Mackenzie Weygandt Mathis
@trackingactions.bsky.social
Scientist 👩🔬 & EPFL Prof 🇨🇭 | DeepLabCut.org , 🦓 cebra.ai | neuroscience & ML 🧠 mackenziemathislab.org | ✨CSO at Kinematik.ai | occasionally 🐦⬛birds/🌱outdoors/🍣food/👠fashion
Interested in the latest advances in neuroscience (neural dynamics and internal models) and how they can be leveraged to build smarter, adaptive AI?
➡️ My first real solo piece 🖤🫶 @natneuro.nature.com
rdcu.be/eWVmA
➡️ My first real solo piece 🖤🫶 @natneuro.nature.com
rdcu.be/eWVmA
Leveraging insights from neuroscience to build adaptive artificial intelligence
Nature Neuroscience - Adaptive intelligence envisions AI that, like animals, learns online, generalizes and adapts quickly. This Perspective reviews biological foundations, progress in AI and...
rdcu.be
December 31, 2025 at 8:00 AM
Interested in the latest advances in neuroscience (neural dynamics and internal models) and how they can be leveraged to build smarter, adaptive AI?
➡️ My first real solo piece 🖤🫶 @natneuro.nature.com
rdcu.be/eWVmA
➡️ My first real solo piece 🖤🫶 @natneuro.nature.com
rdcu.be/eWVmA
Reposted by Mackenzie Weygandt Mathis
Joint modelling of brain and behaviour dynamics with artificial intelligence
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Joint modelling of brain and behaviour dynamics with artificial intelligence - Nature Reviews Neuroscience
Artificial intelligence is rapidly advancing our mechanistic understanding of the shared structure between the brain and higher-order behaviours. In this Review, Mathis and Mathis synthesize state-of-...
www.nature.com
December 3, 2025 at 4:59 PM
Joint modelling of brain and behaviour dynamics with artificial intelligence
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Delighted we made the superlab list @andpru.bsky.social 🫶
List: mailchi.mp/c9edb773c735...
Paper: www.nature.com/articles/s41...
List: mailchi.mp/c9edb773c735...
Paper: www.nature.com/articles/s41...
December 12, 2025 at 6:56 AM
Delighted we made the superlab list @andpru.bsky.social 🫶
List: mailchi.mp/c9edb773c735...
Paper: www.nature.com/articles/s41...
List: mailchi.mp/c9edb773c735...
Paper: www.nature.com/articles/s41...
Reposted by Mackenzie Weygandt Mathis
This is just our second M&M review!
The first one in 2020 was on AI for behavior - and now we discuss advances for jointly modeling behavioral and neural data!! Here is the first www.sciencedirect.com/science/arti...
The first one in 2020 was on AI for behavior - and now we discuss advances for jointly modeling behavioral and neural data!! Here is the first www.sciencedirect.com/science/arti...
December 5, 2025 at 3:13 PM
This is just our second M&M review!
The first one in 2020 was on AI for behavior - and now we discuss advances for jointly modeling behavioral and neural data!! Here is the first www.sciencedirect.com/science/arti...
The first one in 2020 was on AI for behavior - and now we discuss advances for jointly modeling behavioral and neural data!! Here is the first www.sciencedirect.com/science/arti...
Reposted by Mackenzie Weygandt Mathis
Joint modelling of brain and behaviour dynamics with artificial intelligence — a Review by Mackenzie Weygandt Mathis & Alexander Mathis
@trackingactions.bsky.social @trackingskills.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
@trackingactions.bsky.social @trackingskills.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
Joint modelling of brain and behaviour dynamics with artificial intelligence - Nature Reviews Neuroscience
Artificial intelligence is rapidly advancing our mechanistic understanding of the shared structure between the brain and higher-order behaviours. In this Review, Mathis and Mathis synthesize state-of-...
www.nature.com
December 4, 2025 at 9:29 AM
Joint modelling of brain and behaviour dynamics with artificial intelligence — a Review by Mackenzie Weygandt Mathis & Alexander Mathis
@trackingactions.bsky.social @trackingskills.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
@trackingactions.bsky.social @trackingskills.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
Joint modelling of brain and behaviour dynamics with artificial intelligence
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Joint modelling of brain and behaviour dynamics with artificial intelligence - Nature Reviews Neuroscience
Artificial intelligence is rapidly advancing our mechanistic understanding of the shared structure between the brain and higher-order behaviours. In this Review, Mathis and Mathis synthesize state-of-...
www.nature.com
December 3, 2025 at 4:59 PM
Joint modelling of brain and behaviour dynamics with artificial intelligence
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Enjoying the Swiss Animal Science meeting! Inspiring to be around people who are passionate about research animal welfare and open science ❤️
December 3, 2025 at 9:38 AM
Enjoying the Swiss Animal Science meeting! Inspiring to be around people who are passionate about research animal welfare and open science ❤️
Reposted by Mackenzie Weygandt Mathis
If you’re at SfN, see the poster on DeepLabCut 3 where n Monday 8-12
Swing by to talk to @trackingactions.bsky.social and me this and about the DLC ecosystem!
Swing by to talk to @trackingactions.bsky.social and me this and about the DLC ecosystem!
AI tools like DeepLabCut and SuperAnimal are changing how scientists study movement, helping them understand how brain activity drives behavior.
Read more: bit.ly/4qnX7JF
@trackingactions.bsky.social @deeplabcut.bsky.social
Read more: bit.ly/4qnX7JF
@trackingactions.bsky.social @deeplabcut.bsky.social
How AI Is Changing Neuroscience Discovery
AI is altering how scientists study the brain
bit.ly
November 15, 2025 at 11:50 AM
If you’re at SfN, see the poster on DeepLabCut 3 where n Monday 8-12
Swing by to talk to @trackingactions.bsky.social and me this and about the DLC ecosystem!
Swing by to talk to @trackingactions.bsky.social and me this and about the DLC ecosystem!
Want to help shape the SCENE collaboration?! Join us as an executive director: www.cam.ac.uk/jobs/scene-m...
SCENE Manager
The Simons Collaboration on Ecological Neuroscience (SCENE): SCENE is an international consortium of 20 leading researchers in the fields of Computational, Systems and Cognitive Neuroscience, and
www.cam.ac.uk
November 13, 2025 at 5:32 PM
Want to help shape the SCENE collaboration?! Join us as an executive director: www.cam.ac.uk/jobs/scene-m...
Reposted by Mackenzie Weygandt Mathis
AI tools like DeepLabCut and SuperAnimal are changing how scientists study movement, helping them understand how brain activity drives behavior.
Read more: bit.ly/4qnX7JF
@trackingactions.bsky.social @deeplabcut.bsky.social
Read more: bit.ly/4qnX7JF
@trackingactions.bsky.social @deeplabcut.bsky.social
How AI Is Changing Neuroscience Discovery
AI is altering how scientists study the brain
bit.ly
November 1, 2025 at 12:07 AM
AI tools like DeepLabCut and SuperAnimal are changing how scientists study movement, helping them understand how brain activity drives behavior.
Read more: bit.ly/4qnX7JF
@trackingactions.bsky.social @deeplabcut.bsky.social
Read more: bit.ly/4qnX7JF
@trackingactions.bsky.social @deeplabcut.bsky.social
#EPFL has an open faculty position - tenure track or tenured!! - in AI driven biophysics. Deadline is Nov 15th. Please spread the word!
www.epfl.ch/about/workin...
www.epfl.ch/about/workin...
Assistant/associate Professor of AI-assisted Biophysics at the Ecole polytechnique fédérale de Lausanne (EPFL) and Group Leader at the Paul Scherrer Institute (PSI)
The School of Basic Sciences (Physics, Chemistry and Mathematics) at EPFL and the Paul Scherrer Institute (PSI) jointly seek to appoint a Tenure Track Assistant or tenured Associate Professor in AI-As...
www.epfl.ch
October 28, 2025 at 2:56 AM
#EPFL has an open faculty position - tenure track or tenured!! - in AI driven biophysics. Deadline is Nov 15th. Please spread the word!
www.epfl.ch/about/workin...
www.epfl.ch/about/workin...
Reposted by Mackenzie Weygandt Mathis
My lab has been pushing into explainable, robust, & theoretically-tractable AI models for science 💪
New! Accepted to #ICCV2025 we introduce #DISTIL - led by amazing PhD student @mirzious.bsky.social - we propose a trigger-inversion method for DNNs that reconstructs malicious backdoor triggers 1/4
New! Accepted to #ICCV2025 we introduce #DISTIL - led by amazing PhD student @mirzious.bsky.social - we propose a trigger-inversion method for DNNs that reconstructs malicious backdoor triggers 1/4
August 25, 2025 at 7:44 AM
My lab has been pushing into explainable, robust, & theoretically-tractable AI models for science 💪
New! Accepted to #ICCV2025 we introduce #DISTIL - led by amazing PhD student @mirzious.bsky.social - we propose a trigger-inversion method for DNNs that reconstructs malicious backdoor triggers 1/4
New! Accepted to #ICCV2025 we introduce #DISTIL - led by amazing PhD student @mirzious.bsky.social - we propose a trigger-inversion method for DNNs that reconstructs malicious backdoor triggers 1/4
Reposted by Mackenzie Weygandt Mathis
(YouTube) From LSD to AI with Switzerland's brain explorers www.youtube.com/watch?v=HqnA... via @trackingactions.bsky.social
From LSD to AI with Switzerland's Brain Explorers | Hello World with Ashlee Vance
YouTube video by Bloomberg Originals
www.youtube.com
October 9, 2025 at 6:06 PM
(YouTube) From LSD to AI with Switzerland's brain explorers www.youtube.com/watch?v=HqnA... via @trackingactions.bsky.social
Reposted by Mackenzie Weygandt Mathis
Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Motor cortex flexibly deploys a high-dimensional repertoire of subskills
Skilled movement often requires flexibly combining multiple subskills, each requiring dedicated control strategies and underlying computations. How the motor system achieves such versatility remains u...
www.biorxiv.org
September 8, 2025 at 4:34 PM
Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mackenzie Weygandt Mathis
I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 24, 2025 at 12:04 PM
I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Fall US trips booked! I'll be speaking at Scripps, SfN, and ICCV 🚀 Who will be at #ScrippsNeuroSymposium2025, #SfN2025 and/or #ICCV2025? Lots of ☀️🕶️🌴 & 🧠 in Oct/Nov!
September 23, 2025 at 3:12 PM
Fall US trips booked! I'll be speaking at Scripps, SfN, and ICCV 🚀 Who will be at #ScrippsNeuroSymposium2025, #SfN2025 and/or #ICCV2025? Lots of ☀️🕶️🌴 & 🧠 in Oct/Nov!
Not just an amazing dataset, excellent 3D pose, shape, and eye tracking in the real world! Bravo @trackingskills.bsky.social et al!
PS - Exactly this kind of data we predict will be critical for long-term health monitoring @monosovlab.bsky.social et al: www.sciencedirect.com/science/arti...
PS - Exactly this kind of data we predict will be critical for long-term health monitoring @monosovlab.bsky.social et al: www.sciencedirect.com/science/arti...
September 23, 2025 at 7:42 AM
Not just an amazing dataset, excellent 3D pose, shape, and eye tracking in the real world! Bravo @trackingskills.bsky.social et al!
PS - Exactly this kind of data we predict will be critical for long-term health monitoring @monosovlab.bsky.social et al: www.sciencedirect.com/science/arti...
PS - Exactly this kind of data we predict will be critical for long-term health monitoring @monosovlab.bsky.social et al: www.sciencedirect.com/science/arti...
Reposted by Mackenzie Weygandt Mathis
A.I. tools are already shaping patient care—but we should be wary of letting them diagnose us. “Patients and doctors alike could think of A.I. not as a way to solve mysteries but as a way to gather clues,” Dhruv Khullar writes.
If A.I. Can Diagnose Patients, What Are Doctors For?
Large language models are transforming medicine—but the technology comes with side effects.
www.newyorker.com
September 22, 2025 at 2:44 PM
A.I. tools are already shaping patient care—but we should be wary of letting them diagnose us. “Patients and doctors alike could think of A.I. not as a way to solve mysteries but as a way to gather clues,” Dhruv Khullar writes.
Reposted by Mackenzie Weygandt Mathis
New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
PIEZO channels link mechanical forces to uterine contractions in parturition
Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...
www.biorxiv.org
September 18, 2025 at 3:23 PM
New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mackenzie Weygandt Mathis
DeepLabCut pose estimation (@trackingactions.bsky.social) revealed high intitial motor variability, which is essenatial for motor learning (Dhawale et al., 2017, Annu. Rev. Neurosci.).
September 11, 2025 at 10:15 AM
DeepLabCut pose estimation (@trackingactions.bsky.social) revealed high intitial motor variability, which is essenatial for motor learning (Dhawale et al., 2017, Annu. Rev. Neurosci.).
Reposted by Mackenzie Weygandt Mathis
New paper in Nature finds that global geologic CO2 storage potential is ~90% lower than previously believed. Many candidate sites could leak CO2 back into the air or into groundwater, undermining climate mitigation efficacy or putting nearby human health at risk.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A prudent planetary limit for geologic carbon storage - Nature
A risk-based, spatially explicit analysis of carbon storage in sedimentary basins establishes a prudent planetary limit of around 1,460 Gt of geological carbon storage, which requires making explicit ...
www.nature.com
September 4, 2025 at 9:02 AM
New paper in Nature finds that global geologic CO2 storage potential is ~90% lower than previously believed. Many candidate sites could leak CO2 back into the air or into groundwater, undermining climate mitigation efficacy or putting nearby human health at risk.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I might be biased, but I think this is one of the most exciting developments in generalized musculoskeletal control in years ⬇️. Congrats to the team (I’m not involved!) 💪🔥
Something exciting just left the gym -- meet Arnold the first generalist musculoskeletal control policy!
The human body has 600+ muscles, yet we seamlessly coordinate them for everything from whispering a syllable to felling a forrest. How? www.arxiv.org/abs/2508.18066
The human body has 600+ muscles, yet we seamlessly coordinate them for everything from whispering a syllable to felling a forrest. How? www.arxiv.org/abs/2508.18066
September 4, 2025 at 11:05 AM
I might be biased, but I think this is one of the most exciting developments in generalized musculoskeletal control in years ⬇️. Congrats to the team (I’m not involved!) 💪🔥
Reposted by Mackenzie Weygandt Mathis
Something exciting just left the gym -- meet Arnold the first generalist musculoskeletal control policy!
The human body has 600+ muscles, yet we seamlessly coordinate them for everything from whispering a syllable to felling a forrest. How? www.arxiv.org/abs/2508.18066
The human body has 600+ muscles, yet we seamlessly coordinate them for everything from whispering a syllable to felling a forrest. How? www.arxiv.org/abs/2508.18066
September 4, 2025 at 8:45 AM
Something exciting just left the gym -- meet Arnold the first generalist musculoskeletal control policy!
The human body has 600+ muscles, yet we seamlessly coordinate them for everything from whispering a syllable to felling a forrest. How? www.arxiv.org/abs/2508.18066
The human body has 600+ muscles, yet we seamlessly coordinate them for everything from whispering a syllable to felling a forrest. How? www.arxiv.org/abs/2508.18066
Reposted by Mackenzie Weygandt Mathis
Thrilled to share this work, long time in the making! Carried through creatively by @siddjakes.bsky.social after initial design & piloting by @trackingskills.bsky.social, with help from @trackingactions.bsky.social. Modeling in collaboration with Massimo Vergassola & Nicola Rigolli.
Mice navigate scent trails using predictive policies
Animals actively sense their environment to extract features of interest to guide behaviors. For mammals, odors are prominent environmental features which are sampled by active modulation of sniffing ...
www.biorxiv.org
September 1, 2025 at 7:06 PM
Thrilled to share this work, long time in the making! Carried through creatively by @siddjakes.bsky.social after initial design & piloting by @trackingskills.bsky.social, with help from @trackingactions.bsky.social. Modeling in collaboration with Massimo Vergassola & Nicola Rigolli.
Reposted by Mackenzie Weygandt Mathis
EPFL, ETH Zurich & CSCS just released Apertus, Switzerland’s first fully open-source large language model.
Trained on 15T tokens in 1,000+ languages, it’s built for transparency, responsibility & the public good.
Read more: actu.epfl.ch/news/apertus...
Trained on 15T tokens in 1,000+ languages, it’s built for transparency, responsibility & the public good.
Read more: actu.epfl.ch/news/apertus...
September 2, 2025 at 11:48 AM
EPFL, ETH Zurich & CSCS just released Apertus, Switzerland’s first fully open-source large language model.
Trained on 15T tokens in 1,000+ languages, it’s built for transparency, responsibility & the public good.
Read more: actu.epfl.ch/news/apertus...
Trained on 15T tokens in 1,000+ languages, it’s built for transparency, responsibility & the public good.
Read more: actu.epfl.ch/news/apertus...