marius walter
@mariusw.bsky.social
Virologist at the Fred Hutch Cancer Center, Seattle. 🇫🇷 living in 🇺🇸. He/him.
Pinned
marius walter
@mariusw.bsky.social
· Nov 18
Viral gene drive spread during herpes simplex virus 1 infection in mice - Nature Communications
Gene drives are genetic modifications designed to propagate efficiently through a population. Here, the authors develop a viral gene drive against herpes simplex virus 1 (HSV-1) and show that it propa...
www.nature.com
Hi to my new followers!
I am a virologist at @fredhutch.bsky.social in the team of Keith Jerome.
If you are curious about what I do here are 3 options for you:
1. Read our latest paper! We showed that a viral gene drive propagated during HSV-1 infection in mice www.nature.com/articles/s41...
I am a virologist at @fredhutch.bsky.social in the team of Keith Jerome.
If you are curious about what I do here are 3 options for you:
1. Read our latest paper! We showed that a viral gene drive propagated during HSV-1 infection in mice www.nature.com/articles/s41...
Reposted by marius walter
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.
www.science.org/doi/...
1/9
Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.
www.science.org/doi/...
1/9
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that naked mole-rat cyclic guanosine monophosphate–adenosine ...
www.science.org
October 9, 2025 at 9:31 PM
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.
www.science.org/doi/...
1/9
Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.
www.science.org/doi/...
1/9
Reposted by marius walter
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
September 15, 2025 at 5:26 PM
hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
Reposted by marius walter
🥳 Very grateful for the support of the ERC Starting Grant for my newly established lab! We will study how transposable elements contribute to mammalian embryonic development.
We will have positions available next year. Stay tuned!
We will have positions available next year. Stay tuned!
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 1:27 PM
🥳 Very grateful for the support of the ERC Starting Grant for my newly established lab! We will study how transposable elements contribute to mammalian embryonic development.
We will have positions available next year. Stay tuned!
We will have positions available next year. Stay tuned!
Reposted by marius walter
Super interesting deep dive into US excess mortality. We're doing better than we were in 1980 but a *lot* worse than every other high-income country.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
August 21, 2025 at 8:42 PM
Super interesting deep dive into US excess mortality. We're doing better than we were in 1980 but a *lot* worse than every other high-income country.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by marius walter
Pretty surreal to see my artwork on the cover of Nature Genetics! Big congrats to @julianeg.bsky.social, @stemundi.bsky.social and the others, and thank you Juliane for letting me help bring your research to life visually.
www.nature.com/ng/volumes/5...
www.nature.com/ng/volumes/5...
July 23, 2025 at 8:06 AM
Pretty surreal to see my artwork on the cover of Nature Genetics! Big congrats to @julianeg.bsky.social, @stemundi.bsky.social and the others, and thank you Juliane for letting me help bring your research to life visually.
www.nature.com/ng/volumes/5...
www.nature.com/ng/volumes/5...
Reposted by marius walter
⚠️ Discovery of a new mode of viral transmission:
Deltaviruses spread through a viral Trojan Horse !
These viral satellites that do not encode their own glycoproteins, are in fact physically encapsulated within their helper virus particles!
www.biorxiv.org/content/10.1...
A thread 1/14
Deltaviruses spread through a viral Trojan Horse !
These viral satellites that do not encode their own glycoproteins, are in fact physically encapsulated within their helper virus particles!
www.biorxiv.org/content/10.1...
A thread 1/14
May 10, 2025 at 8:12 AM
⚠️ Discovery of a new mode of viral transmission:
Deltaviruses spread through a viral Trojan Horse !
These viral satellites that do not encode their own glycoproteins, are in fact physically encapsulated within their helper virus particles!
www.biorxiv.org/content/10.1...
A thread 1/14
Deltaviruses spread through a viral Trojan Horse !
These viral satellites that do not encode their own glycoproteins, are in fact physically encapsulated within their helper virus particles!
www.biorxiv.org/content/10.1...
A thread 1/14
Reposted by marius walter
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
May 2, 2025 at 2:39 PM
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Reposted by marius walter
I always like to reference this comparison chart that @rrbehringer.bsky.social made awhile back. Hope it helps put things in perspective! -KT
April 24, 2025 at 7:18 PM
I always like to reference this comparison chart that @rrbehringer.bsky.social made awhile back. Hope it helps put things in perspective! -KT
Reposted by marius walter
“One young man sobbed when a guard pushed him to the floor. He said, ‘I’m not a gang member. I’m gay. I’m a barber.’ I believed him. *** He “began to whimper,” as his head was roughly shaved, “folding his hands in prayer as his hair fell.” He “asked for his mother & cried as he was slapped again.”
What the Venezuelans Deported to El Salvador Experienced
Exclusive photos of the arrival of Venezuelan detainees deported from the U.S.
time.com
March 22, 2025 at 8:52 PM
“One young man sobbed when a guard pushed him to the floor. He said, ‘I’m not a gang member. I’m gay. I’m a barber.’ I believed him. *** He “began to whimper,” as his head was roughly shaved, “folding his hands in prayer as his hair fell.” He “asked for his mother & cried as he was slapped again.”
Reposted by marius walter
Pet peeve: I hate how often ppl claim “all the researchers will just move to Europe/Canada!” You vastly under-estimate how little money there is there vs the USA- and unless that changes ASAP this loss is just going to decimate global science, full stop. 🧪🔭
March 16, 2025 at 4:11 PM
Pet peeve: I hate how often ppl claim “all the researchers will just move to Europe/Canada!” You vastly under-estimate how little money there is there vs the USA- and unless that changes ASAP this loss is just going to decimate global science, full stop. 🧪🔭
Reposted by marius walter
I have been doing entirely too much earnest posting about deep things recently, I need to do a proper thread about hippo testicles or something just to keep myself sane.
Oh by the way hippos have migratory testicles.
Oh by the way hippos have migratory testicles.
a statue of a hippopotamus with its mouth open and teeth showing .
Alt: A hippo being tossed a watermelon, which it crushes in its massive jaws.
media.tenor.com
March 12, 2025 at 5:33 AM
I have been doing entirely too much earnest posting about deep things recently, I need to do a proper thread about hippo testicles or something just to keep myself sane.
Oh by the way hippos have migratory testicles.
Oh by the way hippos have migratory testicles.
This is the content we need right now
March 4, 2025 at 7:03 PM
This is the content we need right now
Reposted by marius walter
he was afraid of needles! absolute legend www.npr.org/2025/03/03/n...
James Harrison, whose blood donations saved over 2 million babies, has died
Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.
www.npr.org
March 4, 2025 at 2:10 AM
he was afraid of needles! absolute legend www.npr.org/2025/03/03/n...
I feel virology Bluesky should be talking about that www.nytimes.com/2025/02/25/w...
Unknown Deadly Illness Strikes Western Congo (Gift Article)
The outbreak has been traced, tentatively, to three children who ate a bat, the W.H.O. said, and known threats like Ebola and Marburg have been ruled out.
www.nytimes.com
February 26, 2025 at 12:26 AM
I feel virology Bluesky should be talking about that www.nytimes.com/2025/02/25/w...
Reposted by marius walter
Stand by this: www.politico.com/newsletters/...
February 19, 2025 at 4:42 PM
Stand by this: www.politico.com/newsletters/...
Reposted by marius walter
I maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated.
Seeking suggestions for anywhere that’s hiring!!
Seeking suggestions for anywhere that’s hiring!!
Today, along with 2,000 other NIH employees, I had to clear out my office 😭
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
February 14, 2025 at 11:49 PM
I maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated.
Seeking suggestions for anywhere that’s hiring!!
Seeking suggestions for anywhere that’s hiring!!
Reposted by marius walter
Powerful, provocative piece from @cbo.bsky.social this morning.
"One thing is certain: The changes we make ourselves will be healthier than the ones our adversaries demand."
New work for @undark.org:
undark.org/2025/02/06/o...
New work for @undark.org:
undark.org/2025/02/06/o...
The End of Science’s Peacetime
Opinion | Defending the practice of science from its adversaries will require dealing with some uncomfortable truths.
undark.org
February 6, 2025 at 1:58 PM
Powerful, provocative piece from @cbo.bsky.social this morning.
Reposted by marius walter
I’ve unfortunately needed to add more material to my post from yesterday. The re-election of Donald Trump is looking like the biggest act of American self-destruction since the Civil War.
Same link, new title and some updates.
Same link, new title and some updates.
Revised and Extended: What's Happening Inside the NIH and NSF
www.science.org
February 5, 2025 at 5:17 PM
I’ve unfortunately needed to add more material to my post from yesterday. The re-election of Donald Trump is looking like the biggest act of American self-destruction since the Civil War.
Same link, new title and some updates.
Same link, new title and some updates.
I love to see our work pops up in my feed!
Glad you liked our paper and thank you for sharing it
Glad you liked our paper and thank you for sharing it
New hope for viral coinfection-based therapeutic approach against Herpesviruses!
Gene Drive(GD), a self propagating gene-editing technique via Cas9 mediated homologous recombination inserts the GD with red fluorescent (mCherry) into HSV-1 genome. Specific and non-specific (GD-ns) gRNA were tested.
Gene Drive(GD), a self propagating gene-editing technique via Cas9 mediated homologous recombination inserts the GD with red fluorescent (mCherry) into HSV-1 genome. Specific and non-specific (GD-ns) gRNA were tested.
January 25, 2025 at 7:28 PM
I love to see our work pops up in my feed!
Glad you liked our paper and thank you for sharing it
Glad you liked our paper and thank you for sharing it
Reposted by marius walter
New hope for viral coinfection-based therapeutic approach against Herpesviruses!
Gene Drive(GD), a self propagating gene-editing technique via Cas9 mediated homologous recombination inserts the GD with red fluorescent (mCherry) into HSV-1 genome. Specific and non-specific (GD-ns) gRNA were tested.
Gene Drive(GD), a self propagating gene-editing technique via Cas9 mediated homologous recombination inserts the GD with red fluorescent (mCherry) into HSV-1 genome. Specific and non-specific (GD-ns) gRNA were tested.
January 25, 2025 at 4:25 PM
New hope for viral coinfection-based therapeutic approach against Herpesviruses!
Gene Drive(GD), a self propagating gene-editing technique via Cas9 mediated homologous recombination inserts the GD with red fluorescent (mCherry) into HSV-1 genome. Specific and non-specific (GD-ns) gRNA were tested.
Gene Drive(GD), a self propagating gene-editing technique via Cas9 mediated homologous recombination inserts the GD with red fluorescent (mCherry) into HSV-1 genome. Specific and non-specific (GD-ns) gRNA were tested.
Reposted by marius walter
Hello! this is my first post in Bluesky :)
Like many of you, I have migrated here to share, connect and stay updated on everything happening in the world of science (although epigenetics and embryology–developmental biology are my absolute favorites!).
Let's get started!
Like many of you, I have migrated here to share, connect and stay updated on everything happening in the world of science (although epigenetics and embryology–developmental biology are my absolute favorites!).
Let's get started!
January 13, 2025 at 3:07 PM
Hello! this is my first post in Bluesky :)
Like many of you, I have migrated here to share, connect and stay updated on everything happening in the world of science (although epigenetics and embryology–developmental biology are my absolute favorites!).
Let's get started!
Like many of you, I have migrated here to share, connect and stay updated on everything happening in the world of science (although epigenetics and embryology–developmental biology are my absolute favorites!).
Let's get started!
Reposted by marius walter
Full stream ahead: how one couple is leveraging their love of science to inspire support for research at Fred Hutch
www.fredhutch.org/en/news/cent...
Full stream ahead
Balint and Lita, the husband-and-wife team behind SciAnts Streams, are among a growing number of people who are using their digital platforms — including live gaming and educational streams — to conne...
www.fredhutch.org
December 16, 2024 at 4:39 AM
Full stream ahead: how one couple is leveraging their love of science to inspire support for research at Fred Hutch
www.fredhutch.org/en/news/cent...
Hi to my new followers!
I am a virologist at @fredhutch.bsky.social in the team of Keith Jerome.
If you are curious about what I do here are 3 options for you:
1. Read our latest paper! We showed that a viral gene drive propagated during HSV-1 infection in mice www.nature.com/articles/s41...
I am a virologist at @fredhutch.bsky.social in the team of Keith Jerome.
If you are curious about what I do here are 3 options for you:
1. Read our latest paper! We showed that a viral gene drive propagated during HSV-1 infection in mice www.nature.com/articles/s41...
Viral gene drive spread during herpes simplex virus 1 infection in mice - Nature Communications
Gene drives are genetic modifications designed to propagate efficiently through a population. Here, the authors develop a viral gene drive against herpes simplex virus 1 (HSV-1) and show that it propa...
www.nature.com
November 18, 2024 at 2:36 AM
Hi to my new followers!
I am a virologist at @fredhutch.bsky.social in the team of Keith Jerome.
If you are curious about what I do here are 3 options for you:
1. Read our latest paper! We showed that a viral gene drive propagated during HSV-1 infection in mice www.nature.com/articles/s41...
I am a virologist at @fredhutch.bsky.social in the team of Keith Jerome.
If you are curious about what I do here are 3 options for you:
1. Read our latest paper! We showed that a viral gene drive propagated during HSV-1 infection in mice www.nature.com/articles/s41...
Reposted by marius walter
Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇
May 20, 2024 at 2:19 PM
Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇