Hamish Stewart
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hamishs.bsky.social
Hamish Stewart
@hamishs.bsky.social
270 followers 280 following 89 posts
Analyzer evangelist and mass spectrometry enjoyer. Read about the Astral analyzer:
https://pubs.acs.org/doi/10.1021/acs.analchem.3c02856
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hamishs.bsky.social
Our Orbitrap Astral Zoom mass spectrometer has won its first prize!

Nice little interview here with my teammate Johannes.
theanalyticalscientist.com/issues/2025/...
The Analytical Scientist Innovation Awards 2025: #2
Technical lead Johannes Petzoldt tells the story behind the development of Thermo’s Orbitrap Astral Zoom Mass Spectrometer
theanalyticalscientist.com
November 13, 2025 at 4:50 PM
Reposted by Hamish Stewart
pastelbio.bsky.social
Breaking barriers in crosslinking mass spectrometry with enhanced throughput and sensitivity using Orbitrap Astral www.nature.com/artic...

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#proteomics #prot-paper
November 11, 2025 at 6:40 PM
Reposted by Hamish Stewart
leecantrell.bsky.social
I'm excited to see this paper in press!

pubs.acs.org/doi/10.1021/...
Multiplexed Nanoparticle Protein Corona Enables Accurate and Precise Deep Plasma Proteomics
The Proteograph Product Suite, a multiplexed nanoparticle (NP) protein corona-based workflow, substantially improves the depth of detection of proteins by mass spectrometry (MS) by compressing the dyn...
pubs.acs.org
October 17, 2025 at 3:42 PM
Reposted by Hamish Stewart
baybioms.bsky.social
🧵(4/7)

🔬 We have put together a fascinating #Keynote #Speakers team:
• Prof. Albert Heck - @hecklab.bsky.social
• Dr. Hamish Stewart - @hamishs.bsky.social
• Prof. Olga Vitek - @olgavitek.bsky.social l
• Prof. Ron M.A. Heeren
October 15, 2025 at 5:18 AM
Reposted by Hamish Stewart
kmechtler.bsky.social
It is an honor to inform you that our manuscript with low resolution FAIMS is now online

www.biorxiv.org/content/10.1...
Low-resolution FAIMS for increased peptide coverage in low-load and single-cell proteomics
Field Asymmetric Ion Mobility Spectrometry (FAIMS) enhances signal to noise ratio filtering ions based on their differential mobility, making it an indispensable tool for single-cell and low-input pro...
www.biorxiv.org
August 28, 2025 at 1:01 PM
hamishs.bsky.social
👀 A simple optimization giving substantial benefits. A little like widening an over-tight quadrupole window to help transmission.
August 27, 2025 at 11:42 AM
hamishs.bsky.social
My great colleague Tabi is featured in JASMS. Check out his story.
August 16, 2025 at 2:08 PM
Reposted by Hamish Stewart
baybioms.bsky.social
🎉 BayBioMS turns 10! 🎉

2025 marks our 10th anniversary of Mapping Molecular Mountains.

Thus, we’re excited to invite you to the 10 Years of #BayBioMS #Symposium – a celebration of a decade of accelerating #MassSpectrometry research at the @tum.de!

🧵(1/6)
July 22, 2025 at 4:36 AM
Reposted by Hamish Stewart
jesperolsenlab.bsky.social
🚀 Check out our preprint on the new Thermo Scientific Orbitrap Astral Zoom MS 💫👇🏼

www.biorxiv.org/content/10.1...
Higher-Throughput Proteome Profiling Enabled by Parallelized Pre-Accumulation and Optimized Ion Processing in the Orbitrap Astral Zoom Mass Spectrometer
High-throughput proteomics is critical for understanding biological processes, enabling large-scale studies such as biomarker discovery and systems biology. However, current mass spectrometry technolo...
www.biorxiv.org
July 19, 2025 at 9:22 AM
Reposted by Hamish Stewart
jesperolsenlab.bsky.social
Boosting Orbitrap MS/MS speed to ∼70 Hz? 🚀

Read how we did it in our latest paper 👇

pubs.acs.org/doi/10.1021/...
Enhancing Tandem MS Sensitivity and Peptide Identification via Ion Preaccumulation in an Orbitrap Mass Spectrometer
High-throughput mass spectrometry-based proteomics has gained increasing interest for both academic and industrial applications. As implementation of faster gradients has facilitated higher sample thr...
pubs.acs.org
July 1, 2025 at 12:29 PM
Reposted by Hamish Stewart
rsc.org
🎉 Today we reveal the 2025 RSC Prize winners! 🎉

Celebrating excellence across research, diversity, tech roles, apprentices and partnerships. Join us in congratulating the remarkable individuals and teams advancing chemistry for society. buff.ly/K2un4O1 #Chemistry #ChemSky
Congratulations banner from the Royal Society of Chemistry featuring a medallion with symbolic icons representing various scientific elements and achievements, surrounded by a stardust background with the text "#RSCPrizes".
June 25, 2025 at 10:00 AM
Reposted by Hamish Stewart
cashwood.proteaglyco.com
Orbitrap Astral Team receive the RSC 2025 Analytical Science Horizon Prize: Robert Boyle Prize.

Interesting information about what each role does at TFS.

A good read:
www.rsc.org/standards-an...
June 25, 2025 at 11:43 AM
Reposted by Hamish Stewart
massspecpro.bsky.social
RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot.

nationalmaglab.org/careers/meet...
Alan Marshall: A scientist and a Gentleman - MagLab
Meet one of the greatest innovators in the history of mass spectrometry, hard at work.
nationalmaglab.org
June 12, 2025 at 2:03 PM
hamishs.bsky.social
Perfectly timed for the Orbitrap Astral Zoom launch today.
June 1, 2025 at 2:18 PM
Reposted by Hamish Stewart
jwoessmann.bsky.social
I am excited to share the first project of my PhD on bioRxiv and just in time for #ASMS2025 !
Increasing the sensitivity in single cell proteomics to quantify transcription factors in single hematopoietic stem and progenitor cells by iDIA.
www.biorxiv.org/content/10.1...
Informed Data-Independent Acquisition Enables Targeted Quantification of Key Regulatory Proteins in Cell Fate Decision at Single-Cell Resolution
Cellular differentiation processes are largely orchestrated by variation in transcription factor (TF) abundance. Since these proteins are usually expressed at extremely low levels, studying TF-driven ...
www.biorxiv.org
May 31, 2025 at 6:01 PM
Reposted by Hamish Stewart
erwinschoof.bsky.social
The Cell Diversity Lab is well represented at this year's ASMS; please come and talk with Jakob Woessmann and Benjamin Furtwängler to hear all about their latest efforts in improving, and applying single-cell proteomics by MS.

#singlecellproteomics #teammassspec #cellheterogeneity
May 31, 2025 at 10:55 AM
Reposted by Hamish Stewart
slavov-n.bsky.social
A new dimension for multiplexing mass spec analysis -- time -- is enabling scaling up throughput at new levels.

We demonstrate 27-plex DIA enabling over 500 samples / day.

We project that timePlex will enable throughputs exceeding 1,000 samples / day.

www.biorxiv.org/content/10.1...
May 28, 2025 at 10:32 AM
Reposted by Hamish Stewart
pastelbio.bsky.social
News in Proteomics Research blog post | MAP-MS! Get more Orbitrap dynamic range for free! proteomicsnews.blogs...

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#proteomics #prot-other
May 19, 2025 at 6:40 PM
Reposted by Hamish Stewart
pastelbio.bsky.social
Neil Kelleher: The Human Proteoform Project Could Transform Medicine theanalyticalscienti...

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#proteomics #prot-article
May 3, 2025 at 7:20 PM
Reposted by Hamish Stewart
joostsnijder.bsky.social
Excited to announce our revamped PhD-level BioMS course this September:

Advanced Proteomics for Drug Discovery and Biotherapeutics

Great line-up of instructors and topics, registration is open:
www.hecklab.com/advanced-pro...
April 29, 2025 at 9:32 AM
Reposted by Hamish Stewart
natmethods.nature.com
CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm that deconvolves any MS2 spectrum, regardless of whether it was acquired by DDA, DIA or PRM, thus unifying analysis of bottom-up proteomics data.
@msaid-de.bsky.social @kusterlab.bsky.social www.nature.com/articles/s41...
April 22, 2025 at 5:12 PM
hamishs.bsky.social
Nice reassuring thread on Astral uptime.

Trends away from large injections and towards wider adoption of FAIMS are a boon.
kmechtler.bsky.social kmechtler.bsky.social @kmechtler.bsky.social · Apr 8
A few years ago I reported on the cleaning cycles of a Thermo instrument (Q-Exactive HF-X). This is particularly important in core facilities where high throughput and consistent quality are required.
Now I would like to report briefly on the OrbiTrap Astral: Installation was done 1 year ago!
April 9, 2025 at 6:22 PM
hamishs.bsky.social
Mass spectrometers appearing in the news, in this case the work of the Murdoch Children's Research Institute.

www.foxnews.com/health/inter...
March 17, 2025 at 10:01 AM
Reposted by Hamish Stewart
fourmohryears.bsky.social
We had built something conceptually similar using the front lens on an ICR (or adjacent quad segments) in a segmented PCB quad to trap ions between the LIT and ICR cell on our development instrument to improve trapping for short ICR array cells. Nightmarish to optimize timings, very impressive work
March 6, 2025 at 5:42 PM
hamishs.bsky.social
Really nice results from the Olsen group, evaluating the pre-accumulation method, which multiplies Orbitrap duty cycle at short transients and allows >70 Hz repetition rates.

They then combined it with PhiSDM spectral processing, mitigating the resolution sacrifice.
www.biorxiv.org/content/10.1...
February 26, 2025 at 1:26 PM