Erwin Schoof
@erwinschoof.bsky.social
Biological Mass Spectrometry enthusiast, trying to make sense of cellular hierarchies and heterogeneity
Reposted by Erwin Schoof
NEW
Researcher Profiles in Altmetric
Altmetric tracks research items and where they are mentioned or cited online. Searching by researcher name wasn't a feature unless you imported your own from a repository or CRIS
Today we are launching a global researcher search feature.
1/5
Researcher Profiles in Altmetric
Altmetric tracks research items and where they are mentioned or cited online. Searching by researcher name wasn't a feature unless you imported your own from a repository or CRIS
Today we are launching a global researcher search feature.
1/5
September 16, 2025 at 10:46 AM
NEW
Researcher Profiles in Altmetric
Altmetric tracks research items and where they are mentioned or cited online. Searching by researcher name wasn't a feature unless you imported your own from a repository or CRIS
Today we are launching a global researcher search feature.
1/5
Researcher Profiles in Altmetric
Altmetric tracks research items and where they are mentioned or cited online. Searching by researcher name wasn't a feature unless you imported your own from a repository or CRIS
Today we are launching a global researcher search feature.
1/5
Reposted by Erwin Schoof
@kentsisresearch.bsky.social develop a proteogenomics workflow to detect 1000s of unknown cancer proteins. PG3 combines long-read RNA sequencing with multi-protease MS to discover non-canonical proteins in cancer cells. Used a timsTOF HT, nanoElute 2 & Aurora Ultimate 25x75 column:
bit.ly/4mlQSmu
bit.ly/4mlQSmu
September 16, 2025 at 12:19 AM
@kentsisresearch.bsky.social develop a proteogenomics workflow to detect 1000s of unknown cancer proteins. PG3 combines long-read RNA sequencing with multi-protease MS to discover non-canonical proteins in cancer cells. Used a timsTOF HT, nanoElute 2 & Aurora Ultimate 25x75 column:
bit.ly/4mlQSmu
bit.ly/4mlQSmu
Reposted by Erwin Schoof
When testing a computational data analysis method: simulated data are good for checking whether the method is doing what you think it should be doing, real data for checking whether what you think it should be doing is any good.
August 30, 2025 at 9:37 AM
When testing a computational data analysis method: simulated data are good for checking whether the method is doing what you think it should be doing, real data for checking whether what you think it should be doing is any good.
Reposted by Erwin Schoof
Are Solid Particles Ready for Prime-Time Proteomics? pubs.acs.org/doi/10....
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#proteomics #prot-paper
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#proteomics #prot-paper
August 24, 2025 at 7:00 AM
Are Solid Particles Ready for Prime-Time Proteomics? pubs.acs.org/doi/10....
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#proteomics #prot-paper
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#proteomics #prot-paper
Reposted by Erwin Schoof
Start of the European symposium in single cell proteomics at beautiful Viena with a workshop on spatial proteomics organised by @coscialab.bsky.social
August 25, 2025 at 7:08 AM
Start of the European symposium in single cell proteomics at beautiful Viena with a workshop on spatial proteomics organised by @coscialab.bsky.social
Reposted by Erwin Schoof
Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics www.science.org/doi/...
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#proteomics #prot-paper
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#proteomics #prot-paper
August 25, 2025 at 7:20 AM
Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics www.science.org/doi/...
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#proteomics #prot-paper
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#proteomics #prot-paper
Only a few more hours! 😃
The European Symposium on Single Cell Proteomics (ESCP) will be held in Vienna for the 6th time, from August 26th – 27th 2025 This year's focus will include spatial proteomics studies on the single-cell level. There is no registration fee
Hotel rooms in Vienna are inexpensive.
www.apma.at/6thescp/
Hotel rooms in Vienna are inexpensive.
www.apma.at/6thescp/
6th ESCP 2025 – APMA
www.apma.at
August 26, 2025 at 4:19 AM
Only a few more hours! 😃
Reposted by Erwin Schoof
We’re excited to present this integrative analysis of single-cell proteomics and transcriptomics of the human HSPC hierarchy. Now published in @science.org together with @fabiantheis.bsky.social, @erwinschoof.bsky.social, @porsebo.bsky.social.
www.science.org/doi/10.1126/...
🧵
www.science.org/doi/10.1126/...
🧵
Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics
Single-cell transcriptomics (scRNA-seq) has facilitated the characterization of cell state heterogeneity and recapitulation of differentiation trajectories. However, the exclusive use of mRNA measurem...
www.science.org
August 22, 2025 at 6:03 AM
We’re excited to present this integrative analysis of single-cell proteomics and transcriptomics of the human HSPC hierarchy. Now published in @science.org together with @fabiantheis.bsky.social, @erwinschoof.bsky.social, @porsebo.bsky.social.
www.science.org/doi/10.1126/...
🧵
www.science.org/doi/10.1126/...
🧵
Reposted by Erwin Schoof
Here’s an interesting story for #teammassspec. Liraglutide went generic in December 2024 and we have been developing methods for impurity characterization but we kept seeing an unusual modification with a +12 Da shift. A little digging revealed that others had noticed that the n-terminal histidine..
August 15, 2025 at 11:30 PM
Here’s an interesting story for #teammassspec. Liraglutide went generic in December 2024 and we have been developing methods for impurity characterization but we kept seeing an unusual modification with a +12 Da shift. A little digging revealed that others had noticed that the n-terminal histidine..
Reposted by Erwin Schoof
Pumped to finally show off our spatial proteomics work presented a few weeks ago at the EAS Congress @eassociety.bsky.social and now live on @biorxivpreprint.bsky.social 🥳
Time for a science thread! #TeamMassSpec #SpatialProteomics #AtheroSky 🧵
www.biorxiv.org/content/10.1...
Time for a science thread! #TeamMassSpec #SpatialProteomics #AtheroSky 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 23, 2025 at 6:56 PM
Pumped to finally show off our spatial proteomics work presented a few weeks ago at the EAS Congress @eassociety.bsky.social and now live on @biorxivpreprint.bsky.social 🥳
Time for a science thread! #TeamMassSpec #SpatialProteomics #AtheroSky 🧵
www.biorxiv.org/content/10.1...
Time for a science thread! #TeamMassSpec #SpatialProteomics #AtheroSky 🧵
www.biorxiv.org/content/10.1...
Reposted by Erwin Schoof
Tried presenting my data at #EuPA2025. Then decided to scale things up... Turns out, volcano plots look great in sand and people are more interested in what we scientists do.
#Proteomics #YPIC #YPIContest2025
#Proteomics #YPIC #YPIContest2025
June 19, 2025 at 1:27 PM
Tried presenting my data at #EuPA2025. Then decided to scale things up... Turns out, volcano plots look great in sand and people are more interested in what we scientists do.
#Proteomics #YPIC #YPIContest2025
#Proteomics #YPIC #YPIContest2025
Reposted by Erwin Schoof
The reports of Bluesky’s death have been greatly exaggerated
The trend is still in Bluesky's favour. X is still larger but very regularly Bluesky easily eclipses it in terms of research being shared.
Linda Yaccarino claimed X had 600m users in April. Bluesky has 36m accounts created in total.
Linda Yaccarino claimed X had 600m users in April. Bluesky has 36m accounts created in total.
June 20, 2025 at 9:52 AM
The reports of Bluesky’s death have been greatly exaggerated
Reposted by Erwin Schoof
The financial crisis of the HE sector in the UK now leads to increased numbers of grant and fellowship applications, pushing down the success rates. Since also overheads increased, in some cases we will see success rates halved.
There is a BBSRC fellowship which will have a success rate of 5%.
There is a BBSRC fellowship which will have a success rate of 5%.
June 20, 2025 at 9:08 AM
The financial crisis of the HE sector in the UK now leads to increased numbers of grant and fellowship applications, pushing down the success rates. Since also overheads increased, in some cases we will see success rates halved.
There is a BBSRC fellowship which will have a success rate of 5%.
There is a BBSRC fellowship which will have a success rate of 5%.
On my way home from what was an absolute blast of a EuPA2025 in the lovely Saint-Malo in France. So much great science, amazing people, old & new friends, and not the least, our valuable tech partners. The future of proteomics is clearly still only beginning & we all seem to be enjoying the ride! :)
June 20, 2025 at 4:15 PM
On my way home from what was an absolute blast of a EuPA2025 in the lovely Saint-Malo in France. So much great science, amazing people, old & new friends, and not the least, our valuable tech partners. The future of proteomics is clearly still only beginning & we all seem to be enjoying the ride! :)
Reposted by Erwin Schoof
The year of "How deep can we go?"
Erwin Schoof presents a view of the deepest proteome coverage across various cell types at #EuPA2025, using the newly released Orbitrap Astral Zoom. Analysing 40 HEK2983T cells per day, using an Aurora Ultimate 25x75 will consistently get you ~6,000 protein IDs.
Erwin Schoof presents a view of the deepest proteome coverage across various cell types at #EuPA2025, using the newly released Orbitrap Astral Zoom. Analysing 40 HEK2983T cells per day, using an Aurora Ultimate 25x75 will consistently get you ~6,000 protein IDs.
June 19, 2025 at 6:33 AM
The year of "How deep can we go?"
Erwin Schoof presents a view of the deepest proteome coverage across various cell types at #EuPA2025, using the newly released Orbitrap Astral Zoom. Analysing 40 HEK2983T cells per day, using an Aurora Ultimate 25x75 will consistently get you ~6,000 protein IDs.
Erwin Schoof presents a view of the deepest proteome coverage across various cell types at #EuPA2025, using the newly released Orbitrap Astral Zoom. Analysing 40 HEK2983T cells per day, using an Aurora Ultimate 25x75 will consistently get you ~6,000 protein IDs.
Reposted by Erwin Schoof
Our amazing group of experts: Jenn Abelin, @berndwollscheid.bsky.social, @erwinschoof.bsky.social , Tim Van Den Bossche and Stefanie Hauck 👏
If you would like to join, please register using the QR code or this link: docs.google.com/forms/d/e/1F...
#Proteomics #EuPAFPS2025 #EuPA2025 #SaintMalo
If you would like to join, please register using the QR code or this link: docs.google.com/forms/d/e/1F...
#Proteomics #EuPAFPS2025 #EuPA2025 #SaintMalo
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
June 9, 2025 at 6:55 PM
Our amazing group of experts: Jenn Abelin, @berndwollscheid.bsky.social, @erwinschoof.bsky.social , Tim Van Den Bossche and Stefanie Hauck 👏
If you would like to join, please register using the QR code or this link: docs.google.com/forms/d/e/1F...
#Proteomics #EuPAFPS2025 #EuPA2025 #SaintMalo
If you would like to join, please register using the QR code or this link: docs.google.com/forms/d/e/1F...
#Proteomics #EuPAFPS2025 #EuPA2025 #SaintMalo
Still figuring out which evening workshop to attend tonight at #ASMS2025? Come on by Ballroom II and hear about hands-on tips and tricks for one of the hottest and fastest developing areas within LC-MS based proteomics, namely single-cell. 😃
June 4, 2025 at 6:53 PM
Still figuring out which evening workshop to attend tonight at #ASMS2025? Come on by Ballroom II and hear about hands-on tips and tricks for one of the hottest and fastest developing areas within LC-MS based proteomics, namely single-cell. 😃
Reposted by Erwin Schoof
WE ARE RECRUITING: A tenure-track group leader position in translational cancer research is available at the Finsen Laboratory in Copenhagen. Come join an excellent and friendly research environment combining both hospital and university affiliated groups
candidate.hr-manager.net/ApplicationI...
candidate.hr-manager.net/ApplicationI...
Tenure-track Research Group leader position in translational cancer research at the Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital
A group leader position at the Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital is open for appointment as soon as possible. The position is av
candidate.hr-manager.net
June 3, 2025 at 10:11 AM
WE ARE RECRUITING: A tenure-track group leader position in translational cancer research is available at the Finsen Laboratory in Copenhagen. Come join an excellent and friendly research environment combining both hospital and university affiliated groups
candidate.hr-manager.net/ApplicationI...
candidate.hr-manager.net/ApplicationI...
Reposted by Erwin Schoof
#ASMS2025 offers great evening workshops. If you are interested in real-time decision-making during MS data acquisition or still looking for one to join,
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
June 2, 2025 at 11:55 AM
#ASMS2025 offers great evening workshops. If you are interested in real-time decision-making during MS data acquisition or still looking for one to join,
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
Reposted by Erwin Schoof
#ASMS2025
Come here about the latest in real-time instrument control including applications to single cell proteomics (@parallelsq.bsky.social), #glycotime, and quantitative proteomics!
Come here about the latest in real-time instrument control including applications to single cell proteomics (@parallelsq.bsky.social), #glycotime, and quantitative proteomics!
#ASMS2025 offers great evening workshops. If you are interested in real-time decision-making during MS data acquisition or still looking for one to join,
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
consider the Real time Mass Spectrometry Workshop featuring speakers and panelists Sarah Sipe, Aarthie Senathirajah, and Manuel Peris Diaz.
June 2, 2025 at 12:40 PM
#ASMS2025
Come here about the latest in real-time instrument control including applications to single cell proteomics (@parallelsq.bsky.social), #glycotime, and quantitative proteomics!
Come here about the latest in real-time instrument control including applications to single cell proteomics (@parallelsq.bsky.social), #glycotime, and quantitative proteomics!
Reposted by Erwin Schoof
I am really pleased we managed to squeeze this story out during #ASMS2025. This is our contribution relating to the fantastic Omnitrap/Orbitrap. What we thought would be a straightforward conversation of our exploris-omnitrap turned into quite a journey. (1/n)
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Integrating Alternative Fragmentation Techniques into Standard LC-MS Workflows Using a Single Deep Learning Model Enhances Proteome Coverage
We built and characterised a mass spectrometer capable of performing CID (both beam type and resonant type), UVPD, EID and ECD in an automated fashion during an LCMS type experiment. We exploited this...
www.biorxiv.org
June 1, 2025 at 5:17 PM
I am really pleased we managed to squeeze this story out during #ASMS2025. This is our contribution relating to the fantastic Omnitrap/Orbitrap. What we thought would be a straightforward conversation of our exploris-omnitrap turned into quite a journey. (1/n)
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Erwin Schoof
New Preprint ... This was a bit different of a project than what we normally do for hardware comparisons. I think there is a lot of potential in the methods mentioned here for calibrating the instrument response to a common scale. Nice work by @chrhsu.bsky.social!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Evaluation of an Orbitrap Astral Zoom mass spectrometer prototype for quantitative proteomics - beyond identification lists
Mass spectrometry instrumentation continues to evolve rapidly, yet quantifying these advances beyond conventional peptide and protein detections remains challenging. Here, we evaluate a modified Orbit...
www.biorxiv.org
June 1, 2025 at 4:47 AM
New Preprint ... This was a bit different of a project than what we normally do for hardware comparisons. I think there is a lot of potential in the methods mentioned here for calibrating the instrument response to a common scale. Nice work by @chrhsu.bsky.social!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Erwin Schoof
Evaluation of an Orbitrap Astral Zoom mass spectrometer prototype for quantitative proteomics - beyond identification lists www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
June 1, 2025 at 4:00 PM
Evaluation of an Orbitrap Astral Zoom mass spectrometer prototype for quantitative proteomics - beyond identification lists www.biorxiv.org/cont...
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#proteomics #prot-preprint
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#proteomics #prot-preprint
Reposted by Erwin Schoof
Yesterday, we fired up the grill at our annual Evosep User Meeting. It was inspiring to reconnect with users and colleagues from the #proteomics community.
If you’ve got room for a little more orange in your morning, join us for breakfast tomorrow. www.evosep.com/asms2025/
If you’ve got room for a little more orange in your morning, join us for breakfast tomorrow. www.evosep.com/asms2025/
June 1, 2025 at 4:14 PM
Yesterday, we fired up the grill at our annual Evosep User Meeting. It was inspiring to reconnect with users and colleagues from the #proteomics community.
If you’ve got room for a little more orange in your morning, join us for breakfast tomorrow. www.evosep.com/asms2025/
If you’ve got room for a little more orange in your morning, join us for breakfast tomorrow. www.evosep.com/asms2025/
Thanks for the kind shout out, Ben! 🙏🏻 Hope to catch you in Baltimore!
Interested! I'll sure try to swing by! proteomicsnews.blogspot.com/2025/05/info...
Informed DIA allows transcription factor quan in single cells? Also, new Astral?
If you've seen me talk about single cell proteomics, I like to point out the proteins I can see (50,000 copies and up) and I make a joke s...
proteomicsnews.blogspot.com
June 1, 2025 at 9:45 AM
Thanks for the kind shout out, Ben! 🙏🏻 Hope to catch you in Baltimore!