@mpellicer.bsky.social
Reposted
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
Confiner une semaine plus tôt aurait permis d'éviter 23 000 décès pendant la 1ère vague de #Covid19 en Angleterre, soit la moitié du total, selon une modélisation.
Le gouvernement a reçu des avis "clairs et convaincants", mais il a préféré attendre.
1/3
Le gouvernement a reçu des avis "clairs et convaincants", mais il a préféré attendre.
1/3
Covid inquiry live updates: UK did 'too little, too late', leading to thousands more Covid deaths, says inquiry
The inquiry says an earlier lockdown could have saved 23,000 lives in the first wave in England - and lockdown could have been avoided altogether with earlier interventions.
www.bbc.com
November 20, 2025 at 5:26 PM
Confiner une semaine plus tôt aurait permis d'éviter 23 000 décès pendant la 1ère vague de #Covid19 en Angleterre, soit la moitié du total, selon une modélisation.
Le gouvernement a reçu des avis "clairs et convaincants", mais il a préféré attendre.
1/3
Le gouvernement a reçu des avis "clairs et convaincants", mais il a préféré attendre.
1/3
Reposted
This garbage is what we’re up against.
I have seen multiple families who have received ‘stem cell therapy’ for their child with autism and intellectual disability. Not well-off families, probably spending 5-figure sums.
These bottom-feeding influencer scum are preying on the desperate.
I have seen multiple families who have received ‘stem cell therapy’ for their child with autism and intellectual disability. Not well-off families, probably spending 5-figure sums.
These bottom-feeding influencer scum are preying on the desperate.
How stem cell treatments, without evidence of benefit but with risk of harm, are promoted at YouTube by celebrities and influencers
cell.com/stem-cell-re...
cell.com/stem-cell-re...
Stem cells in your YouTube feed: The complex landscape and unexpected mediators of online information
In this article, Grundtvig and Munsie provide a large-scale analysis, identifying
4,481 stem cell-related videos on YouTube across 1,734 channels and attracting 134
million views. The article explores...
cell.com
November 20, 2025 at 5:34 PM
This garbage is what we’re up against.
I have seen multiple families who have received ‘stem cell therapy’ for their child with autism and intellectual disability. Not well-off families, probably spending 5-figure sums.
These bottom-feeding influencer scum are preying on the desperate.
I have seen multiple families who have received ‘stem cell therapy’ for their child with autism and intellectual disability. Not well-off families, probably spending 5-figure sums.
These bottom-feeding influencer scum are preying on the desperate.
Reposted
Open access link to new study in Science Advances:
Small things matter: Lack of extraislet β cells in type 1 diabetes.
🧪 #medsky
www.science.org/doi/10.1126/...
Small things matter: Lack of extraislet β cells in type 1 diabetes.
🧪 #medsky
www.science.org/doi/10.1126/...
Small things matter: Lack of extraislet β cells in type 1 diabetes
Early loss of small extraislet β cells in children with type 1 diabetes could explain age-related differences in disease.
www.science.org
November 13, 2025 at 6:07 AM
Open access link to new study in Science Advances:
Small things matter: Lack of extraislet β cells in type 1 diabetes.
🧪 #medsky
www.science.org/doi/10.1126/...
Small things matter: Lack of extraislet β cells in type 1 diabetes.
🧪 #medsky
www.science.org/doi/10.1126/...
Reposted
Find out how the dark genome holds clues to Neanderthal face shape and how this could help in future research into human disease in this new study from IGC researchers 👉 edin.ac/443d1j4
@hannahlong.bsky.social
@kirstyuttley.bsky.social
@hannahjuellig.bsky.social
@cmvm-edinburghuni.bsky.social
@hannahlong.bsky.social
@kirstyuttley.bsky.social
@hannahjuellig.bsky.social
@cmvm-edinburghuni.bsky.social
Dark genome holds clues to Neanderthal face shape | Institute of Genetics and Cancer | Institute of Genetics and Cancer
Differences in a specific region of the Neanderthal genetic code may have contributed to their distinctive protruding jawline, a study suggests.
edin.ac
November 10, 2025 at 12:04 PM
Find out how the dark genome holds clues to Neanderthal face shape and how this could help in future research into human disease in this new study from IGC researchers 👉 edin.ac/443d1j4
@hannahlong.bsky.social
@kirstyuttley.bsky.social
@hannahjuellig.bsky.social
@cmvm-edinburghuni.bsky.social
@hannahlong.bsky.social
@kirstyuttley.bsky.social
@hannahjuellig.bsky.social
@cmvm-edinburghuni.bsky.social
Reposted
In our previous work, we explored how chromosomal translocations and large deletions upstream of the SOX9 gene may impact facial development in patients with Pierre Robin sequence (PRS). We identified two candidate enhancers active in facial progenitor cells.
doi.org/10.1016/j.stem.2020.09.001
doi.org/10.1016/j.stem.2020.09.001
November 10, 2025 at 12:29 PM
In our previous work, we explored how chromosomal translocations and large deletions upstream of the SOX9 gene may impact facial development in patients with Pierre Robin sequence (PRS). We identified two candidate enhancers active in facial progenitor cells.
doi.org/10.1016/j.stem.2020.09.001
doi.org/10.1016/j.stem.2020.09.001
Reposted
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
Reposted
I am a Bioinformatics Scientist and write about: Next Generation Sequencing, Single Cell and Spatial Biology, Next Generation Proteomics, Liquid Biopsy, SynBio, Compute Acceleration in biotech // long-form posts at albertvilella.substack.com
Rhymes with Haystack | Albert | Substack
Biotech, Next Generation Sequencing, Single cell and Spatial Biology, Next Generation Proteomics, Synthetic Biology, Small Molecules and Biologics pharma, and related topics. Click to read Rhymes with...
albertvilella.substack.com
November 9, 2025 at 9:37 AM
I am a Bioinformatics Scientist and write about: Next Generation Sequencing, Single Cell and Spatial Biology, Next Generation Proteomics, Liquid Biopsy, SynBio, Compute Acceleration in biotech // long-form posts at albertvilella.substack.com
Reposted
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Reposted
Toward Same-Day Genome Sequencing in the Critical Care Setting | New England Journal of Medicine www.nejm.org/doi/full/10....
Toward Same-Day Genome Sequencing in the Critical Care Setting | NEJM
Decisions about critical care are almost always made without access to genetic information. The authors report the application of a new method of DNA sequencing in infants in a neonatal intensive c...
www.nejm.org
October 18, 2025 at 1:07 PM
Toward Same-Day Genome Sequencing in the Critical Care Setting | New England Journal of Medicine www.nejm.org/doi/full/10....
Reposted
Awesome re-analysis of the Franklin / Crick / Watson story. Explains how Franklin produced (with considerable skill) the *pictures* that made the penny drop for slow-on-the-uptake Watson. Sadly, paywalled.
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
Reassessing Discovery: Rosalind Franklin, Scientific Visualization, and the Structure of DNA | Philosophy of Science | Cambridge Core
Reassessing Discovery: Rosalind Franklin, Scientific Visualization, and the Structure of DNA - Volume 79 Issue 1
www.cambridge.org
October 11, 2025 at 7:43 PM
Awesome re-analysis of the Franklin / Crick / Watson story. Explains how Franklin produced (with considerable skill) the *pictures* that made the penny drop for slow-on-the-uptake Watson. Sadly, paywalled.
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
Reposted
Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells.
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency
In primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associate...
www.biorxiv.org
October 3, 2025 at 3:09 PM
Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells.
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
In a new preprint, we share some clues about when, how, and why this happens!
www.biorxiv.org/content/10.1...
Reposted
Tim Berners-Lee: Why I gave the world wide web away for free.
"My vision was based on sharing, not exploitation – and here’s why it’s still worth fighting for."
🧪💻🛜
www.theguardian.com/technology/2...
"My vision was based on sharing, not exploitation – and here’s why it’s still worth fighting for."
🧪💻🛜
www.theguardian.com/technology/2...
Why I gave the world wide web away for free | Tim Berners-Lee
My vision was based on sharing, not exploitation – and here’s why it’s still worth fighting for
www.theguardian.com
September 29, 2025 at 5:03 AM
Tim Berners-Lee: Why I gave the world wide web away for free.
"My vision was based on sharing, not exploitation – and here’s why it’s still worth fighting for."
🧪💻🛜
www.theguardian.com/technology/2...
"My vision was based on sharing, not exploitation – and here’s why it’s still worth fighting for."
🧪💻🛜
www.theguardian.com/technology/2...
Reposted
The cerebellum isn’t just about coordinating movement. It’s implicated in nearly every domain of cognition—from language to social behavior.
But how exactly does the cerebellum contribute to action and cognition? 🧵
Check out our new paper w/ Rich Ivry.
arxiv.org/abs/2509.09818
But how exactly does the cerebellum contribute to action and cognition? 🧵
Check out our new paper w/ Rich Ivry.
arxiv.org/abs/2509.09818
Cerebellar Contributions to Action and Cognition: Prediction, Timescale, and Continuity
The cerebellum is implicated in nearly every domain of human cognition, yet our understanding of how this subcortical structure contributes to cognition remains elusive. Efforts on this front have ten...
arxiv.org
September 15, 2025 at 12:19 PM
The cerebellum isn’t just about coordinating movement. It’s implicated in nearly every domain of cognition—from language to social behavior.
But how exactly does the cerebellum contribute to action and cognition? 🧵
Check out our new paper w/ Rich Ivry.
arxiv.org/abs/2509.09818
But how exactly does the cerebellum contribute to action and cognition? 🧵
Check out our new paper w/ Rich Ivry.
arxiv.org/abs/2509.09818
Reposted
Our September issue is online! www.embopress.org/toc/17574684...
On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...
Scientific image: R. Hahn & K. Avraham, at Tel Aviv University
On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...
Scientific image: R. Hahn & K. Avraham, at Tel Aviv University
EMBO Molecular Medicine: Vol 17, No 9
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
September 11, 2025 at 8:35 AM
Our September issue is online! www.embopress.org/toc/17574684...
On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...
Scientific image: R. Hahn & K. Avraham, at Tel Aviv University
On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...
Scientific image: R. Hahn & K. Avraham, at Tel Aviv University
Reposted
👶 On ne naît pas parent, on le devient. Comme l'expérimentent celles et ceux qui volent au secours de leur progéniture lorsque leurs #cris de détresse retentissent. Explications de @nicolasmathevon.bsky.social
👉 comprendrebebe.com
#ENES #UJML
theconversation.com/ce-que-les-p...
👉 comprendrebebe.com
#ENES #UJML
theconversation.com/ce-que-les-p...
Ce que les pleurs de bébé nous disent vraiment – et pourquoi l’instinct maternel est un mythe
Est-il possible de traduire les pleurs des bébés pour comprendre avec exactitude leurs besoins ?
theconversation.com
August 28, 2025 at 10:29 AM
👶 On ne naît pas parent, on le devient. Comme l'expérimentent celles et ceux qui volent au secours de leur progéniture lorsque leurs #cris de détresse retentissent. Explications de @nicolasmathevon.bsky.social
👉 comprendrebebe.com
#ENES #UJML
theconversation.com/ce-que-les-p...
👉 comprendrebebe.com
#ENES #UJML
theconversation.com/ce-que-les-p...
Reposted
A. James Hudpseth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals.
By @callimcflurry.bsky.social
www.thetransmitter.org/hearing/reme...
By @callimcflurry.bsky.social
www.thetransmitter.org/hearing/reme...
Remembering A. James Hudspeth, hair cell explorer
Hudspeth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals.
www.thetransmitter.org
August 22, 2025 at 5:54 PM
A. James Hudpseth, who died 16 August at age 79, devoted his 50-year career to untangling how the ear converts sound into electrical signals.
By @callimcflurry.bsky.social
www.thetransmitter.org/hearing/reme...
By @callimcflurry.bsky.social
www.thetransmitter.org/hearing/reme...
Reposted
We are happy to announce that our latest manuscript has been published in Nature Communications! We identified the highly abundant and prevalent (>70% in population) giant (Max. 395kb) extrachromosomal element in the human mouth, named "Inocle".
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Giant extrachromosomal element “Inocle” potentially expands the adaptive capacity of the human oral microbiome - Nature Communications
This study identified prevalent giant extrachromosomal elements from the human oral microbiome. The genetic and ecological analysis provides insight on the potential contribution of this element in ad...
www.nature.com
August 15, 2025 at 7:39 PM
We are happy to announce that our latest manuscript has been published in Nature Communications! We identified the highly abundant and prevalent (>70% in population) giant (Max. 395kb) extrachromosomal element in the human mouth, named "Inocle".
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
New paper from our lab - @bbglab.bsky.social.
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods
academic.oup.com
August 14, 2025 at 1:10 PM
New paper from our lab - @bbglab.bsky.social.
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
academic.oup.com/nar/article/...
Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel
Reposted
Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis
😎 biology but double whammy for cancer patients
www.nature.com/articles/s41...
🧪
😎 biology but double whammy for cancer patients
www.nature.com/articles/s41...
🧪
Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
www.nature.com
July 30, 2025 at 4:54 PM
Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis
😎 biology but double whammy for cancer patients
www.nature.com/articles/s41...
🧪
😎 biology but double whammy for cancer patients
www.nature.com/articles/s41...
🧪
Reposted
I fail to understand the value of using epigenetic aging clocks in any situation.
They are being correlated with...stuff. Name the exposure/condition, someone will find a perturbation in one of today's many epigenetic aging clocks.
More expensive and less meaningful than a fortune telling machine.
They are being correlated with...stuff. Name the exposure/condition, someone will find a perturbation in one of today's many epigenetic aging clocks.
More expensive and less meaningful than a fortune telling machine.
July 15, 2025 at 11:36 AM
I fail to understand the value of using epigenetic aging clocks in any situation.
They are being correlated with...stuff. Name the exposure/condition, someone will find a perturbation in one of today's many epigenetic aging clocks.
More expensive and less meaningful than a fortune telling machine.
They are being correlated with...stuff. Name the exposure/condition, someone will find a perturbation in one of today's many epigenetic aging clocks.
More expensive and less meaningful than a fortune telling machine.
Reposted
Reading:
How a Biofilm’s Strange Shape Emerges From Cellular Geometry www.quantamagazine.org/how-a-biofil... via @QuantaMagazine
How a Biofilm’s Strange Shape Emerges From Cellular Geometry www.quantamagazine.org/how-a-biofil... via @QuantaMagazine
How a Biofilm’s Strange Shape Emerges From Cellular Geometry | Quanta Magazine
Micro decisions can have macro consequences. A soft matter physicist reveals how interactions within simple cellular collectives can lead to emergent physical traits.
www.quantamagazine.org
June 25, 2025 at 4:01 AM
Reading:
How a Biofilm’s Strange Shape Emerges From Cellular Geometry www.quantamagazine.org/how-a-biofil... via @QuantaMagazine
How a Biofilm’s Strange Shape Emerges From Cellular Geometry www.quantamagazine.org/how-a-biofil... via @QuantaMagazine
Reposted
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
May 22, 2025 at 12:42 PM
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
Reposted
A simple path, followed by an equation.
Basic research leads to knowledge, which leads to nonprofitable ideas, which leads to profitable ideas, which leads to commercial products, which leads to jobs, which fuels the economy.
Kill research=kill the economy
Basic research leads to knowledge, which leads to nonprofitable ideas, which leads to profitable ideas, which leads to commercial products, which leads to jobs, which fuels the economy.
Kill research=kill the economy
May 19, 2025 at 11:20 PM
A simple path, followed by an equation.
Basic research leads to knowledge, which leads to nonprofitable ideas, which leads to profitable ideas, which leads to commercial products, which leads to jobs, which fuels the economy.
Kill research=kill the economy
Basic research leads to knowledge, which leads to nonprofitable ideas, which leads to profitable ideas, which leads to commercial products, which leads to jobs, which fuels the economy.
Kill research=kill the economy