Ae Mäkinen
@mrs-microgliae.bsky.social
#Microglia 🧠 #Macrophages 🔬 #Omics 🧬
Ae is pronounced as [ei]. Pinay 🇵🇭. Kidney warrior 💪. Plant mama 🌱. Chef scientist 👩🏻🍳. Matcha-ddicted 🍵.
Ae is pronounced as [ei]. Pinay 🇵🇭. Kidney warrior 💪. Plant mama 🌱. Chef scientist 👩🏻🍳. Matcha-ddicted 🍵.
Reposted by Ae Mäkinen
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
November 18, 2025 at 11:22 AM
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Reposted by Ae Mäkinen
Not only my photos are being stolen now, people are selling them under someone else's name😡😡. I intentionally never sold my images for profit. Check the photos below. Mine is in the left, the stolen one in the right. Does someone knows how to sue them?
www.cell-and-art.com/en/product/a...
www.cell-and-art.com/en/product/a...
November 21, 2025 at 7:19 AM
Not only my photos are being stolen now, people are selling them under someone else's name😡😡. I intentionally never sold my images for profit. Check the photos below. Mine is in the left, the stolen one in the right. Does someone knows how to sue them?
www.cell-and-art.com/en/product/a...
www.cell-and-art.com/en/product/a...
Reposted by Ae Mäkinen
🔬 Research Spotlight
#Microglia-derived extracellular vesicles promote OPC differentiation by rewiring mitochondrial metabolism — revealing new therapeutic targets for demyelinating & neurodegenerative diseases.
👉 https://link.springer.com/article/10.1007/s10571-025-01612-7
#Microglia-derived extracellular vesicles promote OPC differentiation by rewiring mitochondrial metabolism — revealing new therapeutic targets for demyelinating & neurodegenerative diseases.
👉 https://link.springer.com/article/10.1007/s10571-025-01612-7
Microglia-Derived Extracellular Vesicles Enhance Oligodendrocyte Maturation by Transcriptionally Regulating Mitochondrial Molecular Pathways - Cellular and Molecular Neurobiology
Degeneration of myelinating oligodendrocytes and the resulting breakdown of the myelin sheath are key drivers of neurodegeneration and disability across numerous central nervous system pathologies. Thus, a compelling strategy to preserve neuronal function is to promote endogenous myelin repair by oligodendrocyte precursor cells (OPCs). Extracellular vesicles (EVs) secreted by pro-regenerative microglia have been shown to enhance OPC maturation and remyelination across different experimental m...
link.springer.com
November 6, 2025 at 8:03 AM
🔬 Research Spotlight
#Microglia-derived extracellular vesicles promote OPC differentiation by rewiring mitochondrial metabolism — revealing new therapeutic targets for demyelinating & neurodegenerative diseases.
👉 https://link.springer.com/article/10.1007/s10571-025-01612-7
#Microglia-derived extracellular vesicles promote OPC differentiation by rewiring mitochondrial metabolism — revealing new therapeutic targets for demyelinating & neurodegenerative diseases.
👉 https://link.springer.com/article/10.1007/s10571-025-01612-7
Reposted by Ae Mäkinen
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Reposted by Ae Mäkinen
A world-first 🌈🧬 Published today in Nature Medicine: gender-affirming hormone therapy changes the body’s proteins, aligning biology with gender identity.
Led by @unimelb, @MCRI_for_kids & @Austin_Health — a huge step for #TransHealth research.
🔗 www.nature.com/articles/s41...
Led by @unimelb, @MCRI_for_kids & @Austin_Health — a huge step for #TransHealth research.
🔗 www.nature.com/articles/s41...
Plasma proteome adaptations during feminizing gender-affirming hormone therapy - Nature Medicine
Researchers analyzed 5,279 plasma proteins in 40 people undergoing feminizing gender-affirming hormone therapy over 6 months, revealing significant changes in 299 proteins. Such changes could have…
www.nature.com
October 20, 2025 at 10:57 PM
A world-first 🌈🧬 Published today in Nature Medicine: gender-affirming hormone therapy changes the body’s proteins, aligning biology with gender identity.
Led by @unimelb, @MCRI_for_kids & @Austin_Health — a huge step for #TransHealth research.
🔗 www.nature.com/articles/s41...
Led by @unimelb, @MCRI_for_kids & @Austin_Health — a huge step for #TransHealth research.
🔗 www.nature.com/articles/s41...
Thank you soooo much for this. Kudos to the whole team behind this project. 👏👏
A world-first 🌈🧬 Published today in Nature Medicine: gender-affirming hormone therapy changes the body’s proteins, aligning biology with gender identity.
Led by @unimelb, @MCRI_for_kids & @Austin_Health — a huge step for #TransHealth research.
🔗 www.nature.com/articles/s41...
Led by @unimelb, @MCRI_for_kids & @Austin_Health — a huge step for #TransHealth research.
🔗 www.nature.com/articles/s41...
Plasma proteome adaptations during feminizing gender-affirming hormone therapy - Nature Medicine
Researchers analyzed 5,279 plasma proteins in 40 people undergoing feminizing gender-affirming hormone therapy over 6 months, revealing significant changes in 299 proteins. Such changes could have…
www.nature.com
October 23, 2025 at 8:09 PM
Thank you soooo much for this. Kudos to the whole team behind this project. 👏👏
Few days late,but huge thanks to my home institute, TuDMM-UTU, for the finishing grant 😇✨
October 20, 2025 at 7:44 PM
Few days late,but huge thanks to my home institute, TuDMM-UTU, for the finishing grant 😇✨
Reposted by Ae Mäkinen
CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation
Read this #LifelongDevSI Research Article by Brady P. Hammond, Jason Plemel @jrplemel.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Read this #LifelongDevSI Research Article by Brady P. Hammond, Jason Plemel @jrplemel.bsky.social and colleagues:
journals.biologists.com/dev/article/...
October 17, 2025 at 12:18 PM
CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation
Read this #LifelongDevSI Research Article by Brady P. Hammond, Jason Plemel @jrplemel.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Read this #LifelongDevSI Research Article by Brady P. Hammond, Jason Plemel @jrplemel.bsky.social and colleagues:
journals.biologists.com/dev/article/...
In 2018, I presented my Bachelors thesis at the biggest Microbiology conference in the Philippines and won the best presentation award. In 2021, I also got a presentation award for my Masters thesis in Taiwan. Last week, I presented my PhD work to the European Macrophage and DC Society in UK. (1/n)
September 21, 2025 at 1:02 PM
In 2018, I presented my Bachelors thesis at the biggest Microbiology conference in the Philippines and won the best presentation award. In 2021, I also got a presentation award for my Masters thesis in Taiwan. Last week, I presented my PhD work to the European Macrophage and DC Society in UK. (1/n)
Reposted by Ae Mäkinen
If NIH shuts down funding of animal-only grants, get ready for a whole lot of grants to include some pointless organoid experiments just to qualify. What a terrible rule!
www.drugdiscoverytrends.com/nih-announce...
www.drugdiscoverytrends.com/nih-announce...
NIH announces end to funding for animal-only studies - Drug Discovery and Development
Drug Discovery and Development covers strategies and technologies related to pharmaceutical research and development and drug formulation.
www.drugdiscoverytrends.com
July 10, 2025 at 7:43 AM
If NIH shuts down funding of animal-only grants, get ready for a whole lot of grants to include some pointless organoid experiments just to qualify. What a terrible rule!
www.drugdiscoverytrends.com/nih-announce...
www.drugdiscoverytrends.com/nih-announce...
Honeymoon series
📍Italia
📍Italia
July 6, 2025 at 4:46 PM
Honeymoon series
📍Italia
📍Italia
Our first month of marriage and first midsommar as husband and wife in Åland Islands ♥️☀️
June 23, 2025 at 11:07 AM
Our first month of marriage and first midsommar as husband and wife in Åland Islands ♥️☀️
Reposted by Ae Mäkinen
📘 Our #Neuroimmunology & #Neurodegeneration collection covers a broad range of topics including macular degeneration, the role of #microglia, β-amyloid transport, CNS #autoimmunity, and the sympathetic control of cancer progression 👉 rupress.org/jem/collecti...
@keystonesymposia.bsky.social
@keystonesymposia.bsky.social
June 5, 2025 at 2:32 PM
📘 Our #Neuroimmunology & #Neurodegeneration collection covers a broad range of topics including macular degeneration, the role of #microglia, β-amyloid transport, CNS #autoimmunity, and the sympathetic control of cancer progression 👉 rupress.org/jem/collecti...
@keystonesymposia.bsky.social
@keystonesymposia.bsky.social
Reposted by Ae Mäkinen
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease
In this issue, Chadarevian et al. showed that engraftment of human iPSC-derived microglia
(iMG) engineered to express secreted neprilysin (sNEP) under the plaque-responsive
CD9 promoter reduces amyloi...
www.cell.com
June 5, 2025 at 2:45 PM
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...
My month so far. In science, or in life… I love everything that’s been happening! ♥️🥰
May 27, 2025 at 4:46 AM
My month so far. In science, or in life… I love everything that’s been happening! ♥️🥰
Final push in the lab before I prepare for my wedding 🫣🥰🥹👰♀️
May 21, 2025 at 1:11 PM
Final push in the lab before I prepare for my wedding 🫣🥰🥹👰♀️
Reposted by Ae Mäkinen
Join us for the Spatial Biology Seminar by Lunaphore Technologies and Bio-Techne!
📅 Date: May 28
🕝 Time: 14:30-16
📍 Location: Seminar room BEAR, Biocity B, 5th floor
We’ll kick things off with coffee&pulla, followed by presentations on spatial biology solutions from Ronald Pouyo and colleagues.
📅 Date: May 28
🕝 Time: 14:30-16
📍 Location: Seminar room BEAR, Biocity B, 5th floor
We’ll kick things off with coffee&pulla, followed by presentations on spatial biology solutions from Ronald Pouyo and colleagues.
May 20, 2025 at 7:33 AM
Join us for the Spatial Biology Seminar by Lunaphore Technologies and Bio-Techne!
📅 Date: May 28
🕝 Time: 14:30-16
📍 Location: Seminar room BEAR, Biocity B, 5th floor
We’ll kick things off with coffee&pulla, followed by presentations on spatial biology solutions from Ronald Pouyo and colleagues.
📅 Date: May 28
🕝 Time: 14:30-16
📍 Location: Seminar room BEAR, Biocity B, 5th floor
We’ll kick things off with coffee&pulla, followed by presentations on spatial biology solutions from Ronald Pouyo and colleagues.
Reposted by Ae Mäkinen
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
May 19, 2025 at 3:14 PM
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
Reposted by Ae Mäkinen
A study in Science immunology shows the type of dead cell ingested by macrophages governs their functional plasticity. YOU ARE WHAT YOU EAT
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages
MPO activates an immunometabolic rheostat to restrict the functional plasticity of macrophages in favor of proresolving properties.
www.science.org
May 5, 2025 at 7:58 PM
A study in Science immunology shows the type of dead cell ingested by macrophages governs their functional plasticity. YOU ARE WHAT YOU EAT
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
I’m getting married 🥹
It just feels surreal that after crossing the horizons to search for greener pastures, I ended up in the happiest place on Earth and found the love of my life: my strength in times of darkness, my biggest supporter when I felt like losing some grip. I’m lucky.
It just feels surreal that after crossing the horizons to search for greener pastures, I ended up in the happiest place on Earth and found the love of my life: my strength in times of darkness, my biggest supporter when I felt like losing some grip. I’m lucky.
March 23, 2025 at 7:17 PM
I’m getting married 🥹
It just feels surreal that after crossing the horizons to search for greener pastures, I ended up in the happiest place on Earth and found the love of my life: my strength in times of darkness, my biggest supporter when I felt like losing some grip. I’m lucky.
It just feels surreal that after crossing the horizons to search for greener pastures, I ended up in the happiest place on Earth and found the love of my life: my strength in times of darkness, my biggest supporter when I felt like losing some grip. I’m lucky.
Reposted by Ae Mäkinen
MSc Karolina Losenkova Mingeaud's dissertation examines the broad network of enzymes involved in ATP and adenosine metabolism, improving the understanding of adenosine metabolism within the tumor microenvironment.
🎩 Losenkova Mingeaud defends the dissertation on 7 March.
www.utu.fi/en/news/even...
🎩 Losenkova Mingeaud defends the dissertation on 7 March.
www.utu.fi/en/news/even...
March 4, 2025 at 1:30 PM
MSc Karolina Losenkova Mingeaud's dissertation examines the broad network of enzymes involved in ATP and adenosine metabolism, improving the understanding of adenosine metabolism within the tumor microenvironment.
🎩 Losenkova Mingeaud defends the dissertation on 7 March.
www.utu.fi/en/news/even...
🎩 Losenkova Mingeaud defends the dissertation on 7 March.
www.utu.fi/en/news/even...
Reposted by Ae Mäkinen
Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent Treg–microglia crosstalk
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 27, 2025 at 2:56 PM
Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent Treg–microglia crosstalk
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Hi! I’m Ae. I like studying macrophages & microglia. I like being alone in the dark microscope room, playing with flow cytometers, & challenging myself with bioinformatics. I also have many passion outside the lab: I love to cook, take care of plants, sing, & see new places! Nice to meet you here! 🥰
February 10, 2025 at 8:59 PM
Hi! I’m Ae. I like studying macrophages & microglia. I like being alone in the dark microscope room, playing with flow cytometers, & challenging myself with bioinformatics. I also have many passion outside the lab: I love to cook, take care of plants, sing, & see new places! Nice to meet you here! 🥰
Reposted by Ae Mäkinen
PAMs, DAMs, and WAMs: tracking microglia across the development and disease landscape
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Microglial plasticity governed by state-specific enhancer landscapes
Single-cell transcriptomic studies have identified distinct microglial subpopulations with shared and divergent gene signatures across development, aging and disease. Whether these microglial subsets ...
www.biorxiv.org
February 4, 2025 at 2:38 AM
PAMs, DAMs, and WAMs: tracking microglia across the development and disease landscape
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ae Mäkinen
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression: Immunity www.cell.com/immunity/ful...
February 3, 2025 at 4:36 PM
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression: Immunity www.cell.com/immunity/ful...