Valentin Jaumouillé
@jaumouillelab.bsky.social
Exploring the mechanobiology of phagocytes. Assistant prof at SFU.
@mmorrissey.bsky.social's lab is on 🔥
Miller, @mmorrissey.bsky.social et al. demonstrate that the CD47 signaling pathway prevents #phagocytosis through dephosphorylation of the Rac GEF Vav. Cancer cells & synthetic targets with CD47 can still be phagocytosed less efficiently through a Rho-dependent mechanism. rupress.org/jcb/article/...
October 17, 2025 at 3:28 PM
@mmorrissey.bsky.social's lab is on 🔥
Another awesome paper from @mmorrissey.bsky.social lab!
Target cell adhesion limits macrophage #phagocytosis and promotes #trogocytosis, say @kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al.
@ucsantabarbara.bsky.social rupress.org/jcb/article/...
#Macrophages #Immunology
@ucsantabarbara.bsky.social rupress.org/jcb/article/...
#Macrophages #Immunology
October 11, 2025 at 12:35 AM
Another awesome paper from @mmorrissey.bsky.social lab!
Reposted by Valentin Jaumouillé
We look forward to hearing feedback from the community on our #preprint where we used #NETosis as a platform to show that chromatin decompaction inside the nucleus directly regulates cell mechanics. This work identifies long-range biophysical impacts of chromatin in mammalian cells.
Chromatin is a long-range force generator that regulates plasma membrane tension and cell integrity independently of gene expression https://www.biorxiv.org/content/10.1101/2025.10.02.680155v1
October 6, 2025 at 10:18 AM
Really excited about this! Lucy Shapiro pioneered research on the cell biology of bacteria and was a huge inspiration for my PhD project.
September 12, 2025 at 12:48 AM
Really excited about this! Lucy Shapiro pioneered research on the cell biology of bacteria and was a huge inspiration for my PhD project.
Reposted by Valentin Jaumouillé
Our paper on podosome regulation by myosins 1e/f is now online.
We introduce the concept of the podosome base, a region of plasma membrane-associated components 🔬
Cool collaboration with @renaudpoincloux.bsky.social and Krendel labs
www.sciencedirect.com/science/arti...
We introduce the concept of the podosome base, a region of plasma membrane-associated components 🔬
Cool collaboration with @renaudpoincloux.bsky.social and Krendel labs
www.sciencedirect.com/science/arti...
September 2, 2025 at 7:48 AM
Our paper on podosome regulation by myosins 1e/f is now online.
We introduce the concept of the podosome base, a region of plasma membrane-associated components 🔬
Cool collaboration with @renaudpoincloux.bsky.social and Krendel labs
www.sciencedirect.com/science/arti...
We introduce the concept of the podosome base, a region of plasma membrane-associated components 🔬
Cool collaboration with @renaudpoincloux.bsky.social and Krendel labs
www.sciencedirect.com/science/arti...
If you're interested in biophysics in the context of infection and immunity, we're looking forward to seeing you at the ASCB/EMBO meeting.
Thrilled to organize the “Physical Cell Biology of Immunity & Infection” subgroup at Cell Bio 2025 – ASCB/EMBO with @hawa-racine.bsky.social, @jaumouillelab.bsky.social, Marcus Taylor & Shalini Low-Nam. Seeking exciting interdisciplinary speakers! Abstract deadline: Sept 3 www.ascb.org/cellbio2025
Cell Bio 2023-An ASCB|EMBO Meeting
Network, learn, and collaborate with top cell biologists from around the globe.
www.ascb.org
August 18, 2025 at 3:55 PM
If you're interested in biophysics in the context of infection and immunity, we're looking forward to seeing you at the ASCB/EMBO meeting.
Reposted by Valentin Jaumouillé
Why would anyone want to be a scientist?
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
August 15, 2025 at 1:19 PM
Why would anyone want to be a scientist?
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
Reposted by Valentin Jaumouillé
Comment on our @Reproducibility project in @Drosophila immunity. It is a normal that findings—however exciting and important at the time—may later prove to be more complex than initially believed. Re-evaluations is essential to the self-correcting nature of science. www.science.org/content/arti...
Majority of fruit fly immunity studies can be replicated, huge analysis finds
Verification of 50 years of data bolsters immunology research, but identifies “suspicious” papers that don’t hold up
www.science.org
July 16, 2025 at 8:01 AM
Comment on our @Reproducibility project in @Drosophila immunity. It is a normal that findings—however exciting and important at the time—may later prove to be more complex than initially believed. Re-evaluations is essential to the self-correcting nature of science. www.science.org/content/arti...
Reposted by Valentin Jaumouillé
Congratulations to #SFU Molecular Biology and Biochemistry distinguished professor Fiona Brinkman who has received a @genomebc.bsky.social Award for Scientific Excellence from Life Sciences BC! www.sfu.ca/science/news...
July 10, 2025 at 9:38 PM
Congratulations to #SFU Molecular Biology and Biochemistry distinguished professor Fiona Brinkman who has received a @genomebc.bsky.social Award for Scientific Excellence from Life Sciences BC! www.sfu.ca/science/news...
Reposted by Valentin Jaumouillé
SFU invites applications from world renowned researchers for the prestigious Canada Excellence Research Chairs (CERC) 2026 Competition. Please see the ad to see if you qualify. In Vancouver, BC
www.sfu.ca/vpacademic/a...
www.sfu.ca/vpacademic/a...
Canada Excellence Research Chairs (CERC) 2026 Competition
www.sfu.ca
May 28, 2025 at 4:18 AM
SFU invites applications from world renowned researchers for the prestigious Canada Excellence Research Chairs (CERC) 2026 Competition. Please see the ad to see if you qualify. In Vancouver, BC
www.sfu.ca/vpacademic/a...
www.sfu.ca/vpacademic/a...
Reposted by Valentin Jaumouillé
Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!
Read more at:
www.nature.com/articles/s41...
Read more at:
www.nature.com/articles/s41...
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells - Nature Cell Biology
Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadop...
www.nature.com
May 26, 2025 at 12:16 PM
Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation!
Read more at:
www.nature.com/articles/s41...
Read more at:
www.nature.com/articles/s41...
Somehow, I only started to realize this while I became a faculty member. Although, I wonder whether having a better awareness of these challenges would have been discouraging.
New study from the Women in Supramolecular Chemistry (WISC) revealing the unique challenges resulting from being First Gen (first generation of a family to access Higher Education) in science and showing how these persist at every stage of a career in academia:
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Being a first generation university graduate, the impact on a career in science
Being in the first generation to access Higher Education (First Gen) is a barrier to academic success. First Gens face difficulties transitioning into, completing, and attaining competitive grades in ...
pubs.rsc.org
May 10, 2025 at 1:16 AM
Somehow, I only started to realize this while I became a faculty member. Although, I wonder whether having a better awareness of these challenges would have been discouraging.
Reposted by Valentin Jaumouillé
Excited to share our discovery www.science.org/doi/10.1126/...
that the #centrosome is prone to breakage!
Using #motile cells, we identify centrosome breakage during #pathfinding, caused by #actin #forces, & prevented by #Dyrk3
Kudos to 1st author Madeleine & thanks to all collaborators!
(1/6)
that the #centrosome is prone to breakage!
Using #motile cells, we identify centrosome breakage during #pathfinding, caused by #actin #forces, & prevented by #Dyrk3
Kudos to 1st author Madeleine & thanks to all collaborators!
(1/6)
April 28, 2025 at 11:51 AM
Excited to share our discovery www.science.org/doi/10.1126/...
that the #centrosome is prone to breakage!
Using #motile cells, we identify centrosome breakage during #pathfinding, caused by #actin #forces, & prevented by #Dyrk3
Kudos to 1st author Madeleine & thanks to all collaborators!
(1/6)
that the #centrosome is prone to breakage!
Using #motile cells, we identify centrosome breakage during #pathfinding, caused by #actin #forces, & prevented by #Dyrk3
Kudos to 1st author Madeleine & thanks to all collaborators!
(1/6)
Reposted by Valentin Jaumouillé
It used to be thought that T-cell priming occurred as single phase. Now we know it takes two.
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
@science.org
A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals
T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their diff...
www.science.org
April 10, 2025 at 6:30 PM
It used to be thought that T-cell priming occurred as single phase. Now we know it takes two.
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
@science.org
Reposted by Valentin Jaumouillé
We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.
The Coming Out of a Transgender Scientist
"I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."
thereader.mitpress.mit.edu
April 8, 2025 at 8:24 PM
We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.
Reposted by Valentin Jaumouillé
I knew there would be an effect! This has been one of the questions that I had for the longest time. Changing the mechanics of the substrate affects phagocytosis. Very interesting paper!
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
A crosstalk between adhesion and phagocytosis integrates macrophage functions into their microenvironment
Cell biology; Organizational aspects of cell biology; Specialized functions of cells;
Functional aspects of cell biology
www.cell.com
March 29, 2025 at 6:58 PM
I knew there would be an effect! This has been one of the questions that I had for the longest time. Changing the mechanics of the substrate affects phagocytosis. Very interesting paper!
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Reposted by Valentin Jaumouillé
Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A TRPV4–dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin–based lamellipodia protrusions...
www.biorxiv.org
March 30, 2025 at 11:41 AM
Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Valentin Jaumouillé
Our latest publication on #macrophages congrats Anna Mularski and @manondepierre.bsky.social @institutcochin.bsky.social @actin-paris-saclay.bsky.social Martial Balland @grenoblealpes.bsky.social
@cnrsbiologie.bsky.social cnrs physique @anr
@cnrsbiologie.bsky.social cnrs physique @anr
Comment les macrophages sont influencés par leur environnement ? 🧐
Une récente étude menée par @florenceniedergang.bsky.social révèle que leur interaction avec leur milieu joue un rôle clé dans leur activité immunitaire !
Une récente étude menée par @florenceniedergang.bsky.social révèle que leur interaction avec leur milieu joue un rôle clé dans leur activité immunitaire !
L’interaction entre les macrophages et leur milieu environnant affecte leur fonctionnement
Les macrophages sont des cellules du système immunitaire qui ingèrent et dégradent les microorganismes et les débris cellulaires selon un processus appe
buff.ly
March 28, 2025 at 6:44 PM
Our latest publication on #macrophages congrats Anna Mularski and @manondepierre.bsky.social @institutcochin.bsky.social @actin-paris-saclay.bsky.social Martial Balland @grenoblealpes.bsky.social
@cnrsbiologie.bsky.social cnrs physique @anr
@cnrsbiologie.bsky.social cnrs physique @anr
Reposted by Valentin Jaumouillé
Wu et al @sickkidsto.bsky.social show that Snx10 regulates PI(3,5)P2 accumulation on #lysosomes by controlling PI(3)P delivery. Deleting Snx10 inhibits ClC-7, thereby impairing (phago)lysosome resolution. This mechanism may account for Snx10-related #osteopetrosis. rupress.org/jcb/article/...
March 26, 2025 at 7:53 PM
Wu et al @sickkidsto.bsky.social show that Snx10 regulates PI(3,5)P2 accumulation on #lysosomes by controlling PI(3)P delivery. Deleting Snx10 inhibits ClC-7, thereby impairing (phago)lysosome resolution. This mechanism may account for Snx10-related #osteopetrosis. rupress.org/jcb/article/...
Reposted by Valentin Jaumouillé
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
March 21, 2025 at 4:18 PM
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
Reposted by Valentin Jaumouillé
On this day in 1879, Maud Menten was born in Port Lambton, Ontario.
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!
🧵1/10
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!
🧵1/10
March 20, 2025 at 6:01 PM
On this day in 1879, Maud Menten was born in Port Lambton, Ontario.
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!
🧵1/10
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!
🧵1/10
Reposted by Valentin Jaumouillé
Many thanks to the young immunologists of @yefis-immunology.bsky.social for this interview as part of their #WomeninSTEM 🧪 series!
Really enjoyed discussing ways to improve #gender #equality and all forms of #inclusion & #diversity - esp. important now 🙏
Interview 🎥
www.youtube.com/watch?v=4CRx...
Really enjoyed discussing ways to improve #gender #equality and all forms of #inclusion & #diversity - esp. important now 🙏
Interview 🎥
www.youtube.com/watch?v=4CRx...
yEFIS Women in Immunology: Interview with Professor Johanna Joyce
YouTube video by yEFIS
www.youtube.com
March 13, 2025 at 1:12 PM
Many thanks to the young immunologists of @yefis-immunology.bsky.social for this interview as part of their #WomeninSTEM 🧪 series!
Really enjoyed discussing ways to improve #gender #equality and all forms of #inclusion & #diversity - esp. important now 🙏
Interview 🎥
www.youtube.com/watch?v=4CRx...
Really enjoyed discussing ways to improve #gender #equality and all forms of #inclusion & #diversity - esp. important now 🙏
Interview 🎥
www.youtube.com/watch?v=4CRx...
Reposted by Valentin Jaumouillé
A hybrid microscope born at the MBL allows scientists to, for the first time, simultaneously image the full 3D orientation and position of an ensemble of molecules. @czbiohub.bsky.social @hhmi.org @hhmijanelia.bsky.social @pnas.org
More: www.mbl.edu/news/new-mic...
www.youtube.com/watch?v=-b3X...
More: www.mbl.edu/news/new-mic...
www.youtube.com/watch?v=-b3X...
Polarized dual-view light sheet microscopy
YouTube video by Marine Biological Laboratory
www.youtube.com
February 28, 2025 at 6:21 PM
A hybrid microscope born at the MBL allows scientists to, for the first time, simultaneously image the full 3D orientation and position of an ensemble of molecules. @czbiohub.bsky.social @hhmi.org @hhmijanelia.bsky.social @pnas.org
More: www.mbl.edu/news/new-mic...
www.youtube.com/watch?v=-b3X...
More: www.mbl.edu/news/new-mic...
www.youtube.com/watch?v=-b3X...
Reposted by Valentin Jaumouillé
Revisiting 'Women in cancer research & oncology' 🧪⚕️
Thanks to Cancer Cell & @montse-rojo.bsky.social for this article from International Women's Day in 2021
It was great to be part of this perspective - and it all still applies in 2025 - here some thoughts on how much our microenvironment matters!
Thanks to Cancer Cell & @montse-rojo.bsky.social for this article from International Women's Day in 2021
It was great to be part of this perspective - and it all still applies in 2025 - here some thoughts on how much our microenvironment matters!
March 8, 2025 at 3:13 PM
Revisiting 'Women in cancer research & oncology' 🧪⚕️
Thanks to Cancer Cell & @montse-rojo.bsky.social for this article from International Women's Day in 2021
It was great to be part of this perspective - and it all still applies in 2025 - here some thoughts on how much our microenvironment matters!
Thanks to Cancer Cell & @montse-rojo.bsky.social for this article from International Women's Day in 2021
It was great to be part of this perspective - and it all still applies in 2025 - here some thoughts on how much our microenvironment matters!
Reposted by Valentin Jaumouillé
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
February 27, 2025 at 3:54 PM
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....