Alexei Maklakov
@alexeimaklakov.bsky.social
Biology of Ageing and Life History Evolution, University of East Anglia, Norwich, UK
Reposted by Alexei Maklakov
🧠⏰our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration @cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social @meyerdh.bsky.social www.nature.com/articles/s43...
Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging
Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...
www.nature.com
February 3, 2026 at 11:44 AM
🧠⏰our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration @cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social @meyerdh.bsky.social www.nature.com/articles/s43...
Reposted by Alexei Maklakov
How does pre- and post-natal environmental stress affect the seminal foam proteome of Japanese quail? Find out here, Chloe Mason’s second PhD thesis paper: onlinelibrary.wiley.com/doi/10.1111/... @martingarlovsky.bsky.social @oscarvedder.bsky.social
Experimental Evidence That Prenatal and Postnatal Developmental Stress Affects the Adult Seminal Fluid Proteome in a Precocial Bird
Seminal fluid proteins are important modulators of male fertility and reproductive success, yet little is known about how their abundance responds to early-life developmental stress. Japanese quail C...
onlinelibrary.wiley.com
February 1, 2026 at 10:06 AM
How does pre- and post-natal environmental stress affect the seminal foam proteome of Japanese quail? Find out here, Chloe Mason’s second PhD thesis paper: onlinelibrary.wiley.com/doi/10.1111/... @martingarlovsky.bsky.social @oscarvedder.bsky.social
Reposted by Alexei Maklakov
The bots populating Moltbook apparently all come to sound like a familiar kind of internet denizen with delusions of philosophical grandeur. Manifestos and declarations all over the place.
Somebody created an Reddit clone exclusively populated by personal digital agents and let them interact with each other. It’s bonkers, fascinating and terrifying in equal measure.
www.forbes.com/sites/amirhu...
www.forbes.com/sites/amirhu...
An Agent Revolt: Moltbook Is Not A Good Idea
OpenClaw is a breakthrough AI assistant. Moltbook, its new social network for agents, is a security catastrophe waiting to happen. Here's why you should avoid it.
www.forbes.com
January 31, 2026 at 1:01 PM
The bots populating Moltbook apparently all come to sound like a familiar kind of internet denizen with delusions of philosophical grandeur. Manifestos and declarations all over the place.
Reposted by Alexei Maklakov
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
www.science.org/doi/10.1126/...
@science.org @idikic.bsky.social @goetheuni.bsky.social
www.science.org/doi/10.1126/...
@science.org @idikic.bsky.social @goetheuni.bsky.social
January 29, 2026 at 10:38 PM
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
www.science.org/doi/10.1126/...
@science.org @idikic.bsky.social @goetheuni.bsky.social
www.science.org/doi/10.1126/...
@science.org @idikic.bsky.social @goetheuni.bsky.social
Reposted by Alexei Maklakov
The largest randomized trial of medical A.I.
—Over 100,000 women in Sweden
—radiologist + AI vs 2 radiologists, in follow-up
—AI added led to 29% more cancer detected, 44% reduced workload, and
—Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lan...
—Over 100,000 women in Sweden
—radiologist + AI vs 2 radiologists, in follow-up
—AI added led to 29% more cancer detected, 44% reduced workload, and
—Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lan...
January 29, 2026 at 11:47 PM
The largest randomized trial of medical A.I.
—Over 100,000 women in Sweden
—radiologist + AI vs 2 radiologists, in follow-up
—AI added led to 29% more cancer detected, 44% reduced workload, and
—Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lan...
—Over 100,000 women in Sweden
—radiologist + AI vs 2 radiologists, in follow-up
—AI added led to 29% more cancer detected, 44% reduced workload, and
—Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lan...
Reposted by Alexei Maklakov
🆕 @science.org
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
January 29, 2026 at 7:04 PM
🆕 @science.org
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...
Reposted by Alexei Maklakov
Thanks to some great comments and suggestions, we've updated TADA!
Read it here: ecoevorxiv.org/repository/v...
Transferable, Available, Documented, Annotated.
Read it here: ecoevorxiv.org/repository/v...
Transferable, Available, Documented, Annotated.
January 28, 2026 at 8:20 AM
Thanks to some great comments and suggestions, we've updated TADA!
Read it here: ecoevorxiv.org/repository/v...
Transferable, Available, Documented, Annotated.
Read it here: ecoevorxiv.org/repository/v...
Transferable, Available, Documented, Annotated.
Reposted by Alexei Maklakov
🎉New preprint!
"TADA! Simple guidelines to improve code sharing"
tinyurl.com/8rmnwjrk
We present simple guidelines to help researchers of all coding levels improve the transparency and reproducibility of their analytical code, TADA!
Transferable, Accessible, Documented, Annotated.
"TADA! Simple guidelines to improve code sharing"
tinyurl.com/8rmnwjrk
We present simple guidelines to help researchers of all coding levels improve the transparency and reproducibility of their analytical code, TADA!
Transferable, Accessible, Documented, Annotated.
TADA! Simple guidelines to improve code sharing
ecoevorxiv.org
August 2, 2025 at 5:05 PM
🎉New preprint!
"TADA! Simple guidelines to improve code sharing"
tinyurl.com/8rmnwjrk
We present simple guidelines to help researchers of all coding levels improve the transparency and reproducibility of their analytical code, TADA!
Transferable, Accessible, Documented, Annotated.
"TADA! Simple guidelines to improve code sharing"
tinyurl.com/8rmnwjrk
We present simple guidelines to help researchers of all coding levels improve the transparency and reproducibility of their analytical code, TADA!
Transferable, Accessible, Documented, Annotated.
Reposted by Alexei Maklakov
Friends! I am so happy to share our new preprint!
Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago.
How do animals like C. elegans sense it fast and escape?
www.biorxiv.org/content/10.6...
Thread 1/
Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago.
How do animals like C. elegans sense it fast and escape?
www.biorxiv.org/content/10.6...
Thread 1/
January 28, 2026 at 3:13 PM
Friends! I am so happy to share our new preprint!
Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago.
How do animals like C. elegans sense it fast and escape?
www.biorxiv.org/content/10.6...
Thread 1/
Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago.
How do animals like C. elegans sense it fast and escape?
www.biorxiv.org/content/10.6...
Thread 1/
Reposted by Alexei Maklakov
Just renewed my membership for the 5th year with @sortee.bsky.social.
A fantastic organisation to be a part of. If you want to become a member and are interested in open, reliable, and transparent EcoEvo, it’s worth joining!
sortee.org/join/
A fantastic organisation to be a part of. If you want to become a member and are interested in open, reliable, and transparent EcoEvo, it’s worth joining!
sortee.org/join/
Join
Join Society for Open, Reliable, and Transparent Ecology and Evolutionary biology (SORTEE)
sortee.org
January 23, 2026 at 8:48 AM
Just renewed my membership for the 5th year with @sortee.bsky.social.
A fantastic organisation to be a part of. If you want to become a member and are interested in open, reliable, and transparent EcoEvo, it’s worth joining!
sortee.org/join/
A fantastic organisation to be a part of. If you want to become a member and are interested in open, reliable, and transparent EcoEvo, it’s worth joining!
sortee.org/join/
Reposted by Alexei Maklakov
Finding an em dash in the rejection email
January 22, 2026 at 5:52 PM
Finding an em dash in the rejection email
Reposted by Alexei Maklakov
Why do some worms graze on bacteria while others hunt and kill?
Our study, published today in Nature, reveals how predatory aggression evolved in nematodes.
Led by @gunizgozeeren.bsky.social and @leoboeger.bsky.social across the @jameslightfoot.bsky.social and @monikakscholz.bsky.social labs.
Our study, published today in Nature, reveals how predatory aggression evolved in nematodes.
Led by @gunizgozeeren.bsky.social and @leoboeger.bsky.social across the @jameslightfoot.bsky.social and @monikakscholz.bsky.social labs.
Predatory aggression evolved through adaptations to noradrenergic circuits - Nature
Noradrenergic circuits support and balance aggressive behavioural states in predatory nematodes, distinguish predatory from non-predatory nematode species and are associated with the evolution of comp...
www.nature.com
January 21, 2026 at 4:31 PM
Why do some worms graze on bacteria while others hunt and kill?
Our study, published today in Nature, reveals how predatory aggression evolved in nematodes.
Led by @gunizgozeeren.bsky.social and @leoboeger.bsky.social across the @jameslightfoot.bsky.social and @monikakscholz.bsky.social labs.
Our study, published today in Nature, reveals how predatory aggression evolved in nematodes.
Led by @gunizgozeeren.bsky.social and @leoboeger.bsky.social across the @jameslightfoot.bsky.social and @monikakscholz.bsky.social labs.
Reposted by Alexei Maklakov
Nature research paper: Disease tolerance and infection pathogenesis age-related tradeoffs in mice
go.nature.com/4pBODwV
go.nature.com/4pBODwV
Disease tolerance and infection pathogenesis age-related tradeoffs in mice - Nature
Disease course and pathology an infection may cause can change owing to the structural and functional physiological changes that accumulate with age, but therapy can be tailored accordingly; disease tolerance genes show antagonistic pleiotropy.
go.nature.com
January 19, 2026 at 6:36 PM
Nature research paper: Disease tolerance and infection pathogenesis age-related tradeoffs in mice
go.nature.com/4pBODwV
go.nature.com/4pBODwV
Reposted by Alexei Maklakov
Hot off the press! New paper in Biology Letters (@royalsocietypublishing.org) showing that heatwaves impair female but not male fertility in burying beetles 🐞🌡️
Huge congratulations to Izzy (@izzygrieve.bsky.social) on her first first-authored paper! 🥳🙌
royalsocietypublishing.org/rsbl/article...
Huge congratulations to Izzy (@izzygrieve.bsky.social) on her first first-authored paper! 🥳🙌
royalsocietypublishing.org/rsbl/article...
January 19, 2026 at 2:02 PM
Hot off the press! New paper in Biology Letters (@royalsocietypublishing.org) showing that heatwaves impair female but not male fertility in burying beetles 🐞🌡️
Huge congratulations to Izzy (@izzygrieve.bsky.social) on her first first-authored paper! 🥳🙌
royalsocietypublishing.org/rsbl/article...
Huge congratulations to Izzy (@izzygrieve.bsky.social) on her first first-authored paper! 🥳🙌
royalsocietypublishing.org/rsbl/article...
Reposted by Alexei Maklakov
Meet Veronika, the tool-using cow. Veronika uses sticks to scratch herself, using different orientations and motions, an example of multi-purpose tool use. This suggests scientists may have underestimated cows' cognitive abilities. arstechnica.com/science/2026...
Meet Veronika, the tool-using cow
Veronika uses sticks to scratch herself, suggesting scientists have underestimated cow cognition...
arstechnica.com
January 19, 2026 at 4:51 PM
Meet Veronika, the tool-using cow. Veronika uses sticks to scratch herself, using different orientations and motions, an example of multi-purpose tool use. This suggests scientists may have underestimated cows' cognitive abilities. arstechnica.com/science/2026...
Reposted by Alexei Maklakov
Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line
Early life stresses impact reproductive outcomes in many organisms. In response to crowding and starvation, C. elegans nematodes form dauer larvae, in which development arrests until conditions improv...
journals.biologists.com
January 18, 2026 at 9:44 PM
Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted by Alexei Maklakov
The (Yoav) Voichek lab has opened its gates at the Weizmann Institute, and is actively recruiting students and researchers at all levels - come explore gene regulation and computational genomics in a fun, friendly sprouting lab 🤗🥼⚗️🧪
www.weizmann.ac.il/plants/voichek
www.weizmann.ac.il/plants/voichek
January 11, 2026 at 8:41 PM
The (Yoav) Voichek lab has opened its gates at the Weizmann Institute, and is actively recruiting students and researchers at all levels - come explore gene regulation and computational genomics in a fun, friendly sprouting lab 🤗🥼⚗️🧪
www.weizmann.ac.il/plants/voichek
www.weizmann.ac.il/plants/voichek
Reposted by Alexei Maklakov
Hoping the pivotal finding of increased inflammation with #LongCovid will be responsive to tirzepatide (Zepbound) in our ongoing 1,000+ participant randomized, placebo-controlled trial (full enrollment completed in <1 month!)
www.nature.com/articles/s41... @natimmunol.nature.com
www.nature.com/articles/s41... @natimmunol.nature.com
Long COVID involves activation of proinflammatory and immune exhaustion pathways - Nature Immunology
Long COVID (LC) involves a spectrum of chronic symptoms after resolution of acute severe acute respiratory syndrome coronavirus 2 infection. Barouch and colleagues show that LC is characterized by per...
www.nature.com
January 4, 2026 at 5:16 PM
Hoping the pivotal finding of increased inflammation with #LongCovid will be responsive to tirzepatide (Zepbound) in our ongoing 1,000+ participant randomized, placebo-controlled trial (full enrollment completed in <1 month!)
www.nature.com/articles/s41... @natimmunol.nature.com
www.nature.com/articles/s41... @natimmunol.nature.com
Reposted by Alexei Maklakov
A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine - Scientific Reports
Scientific Reports - A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
www.nature.com
December 28, 2025 at 8:19 PM
A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alexei Maklakov
Merry Christmas, Happy Holidays and a Peaceful New Year from everyone in the School of Biological Sciences.
Have a wonderful break. 🎄🥳
Have a wonderful break. 🎄🥳
December 23, 2025 at 10:27 AM
Merry Christmas, Happy Holidays and a Peaceful New Year from everyone in the School of Biological Sciences.
Have a wonderful break. 🎄🥳
Have a wonderful break. 🎄🥳
Reposted by Alexei Maklakov
The one validated intervention to slow aging and extend healthspan is not for sale.
It's exercise.
sciencedirect.com/science/arti...
It's exercise.
sciencedirect.com/science/arti...
December 20, 2025 at 6:22 PM
The one validated intervention to slow aging and extend healthspan is not for sale.
It's exercise.
sciencedirect.com/science/arti...
It's exercise.
sciencedirect.com/science/arti...
Excellent news!!!
UK to rejoin Erasmus student mobility programme from 2027.
The UK will rejoin the European Union’s flagship mobility programme for students in the 2027-28 academic year, the Cabinet Office has announced.
www.researchprofessionalnews.com/rr-news-uk-u...
The UK will rejoin the European Union’s flagship mobility programme for students in the 2027-28 academic year, the Cabinet Office has announced.
www.researchprofessionalnews.com/rr-news-uk-u...
UK to rejoin Erasmus+ student mobility programme from 2027 - Research Professional News
Fee for EU programme lowered as part of deal, as sector celebrates re-entry
www.researchprofessionalnews.com
December 17, 2025 at 1:05 PM
Excellent news!!!
Reposted by Alexei Maklakov
What tools do we need to start engineering #aging and #longevity ? A🧵about something we've been cooking up in lab with Jeremy Vicencio at the @crg.eu : technology that lets us reach inside living animals and precisely dial multiple proteins' levels up and down. 1/10
December 16, 2025 at 12:09 PM
What tools do we need to start engineering #aging and #longevity ? A🧵about something we've been cooking up in lab with Jeremy Vicencio at the @crg.eu : technology that lets us reach inside living animals and precisely dial multiple proteins' levels up and down. 1/10
Reposted by Alexei Maklakov
Please share 📢
We have a Postdoc position available here @uniofeastanglia.bsky.social to develop innovative genetic control strategies for insect agricultural pests in collaboration with @imperialcollegeldn.bsky.social
vacancies.uea.ac.uk/vacancies/19...
We have a Postdoc position available here @uniofeastanglia.bsky.social to develop innovative genetic control strategies for insect agricultural pests in collaboration with @imperialcollegeldn.bsky.social
vacancies.uea.ac.uk/vacancies/19...
December 15, 2025 at 9:35 AM
Please share 📢
We have a Postdoc position available here @uniofeastanglia.bsky.social to develop innovative genetic control strategies for insect agricultural pests in collaboration with @imperialcollegeldn.bsky.social
vacancies.uea.ac.uk/vacancies/19...
We have a Postdoc position available here @uniofeastanglia.bsky.social to develop innovative genetic control strategies for insect agricultural pests in collaboration with @imperialcollegeldn.bsky.social
vacancies.uea.ac.uk/vacancies/19...