Ronald Beavis ❌
@ronbeavis.bsky.social
Doing science for money since 1981.
Putting it online since 1995.
Does not engage in cancer research.
QA >> QC
I enjoy doing things I am not very good at doing.
Putting it online since 1995.
Does not engage in cancer research.
QA >> QC
I enjoy doing things I am not very good at doing.
Looks like another LLM-corpus-stuffing attack is going on this morning: these silly things waste more time than they are probably ever worth for the attackers.
November 11, 2025 at 4:15 PM
Looks like another LLM-corpus-stuffing attack is going on this morning: these silly things waste more time than they are probably ever worth for the attackers.
Does any one really believe in non-linear epitopes any more? They are mentioned in recent reviews (often with names like "conformational" or "discontinuous" epitope), but they do seem to have fallen out of favour.
November 11, 2025 at 2:57 PM
Does any one really believe in non-linear epitopes any more? They are mentioned in recent reviews (often with names like "conformational" or "discontinuous" epitope), but they do seem to have fallen out of favour.
Ankyrin repeat domain 17 (ANKRD17:p) actually has 2 of them, with the regular striping artifact frequently found in calculated structures for this type of domain. The pS acceptor action near the N-terminus and the broader cward pIDR are not identical but clearly evolutionarily conserved. #proteomics
November 11, 2025 at 2:13 PM
Ankyrin repeat domain 17 (ANKRD17:p) actually has 2 of them, with the regular striping artifact frequently found in calculated structures for this type of domain. The pS acceptor action near the N-terminus and the broader cward pIDR are not identical but clearly evolutionarily conserved. #proteomics
Tetratricopeptide repeat, ankyrin repeat & coiled-coil containing 2 (TANC2:p) appears very similar to TANC1:p in this representation, even though they share only a few tryptic peptides (~2% of residues). The same domains (incl. no coiled-coils) & dazzle patterned pIDRs. #proteomics
November 10, 2025 at 12:18 PM
Tetratricopeptide repeat, ankyrin repeat & coiled-coil containing 2 (TANC2:p) appears very similar to TANC1:p in this representation, even though they share only a few tryptic peptides (~2% of residues). The same domains (incl. no coiled-coils) & dazzle patterned pIDRs. #proteomics
Reposted by Ronald Beavis ❌
No one understands speculative bubbles better than Bill Janeway. And while he acknowledges uncertainty about when and how an AI bubble will burst - and its ultimate effects - he’s signalling concern.
“signs of leverage are beginning to emerge.”
www.project-syndicate.org/onpoint/will...
“signs of leverage are beginning to emerge.”
www.project-syndicate.org/onpoint/will...
In Search of the AI Bubble’s Economic Fundamentals
William H. Janeway explains why the sector might be better off if the reckoning comes sooner rather than after leverage piles up.
www.project-syndicate.org
November 8, 2025 at 8:52 PM
No one understands speculative bubbles better than Bill Janeway. And while he acknowledges uncertainty about when and how an AI bubble will burst - and its ultimate effects - he’s signalling concern.
“signs of leverage are beginning to emerge.”
www.project-syndicate.org/onpoint/will...
“signs of leverage are beginning to emerge.”
www.project-syndicate.org/onpoint/will...
Reposted by Ronald Beavis ❌
Kudos to the organizers (Jennifer Geddes-McAlister, @mlaval6.bsky.social, Marie Brunet) for arranging snow to coincide with the start of HUPO 2025 in Toronto!
November 9, 2025 at 6:03 PM
Kudos to the organizers (Jennifer Geddes-McAlister, @mlaval6.bsky.social, Marie Brunet) for arranging snow to coincide with the start of HUPO 2025 in Toronto!
Reposted by Ronald Beavis ❌
In Canada, this has changed significantly -- the rich have never been richer and a majority of low income renters live in property that solely exists to funnel profits to shareholders via rents and disrepair.
Drawn 133 years ago, and the con hasn't changed one bit.
November 9, 2025 at 4:22 PM
In Canada, this has changed significantly -- the rich have never been richer and a majority of low income renters live in property that solely exists to funnel profits to shareholders via rents and disrepair.
Reposted by Ronald Beavis ❌
UK government project using AI to find benefit fraud resulted in:
- A 46% false fraud rate
- Anguish for families who were wrongly accused of fraud and had benefits stopped
- Months of additional work for government, setting up a hotline, correcting false fraud
www.theguardian.com/society/2025...
- A 46% false fraud rate
- Anguish for families who were wrongly accused of fraud and had benefits stopped
- Months of additional work for government, setting up a hotline, correcting false fraud
www.theguardian.com/society/2025...
HMRC trial of child benefit crackdown wrongly suspected fraud in 46% of cases
Exclusive: Almost half of families flagged as emigrants based on Home Office travel data were still living in UK
www.theguardian.com
November 9, 2025 at 3:11 PM
UK government project using AI to find benefit fraud resulted in:
- A 46% false fraud rate
- Anguish for families who were wrongly accused of fraud and had benefits stopped
- Months of additional work for government, setting up a hotline, correcting false fraud
www.theguardian.com/society/2025...
- A 46% false fraud rate
- Anguish for families who were wrongly accused of fraud and had benefits stopped
- Months of additional work for government, setting up a hotline, correcting false fraud
www.theguardian.com/society/2025...
Reposted by Ronald Beavis ❌
This is not a good look, Saskatchewan.
Some Ukrainian university students feel ‘betrayed’ as tuition could increase up to five-fold
Advanced Education Minister Ken Cheveldayoff said the program has been beneficial, and the provincial government wants to give people from Ukraine every opportunity to succeed in the province.
www.ckom.com
November 8, 2025 at 5:52 PM
This is not a good look, Saskatchewan.
Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 (TANC1:p) is one of those sequences in which its coiled-coil seems to have gone missing with time. The sequence is bedazzled with pS acceptors that nicely confirm the location of its IDRs. #proteomics
November 9, 2025 at 2:25 PM
Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 (TANC1:p) is one of those sequences in which its coiled-coil seems to have gone missing with time. The sequence is bedazzled with pS acceptors that nicely confirm the location of its IDRs. #proteomics
The eye wall of Very Strong Typhoon Fung-wong is making landfall on Luzon this morning.
November 9, 2025 at 12:05 PM
The eye wall of Very Strong Typhoon Fung-wong is making landfall on Luzon this morning.
I suspect there will be no shortage of groceries caused by Big John skedaddling to Miami. Wealth generated by consolidating ownership is not the same as creating truly new industries.
www.forbes.com/sites/martin...
www.forbes.com/sites/martin...
Supermarket Billionaire Reacts To Mamdani’s Win
Big Apple billionaire John Catsimatidis planned to move his business to New Jersey if Zohran Mamdani was elected mayor. Now he’s reconsidering.
www.forbes.com
November 8, 2025 at 3:41 PM
I suspect there will be no shortage of groceries caused by Big John skedaddling to Miami. Wealth generated by consolidating ownership is not the same as creating truly new industries.
www.forbes.com/sites/martin...
www.forbes.com/sites/martin...
JUN:p proto-oncogene, activator protein-1 transcription factor subunit is in a family of proteins that form homo/hetero-dimers via their cward basic L-zipper domains with different DNA specificities. They also share pS/T-IDRs: one flanking the L-zipper & a more complex nward set of acceptors.
November 8, 2025 at 2:17 PM
JUN:p proto-oncogene, activator protein-1 transcription factor subunit is in a family of proteins that form homo/hetero-dimers via their cward basic L-zipper domains with different DNA specificities. They also share pS/T-IDRs: one flanking the L-zipper & a more complex nward set of acceptors.
Reposted by Ronald Beavis ❌
Major media still not reporting the $1B cut to student grants becuase they can't get beyong stenography when writing up these pieces.
Here's what each federal department plans to cut under Budget 2025 | CBC News
Tuesday's federal budget offers a glimpse into how dozens of government departments plan to rein in spending following this summer's comprehensive expenditure review. Here's a department-by-departmen...
www.cbc.ca
November 7, 2025 at 4:38 PM
Major media still not reporting the $1B cut to student grants becuase they can't get beyong stenography when writing up these pieces.
Activating transcription factor 2 (ATF2:p) has 2 prominent pS/T acceptors on the cward flank of its C2H2 zinc finger & 2 on the nward flank of its basic L-zipper. To function, it must form a dimer with a complementary basic L-zipper containing sequence. #proteomics
November 7, 2025 at 1:56 PM
Activating transcription factor 2 (ATF2:p) has 2 prominent pS/T acceptors on the cward flank of its C2H2 zinc finger & 2 on the nward flank of its basic L-zipper. To function, it must form a dimer with a complementary basic L-zipper containing sequence. #proteomics
Seems like corporate governance has run up the Jolly Roger. 🏴☠️
www.cbc.ca/news/world/e...
www.cbc.ca/news/world/e...
Musk could become world's 1st trillionaire after Tesla shareholders approve giant pay package | CBC News
Elon Musk won a shareholder vote on Thursday that would give the Tesla CEO stock worth $1 trillion if he hits certain performance targets over the next decade, handing him a chance to become history's...
www.cbc.ca
November 7, 2025 at 12:25 AM
Seems like corporate governance has run up the Jolly Roger. 🏴☠️
www.cbc.ca/news/world/e...
www.cbc.ca/news/world/e...
Human RNF149:p is a leukocyte type I membrane protein. It has 7 experimentally observed ubiquitin acceptors on its cytoplasmic domain. These acceptors are all within its RING/FYVE/PHD-type Zn-finger domain. How many E3 ligases would you expect to be responsible for these modifications? #proteomics
November 6, 2025 at 7:39 PM
Human RNF149:p is a leukocyte type I membrane protein. It has 7 experimentally observed ubiquitin acceptors on its cytoplasmic domain. These acceptors are all within its RING/FYVE/PHD-type Zn-finger domain. How many E3 ligases would you expect to be responsible for these modifications? #proteomics
I am usually annoyed when some screen writer trots out Occam's Razor in a mystery story, but no where near as much as when I see it being used in a supposedly scientific publication as a justification for some lazy reasoning.
November 6, 2025 at 5:52 PM
I am usually annoyed when some screen writer trots out Occam's Razor in a mystery story, but no where near as much as when I see it being used in a supposedly scientific publication as a justification for some lazy reasoning.
Activating transcription factor 1 (ATF1:p) has 2 distinct pIDRs. There is an nward, low complexity S/T pIDR & another on the nward flank of its basic zipper DNA binding domain. The lace-curtain region in the middle may be largely β strands (based on modest evidence). #proteomics
November 6, 2025 at 1:52 PM
Activating transcription factor 1 (ATF1:p) has 2 distinct pIDRs. There is an nward, low complexity S/T pIDR & another on the nward flank of its basic zipper DNA binding domain. The lace-curtain region in the middle may be largely β strands (based on modest evidence). #proteomics
While they do have some stiff competition, I would nominate Genome Canada as the most embarrassing Canadian funding agency. Truly at the forefront 1990's ideas.
www.cbc.ca/news/health/...
www.cbc.ca/news/health/...
Major genetic screening project to check hereditary cancer, high cholesterol risk of up to 100,000 Canadians | CBC News
Over the the next five years, up to 100,000 people in Ontario will be screened for genetic conditions that increase their risk of hereditary cancers and a condition tied to high cholesterol and heart ...
www.cbc.ca
November 6, 2025 at 1:00 PM
While they do have some stiff competition, I would nominate Genome Canada as the most embarrassing Canadian funding agency. Truly at the forefront 1990's ideas.
www.cbc.ca/news/health/...
www.cbc.ca/news/health/...
