@mmayta.bsky.social
Nanobodies to the rescue!
E. coli is a top cause of UTIs and sepsis—but hard to rapidly detect
Seeger lab (U Zurich 🇨🇭) design nanobodies vs the conserved outer membrane protein OmpA that bind >91% of clinical strains
Smart linker engineering was able to overcome O-antigen interference to enable the ultra-sensitive capture
Seeger lab (U Zurich 🇨🇭) design nanobodies vs the conserved outer membrane protein OmpA that bind >91% of clinical strains
Smart linker engineering was able to overcome O-antigen interference to enable the ultra-sensitive capture
Rapid detection and capture of clinical Escherichia coli strains mediated by OmpA-targeting nanobodies - Communications Biology
Two thoroughly characterized nanobodies are sufficient to detect over 90% of clinical Escherichia coli isolates by targeting the conserved and abundant outer membrane protein OmpA.
www.nature.com
August 7, 2025 at 10:24 PM
Nanobodies to the rescue!
So cool!
Who do you call when you need to design novel, potent nanobodies vs a pathogen?
The virtual lab of A.I. agents @nature.com @jameszou.bsky.social @kylewswanson.bsky.social
www.nature.com/articles/s41...
The virtual lab of A.I. agents @nature.com @jameszou.bsky.social @kylewswanson.bsky.social
www.nature.com/articles/s41...
August 7, 2025 at 10:23 PM
So cool!
Cool!
Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
🦟 Transgenic parasites without Pfs230 D13D14 do not transmit
🦙 💉Nanobodies + mRNA induced antibodies reduce transmission
New in @Science.org
www.science.org/doi/10.1126/...
#ScienceResearch #Malaria #WEHI
August 7, 2025 at 10:22 PM
Cool!
Reposted
Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to Yuichi Furuhata, a true master bioengineer, on leading this excellent work! www.nature.com/articles/s41...
Directed evolution of aminoacyl-tRNA synthetases through in vivo hypermutation - Nature Communications
Genetic code expansion (GCE) enables the incorporation of new amino acids into proteins. Here, authors demonstrate the rapid OrthoRep-driven evolution of aminoacyl-tRNA synthetases for GCE, increasing...
www.nature.com
May 24, 2025 at 3:02 PM
Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to Yuichi Furuhata, a true master bioengineer, on leading this excellent work! www.nature.com/articles/s41...
😂
Nanobodies!
What do sharks and camels have in common, (besides sometimes trying to eat children)?
Camelids like llamas, alpacas, camels can produce a type of antibody consisting of only the heavy chain (hcAB or VHH Abs).
So can sharks (& some other cartilaginous fish). So what?🧪
Camelids like llamas, alpacas, camels can produce a type of antibody consisting of only the heavy chain (hcAB or VHH Abs).
So can sharks (& some other cartilaginous fish). So what?🧪
May 29, 2025 at 8:51 PM
😂
Oooh, I want one!!
Neutralizing nanobodies bound to the #SARS-CoV2 #Spike Glycoprotein #Omicron variant. This hybrid #3DPrint combines the ribbon interior of Spike subdivided into the S1 (cyan) and S2 domains (blue) with its volumetric surface. Sumbit a 3D print request at buff.ly/vzX7HCb
May 29, 2025 at 8:49 PM
Oooh, I want one!!
Reposted
🧵
Excited to share our latest preprint!
www.biorxiv.org/content/10.1...
We developed a method to generate high-affinity binders against membrane proteins in their native-like environment!
🧪 #MembraneProteins #Nanobodies
Excited to share our latest preprint!
www.biorxiv.org/content/10.1...
We developed a method to generate high-affinity binders against membrane proteins in their native-like environment!
🧪 #MembraneProteins #Nanobodies
Selection of nanobodies against liponanoparticle-embedded membrane proteins by yeast surface display
Single-domain antibodies, known as nanobodies (Nbs), are widely used in structural biology, therapeutics, and as molecular probes in biology and biotechnology. Nbs towards soluble proteins are routine...
www.biorxiv.org
May 25, 2025 at 6:32 PM
🧵
Excited to share our latest preprint!
www.biorxiv.org/content/10.1...
We developed a method to generate high-affinity binders against membrane proteins in their native-like environment!
🧪 #MembraneProteins #Nanobodies
Excited to share our latest preprint!
www.biorxiv.org/content/10.1...
We developed a method to generate high-affinity binders against membrane proteins in their native-like environment!
🧪 #MembraneProteins #Nanobodies
Nice resource!
"The Microbiome for Clinicians" a new, open-access review of progress, limitations, and next steps
@cellpress.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social
www.cell.com/cell/fulltex...
May 29, 2025 at 8:47 PM
Nice resource!
Wow! So much food for thought
How Type 2 diabetes leads to blood vessel dysfunction and sequelae related to this adverse effect
@jclinical-invest.bsky.social
jci.org/articles/vie...
@jclinical-invest.bsky.social
jci.org/articles/vie...
May 18, 2025 at 9:47 PM
Wow! So much food for thought
Interesting!
Ultraprocessed foods and increased all-cause mortality
A dose relationship from 8 countries, ~240,000 participants, and ~15,000 deaths
www.ajpmonline.org/article/S074...
A dose relationship from 8 countries, ~240,000 participants, and ~15,000 deaths
www.ajpmonline.org/article/S074...
Premature Mortality Attributable to Ultraprocessed Food Consumption in 8 Countries
Ultraprocessed foods are becoming dominant in the global food supply. Prospective
cohort studies have consistently found an association between high consumption of
ultraprocessed foods and increased r...
www.ajpmonline.org
April 28, 2025 at 7:37 PM
Interesting!
Reposted
A call for built-in biosecurity safeguards for generative AI tools go.nature.com/3GIpTlR
A call for built-in biosecurity safeguards for generative AI tools - Nature Biotechnology
Nature Biotechnology - A call for built-in biosecurity safeguards for generative AI tools
go.nature.com
April 28, 2025 at 3:21 PM
A call for built-in biosecurity safeguards for generative AI tools go.nature.com/3GIpTlR
Very important
Best lab assessment for coronary artery risk consists of ApoB particles and LP(a)
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
April 28, 2025 at 3:16 PM
Very important
Oh this is some food for thought...
I am very happy (and anxious) to share with you our most recent work in which we evaluated four of the most popular long-read assemblers,
www.biorxiv.org/content/10.1...
and tell you just a little bit about it in the following 🧵
www.biorxiv.org/content/10.1...
and tell you just a little bit about it in the following 🧵
Assemblies of long-read metagenomes suffer from diverse errors
Genomes from metagenomes have revolutionised our understanding of microbial diversity, ecology, and evolution, propelling advances in basic science, biomedicine, and biotechnology. Assembly algorithms...
www.biorxiv.org
April 28, 2025 at 11:22 AM
Oh this is some food for thought...
Reposted
A Review in Nature Medicine summarizes recent and compelling examples of microbiome-based interventions that are ripe for clinical adoption while also discussing the challenges and opportunities facing the field. go.nature.com/42LUmrU 🔒
April 28, 2025 at 1:23 AM
A Review in Nature Medicine summarizes recent and compelling examples of microbiome-based interventions that are ripe for clinical adoption while also discussing the challenges and opportunities facing the field. go.nature.com/42LUmrU 🔒
Reposted
Fresh in @NatureBiotech! We developed a synthetic biology tool for tracking gene transfer in microbial communities and applied it to study plasmid hosts in a wastewater microbiome. Awesome collab with James Chappell & @joffsilberg.bsky.social and incredible students. www.nature.com/articles/s41...
Information storage across a microbial community using universal RNA barcoding - Nature Biotechnology
Barcoding microbial ribosomal RNA creates a recording of gene transfer events without requiring translation.
www.nature.com
March 18, 2025 at 3:57 PM
Fresh in @NatureBiotech! We developed a synthetic biology tool for tracking gene transfer in microbial communities and applied it to study plasmid hosts in a wastewater microbiome. Awesome collab with James Chappell & @joffsilberg.bsky.social and incredible students. www.nature.com/articles/s41...
Cool!
Along with every geneticist I am a total Mendel groupie and this new figure (www.nature.com/articles/s41...) that shows the chromosome location and underlying basis of his allelic pairs moves me to near-tears. Oh, to fly back in time and show this to him ...
April 27, 2025 at 10:44 AM
Cool!
Reposted
Hugely significant finding for contact site research - can’t wait to read properly!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature
The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of ...
www.nature.com
April 26, 2025 at 6:05 AM
Hugely significant finding for contact site research - can’t wait to read properly!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
The spread of highly pathogenic avian influenza in U.S. dairy cattle can be traced to a single spillover event from a wild bird, researchers report in Science, raising concern over growing pandemic risks as the virus evolves and leaps between species. scim.ag/4jIRUrO
Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle in the United States
Highly pathogenic avian influenza (HPAI) viruses cross species barriers and have the potential to cause pandemics. In North America, HPAI A(H5N1) viruses related to the goose/Guangdong 2.3.4.4b hemagg...
scim.ag
April 25, 2025 at 4:50 PM
The spread of highly pathogenic avian influenza in U.S. dairy cattle can be traced to a single spillover event from a wild bird, researchers report in Science, raising concern over growing pandemic risks as the virus evolves and leaps between species. scim.ag/4jIRUrO
Reposted
We have released the successor to ANARCI - ANARCII - a suite of Seq2Seq language models trained to number antibody (or TCR) sequences!
Read the paper: biorxiv.org/content/10.1...
Play with the webtool: opig.stats.ox.ac.uk/webapps/sabd...
Documentation and codebase: github.com/oxpig/ANARCII
Read the paper: biorxiv.org/content/10.1...
Play with the webtool: opig.stats.ox.ac.uk/webapps/sabd...
Documentation and codebase: github.com/oxpig/ANARCII
GitHub - oxpig/ANARCII: A language model suite for numbering antigen receptor sequences.
A language model suite for numbering antigen receptor sequences. - oxpig/ANARCII
github.com
April 22, 2025 at 8:31 AM
We have released the successor to ANARCI - ANARCII - a suite of Seq2Seq language models trained to number antibody (or TCR) sequences!
Read the paper: biorxiv.org/content/10.1...
Play with the webtool: opig.stats.ox.ac.uk/webapps/sabd...
Documentation and codebase: github.com/oxpig/ANARCII
Read the paper: biorxiv.org/content/10.1...
Play with the webtool: opig.stats.ox.ac.uk/webapps/sabd...
Documentation and codebase: github.com/oxpig/ANARCII
Reposted
“AVIDa-hIL6: A Large-Scale VHH Dataset Produced from an Immunized Alpaca for Predicting Antigen-Antibody Interactions”
arxiv.org/abs/2306.03329
arxiv.org/abs/2306.03329
AVIDa-hIL6: A Large-Scale VHH Dataset Produced from an Immunized...
Antibodies have become an important class of therapeutic agents to treat human diseases. To accelerate therapeutic antibody discovery, computational methods, especially machine learning, have...
arxiv.org
October 12, 2023 at 7:12 AM
“AVIDa-hIL6: A Large-Scale VHH Dataset Produced from an Immunized Alpaca for Predicting Antigen-Antibody Interactions”
arxiv.org/abs/2306.03329
arxiv.org/abs/2306.03329
Wow! Cool!
⚠️ A few important pieces of health news this week:
1. The longest-running longitudinal study of women's health (which has helped us figure out how to prevent cancer, reduce osteoporosis, reduce perimenopause symptoms, and more) has essentially been shuttered.
www.npr.org/2025/04/23/n...
1. The longest-running longitudinal study of women's health (which has helped us figure out how to prevent cancer, reduce osteoporosis, reduce perimenopause symptoms, and more) has essentially been shuttered.
www.npr.org/2025/04/23/n...
Funding cut for landmark study of women's health
The Women's Health Initiative, begun in the 1990s, has made many important discoveries. Now funding to collect more research data will end in September.
www.npr.org
April 24, 2025 at 5:02 PM
Wow! Cool!
Wow!
Why heart attacks peak in frequency and severity in the early morning hours: a pair of circadian clock-related proteins appears to be the underpinning
nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/d41...
nature.com/articles/s41...
Heart-attack outcomes are worse in the morning when activity of protein duo dips
A protein pair that influences how damage to cardiac muscle fluctuates with circadian rhythm could be the key to optimizing heart-attack recovery.
nature.com
April 24, 2025 at 12:08 PM
Wow!
Reposted
NEW Highlight of @nature.com paper by @davidjlynn.bsky.social and colleagues @sahmri.bsky.social reporting a prospective observational study of human immune responses to #vaccination after early-life #antibiotic exposure.
#immunology #immunosky #medsky #IDsky #pedsky #publichealth
#immunology #immunosky #medsky #IDsky #pedsky #publichealth
Neonatal antibiotics impair infant vaccine responses - Nature Reviews Immunology
A prospective observational study of human immune responses to vaccination after early-life antibiotic exposure shows that neonatal exposure reduces the immune response to several vaccine antigens and...
www.nature.com
April 23, 2025 at 1:20 PM
NEW Highlight of @nature.com paper by @davidjlynn.bsky.social and colleagues @sahmri.bsky.social reporting a prospective observational study of human immune responses to #vaccination after early-life #antibiotic exposure.
#immunology #immunosky #medsky #IDsky #pedsky #publichealth
#immunology #immunosky #medsky #IDsky #pedsky #publichealth
Interesting!
Colon cancer is on the rise around the world. This new report concludes that early-life exposure to gut bacteria that produces colibactin, which is mutagenic, may be contributing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Geographic and age variations in mutational processes in colorectal cancer - Nature
Nature - Geographic and age variations in mutational processes in colorectal cancer
www.nature.com
April 23, 2025 at 4:29 PM
Interesting!
Interesting
April 23, 2025 at 12:49 AM
Interesting