Nimesh Chahare
@onenimesa.bsky.social
Doing #EpithelialMechanics! with chick embryo 🐣
Convenor @epimechfc.bsky.social // Postdoc @NerurkarLab at Columbia // PhD @xaviertrepat.bsky.social lab at IBEC Barcelona
nchahare.github.io
Convenor @epimechfc.bsky.social // Postdoc @NerurkarLab at Columbia // PhD @xaviertrepat.bsky.social lab at IBEC Barcelona
nchahare.github.io
Congratulations Isabela 🎉 🎉
September 30, 2025 at 2:30 AM
Congratulations Isabela 🎉 🎉
Reposted by Nimesh Chahare
1/ Link: www.biorxiv.org/content/10.1...
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
Mechanosensitive and Reversible Chromatin-Lamina Dewetting Triggers Cellular Contraction During Wound Healing
Tissue wounding causes rapid mechanical changes in the epithelium, but how these changes affect intracellular organization remains unclear. Using the Drosophila embryonic epidermis, we show that wound...
www.biorxiv.org
September 23, 2025 at 3:40 PM
1/ Link: www.biorxiv.org/content/10.1...
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
Reposted by Nimesh Chahare
If you are interested in cell compression in general (not only in epithelial systems) in how to control it in vitro, in the associated mechanotransduction mechanisms and on their consequences, you can check our latest review!
bsky.app/profile/epim...
bsky.app/profile/epim...
September 21, 2025 at 12:52 PM
If you are interested in cell compression in general (not only in epithelial systems) in how to control it in vitro, in the associated mechanotransduction mechanisms and on their consequences, you can check our latest review!
bsky.app/profile/epim...
bsky.app/profile/epim...
Reposted by Nimesh Chahare
We believe that the combination of various in vitro tools, can complement in vivo observations. By doing so, Conti et al. showed that stem vs differentiated cancer cells present different mechano-phenotypes, suggesting a differential metastatic potential.
bsky.app/profile/epim...
bsky.app/profile/epim...
September 21, 2025 at 12:52 PM
We believe that the combination of various in vitro tools, can complement in vivo observations. By doing so, Conti et al. showed that stem vs differentiated cancer cells present different mechano-phenotypes, suggesting a differential metastatic potential.
bsky.app/profile/epim...
bsky.app/profile/epim...
Reposted by Nimesh Chahare
It allows shaping the electric field, from single cells (first video) to sculpting whole tissues (movie below). This was several years of Yubin and Jeremy's lives; it's now changing what we know and do with electricity to control cell behaviors. It's so cool--please use it, we will help/share!
September 17, 2025 at 5:20 PM
It allows shaping the electric field, from single cells (first video) to sculpting whole tissues (movie below). This was several years of Yubin and Jeremy's lives; it's now changing what we know and do with electricity to control cell behaviors. It's so cool--please use it, we will help/share!