Alexander Mathis
@trackingskills.bsky.social
Hacker, Computational Neuroscience, ML beyond logistic regression, bear and muscle spindle aficionado. Passionate about open source. #deeplabcut and see https://mathislab.org for more.
Pinned
How the brain coordinates the activity of its many muscles to achieve successful control remains an enigma. www.cell.com/issue/S0896-...
Reposted by Alexander Mathis
New faculty job opening at @zuckermanbrain.bsky.social @columbiauniversity.bsky.social
Come be our colleague!
Application deadline: November 22
apply.interfolio.com/176153
Come be our colleague!
Application deadline: November 22
apply.interfolio.com/176153
Apply - Interfolio
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October 21, 2025 at 3:29 PM
New faculty job opening at @zuckermanbrain.bsky.social @columbiauniversity.bsky.social
Come be our colleague!
Application deadline: November 22
apply.interfolio.com/176153
Come be our colleague!
Application deadline: November 22
apply.interfolio.com/176153
Reposted by Alexander Mathis
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Alexander Mathis
Interested in doing a PhD in machine learning at the University of Edinburgh starting Sept 2026?
My group works on topics in vision, machine learning, and AI for climate.
For more information and details on how to get in touch, please check out my website:
homepages.inf.ed.ac.uk/omacaod
My group works on topics in vision, machine learning, and AI for climate.
For more information and details on how to get in touch, please check out my website:
homepages.inf.ed.ac.uk/omacaod
October 16, 2025 at 9:15 AM
Interested in doing a PhD in machine learning at the University of Edinburgh starting Sept 2026?
My group works on topics in vision, machine learning, and AI for climate.
For more information and details on how to get in touch, please check out my website:
homepages.inf.ed.ac.uk/omacaod
My group works on topics in vision, machine learning, and AI for climate.
For more information and details on how to get in touch, please check out my website:
homepages.inf.ed.ac.uk/omacaod
The team just picked up the latest data from the Swiss National Parc. Full of goodies - find out more about the first paper from the project: eceo-epfl.github.io/MammAlps/
October 17, 2025 at 8:58 AM
The team just picked up the latest data from the Swiss National Parc. Full of goodies - find out more about the first paper from the project: eceo-epfl.github.io/MammAlps/
Reposted by Alexander Mathis
“Mapping ion channel function” doi.org/10.7554/eLif... isn’t exactly a citation slayer, but it’s still one of my favourites (& my first independent project). Today we push pt 2, where we trace code origin & unite almost all channel models in a common expression. Boom! www.biorxiv.org/content/10.1...
An ion channel omnimodel for standardized biophysical neuron modelling
Biophysical neuron modeling is an indispensable tool in neuroscience research, with the combination of diverse ion channel kinetics and morphologies being used to explain various single-neuron propert...
www.biorxiv.org
October 6, 2025 at 6:25 PM
“Mapping ion channel function” doi.org/10.7554/eLif... isn’t exactly a citation slayer, but it’s still one of my favourites (& my first independent project). Today we push pt 2, where we trace code origin & unite almost all channel models in a common expression. Boom! www.biorxiv.org/content/10.1...
Reposted by Alexander Mathis
Smuggler's Notchnin Jeffesonville Vermont
October 6, 2025 at 11:08 AM
Smuggler's Notchnin Jeffesonville Vermont
Reposted by Alexander Mathis
The Neuroscience School for Advanced Studies "Brain Plasticity: Neural Basis of Individuality" led by LIP Director Ulman Lindenberger and Tobias Bonhoeffer @mpiforbi.bsky.social has just ended at San Servolo, Venice! #nsas
October 4, 2025 at 7:50 AM
The Neuroscience School for Advanced Studies "Brain Plasticity: Neural Basis of Individuality" led by LIP Director Ulman Lindenberger and Tobias Bonhoeffer @mpiforbi.bsky.social has just ended at San Servolo, Venice! #nsas
Reposted by Alexander Mathis
I get that the news cycle is packed right now, but I just heard from a colleague at the Smithsonian that this is fully a GIANT SQUID BEING EATEN BY A SPERM WHALE and it’s possibly the first ever confirmed video according to a friend at NOAA
10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)
10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)
September 24, 2025 at 8:30 PM
I get that the news cycle is packed right now, but I just heard from a colleague at the Smithsonian that this is fully a GIANT SQUID BEING EATEN BY A SPERM WHALE and it’s possibly the first ever confirmed video according to a friend at NOAA
10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)
10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)
Reposted by Alexander Mathis
Miroslav Sutej, Bombardment of the Optic Nerve, II, 1963
https://botfrens.com/collections/14377/contents/1135340
https://botfrens.com/collections/14377/contents/1135340
September 25, 2025 at 4:38 PM
Miroslav Sutej, Bombardment of the Optic Nerve, II, 1963
https://botfrens.com/collections/14377/contents/1135340
https://botfrens.com/collections/14377/contents/1135340
Reposted by Alexander Mathis
This is one of my favourite things ever. From the awesome @kristorpjensen.bsky.social
I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 24, 2025 at 1:33 PM
This is one of my favourite things ever. From the awesome @kristorpjensen.bsky.social
Reposted by Alexander Mathis
www.bbc.com/news/article... science ftw! Amazing work described here.
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.com
September 24, 2025 at 5:16 PM
www.bbc.com/news/article... science ftw! Amazing work described here.
Understanding behavior requires datasets that capture humans while carrying out complex tasks. The kitchen is an excellent environment for assessing human motor and cognitive function, as many complex actions are naturally exhibited in kitchens from chopping to 🧽!
arxiv.org/abs/2506.01608
arxiv.org/abs/2506.01608
EPFL-Smart-Kitchen-30: Densely annotated cooking dataset with 3D kinematics to challenge video and language models
Understanding behavior requires datasets that capture humans while carrying out complex tasks. The kitchen is an excellent environment for assessing human motor and cognitive function, as many complex...
arxiv.org
September 23, 2025 at 7:18 AM
Understanding behavior requires datasets that capture humans while carrying out complex tasks. The kitchen is an excellent environment for assessing human motor and cognitive function, as many complex actions are naturally exhibited in kitchens from chopping to 🧽!
arxiv.org/abs/2506.01608
arxiv.org/abs/2506.01608
Reposted by Alexander Mathis
GUESS WHAT WEEK IT IS
September 22, 2025 at 11:12 AM
GUESS WHAT WEEK IT IS
Reposted by Alexander Mathis
Tenure-track Assistant Professor in Computational Ecology and/or Evolution @columbiauniversity.bsky.social.
Deadline to apply September 30.
Reach out if you have questions.
apply.interfolio.com/172496
Deadline to apply September 30.
Reach out if you have questions.
apply.interfolio.com/172496
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 20, 2025 at 3:20 PM
Tenure-track Assistant Professor in Computational Ecology and/or Evolution @columbiauniversity.bsky.social.
Deadline to apply September 30.
Reach out if you have questions.
apply.interfolio.com/172496
Deadline to apply September 30.
Reach out if you have questions.
apply.interfolio.com/172496
Reposted by Alexander Mathis
Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Motor cortex flexibly deploys a high-dimensional repertoire of subskills
Skilled movement often requires flexibly combining multiple subskills, each requiring dedicated control strategies and underlying computations. How the motor system achieves such versatility remains u...
www.biorxiv.org
September 8, 2025 at 4:34 PM
Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alexander Mathis
I'm excited to share that my new postdoctoral position is going so well that I submitted a new paper at the end of my first week! www.biorxiv.org/content/10.1... A thread below
Sensory Compression as a Unifying Principle for Action Chunking and Time Coding in the Brain
The brain seamlessly transforms sensory information into precisely-timed movements, enabling us to type familiar words, play musical instruments, or perform complex motor routines with millisecond pre...
www.biorxiv.org
September 6, 2025 at 2:36 PM
I'm excited to share that my new postdoctoral position is going so well that I submitted a new paper at the end of my first week! www.biorxiv.org/content/10.1... A thread below
Reposted by Alexander Mathis
My new essay for @thetransmitter.bsky.social. Why is understanding emotion so challenging? The debates around what counts as an "emotion" shed insight.
These disputes are multidimensional, principled and fascinating. Here, I unpack them.
www.thetransmitter.org/the-big-pict...
These disputes are multidimensional, principled and fascinating. Here, I unpack them.
www.thetransmitter.org/the-big-pict...
Emotion research has a communication conundrum
In 2025, the words we use to describe emotions matter, but their definitions are controversial. Here, I unpack the different positions in this space and the rationales behind them—and I invite 13…
www.thetransmitter.org
September 5, 2025 at 11:15 AM
My new essay for @thetransmitter.bsky.social. Why is understanding emotion so challenging? The debates around what counts as an "emotion" shed insight.
These disputes are multidimensional, principled and fascinating. Here, I unpack them.
www.thetransmitter.org/the-big-pict...
These disputes are multidimensional, principled and fascinating. Here, I unpack them.
www.thetransmitter.org/the-big-pict...
Reposted by Alexander Mathis
How the brain coordinates the activity of its many muscles to achieve successful control remains an enigma. www.cell.com/issue/S0896-...
December 5, 2024 at 11:10 PM
How the brain coordinates the activity of its many muscles to achieve successful control remains an enigma. www.cell.com/issue/S0896-...
Something exciting just left the gym -- meet Arnold the first generalist musculoskeletal control policy!
The human body has 600+ muscles, yet we seamlessly coordinate them for everything from whispering a syllable to felling a forrest. How? www.arxiv.org/abs/2508.18066
The human body has 600+ muscles, yet we seamlessly coordinate them for everything from whispering a syllable to felling a forrest. How? www.arxiv.org/abs/2508.18066
September 4, 2025 at 8:45 AM
Something exciting just left the gym -- meet Arnold the first generalist musculoskeletal control policy!
The human body has 600+ muscles, yet we seamlessly coordinate them for everything from whispering a syllable to felling a forrest. How? www.arxiv.org/abs/2508.18066
The human body has 600+ muscles, yet we seamlessly coordinate them for everything from whispering a syllable to felling a forrest. How? www.arxiv.org/abs/2508.18066
Reposted by Alexander Mathis
Thrilled to share this work, long time in the making! Carried through creatively by @siddjakes.bsky.social after initial design & piloting by @trackingskills.bsky.social, with help from @trackingactions.bsky.social. Modeling in collaboration with Massimo Vergassola & Nicola Rigolli.
Mice navigate scent trails using predictive policies
Animals actively sense their environment to extract features of interest to guide behaviors. For mammals, odors are prominent environmental features which are sampled by active modulation of sniffing ...
www.biorxiv.org
September 1, 2025 at 7:06 PM
Thrilled to share this work, long time in the making! Carried through creatively by @siddjakes.bsky.social after initial design & piloting by @trackingskills.bsky.social, with help from @trackingactions.bsky.social. Modeling in collaboration with Massimo Vergassola & Nicola Rigolli.
Reposted by Alexander Mathis
Forelimb movement control at the basal ganglia - brainstem interface!
Happy to finally share this work from me and @harsh-kanodia.bsky.social with Silvia Arber!
@biozentrum.unibas.ch @fmiscience.bsky.social
www.nature.com/articles/s41...
Happy to finally share this work from me and @harsh-kanodia.bsky.social with Silvia Arber!
@biozentrum.unibas.ch @fmiscience.bsky.social
www.nature.com/articles/s41...
Dynamic basal ganglia output signals license and suppress forelimb movements - Nature
Basal ganglia output neurons fire dynamically in bidirectional and movement-specific patterns to license forelimb movements.
www.nature.com
May 28, 2025 at 3:32 PM
Forelimb movement control at the basal ganglia - brainstem interface!
Happy to finally share this work from me and @harsh-kanodia.bsky.social with Silvia Arber!
@biozentrum.unibas.ch @fmiscience.bsky.social
www.nature.com/articles/s41...
Happy to finally share this work from me and @harsh-kanodia.bsky.social with Silvia Arber!
@biozentrum.unibas.ch @fmiscience.bsky.social
www.nature.com/articles/s41...
Reposted by Alexander Mathis
Summer Workshop Alert‼️
The Okinawa Institute of Science and Technology, Japan organizes on July 1 a hands-on DeepLabCut workshop led by Drs. Mackenzie and Alexander Mathis.
Applications are open at www.oist.jp/conference/d...
The Okinawa Institute of Science and Technology, Japan organizes on July 1 a hands-on DeepLabCut workshop led by Drs. Mackenzie and Alexander Mathis.
Applications are open at www.oist.jp/conference/d...
DeepLabCut Workshop
A one day hands-on workshop on the use of the famous DeepLabCut software to analyze videos of animal behavior, led by Drs. Mackenzie and Alexander Mathis. Participants will be helped to pre-install th...
www.oist.jp
May 13, 2025 at 8:53 AM
Summer Workshop Alert‼️
The Okinawa Institute of Science and Technology, Japan organizes on July 1 a hands-on DeepLabCut workshop led by Drs. Mackenzie and Alexander Mathis.
Applications are open at www.oist.jp/conference/d...
The Okinawa Institute of Science and Technology, Japan organizes on July 1 a hands-on DeepLabCut workshop led by Drs. Mackenzie and Alexander Mathis.
Applications are open at www.oist.jp/conference/d...
Reposted by Alexander Mathis
ISTA scientists and Google Research unveil LICONN: a new expansion microscopy method that can reconstruct mammalian brain tissue with full synaptic detail using light microscopes. This method could transform how we study the brain’s networks.
@nature.com
Read more: https://bit.ly/44f0euV
@nature.com
Read more: https://bit.ly/44f0euV
May 8, 2025 at 8:30 AM
ISTA scientists and Google Research unveil LICONN: a new expansion microscopy method that can reconstruct mammalian brain tissue with full synaptic detail using light microscopes. This method could transform how we study the brain’s networks.
@nature.com
Read more: https://bit.ly/44f0euV
@nature.com
Read more: https://bit.ly/44f0euV
Reposted by Alexander Mathis
Our paper is out in Nature.
By examining various inputs to the motor cortex during learning, we found that thalamic inputs learn to activate the cortical neurons encoding the movement being learned.
Tour de force by Assaf in collab with Felix and Marcus. Congrats!
www.nature.com/articles/s41...
By examining various inputs to the motor cortex during learning, we found that thalamic inputs learn to activate the cortical neurons encoding the movement being learned.
Tour de force by Assaf in collab with Felix and Marcus. Congrats!
www.nature.com/articles/s41...
Motor learning refines thalamic influence on motor cortex - Nature
Imaging and optogenetics in mice provide insight into the interplay between the primary motor cortex and the motor thalamus during learning, showing that thalamic inputs have a key role in the executi...
www.nature.com
May 8, 2025 at 12:12 AM
Our paper is out in Nature.
By examining various inputs to the motor cortex during learning, we found that thalamic inputs learn to activate the cortical neurons encoding the movement being learned.
Tour de force by Assaf in collab with Felix and Marcus. Congrats!
www.nature.com/articles/s41...
By examining various inputs to the motor cortex during learning, we found that thalamic inputs learn to activate the cortical neurons encoding the movement being learned.
Tour de force by Assaf in collab with Felix and Marcus. Congrats!
www.nature.com/articles/s41...