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viroscope.bsky.social
Joe McKellar
@viroscope.bsky.social
480 followers 810 following 51 posts
Post-doc at @IGMM Montpellier
Studying Deltaviruses through the lens of a microscope 🔬
Posts Replies Media Videos
Reposted by Joe McKellar
igmm-montpel.bsky.social
@viroscope.bsky.social (@karimaj.bsky.social team) partage dans The Scientist ses travaux sur les deltavirus et l’imagerie de cellules, des cellules humaines aux cellules de boa constrictor 🐍.

👉 Lire l’article : “Boa Constrictor Brain Cells Slither into Focus”
www.the-scientist.com/boa-constric...
Boa Constrictor Brain Cells Slither into Focus
From reptiles and Tasmanian devils to humans, one researcher zooms in on unseen features of the brain and liver cells, like the cytoskeleton.
www.the-scientist.com
October 13, 2025 at 11:13 AM
viroscope.bsky.social
Go and vote for @dianabrychka.bsky.social's stunning image of a brain organoid ! 🤩
dianabrychka.bsky.social Diana Brychka @dianabrychka.bsky.social · Jun 30
My little brain organoid is in a contest. If you find it pretty, you can vote for it 🤍
Go look at the other images too, they’re stunning!

Here is the link to vote:
m.cmpgn.page/jxZjTb?sre=2...

#MicroscopyMonday #SciArt
June 30, 2025 at 1:14 PM
viroscope.bsky.social
A Boa Constrictor brain-derived cell expressing a viral glycoprotein (magenta) and stained for actin (yellow) and DNA (white).

#FluorescenceFriday
June 27, 2025 at 11:20 AM
viroscope.bsky.social
HFF cells stained for DNA ⚪, intermediate filaments 🟠, microtubules 🔴 and actin 🔵.

#FluorescenceFriday
#SciArt
May 30, 2025 at 2:18 PM
viroscope.bsky.social
For #FluorescenceFriday, a field of individual VSV (rod-shaped, in 🟧) and Deltavirus (dot-shaped, in 🔵) particles imaged by STED (20nm per pixel).

We now know that Deltaviruses can package inside particles of other viruses.

Can you find any of these dual particles in this field?
May 23, 2025 at 12:05 PM
Reposted by Joe McKellar
mathpreu.bsky.social
🔬✨ Today for #FluorescenceFriday:
A close-up of the dorsal part of the first gill arch in a mature zebrafish.
The intricate vascular network supporting respiration, visualized using kdrl:mcherry.

#Zebrafish #DevBio #Microscopy #Fluorescence #SciArt
May 16, 2025 at 1:38 PM
viroscope.bsky.social
Viruses in the forest of the lungs.

Human airway epithelia stained for actin 🟢 and SARS-CoV-2 RNA 🟣.

#FluorescenceFriday
#SciArt
May 16, 2025 at 11:01 AM
Reposted by Joe McKellar
grovearmada.bsky.social
Saw this presented at ECV 2025. Fanastic and thought provoking work! Congrats to @viroscope.bsky.social, @karimaj.bsky.social and coauthors.
viroscope.bsky.social Joe McKellar @viroscope.bsky.social · May 10
⚠️ Discovery of a new mode of viral transmission:

Deltaviruses spread through a viral Trojan Horse !

These viral satellites that do not encode their own glycoproteins, are in fact physically encapsulated within their helper virus particles!

www.biorxiv.org/content/10.1...

A thread 1/14
May 10, 2025 at 10:45 AM
Reposted by Joe McKellar
Deltaviruses spread through a viral Trojan Horse www.biorxiv.org/content/10.1...
Deltaviruses spread through a viral Trojan Horse
Hepatitis D-like viral satellites, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expropriate glycoproteins from helper viruses to form i...
www.biorxiv.org
May 12, 2025 at 12:52 PM
Reposted by Joe McKellar
biorxiv-microbiol.bsky.social
Deltaviruses spread through a viral Trojan Horse https://www.biorxiv.org/content/10.1101/2025.05.09.653040v1
May 10, 2025 at 3:17 AM
Reposted by Joe McKellar
biorxivpreprint.bsky.social
Deltaviruses spread through a viral Trojan Horse https://www.biorxiv.org/content/10.1101/2025.05.09.653040v1
May 10, 2025 at 3:17 AM
Reposted by Joe McKellar
karimaj.bsky.social
With Joe in our lab, we discovered a new mode of how some viral sattelites can spread : A form of viral hitchhiking we termed Viral Trojan Horse ! check our paper on biorXiv : www.biorxiv.org/content/10.1...
viroscope.bsky.social Joe McKellar @viroscope.bsky.social · May 10
⚠️ Discovery of a new mode of viral transmission:

Deltaviruses spread through a viral Trojan Horse !

These viral satellites that do not encode their own glycoproteins, are in fact physically encapsulated within their helper virus particles!

www.biorxiv.org/content/10.1...

A thread 1/14
May 10, 2025 at 8:20 AM
viroscope.bsky.social
⚠️ Discovery of a new mode of viral transmission:

Deltaviruses spread through a viral Trojan Horse !

These viral satellites that do not encode their own glycoproteins, are in fact physically encapsulated within their helper virus particles!

www.biorxiv.org/content/10.1...

A thread 1/14
May 10, 2025 at 8:12 AM
viroscope.bsky.social
The beauty and chaos of structure.

HFF cells stained for cytoskeletal proteins Actin (⚪), Septin (🟡), Tubulin (🟣) and DNA (🔵).

#FluorescenceFriday
#SciArt
May 9, 2025 at 3:25 PM
Reposted by Joe McKellar
karimaj.bsky.social
#ECV #ECV2025 very proud of @viroscope.bsky.social that presented brilliantly his work in our lab “Deltaviruses spread through viral Trojan Horse” at the European Congress of Virology 2025 in Cavtat, Croatia !
April 28, 2025 at 1:24 PM
viroscope.bsky.social
A culture of boa constrictor cells expressing a fusogenic viral protein, leading to cell fusion and giant multinucleated cells!

Actin is in gold, membranes in white and DNA in blue.

#FluorescenceFriday #SciArt
April 11, 2025 at 11:23 AM
Reposted by Joe McKellar
dianabrychka.bsky.social
My monocyte, with a fluorescent membrane (EGFP-CAAX 💛), is transmigrating across the brain microvascular endothelium (VE-cadherin 💙)

#FluorescenceFriday #SciArt
April 4, 2025 at 1:54 PM
viroscope.bsky.social
A human lung cell expressing the antiviral protein MX1.

Actin is in cyan, MX1 in orange and DNA in yellow.

#FluorescenceFriday #SciArt
April 4, 2025 at 5:27 PM
Reposted by Joe McKellar
dianabrychka.bsky.social
My little brain organoid with stained neurons ❤️ and nuclei 🤍

#FluorescenceFriday #SciArt
March 28, 2025 at 4:02 PM
viroscope.bsky.social
Micro-rearrangement of DNA and proteins is a highly dynamic process!

As shown here with cell nucleus (DNA in gray) expressing a fluorescent protein (orange).

1 image acquired every 2 seconds for 2 minutes.

#FluorescenceFriday
#SciArt
March 28, 2025 at 2:59 PM
viroscope.bsky.social
New cell line = New cell morphologies to explore!

This hepatic cell line has fully invested into membrane protrusions!

Actin is shown in 🟦 and DNA in 🟧

#FluorescenceFriday
#SciArt
March 21, 2025 at 1:05 PM
Reposted by Joe McKellar
dianabrychka.bsky.social
One of my favourite images: monocytes 💙 infiltrating a little brain organoid, with post-synaptic protein PSD95 ❤️ and nuclei 🤍 visualized

#FluorescenceFriday
#SciArt
March 14, 2025 at 8:16 PM
viroscope.bsky.social
A Spiky Cell

A boa constrictor brain-derived cell stained for membranes (cyan), actin (yellow) and DNA (pink)

#FluorescenceFriday
#SciArt
March 7, 2025 at 2:09 PM
Reposted by Joe McKellar
carogoujon.bsky.social
I also have a few examples of my own… as a #FirstGen student, I started with a technical training. during my first intership, a postdoc asked me what I wanted to do afterwards and when I said pursuing my studies and do a PhD, the reply was ‘oh, but you’d need to be clever for that… didn’t you know?´
adrianaguatame.bsky.social Adriana Guatame-García @adrianaguatame.bsky.social · Mar 6
A friend included this anti-acknowledgement section on her PhD thesis. She also added the proposition: “Systematic bullying and undermining of girls and women in STEM starts early on and is the reason why they do not stay in science and related fields.”
Absurd we still need to go through this
🧪👩‍🔬
There have been people less than helpful in my journey here. I wanted to acknowledge those too, bc I know I am not unique in this experience. No thank you to the physics study assoc that made me sing songs about how women couldn't study physics without sleeping with the professor, the day I stepped into university life. No thank you to the 5th year physics student that decided to assign me a stripper name within the first minute of meeting me in the physics coffee corner in my first year. No thank you to the technician that was responsible for onboarding me on the use of the cluster in my third year who raised his eyebrows and asked me if that meant I was some sort of computer girl. No thank you to the senior researcher that sent me utterly inappropriate texts after a conference, then proceeded to apologise months later by telling me they had not been meant for me anyway so no hard feelings remain hopefully And no thank you to him for attending every conference I've been to since. No thank you to the people who told me that it was surprising that I was doing a PhD since I was a girl. No thank you to the man who mistook me for a coffee lady at a conference, and after having to correct him two times that I did not work there, responded with you should consider it. No thank you to the researcher that asked me what I was wearing underneath my outfit during a conference. No thank you to the physicist who declared to a room full of other physicists that biologists don't know how to design an experiment. No thank you to the people who have called me scary instead of strong and intimidating instead of intelligent. And finally, no thank you to the exec board of the TU Delft, whose knee-jerk reaction to being held up a mirror about the social safety at the university, was to sue the party holding up the mirror instead of looking at the problems they highlighted. ... You have made me feel like I do not belong in science & I cannot forgive you for that.
March 7, 2025 at 7:12 AM
Reposted by Joe McKellar
joncooper-us.bsky.social
Pass it on.
#StandWithUkraine
February 28, 2025 at 8:44 PM