David Meyer
@meyerdh.bsky.social
Dr. rer. nat. | Bioinformatician 🧬 |
Exploring Aging & Longevity with Machine Learning 🔍 | Unraveling Life's Code | C.elegans | Consultant
Exploring Aging & Longevity with Machine Learning 🔍 | Unraveling Life's Code | C.elegans | Consultant
Reposted by David Meyer
A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine - Scientific Reports
Scientific Reports - A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
www.nature.com
December 28, 2025 at 8:19 PM
A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Meyer
Happy to share that this is now out in Microbial Ecology 🥳 Huge thanks to the whole team, especially @sultanova.bsky.social 🙌
link.springer.com/article/10.1...
@leibnizfli.bsky.social @uniofeastanglia.bsky.social
link.springer.com/article/10.1...
@leibnizfli.bsky.social @uniofeastanglia.bsky.social
December 27, 2025 at 10:25 AM
Happy to share that this is now out in Microbial Ecology 🥳 Huge thanks to the whole team, especially @sultanova.bsky.social 🙌
link.springer.com/article/10.1...
@leibnizfli.bsky.social @uniofeastanglia.bsky.social
link.springer.com/article/10.1...
@leibnizfli.bsky.social @uniofeastanglia.bsky.social
Reposted by David Meyer
1/6 In a new preprint we ask a question:
Why do males and females so often age and die at different rates?
We argue that sex-specific mutation accumulation may be the most parsimonious evolutionary explanation for sex-biased ageing:
ecoevorxiv.org/repository/v...
Why do males and females so often age and die at different rates?
We argue that sex-specific mutation accumulation may be the most parsimonious evolutionary explanation for sex-biased ageing:
ecoevorxiv.org/repository/v...
Sex-specific mutation accumulation: A parsimonious explanation for sex differences in lifespan and ageing
ecoevorxiv.org
November 19, 2025 at 12:08 PM
1/6 In a new preprint we ask a question:
Why do males and females so often age and die at different rates?
We argue that sex-specific mutation accumulation may be the most parsimonious evolutionary explanation for sex-biased ageing:
ecoevorxiv.org/repository/v...
Why do males and females so often age and die at different rates?
We argue that sex-specific mutation accumulation may be the most parsimonious evolutionary explanation for sex-biased ageing:
ecoevorxiv.org/repository/v...
Happy to share our recent publication, which grew out of a consulting job I did last year:
www.nature.com/articles/s41...
🧵
www.nature.com/articles/s41...
🧵
https://nature.com/articles/s4159…
December 19, 2025 at 6:27 PM
Happy to share our recent publication, which grew out of a consulting job I did last year:
www.nature.com/articles/s41...
🧵
www.nature.com/articles/s41...
🧵
Reposted by David Meyer
New study by our #CRC1678 members @bjornschumacher.bsky.social, @meyerdh.bsky.social and Walter Sandt showing that C. elegans dauer stage decelerates aging and even reverses biological age upon exit, revealing natural gene patterns of rejuvenation. Congratulations! 🎉
#AgingResearch #Longevity
#AgingResearch #Longevity
🚀 Now out in print: AGE DECELERATION AND REVERSAL GENE PATTERNS IN DAUER DIAPAUSE. How we can learn from nature of to slow aging and rejuvenate. Big congrats to Khrystyna Totska, João Barata, Walter Sandt, and @meyerdavid.bsky.social! @cecad.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
onlinelibrary.wiley.com
December 10, 2025 at 12:36 PM
New study by our #CRC1678 members @bjornschumacher.bsky.social, @meyerdh.bsky.social and Walter Sandt showing that C. elegans dauer stage decelerates aging and even reverses biological age upon exit, revealing natural gene patterns of rejuvenation. Congratulations! 🎉
#AgingResearch #Longevity
#AgingResearch #Longevity
Reposted by David Meyer
🎥 Meet the 2025 SIB Bioinformatics Awards laureates:
⭐ David Meyer @meyerdh.bsky.social, PhD Paper Award
⭐ Michael Skinnider @skinnider.bsky.social Early Career Award
⭐ scverse @scverse.bsky.social, Innovative Resource Award, accepted by Ilan Gold
Watch their award ceremony talks👇& congrats to all!
⭐ David Meyer @meyerdh.bsky.social, PhD Paper Award
⭐ Michael Skinnider @skinnider.bsky.social Early Career Award
⭐ scverse @scverse.bsky.social, Innovative Resource Award, accepted by Ilan Gold
Watch their award ceremony talks👇& congrats to all!
Celebrating excellence: meet the 2025 SIB Bioinformatics Awards laureates
Two early career bioinformaticians have been recognized for their mathematical and AI models, along with a collaborative resource for single-cell data analyses. The three 2025 SIB Bioinformatics Award...
www.sib.swiss
October 28, 2025 at 8:29 AM
🎥 Meet the 2025 SIB Bioinformatics Awards laureates:
⭐ David Meyer @meyerdh.bsky.social, PhD Paper Award
⭐ Michael Skinnider @skinnider.bsky.social Early Career Award
⭐ scverse @scverse.bsky.social, Innovative Resource Award, accepted by Ilan Gold
Watch their award ceremony talks👇& congrats to all!
⭐ David Meyer @meyerdh.bsky.social, PhD Paper Award
⭐ Michael Skinnider @skinnider.bsky.social Early Career Award
⭐ scverse @scverse.bsky.social, Innovative Resource Award, accepted by Ilan Gold
Watch their award ceremony talks👇& congrats to all!
Reposted by David Meyer
🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
onlinelibrary.wiley.com
October 17, 2025 at 2:06 PM
🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by David Meyer
🚨🚨Job! 🚨🚨Permanent (75% time) job! We are a pretty awesome research group & seek a manager who deals with everything: personnel tasks, organizing retreats, preparing code for teaching / data structures for research... Fluency in German & English essential. stellenboerse.uni-mainz.de#/jgu/job/51527
stellenboerse.uni-mainz.de
October 17, 2025 at 7:38 AM
🚨🚨Job! 🚨🚨Permanent (75% time) job! We are a pretty awesome research group & seek a manager who deals with everything: personnel tasks, organizing retreats, preparing code for teaching / data structures for research... Fluency in German & English essential. stellenboerse.uni-mainz.de#/jgu/job/51527
Reposted by David Meyer
Super grateful that our scETM work (from my summer internship with Dr. Yue Li, in collab. with Huiyu Cai and @tangjian.bsky.social) was recognized with an honourable mention at SIB PhD Paper Award competition. Many thanks to the jury and congrats to @meyerdh.bsky.social and Can Chen! #bc2basel
The PhD Paper Award jury gives honourable mentions to:
Can Chen for “Structure-Aware Protein Self-Supervised Learning” doi.org/10.1093/bioi...
Yifan Zhao for “Learning interpretable cellular and gene signature embeddings from single-cell transcriptomic data” doi.org/10.1038/s414...
#bc2basel
Can Chen for “Structure-Aware Protein Self-Supervised Learning” doi.org/10.1093/bioi...
Yifan Zhao for “Learning interpretable cellular and gene signature embeddings from single-cell transcriptomic data” doi.org/10.1038/s414...
#bc2basel
Structure-aware protein self-supervised learning
AbstractMotivation. Protein representation learning methods have shown great potential to many downstream tasks in biological applications. A few recent st
doi.org
October 5, 2025 at 10:14 AM
Super grateful that our scETM work (from my summer internship with Dr. Yue Li, in collab. with Huiyu Cai and @tangjian.bsky.social) was recognized with an honourable mention at SIB PhD Paper Award competition. Many thanks to the jury and congrats to @meyerdh.bsky.social and Can Chen! #bc2basel
Reposted by David Meyer
A fantastic few days of ageing talks, great people, and excellent food!
Massive thanks to (Hanna!) @kokkonut.bsky.social, Margaux Bieuville, Victor Ronget, and the fantastic people at The Gutenberg Workshops in the Life Sciences
Massive thanks to (Hanna!) @kokkonut.bsky.social, Margaux Bieuville, Victor Ronget, and the fantastic people at The Gutenberg Workshops in the Life Sciences
October 2, 2025 at 2:04 PM
A fantastic few days of ageing talks, great people, and excellent food!
Massive thanks to (Hanna!) @kokkonut.bsky.social, Margaux Bieuville, Victor Ronget, and the fantastic people at The Gutenberg Workshops in the Life Sciences
Massive thanks to (Hanna!) @kokkonut.bsky.social, Margaux Bieuville, Victor Ronget, and the fantastic people at The Gutenberg Workshops in the Life Sciences
Reposted by David Meyer
Ribonucleotide incorporation into mitochondrial DNA drives inflammation
www.nature.com/articles/s41...
Congratulations to the Langer lab @mpiage.bsky.social, Amir, and the rest of the team!
www.nature.com/articles/s41...
Congratulations to the Langer lab @mpiage.bsky.social, Amir, and the rest of the team!
Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature
Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.
www.nature.com
September 24, 2025 at 4:31 PM
Ribonucleotide incorporation into mitochondrial DNA drives inflammation
www.nature.com/articles/s41...
Congratulations to the Langer lab @mpiage.bsky.social, Amir, and the rest of the team!
www.nature.com/articles/s41...
Congratulations to the Langer lab @mpiage.bsky.social, Amir, and the rest of the team!
Reposted by David Meyer
This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!
🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 22, 2025 at 11:22 AM
This review of our @crc1678.bsky.social member @bjornschumacher.bsky.social and @meyerdh.bsky.social is greatly summarizing fundamentals of the molecular biology of aging. What causes aging? Read the answer!
Reposted by David Meyer
🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 20, 2025 at 4:31 AM
🔥🔥🔥Out now: our Perspectives article in @nataging.nature.com outlining how aging is driven by molecular damage leading to increasing molecular noise whose quantification could track aging with the precision of a clock @meyerdh.bsky.social @alexeimaklakov.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by David Meyer
We argue that selection shadow - gradual decline in the force of selection after the onset of reproduction - is sufficient/parsimonious to explain why damage accumulates with age. 'Aging clocks' measure damage accumulation, they neither require nor support any kind of 'program'-based explanation.
🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 18, 2025 at 2:44 PM
We argue that selection shadow - gradual decline in the force of selection after the onset of reproduction - is sufficient/parsimonious to explain why damage accumulates with age. 'Aging clocks' measure damage accumulation, they neither require nor support any kind of 'program'-based explanation.
Reposted by David Meyer
👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳
🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 18, 2025 at 12:22 PM
👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳
September 18, 2025 at 10:30 AM
🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social
Aging by the clock and yet without a program - Nature Aging
Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...
www.nature.com
September 18, 2025 at 9:08 AM
🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social
Reposted by David Meyer
💪🎉Congratulations to our #CRC1678 member @meyerdh.bsky.social for winning the SIB Bioinformatics PhD Paper Award 2025 for his work on Ageing Clocks ⏰ 👵🏻👴🏻
✨ I’m honored and grateful to have received the SIB Bioinformatics PhD Paper Award 2025 for part of my PhD work.
Thank you for your guidance and inspiration @bjornschumacher.bsky.social
#SIBAwards #bc2basel #Bioinformatics
Thank you for your guidance and inspiration @bjornschumacher.bsky.social
#SIBAwards #bc2basel #Bioinformatics
💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫
“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.
#Bioinformatics #SIBawards #bc2basel
“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.
#Bioinformatics #SIBawards #bc2basel
September 15, 2025 at 4:04 PM
💪🎉Congratulations to our #CRC1678 member @meyerdh.bsky.social for winning the SIB Bioinformatics PhD Paper Award 2025 for his work on Ageing Clocks ⏰ 👵🏻👴🏻
✨ I’m honored and grateful to have received the SIB Bioinformatics PhD Paper Award 2025 for part of my PhD work.
Thank you for your guidance and inspiration @bjornschumacher.bsky.social
#SIBAwards #bc2basel #Bioinformatics
Thank you for your guidance and inspiration @bjornschumacher.bsky.social
#SIBAwards #bc2basel #Bioinformatics
💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫
“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.
#Bioinformatics #SIBawards #bc2basel
“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.
#Bioinformatics #SIBawards #bc2basel
September 11, 2025 at 8:17 AM
✨ I’m honored and grateful to have received the SIB Bioinformatics PhD Paper Award 2025 for part of my PhD work.
Thank you for your guidance and inspiration @bjornschumacher.bsky.social
#SIBAwards #bc2basel #Bioinformatics
Thank you for your guidance and inspiration @bjornschumacher.bsky.social
#SIBAwards #bc2basel #Bioinformatics
Reposted by David Meyer
Read David’s award winning article ‘Aging clocks based on accumulating stochastic variation’. www.nature.com/articles/s43... #bc2basel
Aging clocks based on accumulating stochastic variation - Nature Aging
Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induce...
www.nature.com
September 9, 2025 at 9:15 AM
Read David’s award winning article ‘Aging clocks based on accumulating stochastic variation’. www.nature.com/articles/s43... #bc2basel
Reposted by David Meyer
💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫
“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.
#Bioinformatics #SIBawards #bc2basel
“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.
#Bioinformatics #SIBawards #bc2basel
September 9, 2025 at 9:10 AM
💫 The PhD Paper Award goes to @meyerdh.bsky.social from Uni-Köln 💫
“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.
#Bioinformatics #SIBawards #bc2basel
“David Meyer’s paper ‘Aging clocks based on accumulating stochastic variation’ presents a completely novel concept and a fresh way to address the problem”.
#Bioinformatics #SIBawards #bc2basel
Reposted by David Meyer
#bc2basel @SIB PhD Paper Award 👏 David Meyer: Aging clocks based on accumulating variation
https://doi.org/10.1038/s43587-024-00619-x
https://doi.org/10.1038/s43587-024-00619-x
Aging clocks based on accumulating stochastic variation - Nature Aging
Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induced by smoking, calorie restriction, parabiosis and reprogramming.
www.nature.com
September 9, 2025 at 9:08 AM
#bc2basel @SIB PhD Paper Award 👏 David Meyer: Aging clocks based on accumulating variation
https://doi.org/10.1038/s43587-024-00619-x
https://doi.org/10.1038/s43587-024-00619-x
Reposted by David Meyer
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
www.nature.com
September 3, 2025 at 9:19 AM
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
Reposted by David Meyer
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...
febs.onlinelibrary.wiley.com
September 2, 2025 at 7:11 AM
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
Can't wait to be at the #ARDD2025 next week! agingpharma.org
I'm presenting
"Aging by the clock and yet without a program" on Tuesday in the GeroPhysics session.
If you're at the conference, let's grab a coffee and chat!
🧪
#AgingResearch #Longevity #Science
I'm presenting
"Aging by the clock and yet without a program" on Tuesday in the GeroPhysics session.
If you're at the conference, let's grab a coffee and chat!
🧪
#AgingResearch #Longevity #Science
ARDD 2025
In this symposium, leaders in the aging and longevity field will describe the latest progress in the molecular, cellular and organismal basis of aging and our search for interventions. A panel of thou...
agingpharma.org
August 21, 2025 at 11:02 AM
Can't wait to be at the #ARDD2025 next week! agingpharma.org
I'm presenting
"Aging by the clock and yet without a program" on Tuesday in the GeroPhysics session.
If you're at the conference, let's grab a coffee and chat!
🧪
#AgingResearch #Longevity #Science
I'm presenting
"Aging by the clock and yet without a program" on Tuesday in the GeroPhysics session.
If you're at the conference, let's grab a coffee and chat!
🧪
#AgingResearch #Longevity #Science