
September 24, 2025 at 2:12 AM
👀🚨 Fantastic preprint from @andreuion.bsky.social
There's a lot going on inside the nucleus. #EpithelialMechanics
There's a lot going on inside the nucleus. #EpithelialMechanics
Reposted by Nimesh Chahare
We know tissue mechanics matter in healing, but what happens at the chromatin level?
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
September 23, 2025 at 3:40 PM
We know tissue mechanics matter in healing, but what happens at the chromatin level?
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
Reposted by Nimesh Chahare
If you are interested in cell compression in general (not only in epithelial systems) in how to control it in vitro, in the associated mechanotransduction mechanisms and on their consequences, you can check our latest review!
bsky.app/profile/epim...
bsky.app/profile/epim...
September 21, 2025 at 12:52 PM
If you are interested in cell compression in general (not only in epithelial systems) in how to control it in vitro, in the associated mechanotransduction mechanisms and on their consequences, you can check our latest review!
bsky.app/profile/epim...
bsky.app/profile/epim...
Reposted by Nimesh Chahare
We believe that the combination of various in vitro tools, can complement in vivo observations. By doing so, Conti et al. showed that stem vs differentiated cancer cells present different mechano-phenotypes, suggesting a differential metastatic potential.
bsky.app/profile/epim...
bsky.app/profile/epim...
September 21, 2025 at 12:52 PM
We believe that the combination of various in vitro tools, can complement in vivo observations. By doing so, Conti et al. showed that stem vs differentiated cancer cells present different mechano-phenotypes, suggesting a differential metastatic potential.
bsky.app/profile/epim...
bsky.app/profile/epim...
Reposted by Nimesh Chahare
Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.
September 21, 2025 at 12:52 PM
Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.