Raquel Pérez Palacios
@rqperezpalacios.bsky.social
Associate professor at @www.unizar.es
Embryology, Developmental Biology, Epigenetics and Aging Researcher_Vet_2XMum
Embryology, Developmental Biology, Epigenetics and Aging Researcher_Vet_2XMum
Reposted by Raquel Pérez Palacios
New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development.
These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...
These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...
September 30, 2025 at 6:55 AM
New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development.
These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...
These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...
Reposted by Raquel Pérez Palacios
🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 18, 2025 at 9:08 AM
🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social
🧪 A variant in the Jumonji cofactor Jarid2 – and thus in H3K27 methylation – is associated to compromised fertility in both humans and mice.
Another clue pointing to the role of #epigenetics in #fertility: rdcu.be/eD4S2
Another clue pointing to the role of #epigenetics in #fertility: rdcu.be/eD4S2
Homozygous variant in JARID2 causes female infertility characterized by compromised blastulation efficiency | Journal of Ovarian Research
rdcu.be
September 4, 2025 at 8:21 AM
🧪 A variant in the Jumonji cofactor Jarid2 – and thus in H3K27 methylation – is associated to compromised fertility in both humans and mice.
Another clue pointing to the role of #epigenetics in #fertility: rdcu.be/eD4S2
Another clue pointing to the role of #epigenetics in #fertility: rdcu.be/eD4S2
Did you know organ systems and organ apparatuses aren’t the same? An apparatus is a group of organs with similar functions but different origins (analogous). A system is a group of organs that share both function and embryonic origin (homologous).
#AnatomyFacts #EmbryologyInAction #DidYouKnowScience
#AnatomyFacts #EmbryologyInAction #DidYouKnowScience
September 2, 2025 at 11:39 AM
Did you know organ systems and organ apparatuses aren’t the same? An apparatus is a group of organs with similar functions but different origins (analogous). A system is a group of organs that share both function and embryonic origin (homologous).
#AnatomyFacts #EmbryologyInAction #DidYouKnowScience
#AnatomyFacts #EmbryologyInAction #DidYouKnowScience
This year I’ll try to also include some posts about how fascinating anatomy and embryology are — in both veterinary and human fields, since they share so many processes!
Let's try...
Let's try...
September 2, 2025 at 11:34 AM
This year I’ll try to also include some posts about how fascinating anatomy and embryology are — in both veterinary and human fields, since they share so many processes!
Let's try...
Let's try...
Here comes September and a brand-new 2025/2026 academic year — Let's get started!
September 1, 2025 at 9:36 AM
Here comes September and a brand-new 2025/2026 academic year — Let's get started!
Interesting!! (Apart from the eye-catching animation :) )
If you like transposons...
If you you love genome editing...
Or if you just like random bird animations,
we have the paper for you!
We (@kedmonds.bsky.social et al) are happy to share our work turning a songbird retrotransposon into a genome editing tool. 🐣 (1/n)
If you you love genome editing...
Or if you just like random bird animations,
we have the paper for you!
We (@kedmonds.bsky.social et al) are happy to share our work turning a songbird retrotransposon into a genome editing tool. 🐣 (1/n)
July 3, 2025 at 3:40 PM
Interesting!! (Apart from the eye-catching animation :) )
Reposted by Raquel Pérez Palacios
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
March 17, 2025 at 11:56 AM
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
Reposted by Raquel Pérez Palacios
In this Review, @eliananehme.bsky.social, @amiteshp.bsky.social, Isabelle Migeotte and @pasquelab.bsky.social give an overview of the embryonic origin and function of extra-embryonic mesoderm in vertebrates from in vivo studies.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
March 17, 2025 at 4:29 PM
In this Review, @eliananehme.bsky.social, @amiteshp.bsky.social, Isabelle Migeotte and @pasquelab.bsky.social give an overview of the embryonic origin and function of extra-embryonic mesoderm in vertebrates from in vivo studies.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Changing profile to:
Associate professor at @www.unizar.es ...
...
I got tenured!
... Looking forward to start new long-lasting scientific projects and collaborations! :)
Associate professor at @www.unizar.es ...
...
I got tenured!
... Looking forward to start new long-lasting scientific projects and collaborations! :)
March 17, 2025 at 8:32 AM
Changing profile to:
Associate professor at @www.unizar.es ...
...
I got tenured!
... Looking forward to start new long-lasting scientific projects and collaborations! :)
Associate professor at @www.unizar.es ...
...
I got tenured!
... Looking forward to start new long-lasting scientific projects and collaborations! :)
Reposted by Raquel Pérez Palacios
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...
doi.org
January 22, 2025 at 1:56 PM
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
Reposted by Raquel Pérez Palacios
Excited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability
Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.
tinyurl.com
February 20, 2025 at 7:42 AM
Excited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇
Reposted by Raquel Pérez Palacios
One of the coolest and most novel findings I’ve seen in years. This is why I work in worms. To find things no one even really knew to look for. Like a conserved system that splices transposons out of mRNAs to prevent otherwise lethal insertions in essential genes! - www.biorxiv.org/content/10.1...
An RNA Splicing System that Excises Transposons from Animal mRNAs
All genomes harbor mobile genetic parasites called transposable elements (TEs). Here we describe a system, which we term SOS splicing, that protects C. elegans and human genes from DNA transposon-medi...
www.biorxiv.org
February 18, 2025 at 11:10 AM
One of the coolest and most novel findings I’ve seen in years. This is why I work in worms. To find things no one even really knew to look for. Like a conserved system that splices transposons out of mRNAs to prevent otherwise lethal insertions in essential genes! - www.biorxiv.org/content/10.1...
Reposted by Raquel Pérez Palacios
Delighted to share that my PhD work from the Hiiragi Lab is now published in Nature Cell Biology! We uncover the cellular mechanisms underlying pattern formation and how patterning robustness can be ensured during embryo development. Check out the full story: nature.com/articles/s41556-025-01618-9
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness - Nature Cell Biology
Moghe et al. show that mouse embryonic primitive endoderm cells migrate towards the inner cell mass-cavity interface, depositing an extracellular matrix gradient that may guide migration. Primitive en...
nature.com
February 18, 2025 at 10:07 AM
Delighted to share that my PhD work from the Hiiragi Lab is now published in Nature Cell Biology! We uncover the cellular mechanisms underlying pattern formation and how patterning robustness can be ensured during embryo development. Check out the full story: nature.com/articles/s41556-025-01618-9
Reposted by Raquel Pérez Palacios
How do cells find their place in a developing embryo? Scientists have long wondered. A new study by the Hiiragi group uncovers how embryos achieve precise cell organization. Curious what breadcrumbs have to do with this? @prachitimoghe.bsky.social explains it here: www.hubrecht.eu/breadcrumb-t...
February 18, 2025 at 10:24 AM
How do cells find their place in a developing embryo? Scientists have long wondered. A new study by the Hiiragi group uncovers how embryos achieve precise cell organization. Curious what breadcrumbs have to do with this? @prachitimoghe.bsky.social explains it here: www.hubrecht.eu/breadcrumb-t...
Today's plan: taking my little boys to see how awesome women and girls are in science!
Happy International Day of Women and Girls in Science!👩🔬🧬👧🧑🦰🧬🔬
Happy International Day of Women and Girls in Science!👩🔬🧬👧🧑🦰🧬🔬
February 11, 2025 at 3:06 PM
Today's plan: taking my little boys to see how awesome women and girls are in science!
Happy International Day of Women and Girls in Science!👩🔬🧬👧🧑🦰🧬🔬
Happy International Day of Women and Girls in Science!👩🔬🧬👧🧑🦰🧬🔬
Reposted by Raquel Pérez Palacios
CRISPR targeting of H3K4me3 activates gene expression and unlocks centromeric crossover recombination in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.02.07.636860v1
February 9, 2025 at 2:04 AM
CRISPR targeting of H3K4me3 activates gene expression and unlocks centromeric crossover recombination in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.02.07.636860v1
Reposted by Raquel Pérez Palacios
SIMPLE-seq measures both 5-methylcytosine and 5-hydroxymethylcytosine at base resolution in single cells go.nature.com/49NeNFN
rdcu.be/d8LYD
rdcu.be/d8LYD
Simultaneous single-cell analysis of 5mC and 5hmC with SIMPLE-seq - Nature Biotechnology
SIMPLE-seq measures both 5-methylcytosine and 5-hydroxymethylcytosine at base resolution in single cells.
go.nature.com
February 7, 2025 at 2:02 AM
SIMPLE-seq measures both 5-methylcytosine and 5-hydroxymethylcytosine at base resolution in single cells go.nature.com/49NeNFN
rdcu.be/d8LYD
rdcu.be/d8LYD
Reposted by Raquel Pérez Palacios
📢‼️ Exciting new preprint from the lab by @nikhil-mishra.bsky.social et al, now out on @biorxivpreprint.bsky.social, reveals that the early embryo geometry spatiotemporally patterns zygotic genome activation (ZGA) in zebrafish. 🐟 tinyurl.com/Biorxiv-nmis...
Read on to learn more... 👇
Read on to learn more... 👇
February 6, 2025 at 11:31 AM
📢‼️ Exciting new preprint from the lab by @nikhil-mishra.bsky.social et al, now out on @biorxivpreprint.bsky.social, reveals that the early embryo geometry spatiotemporally patterns zygotic genome activation (ZGA) in zebrafish. 🐟 tinyurl.com/Biorxiv-nmis...
Read on to learn more... 👇
Read on to learn more... 👇
Reposted by Raquel Pérez Palacios
Here is the 2025 embryo alphabet from alligator to zebrafish. Developmental biology is stunning & leads to important discoveries for human medicine.
@socdevbio.bsky.social
@socdevbio.bsky.social
February 1, 2025 at 3:03 PM
Here is the 2025 embryo alphabet from alligator to zebrafish. Developmental biology is stunning & leads to important discoveries for human medicine.
@socdevbio.bsky.social
@socdevbio.bsky.social
Reposted by Raquel Pérez Palacios
📢 CUT&Tag version 3
Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript:
www.biorxiv.org/content/10.1...
Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript:
www.biorxiv.org/content/10.1...
CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks
Techniques for genome-wide epigenetic profiling have been undergoing accelerated development toward recovery of high-quality data from bulk and single cell samples. DNA-protein interactions have tradi...
www.biorxiv.org
January 30, 2025 at 3:22 PM
📢 CUT&Tag version 3
Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript:
www.biorxiv.org/content/10.1...
Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript:
www.biorxiv.org/content/10.1...
Reposted by Raquel Pérez Palacios
Dear all, registrations are open for the Mobile Genome @EMBO workshop. Many slots for posters, short talks but also long talks for last minute groundbreaking results! Let’s meet again on Nov 4-7, 2025 in Heidelberg. www.embl.org/about/info/c...
The mobile genome: genetic and physiological impacts of transposable elements
www.embl.org
January 27, 2025 at 7:58 AM
Dear all, registrations are open for the Mobile Genome @EMBO workshop. Many slots for posters, short talks but also long talks for last minute groundbreaking results! Let’s meet again on Nov 4-7, 2025 in Heidelberg. www.embl.org/about/info/c...
Reposted by Raquel Pérez Palacios
We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
www.science.org/doi/full/10....
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
www.science.org/doi/full/10....
www.science.org
January 24, 2025 at 11:02 AM
We thrilled to see our latest study led by @jeremie-subrini.bsky.social now out in @science.org 🔬
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
www.science.org/doi/full/10....
What are the specific functions of each Y-chromosome gene in fertility ? We generated and studied 13 Y-gene KO mouse models to find out! 🧬
www.science.org/doi/full/10....
Reposted by Raquel Pérez Palacios
I am thrilled to share our latest work, released today 🤩
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
January 21, 2025 at 10:34 AM
I am thrilled to share our latest work, released today 🤩
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
Top in my to read list!
Tour de force! @metorrespadilla.bsky.social & team develop Smart-seq+5′ to map TSS in single embryos with unprecedented res revealing plethora of TE-driven transcripts in 5 mammal species. Some surprisingly old & conserved. Treasure trove of new biology for yrs to come!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development
Mapping transcription start sites across five mammalian species before, during, and
after embryonic genome activation unveils widespread transposable element-driven transcription
and co-option of evol...
www.cell.com
January 20, 2025 at 8:23 PM
Top in my to read list!