Aging Science News
@agingbiology.bsky.social
Latest news in the biology and genetics of aging, covering longevity science, rejuvenation technologies and life-extension research.
The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism
Breaking up a phosphatase complex can help restore balance in metabolism and support healthy aging.
www.science.org
November 13, 2025 at 11:00 PM
The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
SIRT1/3/6 Landscape of Human Longevity: A Sex- and Health-Stratified Pilot Study
www.mdpi.com/2079-7737/14...
www.mdpi.com/2079-7737/14...
www.mdpi.com
November 13, 2025 at 9:35 PM
SIRT1/3/6 Landscape of Human Longevity: A Sex- and Health-Stratified Pilot Study
www.mdpi.com/2079-7737/14...
www.mdpi.com/2079-7737/14...
Could humans live to 150? Why some researchers think we’re on the cusp of a major longevity breakthrough
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Could humans live to 150? Why some researchers think we’re on the cusp of a major longevity breakthrough
Other scientists believe extending lifespan might be difficult but are pursuing therapies that aim to make us feel younger for longer.
www.nature.com
November 13, 2025 at 3:46 PM
Could humans live to 150? Why some researchers think we’re on the cusp of a major longevity breakthrough
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Are GLP-1s the first longevity drugs?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Are GLP-1s the first longevity drugs? - Nature Biotechnology
As pharma ramps up efforts on disorders of aging, a new era of disease prevention comes into focus.
www.nature.com
November 13, 2025 at 1:58 PM
Are GLP-1s the first longevity drugs?
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PCBP2 Regulates p16INK4a-Dependent Cellular Senescence in Response to Iron
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
PCBP2 Regulates p16INK4a‐Dependent Cellular Senescence in Response to Iron
PCBP2 induces cellular senescence by modulating the expression of p16INK4a and CD40 in response to iron. PCBP2 activates p16INK4a via the functional SNP rs1333046 on the atherosclerosis-associated CD...
onlinelibrary.wiley.com
November 12, 2025 at 8:52 PM
PCBP2 Regulates p16INK4a-Dependent Cellular Senescence in Response to Iron
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
The biological scaling of Alzheimer’s disease neuropathological changes across primate species
alzres.biomedcentral.com/articles/10....
alzres.biomedcentral.com/articles/10....
The biological scaling of Alzheimer’s disease neuropathological changes across primate species - Alzheimer's Research & Therapy
Background Studying the spontaneous emergence of biological anomalies within the animal kingdom can provide insights into the causes of diseases. It is often assumed that Alzheimer’s Disease (AD), lik...
alzres.biomedcentral.com
November 12, 2025 at 2:50 PM
The biological scaling of Alzheimer’s disease neuropathological changes across primate species
alzres.biomedcentral.com/articles/10....
alzres.biomedcentral.com/articles/10....
Fast females, slow males: accelerated ageing and reproductive senescence in Drosophila melanogaster females across diverse social environments
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academic.oup.com/evlett/advan...
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academic.oup.com
November 11, 2025 at 11:36 PM
Fast females, slow males: accelerated ageing and reproductive senescence in Drosophila melanogaster females across diverse social environments
academic.oup.com/evlett/advan...
academic.oup.com/evlett/advan...
Reposted by Aging Science News
New study showing that aging rewires muscle microRNAs, but calorie restriction reverses many of these changes!
In rats, 35% of age-related miRNAs returned to youthful levels under CR, including pathways related to metabolism, autophagy & inflammation.
link.springer.com/article/10.1...
In rats, 35% of age-related miRNAs returned to youthful levels under CR, including pathways related to metabolism, autophagy & inflammation.
link.springer.com/article/10.1...
miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function - Biogerontology
The mechanisms underlying skeletal muscle ageing, whilst poorly understood, are thought to involve dysregulated micro (mi)RNA expression. Using young and aged rat skeletal muscle tissue, we applied hi...
link.springer.com
November 11, 2025 at 7:14 PM
New study showing that aging rewires muscle microRNAs, but calorie restriction reverses many of these changes!
In rats, 35% of age-related miRNAs returned to youthful levels under CR, including pathways related to metabolism, autophagy & inflammation.
link.springer.com/article/10.1...
In rats, 35% of age-related miRNAs returned to youthful levels under CR, including pathways related to metabolism, autophagy & inflammation.
link.springer.com/article/10.1...
Integrated Analysis of Proteomic Marker Databases and Studies Associated with Aging Processes and Age-Dependent Conditions: Optimization Proposals for Biomedical Research
www.mdpi.com/2227-7382/13...
www.mdpi.com/2227-7382/13...
www.mdpi.com
November 11, 2025 at 2:45 PM
Integrated Analysis of Proteomic Marker Databases and Studies Associated with Aging Processes and Age-Dependent Conditions: Optimization Proposals for Biomedical Research
www.mdpi.com/2227-7382/13...
www.mdpi.com/2227-7382/13...
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy
link.springer.com/article/10.1...
link.springer.com/article/10.1...
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy - Molecular Cancer
Cellular senescence, characterized by partially irreversible cell cycle arrest, has a dual role in cancer progression via the senescence-associated secretory phenotype (SASP). SASP encompasses a wide ...
link.springer.com
November 11, 2025 at 12:33 AM
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy
link.springer.com/article/10.1...
link.springer.com/article/10.1...
An Integrative Perspective on Bat Evolution
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
An Integrative Perspective on Bat Evolution
Bats are one of the most widespread, species-rich, ecologically and morphologically diverse mammal lineages, and the only mammals capable of powered flight. Due to their evolution within the constrain...
www.annualreviews.org
November 10, 2025 at 10:57 PM
An Integrative Perspective on Bat Evolution
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Microvascular Health as a Key Determinant of Organismal Aging
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Microvascular Health as a Key Determinant of Organismal Aging
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during agin....
advanced.onlinelibrary.wiley.com
November 10, 2025 at 8:47 PM
Microvascular Health as a Key Determinant of Organismal Aging
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Nuclear-lamin-guided plastic positioning and folding of the human genome
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Nuclear-lamin-guided plastic positioning and folding of the human genome
Wang et al. systematically depicted the lamins-guided 3D epigenome in human stem cells
and demonstrated that lamins not only serve as key regulators of chromatin-NL tethering
and large-scale genome or...
www.cell.com
November 10, 2025 at 7:23 PM
Nuclear-lamin-guided plastic positioning and folding of the human genome
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Aging Science News
I'm delighted to share our curated list of 100 open problems in ageing science.
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
Open problems in ageing science: a roadmap for biogerontology - GeroScience
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems ...
link.springer.com
November 9, 2025 at 11:46 PM
I'm delighted to share our curated list of 100 open problems in ageing science.
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.
link.springer.com/article/10.1...
Defining Microbiota-Derived Metabolite Butyrate as a Senomorphic: Therapeutic Potential in the Age-Related T Cell Senescence
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Defining Microbiota‐Derived Metabolite Butyrate as a Senomorphic: Therapeutic Potential in the Age‐Related T Cell Senescence
An age-associated accumulation of senescent T cells is characterized by increased cellular damage and the secretion of pro-inflammatory molecules collectively known as the senescence-associated secre....
onlinelibrary.wiley.com
November 9, 2025 at 12:23 PM
Defining Microbiota-Derived Metabolite Butyrate as a Senomorphic: Therapeutic Potential in the Age-Related T Cell Senescence
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Cellular senescence and cell therapy in cardiovascular diseases
stemcellres.biomedcentral.com/articles/10....
stemcellres.biomedcentral.com/articles/10....
Cellular senescence and cell therapy in cardiovascular diseases - Stem Cell Research & Therapy
The issue of population aging presents a significant challenge for many countries, and the related physical health implications have been receiving increasing attention. Senescence impacts several asp...
stemcellres.biomedcentral.com
November 8, 2025 at 9:56 PM
Cellular senescence and cell therapy in cardiovascular diseases
stemcellres.biomedcentral.com/articles/10....
stemcellres.biomedcentral.com/articles/10....
Cellular Senescence and Inter-Organ Communication in Health and Disease
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
Cellular Senescence and Inter-Organ Communication in Health and Disease | Physiology | American Physiological Society
As populations age worldwide, understanding the biology of aging and its contribution to disease becomes increasingly important. Cellular senescence, a hallmark of aging, plays a pivotal role in shapi...
journals.physiology.org
November 8, 2025 at 1:00 PM
Cellular Senescence and Inter-Organ Communication in Health and Disease
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
Cancer and Aging Biomarkers: Classification, Early Detection Technologies and Emerging Research Trends
www.mdpi.com/2079-6374/15...
www.mdpi.com/2079-6374/15...
www.mdpi.com
November 7, 2025 at 5:37 PM
Cancer and Aging Biomarkers: Classification, Early Detection Technologies and Emerging Research Trends
www.mdpi.com/2079-6374/15...
www.mdpi.com/2079-6374/15...
FOXM1 enhances DNA repair in aged cells to maintain the peripheral heterochromatin barrier to senescence enhancers
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
FOXM1 enhances DNA repair in aged cells to maintain the peripheral heterochromatin barrier to senescence enhancers
DNA damage is a key driver of aging, contributing to epigenetic erosion, senescence, and chronic inflammation. However, genoprotective strategies to counteract aging remain intangible. Here we show th...
www.biorxiv.org
November 7, 2025 at 4:16 PM
FOXM1 enhances DNA repair in aged cells to maintain the peripheral heterochromatin barrier to senescence enhancers
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Post-reproductive lifespan in wild mountain gorillas
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Post-reproductive lifespan in wild mountain gorillas | PNAS
Animals can typically maximize their fitness by reproducing throughout adulthood.
Yet, in a handful of species, females cease reproduction long bef...
www.pnas.org
November 7, 2025 at 1:15 PM
Post-reproductive lifespan in wild mountain gorillas
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Against “Extending Healthspan but Not Lifespan” as a Goal for Biogerontology
www.preprints.org/manuscript/2...
www.preprints.org/manuscript/2...
www.preprints.org
November 7, 2025 at 12:24 AM
Against “Extending Healthspan but Not Lifespan” as a Goal for Biogerontology
www.preprints.org/manuscript/2...
www.preprints.org/manuscript/2...
Aging alters genomic instability at endogenous mutation hotspots in mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Aging alters genomic instability at endogenous mutation hotspots in mice - Scientific Reports
Scientific Reports - Aging alters genomic instability at endogenous mutation hotspots in mice
www.nature.com
November 6, 2025 at 6:39 PM
Aging alters genomic instability at endogenous mutation hotspots in mice
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prepupal diapause reduces adult lifespan in the solitary alfalfa leafcutter bee
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Prepupal diapause reduces adult lifespan in the solitary alfalfa leafcutter bee - Scientific Reports
Scientific Reports - Prepupal diapause reduces adult lifespan in the solitary alfalfa leafcutter bee
www.nature.com
November 6, 2025 at 1:53 PM
Prepupal diapause reduces adult lifespan in the solitary alfalfa leafcutter bee
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial - Nature Aging
Immune aging fosters multimorbidity and compromises control of infection and cancer. In a phase 1 randomized controlled trial in middle-aged adults, Denk and colleagues administer the mitophagy induce...
www.nature.com
November 5, 2025 at 10:48 PM
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Immunosenescence and organoids: pathophysiology and therapeutic opportunities
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Immunosenescence and organoids: pathophysiology and therapeutic opportunities - Immunity & Ageing
Immunosenescence is the gradual deterioration in the functionality of the immune system that has various clinical manifestations, such as a weakened response to vaccination, higher susceptibility to v...
link.springer.com
November 5, 2025 at 4:41 PM
Immunosenescence and organoids: pathophysiology and therapeutic opportunities
link.springer.com/article/10.1...
link.springer.com/article/10.1...