Jamie Cate
@jhdcate.bsky.social
Ribosomes and RNA language models.
Professor at UC Berkeley.
https://sites.google.com/berkeley.edu/cate-lab/home
Professor at UC Berkeley.
https://sites.google.com/berkeley.edu/cate-lab/home
Pinned
Jamie Cate
@jhdcate.bsky.social
· Nov 10
RNA language models predict mutations that improve RNA function
Structured RNA lies at the heart of many central biological processes, from gene expression to catalysis. While advances in deep learning enable the prediction of accurate protein structural models, R...
doi.org
RNA language models and ribosome engineering. Built from a hackathon sponsored by @innovativegenomics.bsky.social with @cgemcci.bsky.social. What a great experience!
doi.org/10.1101/2024...
doi.org/10.1101/2024...
Reposted by Jamie Cate
“The Constitution was meant, in other words, to be a bulwark against corruption of the system and thus of the people. It is obviously not working.”
@jamellebouie.net is absolutely right. Our Constitutional order has broken down. We can’t pretend otherwise and we have to start by realizing it.
@jamellebouie.net is absolutely right. Our Constitutional order has broken down. We can’t pretend otherwise and we have to start by realizing it.
Opinion | The White House Gold Rush Is On
www.nytimes.com
November 19, 2025 at 1:12 PM
“The Constitution was meant, in other words, to be a bulwark against corruption of the system and thus of the people. It is obviously not working.”
@jamellebouie.net is absolutely right. Our Constitutional order has broken down. We can’t pretend otherwise and we have to start by realizing it.
@jamellebouie.net is absolutely right. Our Constitutional order has broken down. We can’t pretend otherwise and we have to start by realizing it.
Reposted by Jamie Cate
"We can no longer trust that survey responses are coming from real people" www.404media.co/a-researcher...
A Researcher Made an AI That Completely Breaks the Online Surveys Scientists Rely On
We can no longer trust that survey responses are coming from real people.”
www.404media.co
November 19, 2025 at 12:47 PM
"We can no longer trust that survey responses are coming from real people" www.404media.co/a-researcher...
Reposted by Jamie Cate
I spoke with the Boston Globe about the Summers situation
TLDR: other professors like myself can no longer trust Summers to perform a key duty of a university professor, which is to advise & mentor students
www.bostonglobe.com/2025/11/18/m...
TLDR: other professors like myself can no longer trust Summers to perform a key duty of a university professor, which is to advise & mentor students
www.bostonglobe.com/2025/11/18/m...
Long a coveted voice, Larry Summers withdraws from a half-dozen groups amid Epstein ties. Harvard’s not among them. - The Boston Globe
Former Harvard president Larry Summers is no longer affiliated with a series of centers and think tanks with which he’s long been involved, officials confirmed Tuesday.
www.bostonglobe.com
November 19, 2025 at 2:01 PM
I spoke with the Boston Globe about the Summers situation
TLDR: other professors like myself can no longer trust Summers to perform a key duty of a university professor, which is to advise & mentor students
www.bostonglobe.com/2025/11/18/m...
TLDR: other professors like myself can no longer trust Summers to perform a key duty of a university professor, which is to advise & mentor students
www.bostonglobe.com/2025/11/18/m...
Reposted by Jamie Cate
Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 18, 2025 at 10:43 PM
Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jamie Cate
WE JUST KEEP WINNING. (UC President's Postdoctoral Fellowship Program RESTORED!!!!)
![On official UC letterhead:
UNIVERSITY
OF
CALIFORNIA
James B. Milliken President
Office of the President
1111 Franklin Street Oakland, CA 94607
universityofcalifornia.edu
CAMPUSES Berkeley
Davis
Irvine
UCLA
Merced
Riverside San Diego San Francisco
Santa Barbara Santa Cruz
MEDICAL CENTERS
Davis
Irvine
UCLA
San Diego
San Francisco
NATIONAL LABORATORIES Lawrence Berkeley Lawrence Livermore Los Alamos
DIVISION OF AGRICULTURE AND NATURAL RESOURCES
November 18, 2025
Dear Chancellors:
I'm writing with regard to the President's Postdoctoral Fellowship Program (PPFP) and the program's associated faculty hiring incentive.
As you know, for more than 40 years, PPFP has provided postdoctoral research fellowships, professional development, and faculty mentoring to scholars in all fields whose research, teaching, and service advance the academic and research missions of the University of California.
Since 2003, UC campuses that hire current and former PPFP fellows into ladder-rank positions have been eligible for a hiring incentive funded by the University that provides support for newly hired fellows for five years. Since the creation of the incentive, more than $162 million has been invested by the University to support PPFP faculty hires. This commitment has enabled our campuses to successfully recruit and retain outstanding faculty across a range of disciplines.
Given the myriad challenges currently facing UC - including disruptions to billions of dollars in annual federal support, as well as uncertainty around the state budget- reasonable questions were raised in recent months about whether the University could maintain the commitment to current levels of incentive funding. After considering a recommendation to sunset the incentive program due to these significant fiscal constraints, I consulted with all of you as well as faculty and campus academic administrators and systemwide Academic Senate leadership.
[continued on next image]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:rzn6yramffebefeitqifiqqz/bafkreigiwq5ongzwpj4wqmgjam3yfvhyjnv5e3dbq6cnrrbwblqvs624gq@jpeg)
November 18, 2025 at 10:34 PM
WE JUST KEEP WINNING. (UC President's Postdoctoral Fellowship Program RESTORED!!!!)
Reposted by Jamie Cate
Our latest paper is out with @adiop.bsky.social and @gmdouglas.bsky.social. We analyzed the extent of homologous recombination between bacterial species (introgression) and how it affects species borders (it can vary a lot depending on the approach used to classify species!). rdcu.be/eQAMf
Introgression impacts the evolution of bacteria, but species borders are rarely fuzzy
Nature Communications - It is commonly thought that bacterial species borders tend to be fuzzy, due to frequent exchange of DNA. Here, Diop et al. quantify the patterns of gene flow between core...
rdcu.be
November 18, 2025 at 9:01 PM
Our latest paper is out with @adiop.bsky.social and @gmdouglas.bsky.social. We analyzed the extent of homologous recombination between bacterial species (introgression) and how it affects species borders (it can vary a lot depending on the approach used to classify species!). rdcu.be/eQAMf
Reposted by Jamie Cate
We are thrilled to announce our latest publication in the Microbiome journal in collaboration with
@thehesslab.bsky.social
Supplementation with red seaweed in cows reduces methane and induces previously uncharacterized hydrogenotropic bacteria.
microbiomejournal.biomedcentral.com/articles/10....
@thehesslab.bsky.social
Supplementation with red seaweed in cows reduces methane and induces previously uncharacterized hydrogenotropic bacteria.
microbiomejournal.biomedcentral.com/articles/10....
Red seaweed supplementation suppresses methanogenesis in the rumen, revealing potentially advantageous traits among hydrogenotrophic bacteria - Microbiome
Background Macroalgae belonging to the genus Asparagopsis have shown to reduce methane (CH4) production during rumen fermentation, while increasing feed efficiency when added to the feed of cattle. Ho...
microbiomejournal.biomedcentral.com
November 19, 2025 at 12:09 AM
We are thrilled to announce our latest publication in the Microbiome journal in collaboration with
@thehesslab.bsky.social
Supplementation with red seaweed in cows reduces methane and induces previously uncharacterized hydrogenotropic bacteria.
microbiomejournal.biomedcentral.com/articles/10....
@thehesslab.bsky.social
Supplementation with red seaweed in cows reduces methane and induces previously uncharacterized hydrogenotropic bacteria.
microbiomejournal.biomedcentral.com/articles/10....
Reposted by Jamie Cate
An absolute disgrace that @ox.ac.uk hosted this celebration of murdering a journalist.
See also Curtis Yarvin's remarks in a recent Oxford lecture:
"Say what you want about MBS, he's quite an effective king I think in a lot of different ways. Um love the Ritz thing, the whole Saudi embassy thing, I don't know, but I mean he was a journalist". [Giggles]
www.youtube.com/watch?v=zXYl...
"Say what you want about MBS, he's quite an effective king I think in a lot of different ways. Um love the Ritz thing, the whole Saudi embassy thing, I don't know, but I mean he was a journalist". [Giggles]
www.youtube.com/watch?v=zXYl...
November 18, 2025 at 10:34 PM
An absolute disgrace that @ox.ac.uk hosted this celebration of murdering a journalist.
Reposted by Jamie Cate
/4 Anyway, the notion we should be surprised when big corporations do overtly corrupt things is quaint, because megacorps do not acknowledge or understand things like moral or civic responsibility or good citizenship.
November 18, 2025 at 9:32 PM
/4 Anyway, the notion we should be surprised when big corporations do overtly corrupt things is quaint, because megacorps do not acknowledge or understand things like moral or civic responsibility or good citizenship.
Excited about Kolya Aleksashin's new work, enabling preparation of active in vitro translation systems from primary human cells and difficult-to-edit cells (fibroblasts and cardiomyocytes). This opens new opportunities to probe mechanisms of translation regulation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Overcoming the eIF2α Brake in Human Cell-Derived Translation Systems
Cell-free translation from human cells is a powerful platform for studying mammalian gene expression and building synthetic biology tools, but productivity is often curtailed by inhibitory phosphoryla...
www.biorxiv.org
November 18, 2025 at 6:29 PM
Excited about Kolya Aleksashin's new work, enabling preparation of active in vitro translation systems from primary human cells and difficult-to-edit cells (fibroblasts and cardiomyocytes). This opens new opportunities to probe mechanisms of translation regulation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jamie Cate
Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals.
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
November 18, 2025 at 8:56 AM
Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals.
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
Reposted by Jamie Cate
The fight has come to NC, and it just hit close to home. Our daughter teaches in Durham public schools and she said almost all of the Latinx kids are not in school today. ICE is targeting everyone who "looks Hispanic", citizen or not. I am even more angry today-kids need to go to school!
November 18, 2025 at 4:34 PM
The fight has come to NC, and it just hit close to home. Our daughter teaches in Durham public schools and she said almost all of the Latinx kids are not in school today. ICE is targeting everyone who "looks Hispanic", citizen or not. I am even more angry today-kids need to go to school!
Reposted by Jamie Cate
“Time and again, these agents — and the broader DHS and White House policies behind it — are being exposed not for their strength, but their weakness. Ordinary Americas are stronger — braver and better.”
Must read (and subscribe) from @vermontgmg.bsky.social:
www.doomsdayscenario.co/p/trump-bord...
Must read (and subscribe) from @vermontgmg.bsky.social:
www.doomsdayscenario.co/p/trump-bord...
Trump, Border Patrol Retreat in Failure from Chicago
Five important lessons of the first six months of Trump’s immigration raids — and why CBP’s Greg Bovino is the Nathan Bedford Forrest of the Trump era.
www.doomsdayscenario.co
November 18, 2025 at 2:01 PM
“Time and again, these agents — and the broader DHS and White House policies behind it — are being exposed not for their strength, but their weakness. Ordinary Americas are stronger — braver and better.”
Must read (and subscribe) from @vermontgmg.bsky.social:
www.doomsdayscenario.co/p/trump-bord...
Must read (and subscribe) from @vermontgmg.bsky.social:
www.doomsdayscenario.co/p/trump-bord...
Reposted by Jamie Cate
Europe's electricity system is changing rapidly and often in places that don't make the headlines.
Look at Estonia - not that long ago and fossil fuels dominated around 90% of electricity generation.
Today solar and wind eat more and more into the share of fossil fuel-generated electricity.
Look at Estonia - not that long ago and fossil fuels dominated around 90% of electricity generation.
Today solar and wind eat more and more into the share of fossil fuel-generated electricity.
November 18, 2025 at 2:32 PM
Europe's electricity system is changing rapidly and often in places that don't make the headlines.
Look at Estonia - not that long ago and fossil fuels dominated around 90% of electricity generation.
Today solar and wind eat more and more into the share of fossil fuel-generated electricity.
Look at Estonia - not that long ago and fossil fuels dominated around 90% of electricity generation.
Today solar and wind eat more and more into the share of fossil fuel-generated electricity.
Reposted by Jamie Cate
A consistent theme of the current era is that if you appoint unqualified people to do important jobs so they will follow your orders, they may do what they are told to do, but they will also be very bad at those very important jobs.
BREAKING: Magistrate orders DOJ to turn over grand jury materials to Comey, finding real prospect that "government misconduct" may have tainted the case.
November 17, 2025 at 4:54 PM
A consistent theme of the current era is that if you appoint unqualified people to do important jobs so they will follow your orders, they may do what they are told to do, but they will also be very bad at those very important jobs.
Reposted by Jamie Cate
i'd say it did. the public put a group of thieves, vandals and extremists in office last november and they promptly went about destroying everything that might work to limit their ability to loot, steal and inflicting pain on the people they hate
This whole NYT account about the weaponization of DOJ is beyond disturbing. Kinda feels like the US government fell in January.
Gift link: www.nytimes.com/interactive/...
Gift link: www.nytimes.com/interactive/...
November 17, 2025 at 2:19 PM
i'd say it did. the public put a group of thieves, vandals and extremists in office last november and they promptly went about destroying everything that might work to limit their ability to loot, steal and inflicting pain on the people they hate
Reposted by Jamie Cate
periodic reminder of the existence of Atkinson Hyperlegible, a free font available from the Braille Institute designed to improve readability for people with low vision
I use it in talks because it's pretty and also because, as an audience member, I am perpetually squinting at people's slides
I use it in talks because it's pretty and also because, as an audience member, I am perpetually squinting at people's slides
Atkinson Hyperlegible Font - Braille Institute
Read easier with Atkinson Hyperlegible Font, crafted for low-vision readers. Download for free and enjoy clear letters and numbers on your computer!
www.brailleinstitute.org
November 17, 2025 at 4:19 AM
periodic reminder of the existence of Atkinson Hyperlegible, a free font available from the Braille Institute designed to improve readability for people with low vision
I use it in talks because it's pretty and also because, as an audience member, I am perpetually squinting at people's slides
I use it in talks because it's pretty and also because, as an audience member, I am perpetually squinting at people's slides
Reposted by Jamie Cate
This subject came up in the Nobel Minds broadcast (2022) during the conversation at 25:50, note economics Laureate Ben Bernanke’s “puzzlement” as to Why, and the audience’s response to the entire exchange.
youtu.be/LutI8YqJkqM?...
youtu.be/LutI8YqJkqM?...
November 17, 2025 at 6:31 AM
This subject came up in the Nobel Minds broadcast (2022) during the conversation at 25:50, note economics Laureate Ben Bernanke’s “puzzlement” as to Why, and the audience’s response to the entire exchange.
youtu.be/LutI8YqJkqM?...
youtu.be/LutI8YqJkqM?...
Reposted by Jamie Cate
Reposted by Jamie Cate
Plausible that Trump’s policy of mass deportations will not just end a “temporary shift” among Hispanic voters but also lead to a more durable U-turn. In California, the 1994 “anti-immigrant ballot measure Prop 187 marked the death knell of the Republican Party.” calmatters.org/commentary/2...
The New Jersey governor’s race is the first significant sign that Trump’s success with Hispanic voters in 2024 may have been a temporary shift.
Via @christinezhang.bsky.social and @shanegoldmacher.bsky.social
www.nytimes.com/2025/11/15/u...
Via @christinezhang.bsky.social and @shanegoldmacher.bsky.social
www.nytimes.com/2025/11/15/u...
Maps Show How Latinos Who Shifted Right in 2024 Snapped Back Left in 2025
www.nytimes.com
November 15, 2025 at 3:38 PM
Plausible that Trump’s policy of mass deportations will not just end a “temporary shift” among Hispanic voters but also lead to a more durable U-turn. In California, the 1994 “anti-immigrant ballot measure Prop 187 marked the death knell of the Republican Party.” calmatters.org/commentary/2...
Reposted by Jamie Cate
NEW: Epstein survivors release the most powerful PSA I have ever seen.
Make this go viral so every member of the House of Representatives sees it.
Make this go viral so every member of the House of Representatives sees it.
November 16, 2025 at 11:43 PM
NEW: Epstein survivors release the most powerful PSA I have ever seen.
Make this go viral so every member of the House of Representatives sees it.
Make this go viral so every member of the House of Representatives sees it.
Reposted by Jamie Cate
i want to put this in front of conservative pundits who defended this raid bsky.app/profile/raws...
Homeland Security Secretary Kristi Noem should resign and be criminally charged, according to critics who seized on a report revealing that zero people who were arrested in a high-profile raid were charged with a crime.
'Noem should resign over this': Fury over alleged DHS 'child kidnapping and trafficking'
Homeland Security Secretary Kristi Noem should resign and be criminally charged, according to critics who seized on a report revealing that zero people who were arrested in a high-profile raid were charged with a crime.ProPublica recently reported on the DHS raid on an apartment building that was al...
bit.ly
November 16, 2025 at 5:05 PM
i want to put this in front of conservative pundits who defended this raid bsky.app/profile/raws...
Reposted by Jamie Cate
matt yglesias' primary claim about politics is that to win elections, democrats should adopt the strategy which has given starmer a 13% approval rating in the UK
November 16, 2025 at 8:26 PM
matt yglesias' primary claim about politics is that to win elections, democrats should adopt the strategy which has given starmer a 13% approval rating in the UK
Reposted by Jamie Cate
We miss the pedo club, says the NYT
November 16, 2025 at 5:00 PM
We miss the pedo club, says the NYT
Reposted by Jamie Cate
In 2024, renewable energy accounted for over 90% of global power capacity expansion. That is because it makes economic sense. IRENA_DAT_RE_Capacity_Highlights_2025-1.pdf
November 16, 2025 at 11:22 AM
In 2024, renewable energy accounted for over 90% of global power capacity expansion. That is because it makes economic sense. IRENA_DAT_RE_Capacity_Highlights_2025-1.pdf