During development, neural circuits are shaped continuously as we learn to control our bodies. The ultimate goal of this process is to produce neural dynamics that enable the rich repertoire of behavi...

Humans exhibit a striking tendency to persist with chosen goals. This strong attachment to goals can often appear irrational – a perspective captured by terms such as perseverance or sunk-cost biases. In this review, we explore how goal commitment could stem from several adaptive mechanisms, including those that optimise cognitive resources, shield decisions from interference, and scaffold motivation in the absence of accessible reward signals. We propose that these computational considerations have important implications for algorithmic architectures supporting decision making, including separate algorithms for goal selection and implementation, and for monitoring ongoing goals versus alternative sources of reward. Finally, we discuss how a variety of mechanisms supporting goal commitment and abandonment could relate to dimensions affected in mental health.

Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...

The Medial Temporal Lobe (MTL) is key to human cognition, supporting memory, emotional processing, navigation, and semantic coding. Rare direct human MTL recordings revealed concept cells, which were ...