ProteomicsNews (Ben Orsburn)
@proteomicsnews.bsky.social
Assistant Professor at the University of Pittsburgh. What?? Previous industry CSO. Proteomics researcher with time consuming hobbies in scientific outreach. Opinions are often loud and exclusively my own. www.proteomics.rocks (he/him/his/dude)
After our recent neverending snow I worked from home a lot and got back to crunching piles of data on my @omicspcs.bsky.social Destroyer I bought at ASMS INDIANAPOLIS. It's happily tearing through Zoom and Ultra data right now. It's almost 9 years old! Ridiculously great hardware investment.
February 20, 2026 at 1:42 PM
After our recent neverending snow I worked from home a lot and got back to crunching piles of data on my @omicspcs.bsky.social Destroyer I bought at ASMS INDIANAPOLIS. It's happily tearing through Zoom and Ultra data right now. It's almost 9 years old! Ridiculously great hardware investment.
Okay, it's super messed up that malaria epigenetics is the same time as my US HUPO talk. What did I do to the organizers? I made the mascot, for crying out loud. I would totally skip my talk to see malaria epigenetics, but my dumb ass has to be on stage. Wait. OMG, ROFLMAO
February 19, 2026 at 1:07 AM
Okay, it's super messed up that malaria epigenetics is the same time as my US HUPO talk. What did I do to the organizers? I made the mascot, for crying out loud. I would totally skip my talk to see malaria epigenetics, but my dumb ass has to be on stage. Wait. OMG, ROFLMAO
Astral with 2 minute gradients! More quantification off of triangles! www.nature.com/articles/s41... - I get it, I'm being the old jerk shouting at cars about how in my day we had to have more than 1 scan/peak.
February 16, 2026 at 9:02 PM
Astral with 2 minute gradients! More quantification off of triangles! www.nature.com/articles/s41... - I get it, I'm being the old jerk shouting at cars about how in my day we had to have more than 1 scan/peak.
Docusign continuing to allow me to draw my signature on things like mortgage documents is possibly my favorite part of being a grown up in the age of the internet.
February 11, 2026 at 10:33 PM
Docusign continuing to allow me to draw my signature on things like mortgage documents is possibly my favorite part of being a grown up in the age of the internet.
Wait. Is vibe coding just typing stuff into Claude and having it make you shitty code?
February 10, 2026 at 11:34 PM
Wait. Is vibe coding just typing stuff into Claude and having it make you shitty code?
Whenever Indeed sends me a job listing that is like "your expertise in mass spectrometry would make you an ideal fit for this opening in Florida for a clinical psychiatrist" I always take the time to confirm that their AI is doing a great job.
February 6, 2026 at 4:35 PM
Whenever Indeed sends me a job listing that is like "your expertise in mass spectrometry would make you an ideal fit for this opening in Florida for a clinical psychiatrist" I always take the time to confirm that their AI is doing a great job.
Reposted by ProteomicsNews (Ben Orsburn)
Ben @proteomicsnews.bsky.social and I did our big 100th episode of #THEProteomicsShow, but our guest was an extremely snarky AI overlord super fan. Not sure where it ranks on our dumb ideas list, but fun as always. Find it wherever you find fine podcasts. Upcoming live episode has real guests.
February 4, 2026 at 5:33 AM
Ben @proteomicsnews.bsky.social and I did our big 100th episode of #THEProteomicsShow, but our guest was an extremely snarky AI overlord super fan. Not sure where it ranks on our dumb ideas list, but fun as always. Find it wherever you find fine podcasts. Upcoming live episode has real guests.
UofK is looking for a mass spec core director. Deadline to apply is 2/22. ukjobs.uky.edu/postings/617...
Service Core Director
The Mass Spectrometry Core Facility Director at the University of Kentucky provides strategic and scientific leadership guiding innovation, growth, and operational excellence. The role leads the devel...
ukjobs.uky.edu
February 2, 2026 at 3:18 PM
UofK is looking for a mass spec core director. Deadline to apply is 2/22. ukjobs.uky.edu/postings/617...
Reposted by ProteomicsNews (Ben Orsburn)
Setting technological improvements aside, what the top biological findings of the last 30 years of #proteomics?
February 1, 2026 at 3:58 PM
Setting technological improvements aside, what the top biological findings of the last 30 years of #proteomics?
Reposted by ProteomicsNews (Ben Orsburn)
Authors who need to comply with U.S. federal funder requirements for immediate #PublicAccess have multiple publishing options in ACS journals. Following recent engagements with NIH, we’re confident all options may be expensed against grants.
Learn more: buff.ly/GFA7OzI
#OpenAccess #OpenScience
Learn more: buff.ly/GFA7OzI
#OpenAccess #OpenScience
Grant-Compliant Options to Publish Immediate Public Access in ACS Journals
Authors who need to comply with U.S. federal funder requirements for immediate public access have multiple publishing options in ACS journals. Following recent engagements with NIH, we’re confident…
buff.ly
February 1, 2026 at 6:34 PM
Authors who need to comply with U.S. federal funder requirements for immediate #PublicAccess have multiple publishing options in ACS journals. Following recent engagements with NIH, we’re confident all options may be expensed against grants.
Learn more: buff.ly/GFA7OzI
#OpenAccess #OpenScience
Learn more: buff.ly/GFA7OzI
#OpenAccess #OpenScience
(1/2) After searching 10 years for ANY evidence that SomaScan can provide ANY useful protein measurement data, my reanalysis of the data from this study found (TWO!) proteins quantified by aptamers that can be supported by real methods. this is still the dumbest f'ing way to "measure" a protein,
February 1, 2026 at 5:26 PM
(1/2) After searching 10 years for ANY evidence that SomaScan can provide ANY useful protein measurement data, my reanalysis of the data from this study found (TWO!) proteins quantified by aptamers that can be supported by real methods. this is still the dumbest f'ing way to "measure" a protein,
Steaming hot new method alert! ShtMtPro! proteomicsnews.blogspot.com/2026/02/targ...
Target PTMs in single cells with ShtMtPro!
YES! Okay, so this is may finally be the smart solution to something we tried (and probably just about everyone else) with the SCoPE-MS/Sc...
proteomicsnews.blogspot.com
February 1, 2026 at 12:33 PM
Steaming hot new method alert! ShtMtPro! proteomicsnews.blogspot.com/2026/02/targ...
Reposted by ProteomicsNews (Ben Orsburn)
Yep, Ben @proteomicsnews.bsky.social and I finally got Bill Noble on #THEProteomicsShow. We had been wanting him on forever so he went and won an award to make it easier for us to meet. Enjoy the rambles (I hope), and mind the monkeys. Find it wherever you find fine podcasts.
January 30, 2026 at 4:46 PM
Yep, Ben @proteomicsnews.bsky.social and I finally got Bill Noble on #THEProteomicsShow. We had been wanting him on forever so he went and won an award to make it easier for us to meet. Enjoy the rambles (I hope), and mind the monkeys. Find it wherever you find fine podcasts.
Anyone know if tools exist that can help identify LCMS files that are altered...or...umm... completely fabricated...? @magnuspalmblad.bsky.social ?
January 30, 2026 at 3:30 PM
Anyone know if tools exist that can help identify LCMS files that are altered...or...umm... completely fabricated...? @magnuspalmblad.bsky.social ?
Episode 98? Finally! (I've been busy) With 2026 Gilman Award for Computational Proteomics Award Winner Bill Noble!
January 30, 2026 at 1:56 PM
Episode 98? Finally! (I've been busy) With 2026 Gilman Award for Computational Proteomics Award Winner Bill Noble!
Reposted by ProteomicsNews (Ben Orsburn)
Ep 98: bridgerton, cocaine monkeys, and birding… making sure you know we aren’t AI, right @proteomicsnews.bsky.social.
January 29, 2026 at 8:15 PM
Ep 98: bridgerton, cocaine monkeys, and birding… making sure you know we aren’t AI, right @proteomicsnews.bsky.social.
Single cell proteomics of the developing human brain! Question everything you thought made sense in LCMS based proteomics? proteomicsnews.blogspot.com/2026/01/sing...
Single cell proteomics of the developing human brain!
Big thanks to Matt MacDonald for sending this last night with a "Wow" as the total email content so that I got to sleep at like 1am after ...
proteomicsnews.blogspot.com
January 28, 2026 at 2:01 PM
Single cell proteomics of the developing human brain! Question everything you thought made sense in LCMS based proteomics? proteomicsnews.blogspot.com/2026/01/sing...
Spatial RnaSeq plus a cocktail of dozens of antibodies (oligonucleotide tagged) squeezes loads of data out of every slide! www.nature.com/articles/s41... 6 months and $30k/slide? Probably! But it’s beautiful!
Integration of imaging-based and sequencing-based spatial omics mapping on the same tissue section via DBiTplus - Nature Methods
DBiTplus represents an integrated experimental and computational workflow that unifies sequencing-based and imaging-based spatial omics, demonstrated by combining transcriptomic profiling and multiple...
www.nature.com
January 15, 2026 at 11:08 PM
Spatial RnaSeq plus a cocktail of dozens of antibodies (oligonucleotide tagged) squeezes loads of data out of every slide! www.nature.com/articles/s41... 6 months and $30k/slide? Probably! But it’s beautiful!
www.technology.org/2026/01/10/n.... Has anyone seen this paper? It’s not linked in the press release and I couldn’t find it with a phone.
www.technology.org
January 14, 2026 at 10:54 PM
www.technology.org/2026/01/10/n.... Has anyone seen this paper? It’s not linked in the press release and I couldn’t find it with a phone.
Reposted by ProteomicsNews (Ben Orsburn)
I made a google notebook llm based on this www.nature.com/articles/s41... and new data concerning mRNA - Protein expression correlation over the last year. It even wrote a grant , which you can find in there if anyone wants to submit it ! notebooklm.google.com/notebook/2c7...
January 14, 2026 at 10:25 PM
I made a google notebook llm based on this www.nature.com/articles/s41... and new data concerning mRNA - Protein expression correlation over the last year. It even wrote a grant , which you can find in there if anyone wants to submit it ! notebooklm.google.com/notebook/2c7...
..dear bluesky... today I saw a 1 star product review because a Pennsylvania 11 year old child's semi-automatic rifle jammed and shells detonated inside said child's semi-automatic rifle. The store has reduced said rifle by $50 to $199.99... So....ummm....how is your country today...?
January 14, 2026 at 1:21 PM
..dear bluesky... today I saw a 1 star product review because a Pennsylvania 11 year old child's semi-automatic rifle jammed and shells detonated inside said child's semi-automatic rifle. The store has reduced said rifle by $50 to $199.99... So....ummm....how is your country today...?
Proteomics of butterfly metamorphosis with eccentric data processing still outperforms transcriptomics! proteomicsnews.blogspot.com/2026/01/prot...
Proteomics of butterfly metamorphosis!
A little disappointed by this picture, but nothing else in this great new study! Fixed it! Wrong butterfly, but I don't care and neither...
proteomicsnews.blogspot.com
January 13, 2026 at 10:07 AM
Proteomics of butterfly metamorphosis with eccentric data processing still outperforms transcriptomics! proteomicsnews.blogspot.com/2026/01/prot...
How does COVID affect hamsters?!? Proteomics answers the question at the front of all of our minds today. proteomicsnews.blogspot.com/2026/01/how-...
a close up of a hamster with its mouth open and a pink nose .
ALT: a close up of a hamster with its mouth open and a pink nose .
media.tenor.com
January 12, 2026 at 10:10 PM
How does COVID affect hamsters?!? Proteomics answers the question at the front of all of our minds today. proteomicsnews.blogspot.com/2026/01/how-...
...pushed publish by accident on a post on a new SomaScan paper that is on something truly important that really truly matters. Deleted. Please disregard. Might need to hide the keyboards. ONE PATIENT EVER. THE ONLY ONE. APTAMERS?!?!?
January 10, 2026 at 9:27 PM
...pushed publish by accident on a post on a new SomaScan paper that is on something truly important that really truly matters. Deleted. Please disregard. Might need to hide the keyboards. ONE PATIENT EVER. THE ONLY ONE. APTAMERS?!?!?
