Markus Mukenhirn
@markusmukenhirn.bsky.social
Post-Doc @katjaroeper.bsky.social lab @pdncambridge.bsky.social
Interested in kidney organoids and lumen formation; Former @honigmann_lab,
@biotec-tud.bsky.social, @cmcb-tud.bsky.social,@mpicbg.bsky.social
and @boulantlab
Interested in kidney organoids and lumen formation; Former @honigmann_lab,
@biotec-tud.bsky.social, @cmcb-tud.bsky.social,@mpicbg.bsky.social
and @boulantlab
Pinned
How do cells control the lumen shape and size? Check out our combined work from the
Honigmann_Lab
and
RivelineLab
where we look at the mechanical role of #TightJunctions in #lumen formation: www.sciencedirect.com/science/arti...
Honigmann_Lab
and
RivelineLab
where we look at the mechanical role of #TightJunctions in #lumen formation: www.sciencedirect.com/science/arti...
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets | Nature Biotechnology share.google/fzkzh3rZEa53...
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets - Nature Biotechnology
A multi-institute, multi-platform initiative generates standard metrics and best practices for spatial transcriptomics analysis.
share.google
December 7, 2025 at 10:11 PM
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets | Nature Biotechnology share.google/fzkzh3rZEa53...
Reposted by Markus Mukenhirn
Cytoskeleton shapes tissues during development. What signaling drives these changes?
I'm @onenimesa.bsky.social and let's explore FGF signaling's crucial role with examples.
Trust me, you need to know this!
I'm @onenimesa.bsky.social and let's explore FGF signaling's crucial role with examples.
Trust me, you need to know this!
December 6, 2025 at 9:57 AM
Cytoskeleton shapes tissues during development. What signaling drives these changes?
I'm @onenimesa.bsky.social and let's explore FGF signaling's crucial role with examples.
Trust me, you need to know this!
I'm @onenimesa.bsky.social and let's explore FGF signaling's crucial role with examples.
Trust me, you need to know this!
Reposted by Markus Mukenhirn
Non-invasive Biomechanical Characterization of Embryos Using Microfluidic Cantilevers https://www.biorxiv.org/content/10.64898/2025.12.02.691595v1
December 5, 2025 at 5:46 PM
Non-invasive Biomechanical Characterization of Embryos Using Microfluidic Cantilevers https://www.biorxiv.org/content/10.64898/2025.12.02.691595v1
Reposted by Markus Mukenhirn
Hi bsky!
How do cells coordinate fate with migration during development? 🐣 Turns out EMT doesn't just drive cell behaviour changes... it actively primes BMP signalling competence, creating a reciprocal coupling that drives collective invasion!
(@bensteventon.bsky.social lab)
tinyurl.com/2ncc8zap
How do cells coordinate fate with migration during development? 🐣 Turns out EMT doesn't just drive cell behaviour changes... it actively primes BMP signalling competence, creating a reciprocal coupling that drives collective invasion!
(@bensteventon.bsky.social lab)
tinyurl.com/2ncc8zap
December 5, 2025 at 3:16 PM
Hi bsky!
How do cells coordinate fate with migration during development? 🐣 Turns out EMT doesn't just drive cell behaviour changes... it actively primes BMP signalling competence, creating a reciprocal coupling that drives collective invasion!
(@bensteventon.bsky.social lab)
tinyurl.com/2ncc8zap
How do cells coordinate fate with migration during development? 🐣 Turns out EMT doesn't just drive cell behaviour changes... it actively primes BMP signalling competence, creating a reciprocal coupling that drives collective invasion!
(@bensteventon.bsky.social lab)
tinyurl.com/2ncc8zap
Reposted by Markus Mukenhirn
Check out this work from @yuritakahashi.bsky.social that reveals reciprocal interactions between cell migration and fate specific to drive collective cell invasion. And follow Yuri at the same time
Hi bsky!
How do cells coordinate fate with migration during development? 🐣 Turns out EMT doesn't just drive cell behaviour changes... it actively primes BMP signalling competence, creating a reciprocal coupling that drives collective invasion!
(@bensteventon.bsky.social lab)
tinyurl.com/2ncc8zap
How do cells coordinate fate with migration during development? 🐣 Turns out EMT doesn't just drive cell behaviour changes... it actively primes BMP signalling competence, creating a reciprocal coupling that drives collective invasion!
(@bensteventon.bsky.social lab)
tinyurl.com/2ncc8zap
December 5, 2025 at 3:59 PM
Check out this work from @yuritakahashi.bsky.social that reveals reciprocal interactions between cell migration and fate specific to drive collective cell invasion. And follow Yuri at the same time
Reposted by Markus Mukenhirn
Thanks to Advanced Functional Materials for highlighting our work on their back cover!
December 3, 2025 at 2:06 PM
Thanks to Advanced Functional Materials for highlighting our work on their back cover!
Reposted by Markus Mukenhirn
🥳 Thrilled, honored & very happy to become part of the amazing EMBO Young Investigator Programme! Looking forward to the new opportunities, interactions, ideas & collaborations it will spark. Very grateful to my fantastic team @mpi-cbg.de, colleagues, collaborators & mentors who made this possible!
Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome!
Read the press release here:
https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/
Read the press release here:
https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/
December 2, 2025 at 4:10 PM
🥳 Thrilled, honored & very happy to become part of the amazing EMBO Young Investigator Programme! Looking forward to the new opportunities, interactions, ideas & collaborations it will spark. Very grateful to my fantastic team @mpi-cbg.de, colleagues, collaborators & mentors who made this possible!
Reposted by Markus Mukenhirn
Tissue stress measurements — our latest preprint is out: arxiv.org/abs/2512.00550
(publication coming soon!)
Fantastic work by the three musketeers — @luanger.bsky.social, @andreasschoenit.bsky.social and @fanny-wodrascka.bsky.social — in collaboration with P. Marcq!
(publication coming soon!)
Fantastic work by the three musketeers — @luanger.bsky.social, @andreasschoenit.bsky.social and @fanny-wodrascka.bsky.social — in collaboration with P. Marcq!
Tissue stress measurements with Bayesian Inversion Stress Microscopy
Cells within biological tissue are constantly subjected to dynamic mechanical forces. Measuring the internal stress of tissues has proven crucial for our understanding of the role of mechanical forces...
arxiv.org
December 2, 2025 at 11:15 AM
Tissue stress measurements — our latest preprint is out: arxiv.org/abs/2512.00550
(publication coming soon!)
Fantastic work by the three musketeers — @luanger.bsky.social, @andreasschoenit.bsky.social and @fanny-wodrascka.bsky.social — in collaboration with P. Marcq!
(publication coming soon!)
Fantastic work by the three musketeers — @luanger.bsky.social, @andreasschoenit.bsky.social and @fanny-wodrascka.bsky.social — in collaboration with P. Marcq!
Reposted by Markus Mukenhirn
New preprint!
SOSEKI polarity proteins are mechanoresponsive integrators linking growth and tissue mechanics during lateral root formation. Their polarity marks growth boundaries and reorganises in response to mechanical alterations —reshaping how we think about axis formation.
tinyurl.com/28p7af2w
SOSEKI polarity proteins are mechanoresponsive integrators linking growth and tissue mechanics during lateral root formation. Their polarity marks growth boundaries and reorganises in response to mechanical alterations —reshaping how we think about axis formation.
tinyurl.com/28p7af2w
December 1, 2025 at 11:28 AM
New preprint!
SOSEKI polarity proteins are mechanoresponsive integrators linking growth and tissue mechanics during lateral root formation. Their polarity marks growth boundaries and reorganises in response to mechanical alterations —reshaping how we think about axis formation.
tinyurl.com/28p7af2w
SOSEKI polarity proteins are mechanoresponsive integrators linking growth and tissue mechanics during lateral root formation. Their polarity marks growth boundaries and reorganises in response to mechanical alterations —reshaping how we think about axis formation.
tinyurl.com/28p7af2w
Reposted by Markus Mukenhirn
FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation: pubs.acs.org/doi/10.1021/...
December 1, 2025 at 11:36 AM
FLASH-AWAY: Intrabody-Directed Targeting of Optogenetic Tools for Protein Degradation: pubs.acs.org/doi/10.1021/...
Reposted by Markus Mukenhirn
It is a nice way to end the week: our improved RAB GTPase BioID map now online! www.nature.com/articles/s42... We hope it will be useful to the community, and we're happy to share any reagents!
A proximity map of RAB GTPases delineates roles for RAB14 in EARP complex and UHRF1BP1 endosomal recruitments
Communications Biology - Proximity labeling proteomics of RAB GTPases identifies an array of neighboring RAB proteins. Functional validation studies reveal links between RAB25 and DENND6A, or...
www.nature.com
November 28, 2025 at 4:27 PM
It is a nice way to end the week: our improved RAB GTPase BioID map now online! www.nature.com/articles/s42... We hope it will be useful to the community, and we're happy to share any reagents!
Reposted by Markus Mukenhirn
November 30, 2025 at 8:57 AM
Reposted by Markus Mukenhirn
Thank you A. Perez-Ramos and P. Bovolenta for this great perspective on our article about Optic Cup morphogenesis @dev-journal.bsky.social !
In preprints: folding from the top – apical forces drive eye cup formation
Adrian Perez-Ramos and Paola Bovolenta discuss the recent preprint by Ramos et al. (2025) “The Optic cup is actively shape programmed by independently patterned apical forces”:
journals.biologists.com/dev/article/...
Adrian Perez-Ramos and Paola Bovolenta discuss the recent preprint by Ramos et al. (2025) “The Optic cup is actively shape programmed by independently patterned apical forces”:
journals.biologists.com/dev/article/...
November 26, 2025 at 1:22 PM
Thank you A. Perez-Ramos and P. Bovolenta for this great perspective on our article about Optic Cup morphogenesis @dev-journal.bsky.social !
Reposted by Markus Mukenhirn
Super proud to be part of SFB1348 — and excited to share that I now officially have my own lab in Münster! 🎉🪰
We’ll study #cellbio & #morphogenesis, focusing on organ sculpting and #chirality in #Drosophila.
I’ll soon hire my first #PhD student — feel free to reach out!
#juniorPI #Science #devbio
We’ll study #cellbio & #morphogenesis, focusing on organ sculpting and #chirality in #Drosophila.
I’ll soon hire my first #PhD student — feel free to reach out!
#juniorPI #Science #devbio
November 25, 2025 at 3:57 PM
Super proud to be part of SFB1348 — and excited to share that I now officially have my own lab in Münster! 🎉🪰
We’ll study #cellbio & #morphogenesis, focusing on organ sculpting and #chirality in #Drosophila.
I’ll soon hire my first #PhD student — feel free to reach out!
#juniorPI #Science #devbio
We’ll study #cellbio & #morphogenesis, focusing on organ sculpting and #chirality in #Drosophila.
I’ll soon hire my first #PhD student — feel free to reach out!
#juniorPI #Science #devbio
Reposted by Markus Mukenhirn
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
November 23, 2025 at 8:01 AM
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
Reposted by Markus Mukenhirn
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
November 20, 2025 at 11:42 AM
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
Reposted by Markus Mukenhirn
Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2)
forum.image.sc/t/bigvolumeb...
forum.image.sc/t/bigvolumeb...
BigVolumeBrowser: a new 3D multi volume/mesh/point clould (SMLM) data viewer
Hello everyone, I’d like to share with you another 3D viewer for FIJI, BigVolumeBrowser (full documentation link). It‘s a first initial public release, so there is still space for improvements. Le...
forum.image.sc
November 21, 2025 at 10:02 AM
Reposted by Markus Mukenhirn
TEAD4 regulates apical domain homeostasis and cell-positioning to maintain the trophectoderm lineage during preimplantation mouse embryo development. https://www.biorxiv.org/content/10.1101/2025.11.18.689016v1
November 18, 2025 at 5:31 PM
TEAD4 regulates apical domain homeostasis and cell-positioning to maintain the trophectoderm lineage during preimplantation mouse embryo development. https://www.biorxiv.org/content/10.1101/2025.11.18.689016v1
Reposted by Markus Mukenhirn
Version 2 is out! More comprehensive text plus new tissue- and pathway-specific analysis revealing how different viruses trigger systemic aging through diverse mechanisms.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 16, 2025 at 12:44 AM
Version 2 is out! More comprehensive text plus new tissue- and pathway-specific analysis revealing how different viruses trigger systemic aging through diverse mechanisms.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Markus Mukenhirn
I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...
November 13, 2025 at 8:49 PM
I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...
Reposted by Markus Mukenhirn
Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 14, 2025 at 2:14 PM
Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Reposted by Markus Mukenhirn
Finally out in #PRXLife: our theory on the effect of temperature on the completion time of large networks. Using graph theory, one can show that the Arrhenius plot is quadratic, in excellent agreement with experimental data from fly development. Read the open access paper here: go.aps.org/48brig2
November 14, 2025 at 6:39 AM
Finally out in #PRXLife: our theory on the effect of temperature on the completion time of large networks. Using graph theory, one can show that the Arrhenius plot is quadratic, in excellent agreement with experimental data from fly development. Read the open access paper here: go.aps.org/48brig2
Reposted by Markus Mukenhirn
Today I lift up survivors of sexual violence. I am centering your pain, your need to see justice, your healing. I am so sorry for what happened and I am so sorry this country and world protect wealthy men who rape and abuse children and women. May they start to fear the truth.
November 12, 2025 at 6:14 PM
Today I lift up survivors of sexual violence. I am centering your pain, your need to see justice, your healing. I am so sorry for what happened and I am so sorry this country and world protect wealthy men who rape and abuse children and women. May they start to fear the truth.
Reposted by Markus Mukenhirn
In their Perspective article, Ruxandra Bachmann-Gagescu, and John Sayer explore how ciliary specialisation might explain the high variability of ciliopathies and propose priority research directions.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 12, 2025 at 3:04 PM
In their Perspective article, Ruxandra Bachmann-Gagescu, and John Sayer explore how ciliary specialisation might explain the high variability of ciliopathies and propose priority research directions.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...